Éditeur(s) : Ieee-inst Electrical Electronics Engineers Inc
Résumé : Analyzing the precision of vegetation height estimation with compact (i.e., single transmit instead of dual transmit) polarimetric interferometric synthetic aperture radar (PolInSAR) with the homogeneous random volume over ground model can help justify the use of this type of radar rather than using the full PolInSAR. However, since compact PolInSAR provides less information than full PolInSAR, a loss of precision in the vegetation height estimation is expected, which can depend on the single transmit polarization. The adaptation of the Cramer-Rao bound (CRB) derived for full PolInSAR in our earlier work to compact PolInSAR measurement provides a general methodology to characterize this loss of precision. Indeed, the CRB is a lower bound of the variance of unbiased estimators that does not depend on the choice of a particular estimation method. We illustrate this methodology for P-band measurements with three synthetic examples chosen for their variability of polarimetric responses. For these examples, it is shown that there can exist a large set of transmit polarizations for which the loss of precision described by the CRB is small (smaller than a factor 2) although there also exist transmit polarizations for which the loss can be large (about a factor 100). This loss of precision is compared with the large dependency of the precision to the vegetation height estimation that can be observed with the vegetation height (more than a factor 100 in the precision described by the CRB) when all the other parameters of the vegetation, ground, and radar system are constant.
Ieee Transactions On Geoscience And Remote Sensing (0196-2892) (Ieee-inst Electrical Electronics Engineers Inc), 2014-03 , Vol. 52 , N. 3 , P. 1879-1891

Droits : Copyright 2014 IEEE - All rights reserved.
http://archimer.ifremer.fr/doc/00174/28551/26968.pdf
DOI:10.1109/TGRS.2013.2256362
http://archimer.ifremer.fr/doc/00174/28551/

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
There are emerging concerns about potential effects on child health and development of early-life exposure to substances such as brominated flame retardants (BFRs), perfluorinated compounds (PFCs), phthalates and phenols (including bisphenol A (BPA)); pregnancy and birth cohort studies are ideally designed to study such concerns prospectively. As part of the ENRIECO project, we evaluated existing human biomonitoring data for these substances in European birth cohorts and develop recommendations for more harmonized methods that will enable combination and comparison of cohort data in the future. The ENRIECO inventory shows that 20 European birth cohorts have measured or are measuring BFRs (N=10), PFCs (N=11), phthalates (N=16) or phenols (N=8). Generally, samples were collected prenatally or at birth and measurements involved few subjects in each cohort (a few hundred maximum). Biological matrices, timing, and analytical methods of the measurements varied between cohorts. Few cohorts have measured at multiple time points or in children. In European cohorts, levels of BFRs were very low and at least 10-fold lower than in US; levels of PFCs and phthalates have decreased over the last decade since the phasing out of certain of these compounds; concentrations of phenols are comparable to those in the US. Although there is little published data in the cohorts now, many measurements are ongoing and we recommend that cohorts start working towards combined and comparison studies. Specific recommendations for use of existing data include the development of conversion models for the different media used for measurement of persistent chemicals, and inter-laboratory comparisons and calibrations. Recommendations for further data collection include more evaluation of exposure to these chemicals in children; repeated measurements of non-persistent chemicals; validation and harmonisation of questionnaires; and the development of mechanisms for fast European birth cohort response for the detection and prioritisation of new chemicals of concern.
ISSN: 1438-4639

hal-01118579
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01118579
DOI : 10.1016/j.ijheh.2012.05.009
PUBMED : 22795704

Éditeur(s) : HAL CCSD National Institute of Environmental Health Sciences
Résumé : International audience
BACKGROUND: Women of reproductive age can be exposed to endocrine-disrupting chemicals (EDCs) at work, and exposure to EDCs in pregnancy may affect fetal growth. OBJECTIVES: We assessed whether maternal occupational exposure to EDCs during pregnancy as classified by application of a job exposure matrix was associated with birth weight, term low birth weight (LBW), length of gestation, and preterm delivery. METHODS: Using individual participant data from 133,957 mother-child pairs in 13 European cohorts spanning births from 1994 through 2011, we linked maternal job titles with exposure to 10 EDC groups as assessed through a job exposure matrix. For each group, we combined the two levels of exposure categories (possible and probable) and compared birth outcomes with the unexposed group (exposure unlikely). We performed meta-analyses of cohort-specific estimates. RESULTS: Eleven percent of pregnant women were classified as exposed to EDCs at work during pregnancy, based on job title. Classification of exposure to one or more EDC group was associated with an increased risk of term LBW [odds ratio (OR) = 1.25; 95% CI: 1.04, 1.49], as were most specific EDC groups; this association was consistent across cohorts. Further, the risk increased with increasing number of EDC groups (OR = 2.11; 95% CI: 1.10, 4.06 for exposure to four or more EDC groups). There were few associations (p < 0.05) with the other outcomes; women holding job titles classified as exposed to bisphenol A or brominated flame retardants were at higher risk for longer length of gestation. CONCLUSION: Results from our large population-based birth cohort design indicate that employment during pregnancy in occupations classified as possibly or probably exposed to EDCs was associated with an increased risk of term LBW.
ISSN: 0091-6765

hal-01405823
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01405823
DOI : 10.1289/EHP208
PUBMED : 27152464

Éditeur(s) : HAL CCSD Springer New York
Résumé : International audience
Estrogen receptor α (ERα) exerts regulatory actions through genomic mechanisms. In the classical pathway, ligand-activated ERα binds directly to DNA through estrogen response elements (ERE) located in the promoter of target genes. ERα can also exert indirect regulation of transcription via protein-protein interaction with other transcription factors such as AP-1. Several ERα synonymous polymorphisms have been identified and efforts to understand their implications have been made. Nevertheless effects of synonymous polymorphisms are still neglected. This chapter focuses on the experimental procedure employed in order to characterize the transcriptional activity of a synonymous polymorphism of the ERα (rs746432) called Alanine 87 (Ala87). Activity of both WT and Ala87 ERα isoforms on transcriptional pathways can be analyzed in transiently transfected cells using different reporter constructs. ERα efficiency on the classical genomic pathway can be analyzed by determining its transactivation activity on an ERE-driven thymidine kinase (TK) promoter controlling the expression of the luciferase reporter gene. Transcriptional activity through the indirect genomic pathway can be analyzed by employing an AP-1 DNA response element-driven promoter also controlling the expression of luciferase reporter gene
Estrogen Receptors

ISBN : 978-1-4939-3126-2
hal-01237073
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01237073
DOI : 10.1007/978-1-4939-3127-9_22

Éditeur(s) : Paris : Treuttel et Wurtz
Extrait de : Collection des voyages et des découvertes des espagnols depuis la fin du XVème siècle
Siècle(s) traité(s) : 15
Droits : Domaine public
Provenance : Archives départementales de Guadeloupe
Permalien : http://www.manioc.org/patrimon/ADG17081
ADG17081

Éditeur(s) : Paris : Treuttel et Wurtz
Extrait de : Collection des voyages et des découvertes des espagnols depuis la fin du XVème siècle
Siècle(s) traité(s) : 15
Droits : Domaine public
Provenance : Archives départementales de Guadeloupe
Permalien : http://www.manioc.org/patrimon/ADG17079
ADG17079

Éditeur(s) : Paris : Treuttel et Wurtz
Extrait de : Collection des voyages et des découvertes des espagnols depuis la fin du XVème siècle
Siècle(s) traité(s) : 15
Droits : Domaine public
Provenance : Archives départementales de Guadeloupe
Permalien : http://www.manioc.org/patrimon/ADG17080
ADG17080

Éditeur(s) : Madrid : Yenes

Droits : Domaine public
Provenance : Institut des Hautes Études de l'Amérique latine, Bibliothèque Pierre-Monbeig
Permalien : http://www.manioc.org/patrimon/IHE14014
IHE14014