Éditeur(s) :
HAL CCSD Elsevier Résumé : 00000 ăWOS:000386415300011
International audience
Highly biologically active marine sesquiterpene ilimaquinone was selected for chemical modifications. Its biotransformation was investigated using a combinatorial approach as an original way to screen different strains of microorganisms. Mucor circinelloides ATCC 8541 was able to structurally modify ilimaquinone into three different compounds. A stereospecific epoxidation was observed and compared to chemical epoxidation. A hydroxylation of the decalin ring was also observed as well as an unexpected substitution on the quinone ring by ethanolamine. Compounds were evaluated against several cell lines. (C) 2016 Elsevier Ltd. All rights reserved.
ISSN: 0040-4039
hal-01483185
https://hal.archives-ouvertes.fr/hal-01483185 DOI : 10.1016/j.tetlet.2016.09.075