Manioc : Portail | resultats 41 - 60 pour la recherche: Nodal planes

L'illustration. N°3358
Auteur(s) : Galmot, Jean (1879-1928)
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Monde. N° 222
Auteur(s) : De Brussey, J.
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Arrêté n°1050 du 17 octobre 1906 promulguant le décret du 10 mars 1906, portant modifications à la règlementation minière de la Guyane
Auteur(s) : Gouvernement de la Guyane française
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Bulletin officiel de la Guyane française
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Glossaire nautique : répertoire polyglotte de termes de marine anciens et modernes (A-J)
Auteur(s) : Jal, Auguste (1795-1873)
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Report on sugar-cane borers at Soledad, Cuba. [Suivi de] Dry-season studies of cane homoptera at Soledad, Cuba : with a list of the coccids of the district
Auteur(s) : Salt, George W. (1903-2003) Myers, John Golding (1897-1942)
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Patagonie, Terre-du-feu et archipel des Malouines
Auteur(s) : Lacroix, Frédéric (18..?-1864)
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Guidelines for the use and interpretation of assays for monitoring autophagy.
Auteur(s) : Klionsky, Daniel J Abdalla, Fabio C Abeliovich, Hagai Abraham, Robert T Acevedo-Arozena, Abraham Adeli, Khosrow Agholme, Lotta Agnello, Maria
Auteurs secondaires : Molecular and Cellular Biology ; University of Leuven Laboratoire d'Epigénétique et Cancer ; CNRS - Université Paris-Sud - Paris 11 (UP11) Department of Pharmacology ; Department of Pharmacology Immunobiologie des Cellules Dendritiques ; INSERM - Institut Pasteur de Paris Franche-Comté Électronique Mécanique, Thermique et Optique - Sciences et Technologies (FEMTO-ST) ; CNRS - Université de Franche-Comté - Université de Technologie de Belfort-Montbeliard - Ecole Nationale Supérieure de Mécanique et des Microtechniques Telethon Institute for Genetics and Medicine ; Telethon Institute Medical Genetics ; Federico II University Department of Molecular and Human Genetics ; Baylor College of Medicine

Éditeur(s) : HAL CCSD Landes Bioscience
Résumé : International audience
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.
Autophagy

hal-00735751
https://hal.archives-ouvertes.fr/hal-00735751
PUBMED : 22966490

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Physical characteristics of subduction interface type seismogenic zones revisited
Auteur(s) : Heuret, Arnauld Lallemand, Serge Funiciello, Francesca Piromallo, Claudia Faccenna, Claudio
Auteurs secondaires : Dipartimento di Scienze Geologiche, Università degli Studi "Roma Tre," ; Université du Québec Dynamique de la Lithosphere ; Géosciences Montpellier ; Université des Antilles et de la Guyane (UAG) - Institut national des sciences de l'Univers (INSU - CNRS) - Université de Montpellier (UM) - Centre National de la Recherche Scientifique (CNRS) - Université des Antilles et de la Guyane (UAG) - Institut national des sciences de l'Univers (INSU - CNRS) - Université de Montpellier (UM) - Centre National de la Recherche Scientifique (CNRS) INGV, Rome ; Université du Québec

Éditeur(s) : HAL CCSD AGU and the Geochemical Society
Résumé : International audience
Based on global earthquake catalogs, the hypocenters, nodal planes, and seismic moments of worldwide subduction plate interface earthquakes were extracted for the period between 1900 and 2007. Assuming that the seismogenic zone coincides with the distribution of 5.5 <= M < 7 earthquakes, the subduction interface seismogenic zones were mapped for 80% of the trench systems and characterized with geometrical and mechanical parameters. Using this database, correlations were isolated between significant parameters to identify cause-effect relationships. Empirical laws obtained in previous studies were revisited in light of this more complete, accurate, and uniform description of the subduction interface seismogenic zone. The seismogenic zone was usually found to end in a fore-arc mantle, rather than at a Moho depth. The subduction velocity was the first-order controlling parameter for variations in the physical characteristics of plate interfaces, determining both the geometry and mechanical behavior. As such, the fast subduction zones and cold slabs were associated with large and steep plate interfaces, which, in turn, had large seismic rates. The subduction velocity could not account for the potential earthquake magnitude diversity that was observed along the trenches. Events with M-w >= 8.5 preferentially occurred in the vicinity of slab edges, where the upper plate was continental and the back-arc strain was neutral. This observation was interpreted in terms of compressive normal stresses along the plate interface. Large lateral ruptures should be promoted in neutral subduction zones due to moderate compressive stresses along the plate interface that allow the rupture to propagate laterally.
ISSN: 1525-2027

hal-00617681
https://hal.archives-ouvertes.fr/hal-00617681
https://hal.archives-ouvertes.fr/hal-00617681/document
https://hal.archives-ouvertes.fr/hal-00617681/file/heuretG32011.pdf
DOI : 10.1029/2010GC003230

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