Manioc : Portail | resultats 61 - 80 pour la recherche: Amsterdam

Éditeur(s) : HAL CCSD
Résumé : International audience
Objective To guide nosology and classification of patients with eosinophilic granulomatosis with polyangiitis (EGPA) based on phenotype and presence or absence of ANCA. Methods Organ manifestations and ANCA status were retrospectively analyzed based on the presence or not of predefined definite vasculitis features or surrogates of vasculitis in patients asthma, eosinophilia, and at least one systemic organ manifestation attributable to systemic disease. Results The study population included 157 patients (mean age 49.4 ± 14.1), with a follow-up of 7.4 ± 6.4 years. Patients with ANCA (31%) more frequently had weight loss, myalgias, arthralgias, biopsy-proven vasculitis, glomerulonephritis on biopsy, hematuria, leukocytoclastic capillaritis and/or eosinophilic infiltration of arterial wall on biopsy, and other renal disease. A total of 41% of patients had definite vasculitis manifestations (37%) or strong surrogates of vasculitis (4%), of whom only 53% had ANCA. Mononeuritis multiplex was associated with systemic vasculitis (p = 0.005) and with the presence of ANCA (p < 0.001). Overall, 59% of patients had polyangiitis as defined by definite vasculitis, strong surrogate of vasculitis, mononeuritis multiplex, and/or ANCA with at least one systemic manifestation other than ENT or respiratory. Patients with polyangiitis had more systemic manifestations including arthralgias (p = 0.02) and renal disease (p = 0.024), had higher peripheral eosinophilia (p = 0.027), and a trend towards less myocarditis (p = 0.057). Using predefined criteria of vasculitis and surrogates of vasculitis, ANCA alone were found to be insufficient to categorise patients with vasculitis features. Conclusion We suggest a revised nomenclature and definition for EGPA and a new proposed entity referred to as hypereosinophilic asthma with systemic (non vasculitic) manifestations. © 2016 Elsevier B.V.
Autoimmunity Reviews

hal-01467544
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01467544
DOI : 10.1016/j.autrev.2016.09.018
PUBMED : 27671089

| Plus

De West-Indische gids ; West-Indische gids

| Plus

Voyage à la Guiane et a Cayenne : fait en 1789 et années suivantes : contenant une description géographique de ces contrées, l'histoire de leur découverte; les possessions et etablissemens des Français, des Hollandais, des Espagnols et des Portugais... Suivi d'un vocabulaire français et galibi...
Auteur(s) : Prudhomme, Louis-Marie (1752-1830)
Année de publication :

| Plus

Some characteristics of the rift valley in the atlantic ocean near 36°48' north
Auteur(s) : Needham, H.d. Francheteau, Jean

Éditeur(s) : North-Holland Publishing Company
Résumé : The Rift Valley between 36° 42'N and 36° 55'N in the Atlantic Ocean is 31 km wide, with half-widths of 12 and 19 km for the western and eastern sides respectively. Both outer edges of the Rift Valley stand about 1500 m above an Inner Floor where very fresh pillow lavas occur. The Inner Floor probably includes the locus of new crust ; and its bordering slopes, which are particularly well-defined on the western side, limit to less than about 2.5 km the width of the zone over which new crust may have evolved with little or no vertical displacement. The width of the locus of new crust may be less than 0.5 km between 36° 45'N and 36° 47'N, where the deepest slopes of the Rift Valley walls nearly merge. Near 36° 50'N, the Inner Floor accommodates an approximately 1 km wide, 4 km long Central High, with a height of up to 250 m. In this area, the locus of new crust may also occupy a very narrow zone ; it may lie either along the Central High or along a trough flanking the Central High. The magnetic anomaly pattern indicates that, since the beginning of the Brunhes epoch (6.9 X 10(5) yr B.P.), the eastern limb has grown approximately twice as fast as the western limb. Using extrapolated spreading rates, the ages of the outer edges of the Rift Valley are 1.3 and 1.7 m.y. for the eastern and western sides respectively. Comparison with data for the Rift Valley in other parts of the ocean further suggests that the residence time of new crust in the Rift Valley is about 1.5 m.y. Uplift of crust from the Inner Floor, which may be dominated by lithospheric thickening, may thus be primarily a function of age. [NOT CONTROLLED OCR]
Earth and Planetary Science Letters (North-Holland Publishing Company), 1974 , Vol. 22 , P. 29-43

Droits : North-Holland Publishing Company, Amsterdam
http://archimer.ifremer.fr/doc/1974/publication-5159.pdf
http://archimer.ifremer.fr/doc/00000/5159/

| Plus