Manioc : Portail | resultats 1 - 20 pour la recherche: Loubet, Paul

Le calvaire d'un innocent ; n° 141
Auteur(s) : D' Arzac, Jules
Année de publication :

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Complete story of the Martinique and St. Vincent horrors
Auteur(s) : Garesche, William A. (1852-1905)
Auteurs secondaires : Demessimy, Vincent (18..-1)
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Le calvaire d'un innocent ; n° 108
Auteur(s) : D' Arzac, Jules
Année de publication :

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Le calvaire d'un innocent ; n° 120
Auteur(s) : D' Arzac, Jules
Année de publication :

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Bulletin officiel de la Guyane française
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Factors associated with poor outcomes among adults hospitalised for influenza in France: A three-year prospective multicenter study
Auteur(s) : Loubet, Paul Samih-Lenzi, Nezha Galtier, Florence Vanhems, Philippe Loulergue, Pierre Duval, Xavier Jouneau, Stéphane Postil, Déborah
Auteurs secondaires : Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP) ; Université Pierre et Marie Curie - Paris 6 (UPMC) - Institut National de la Santé et de la Recherche Médicale (INSERM) Service des Maladies Infectieuses ; CHU Cochin [AP-HP] CIC Cochin Pasteur (CIC 1417) ; Assistance publique - Hôpitaux de Paris (AP-HP) - CHU Cochin [AP-HP] - Hôtel-Dieu - Université Paris Descartes - Paris 5 (UPD5) - Groupe hospitalier Broca - Institut National de la Santé et de la Recherche Médicale (INSERM) F-CRIN, Innovative clinical research network in vaccinology (I-REIVAC) CIC Montpellier ; Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Hôpital Saint Eloi CHU Saint-Eloi Service d'Hygiène, Epidémiologie et Prévention [Lyon] ; Hôpital Edouard Herriot Centre International de Recherche en Infectiologie (CIRI) ; École normale supérieure - Lyon (ENS Lyon) - Université Claude Bernard Lyon 1 (UCBL) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Centre National de la Recherche Scientifique (CNRS)

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Background: Influenza is an important cause of serious illness and death, particularly in elderly and high-risk groups. Objectives Aim of this study was to identify factors associated with poor outcomes among adults hospitalized in France for laboratory-confirmed seasonal influenza. Study design Patients hospitalized for influenza were identified in a prospective, multicenter study carried out in French hospitals during three consecutive influenza seasons (2012–2015). Influenza virus infection was confirmed by reverse transcription polymerase chain reaction. Sociodemographic and clinical variables were compared according to the virus type and subtype. Risk factors for complications, intensive care unit (ICU) admission and death were analyzed by backward stepwise logistic regression. Results The study population consisted of 566 patients, of whom 56% were older than 65 years and 82% had underlying chronic illnesses. Type A influenza viruses infected 422 patients (75%), including subtype H3N2 in 239 patients (57%). The prior vaccine coverage rate was 38%. Complications occurred in 255 patients (45%), consisting mainly of pneumonia (n = 143, 30%) and respiratory failure (n = 116, 20%). Eighty-three patients (15%) were admitted to an ICU, and the in-hospital mortality rate was 4% (n = 21). Sixty-six patients (12%) received oseltamivir. Age over 65 years was the only identified risk factor for complications. Risk factors for ICU admission were an absence of vaccination, no oseltamivir administration before admission, pre-existing chronic respiratory disease, and current smoking. Age over 65 years and ICU admission were risk factors for death. Conclusions Older individuals and patients with underlying conditions are most at risk of influenza complications. Vaccination and early oseltamivir administration, both of which are recommended for these patients, appear to reduce ICU admissions
ISSN: 1386-6532

hal-01302409
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01302409
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01302409/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01302409/file/Factors%20associated%20with%20poor%20outcomes.pdf
DOI : 10.1016/j.jcv.2016.04.005

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