| Moderate endurance exercise is not a risk for rhabdomyolysis or renal failure in sickle cell trait carriers Auteur(s) : Messonnier, Laurent Samb, Abdoulaye Tripette, Julien Doubi Gogh, Bertin Loko, Gylna Diop Sall, Niama Féasson, Léonard Hue, Olivier Auteurs secondaires : Laboratory of Exercise Physiology, University of Savoie, Chambery, and University Jean Monnet of Saint-Etienne, Saint-Etienne ; Laboratory of Exercise Physiology Adaptations au Climat Tropical, Exercice et Santé (ACTES) ; Université des Antilles et de la Guyane (UAG) UMR Inserm University of The French West Indies, Pointe-a-Pitre, Guadeloupe ; UMR Inserm, University of The French West Indies Laboratoire de Physiologie et d'Explorations Fonctionnelles ; Unité de Formation et de Recherche en Sciences Médicales Centre intégré de drépanocytoses ; Hôpital du Lamentin Laboratory of Physiology, Faculty of Medicine and Pharmacy, ; Laboratory of Physiology, Faculty of Medicine and Pharmacy Département de physiologie clinique et de l'exercice, University of Savoie, Chambery ; Université Jean Monnet [Saint-Étienne] (UJM) - Département de physiologie clinique et de l'exercice, University of Savoie, Chambery Sickle Cell Center, Academic Medical Center, Pointe-a-Pitre, Guadeloupe ; Sickle Cell Center, Academic Medical Center, Pointe-a-Pitre, Éditeur(s) : HAL CCSD IOS Press Résumé : International audience This study tested the hypothesis that trained sickle cell trait (SCT) carriers are not subjected to greater risk of rhabdomyolysis or renal failure in response to moderate submaximal exercise than subjects with normal hemoglobin (CONT). Blood markers in 11 trained SCT carriers and 12 control counterparts were measured before and after 40 min of exercise at 55% of peak power output (Ppeak) conducted in thermoneutral environment. Body weights decreased with exercise in the same proportion in the two groups (from 65.1 ± 7.0 kg to 64.1 ± 7.0 kg and from 70.2 ± 6.6 to 68.6 ± 6.6 kg at the end of exercise in SCT and CONT, respectively). Heart rate and rectal temperature increased in the two groups in response to exercise, but the groups remained closely matched. Serum urea, CRP, CK and LDH were similar in the two groups and remained unchanged in response to exercise. Creatinine, Na + , K + , Cl − and myoglobin concentrations increased above baseline in response to exercise, with changes of the same magnitude in the two groups. In summary, the results of the present study suggest that moderate submaximal exercise is not unsafe from a biochemical point of view for sportsmen carrying SCT. ISSN: 1386-0291 hal-01163943 https://hal.univ-antilles.fr/hal-01163943 DOI : 10.3233/CH-2011-1524 | Partager
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