| Constitutive calcium entry and cancer: updated views and insights. Auteur(s) : Mignen, Olivier Constantin, Bruno Potier-Cartereau, Marie Penna, Aubin Gautier, Mathieu Guéguinou, Maxime Renaudineau, Yves Shoji, Kenji Auteurs secondaires : Génétique, génomique fonctionnelle et biotechnologies ; Institut National de la Santé et de la Recherche Médicale (INSERM) - Université de Brest (UBO) - EFS Network “Ion channels and Cancer-Canceropole Grand Ouest” [Nantes] (IC-CGO) ; Cancéropôle Grand-Ouest [Bretagne-Centre-Pays de Loire] Signalisation et Transports Ioniques Membranaires (STIM) ; Université de Poitiers - Centre National de la Recherche Scientifique (CNRS) Nutrition, croissance et cancer (N2C) ; Université François Rabelais - Tours - Institut National de la Santé et de la Recherche Médicale (INSERM) Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) Laboratoire de Physiologie Cellulaire et Moléculaire [Amiens] (EA 4667) ; Université de Picardie Jules Verne (UPJV) Immunologie et Pathologie (EA 2216) ; Université de Brest (UBO) - Institut National de la Santé et de la Recherche Médicale (INSERM) This work was supported by la Ligue Contre le Cancer (comités des régions Bretagne, Pays de la Loire, Centre, and Poitou-Charentes), Region Centre (LIPIDS project of ARD2020-Biomédicaments), Inserm, CNRS, Cancéropôle Grand Ouest, the association “CANCEN”, Tours’ Hospital oncology association ACORT”, Fondation ARC, ANR (ANR-12-JSV2-0004-001), Biosit, University of Brest, University of Rennes 1, University of Poitiers, University of Tours and Roche-SFD. Éditeur(s) : HAL CCSD Springer Verlag (Germany) Résumé : International audience Tight control of basal cytosolic Ca2+ concentration is essential for cell survival and to fine-tune Ca2+-dependent cell functions. A way to control this basal cytosolic Ca2+ concentration is to regulate membrane Ca2+ channels including store-operated Ca2+ channels and secondary messenger-operated channels linked to G-protein-coupled or tyrosine kinase receptor activation. Orai, with or without its reticular STIM partner and Transient Receptor Potential (TRP) proteins, were considered to be the main Ca2+ channels involved. It is well accepted that, in response to cell stimulation, opening of these Ca2+ channels contributes to Ca2+ entry and the transient increase in cytosolic Ca2+ concentration involved in intracellular signaling. However, in various experimental conditions, Ca2+ entry and/or Ca2+ currents can be recorded at rest, without application of any experimental stimulation. This led to the proposition that some plasma membrane Ca2+ channels are already open/activated in basal condition, contributing therefore to constitutive Ca2+ entry. This article focuses on direct and indirect observations supporting constitutive activity of channels belonging to the Orai and TRP families and on the mechanisms underlying their basal/constitutive activities. ISSN: 0175-7571 inserm-01526286 http://www.hal.inserm.fr/inserm-01526286 http://www.hal.inserm.fr/inserm-01526286/document http://www.hal.inserm.fr/inserm-01526286/file/EBJO-D-16-00056_R1-2%20%282%29.pdf PUBMED : 28516266 | Partager
|