Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : International audience
AIM: To describe the amount of medical and paramedical involvement in a sample of Breton children with cerebral palsy as a function of the Gross Motor Function Classification System (GMFCS). MATERIALS AND METHODS: This is a transversal descriptive study. All children with cerebral palsy in Brittany were eligible. Parents who accepted to participate were asked to fill in a questionnaire regarding medical and paramedical involvement with their child. RESULTS: One hundred and thirty-three parents participated. 40.6% of the children were level I on the GMFCS, 20.3% II, 12.03% III, 13.53% IV and 13.53% were level V. Thirty-nine percent of the children took at least one medication (of which 43% were antiepileptic drugs). 33.1% of the children had received at least one injection of botulinum toxin within the year. Forty-four percent used a mobility aid. Eighty-five percent of the children had at least one orthotic device, most often a night ankle-foot orthosis. The median number of rehabilitation sessions per week was 3.85 [0.5-11.5]. The frequency and type of sessions were mostly related to the GMFCS level. CONCLUSION: This study reports high levels of medical and paramedical involvement. Studies must attempt to define optimal practice.
ISSN: 1877-0657

hal-00876456
https://hal.archives-ouvertes.fr/hal-00876456
PUBMED : 23312436
DOI : 10.1016/j.rehab.2012.11.003

Éditeur(s) : HAL CCSD American Geophysical Union (AGU)
Résumé : International audience
The current structure of the South Armorican Domain in the French Variscan Belt, provides an excellent record of the late orogenic evolution, as documented by the complex interactions between extensional structures and partial melting. In the Golfe du Morbihan, the South Brittany Migmatite Belt (SBMB), tectonically overlain by non-melted metamorphic units, was studied by combined structural and 40Ar/39Ar methods. The recognition of successive deformation stages points to a strain continuum initiated at depth at the end of a partial melting event, and continued to near-surface brittle faulting, encompassing ductile strain localization over a major top-to-the-ESE extensional shear zone (SSZ) consistent with an overall WNW-ESE orogen-parallel stretching. This multidisciplinary study making the link between structure, texture, microchemistry and 40Ar/39Ar geochronology allow distinguishing between cooling, recrystallization and syn-tectonic crystallization ages. The first extensional insights, witnessed by dyke intrusion were dated at ~319 ± 6 Ma immediately after the SBMB partial melting. Strain localization along the SSZ, occurred until ~302-298 Ma when SBMB crossed the ductile-brittle transition. Moreover, in situ 40Ar/39Ar analysis, of syn-tectonic white micas sampled in the ductile and brittle structures yield similar ~300 Ma. Formation or reactivation of the SSZ may have occurred during the rapid cooling of the SBMB settled at ~305 Ma by conventional 40Ar/39Ar analysis. Large-scale late orogenic extensional event of the previously overthickened Variscan crust thus lasted over ~20 ± 3 Myr in the same extensional tectonic regime guided by the South Armorican Shear Zone.
ISSN: 0278-7407

insu-00628699
https://hal-insu.archives-ouvertes.fr/insu-00628699
https://hal-insu.archives-ouvertes.fr/insu-00628699/document
https://hal-insu.archives-ouvertes.fr/insu-00628699/file/2010TC002788.pdf
DOI : 10.1029/2010TC002788

Éditeur(s) : HAL CCSD
Résumé : International audience
Obesity is currently an increasing public health problem. The intra-uterine environment plays a critical role in foetal development. The objective of this study is to investigate the association of obesity with modifications in the metabolic profiles of pregnant women, and their new-borns. Based on the PELAGIE cohort (Brittany, France), a sample of 321 pregnant women was divided into three groups according to their body mass index (BMI) (normal, over-weight and obese). Nuclear magnetic resonance-based metabolomics analyses were performed on maternal urine and cord-blood samples. Partial least squares regression-discriminant analysis (PLS-DA), polytomous and logistic regressions were used to differentiate the metabolic profiles of the three BMI groups after adjusting for potential confounders. Specific profiles were observed for the overweight and obese women (BMI > 25) compared to the normal-weight women: they had a decrease in urinary hippurate excretion associated with a decrease in phenylalanine and an increase in creatinine. We also showed an increase in the urinary excretion of lactate, citrate, acetate, creatine, and lysine only in obese women (BMI > 30) compared to the normal-weight women. The PLS-DA modelling did not reveal any significant difference between the cord-blood metabolic profiles of newborns according to maternal BMI—although infants born of obese women had a higher birth weight and a lower Apgar score. Our results confirmed the potential link between obesity and gut microbiota disruption (changes in urinary acids), as well as energy and amino-acid metabolism but did not reveal any disruption among newborns.
Metabolomics

Droits : info:eu-repo/semantics/OpenAccess
hal-01195742
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01195742
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01195742/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01195742/file/Impact%20of%20maternal%20obesity_accepted.pdf
DOI : 10.1007/s11306-015-0836-1