Éditeur(s) : Elsevier
Résumé : Foraminifera and ostracods have been quantitatively studied in core MD01-2472, from the upper continental slope (at water depth of 501 m), to evaluate their relationship with bottom water condition variability and decipher the control of the Levantine Intermediate Water (LIW) current on benthic faunas. The occurrence of reworked ostracod species (originating from the continental shelf) and, the presence of shallow water Elphidium/Ammonia benthic foraminifera are used to estimate the degree of along-slope transport at the core site. This has revealed two intervals of along-slope transport also associated with coarse-grained contourite deposits, deposited during the YD and HS2 episodes. Planktonic-benthic foraminiferal and ostracod assemblages reflect climate oscillations. Peaks of the polar planktonic Neogloboquadrina pachyderma (left-coiling S) may be used to identify Heinrich Events. Interstadials are marked by abundant ostracod species such as Paracypris sp., Argilloecia acuminata, and Cytheropteron alatum and the presence of benthic foraminifera like Bulimina marginata, Bulimina costata and Gyroidina altiformis. The B–A and Holocene are characterized by abundant warm water species of planktonic foraminifera and by the ostracod species Polycope sp. We hypothesize that there is relationship between LIW intensification during cold rapid climate events and benthic fauna assemblage variations due to changes in: 1) bottom water ventilation; and 2) the export of nutrients and/or sediment particles by bottom currents.
Quaternary International (1040-6182) (Elsevier), 2015-01 , Vol. 357 , P. 295-313

Droits : 2014 Elsevier Ltd and INQUA. All rights reserved.
http://archimer.ifremer.fr/doc/00245/35648/34208.pdf
DOI:10.1016/j.quaint.2014.11.038
http://archimer.ifremer.fr/doc/00245/35648/

Éditeur(s) : HAL CCSD Taylor & Francis
Résumé : International audience
ISSN: 1028-6020

hal-01095384
https://hal-agroparistech.archives-ouvertes.fr/hal-01095384
DOI : 10.1021/np1001412

Résumé : Aujourd’hui, il est indispensable de découvrir de nouveaux agents thérapeutiques pour faire face à l’expansion des infections fongiques humaines. D’un autre côté, certains arbres amazoniens ont acquis des moyens pour se protéger contre la dégradation fongique. Ces composés d’origine végétale pourraient donc être des candidats potentiels au développement de composés antifongiques. Il est ainsi exposé dans ce travail la sélection bio-inspirée et la récolte d’espèces d’arbres amazoniens résistants à la dégradation fongique ; à partir desquelles il est proposé d’isoler, d’identifier et de valoriser les métabolites responsables de la durabilité naturelle et d’étudier leurs propriétés sur des champignons pathogènes humains. Cette étude a conduit à l’isolement de molécules inédites apportant un complément d’information chimiotaxonomique pour les espèces étudiées. De plus, il a pu être mis en avant deux molécules pouvant devenir des composés pertinents pour le développement de traitements antimycotiques.
It is now essential to discover new therapeutic agents against the increase of human fungal infections. On the other hand, some Amazonian trees have succeeded to develop a chemical defense arsenal to protect themselves against fungal degradation. These compounds of plant origin could become potential candidates for the development of antifungal compounds for the treatment of human fungal diseases. Therefore, this manuscript describes the bio-inspired selection and collection of Amazonian tree species capable of specializing a highly fungiresistant wood; from which it is proposed to isolate, identify and valorize the secondary metabolites responsible for the natural durability, and study their properties on human pathogenic fungi. Ultimately, this study led to the isolation of new compounds and providing additional important chemotaxonomic information for the species studied. In addition, it as been established that two compounds could be relevant for the development of antimitotic therapies.

http://www.theses.fr/2011AGUY0467/document