Manioc : Portail | resultats 1 - 1 pour la recherche: Birks, Laura

1 document satisfait la requête. Vérifiez les termes recherchés ou relancez la recherche sur le texte intégral

Occupational Exposure to Endocrine-Disrupting Chemicals and Birth Weight and Length of Gestation: A European Meta-Analysis
Auteur(s) : Birks, Laura Casas, Maribel Garcia, Ana M. Alexander, Jan Barros, Henrique Bergström, Anna Bonde, Jens Peter Burdorf, Alex
Auteurs secondaires : Center for Research in Environmental Epidemiology (CREAL) ; Universitat Pompeu Fabra [Barcelona] - Catalunya ministerio de salud Universitat Pompeu Fabra [Barcelona] CIBER de Epidemiología y Salud Pública (CIBERESP) University of Valencia Norwegian Institute of Public Health ; Norwegian Institute of Public Health University of Porto Medical School and Institute of Public Health University of Porto Medical School ; University of Porto Medical School Institute of Environmental Medicine ; Karolinska Institutet [Stockholm] - Sachs' Children's Hospital

Éditeur(s) : HAL CCSD National Institute of Environmental Health Sciences
Résumé : International audience
BACKGROUND: Women of reproductive age can be exposed to endocrine-disrupting chemicals (EDCs) at work, and exposure to EDCs in pregnancy may affect fetal growth. OBJECTIVES: We assessed whether maternal occupational exposure to EDCs during pregnancy as classified by application of a job exposure matrix was associated with birth weight, term low birth weight (LBW), length of gestation, and preterm delivery. METHODS: Using individual participant data from 133,957 mother-child pairs in 13 European cohorts spanning births from 1994 through 2011, we linked maternal job titles with exposure to 10 EDC groups as assessed through a job exposure matrix. For each group, we combined the two levels of exposure categories (possible and probable) and compared birth outcomes with the unexposed group (exposure unlikely). We performed meta-analyses of cohort-specific estimates. RESULTS: Eleven percent of pregnant women were classified as exposed to EDCs at work during pregnancy, based on job title. Classification of exposure to one or more EDC group was associated with an increased risk of term LBW [odds ratio (OR) = 1.25; 95% CI: 1.04, 1.49], as were most specific EDC groups; this association was consistent across cohorts. Further, the risk increased with increasing number of EDC groups (OR = 2.11; 95% CI: 1.10, 4.06 for exposure to four or more EDC groups). There were few associations (p < 0.05) with the other outcomes; women holding job titles classified as exposed to bisphenol A or brominated flame retardants were at higher risk for longer length of gestation. CONCLUSION: Results from our large population-based birth cohort design indicate that employment during pregnancy in occupations classified as possibly or probably exposed to EDCs was associated with an increased risk of term LBW.
ISSN: 0091-6765

hal-01405823
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01405823
DOI : 10.1289/EHP208
PUBMED : 27152464

| Plus