Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : In southern Corsica, three successive Upper Burdigalian coral reef episodes (R1, R2 subdivided into R2A and R2B subunits, and R3) developed within the Cala di Labra Formation. Tabular corals dominated under high water energy and siliciclastic input conditions. The R1 reefs show the highest coral diversity with 16 species described for the first time. A coral impoverishment was recorded in the R2 and R3 reefal episodes. The reefs did not reach a climax growth stage, except the R1 ones. Analogous to North Sardinian reefs, they reflect local vanishing conditions in the Corsican-Sardinian block through Upper Burdigalian because of constant siliciclastic inputs and deepening of the Bonifacio straight.
ISSN: 1631-0713

hal-01054332
https://hal.archives-ouvertes.fr/hal-01054332
DOI : 10.1016/j.crte.2014.02.003

Éditeur(s) : HAL CCSD Museum National d'Histoire Naturelle Paris
Résumé : Au Burdigalien supérieur, des récifs coralliens se sont développés dans la Formation de Cala di Labra, aux alentours de Bonifacio (Corse-du-Sud, France). Ils sont organisés en trois épisodes successifs R1, R2 et R3. La faune corallienne comprenant 16 espèces récifales, est décrite pour la première fois. Deux associations coralliennes sont distinguées. Les principaux genres constructeurs sont Porites Link, 1807, Tarbellastraea Alloiteau, 1950 et Thegioastraea Sismonda, 1871. La diversité corallienne est maximale avec 15 espèces (8 genres) dans l'épisode R1, puis réduite (4 espèces appartenant à 3 genres) pour l'épisode R2, l'épisode R3 renfermant des coraux mal préservés pour être identifiés. Les formes de croissance sont en grande majorité massives étalées et superposées, associées à des conditions paléoenvironnementales de haute à moyenne énergie (rides de courant, bioclastes usés, peu de formes branchues), sous apports terrigènes réguliers. Les récifs, pour la plupart frangeants et à zonation récifale discrète, se sont développés en domaine de plate-forme peu profonde. Cette étude reprend également toutes les citations d'espèces dans la littérature pour cette région et replace ces épisodes coralliens remarquables dans l'évolution plus générale du Bassin Liguro-Provençal.
ISSN: 1280-9659

hal-01236095
https://hal.archives-ouvertes.fr/hal-01236095
DOI : 10.5252/g2015n3a5

Éditeur(s) : HAL CCSD Lippincott, Williams & Wilkins
Résumé : International audience
OBJECTIVES: The ANRS-112 INTERPRIM trial assessed whether fixed-cycles of antiretroviral treatment interruption (ART-STI) combined or not with pegylated interferon alpha-2b (peg-IFN) could lower viral load and achieve a healthier immune system in patients diagnosed during primary HIV-1-infection (PHI). DESIGN AND METHODS: Patients were randomized to receive either continuous ART (cART) during 72 weeks, or cART during 36 weeks followed by three ART-STIs, or the same ART-STIs associated with peg-IFN during the first 14 weeks and each interruption (ART-STI-IFN). Treatment was stopped at week 72. Final evaluation was based on plasma HIV-RNA level 6 months after the last treatment interruption. RESULTS: Eighty-seven percent of patients achieved undetectable HIV-RNA at week 32, with no deleterious impact of sequential treatment interruptions (STIs). Viral rebounds during interruptions were lower in the ART-STI-IFN than in the ART-STI group and during the second and third interruptions compared with the first one. However, HIV-RNA levels, CD4 T-cell counts and CD4 T/CD8 T ratios were similar between groups after the 6-month interruption, with a persistent effect on CD4 T cells and total cell-associated HIV-DNA levels. Predictive factors of virological outcome were HIV-RNA and HIV-DNA levels at PHI and HIV-DNA levels at treatment interruption. HIV-specific responses did not differ between strategies and were not associated with outcome. Forty-eight percent of patients experienced treatment resumption during long-term follow-up without difference between groups. CONCLUSION: When initiated during PHI, STIs associated or not with IFN did not result in a different outcome as compared to cART. All regimens showed a high response rate and a sustained immunological benefit after cessation.
ISSN: 0269-9370

hal-00875175
https://hal.archives-ouvertes.fr/hal-00875175
DOI : 10.1097/QAD.0b013e32835844d9
PUBMED : 22842994

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
New investigations in the Neogene Boudinar basin (Morocco) provide new information about the Messinian Salinity Crisis (MSC) and Zanclean reflooding in the southern part of the Alboran realm (westernmost Mediterranean). Based on a new field, sedimentological and palaeontological analyses, the age and the geometry of both the Messinian erosional surface (MES) and the overlying deposits have been determined. The MES is of late Messinian age and was emplaced in subaerial settings. In the Boudinar basin, a maximum of 200 m of Miocene sediments was eroded, including late Messinian gypsum blocks. The original geometry of the MES is preserved only when it is overlain by late Messinian continental deposits, conglomeratic alluvial fans or lacustrine marly sediments. These sediments are interpreted as indicators of the sea-level fall during the MSC. Elsewhere in the basin, the contact between late Messinian and early Pliocene deposits is a low-angle dipping, smooth surface that corresponds to the early Pliocene transgression surface that subsequently re-shaped the regressive MES. The early Pliocene deposits are characterized by: (i) their onlap onto either the basement of the Rif chain or the late Miocene deposits; (ii) lagoonal deposits at the base to offshore marls and sands at the top (earliest Pliocene; 5.33–5.04 Ma interval; foraminifer zone PL1); (iii) marine recovery occurring in the 5.32–5.26 Ma interval; and (iv) the change from lagoonal to offshore environments occurring within deposits tens of metres thick. This information indicates that at least the end of the reflooding period was progressive, not catastrophic as previously thought.
ISSN: 0037-0738

hal-01306672
https://hal.archives-ouvertes.fr/hal-01306672
DOI : 10.1016/j.sedgeo.2015.12.014

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
BACKGROUND: Surveillance of HIV-1 drug resistance in treated patients with plasma viral load (VL) >50 copies/mL. METHODS: The protease and reverse transcriptase (RT) genes were systematically sequenced in samples from 756 patients with VL >50 copies/mL in 2009. The genotyping results were interpreted for each antiretroviral drug (ARV) by using the ANRS algorithm v21. Weighted analyses were used to derive representative estimates of percentages of patients. Prevalence rates were compared with those obtained in 2004 among patients with VL >1000 copies/mL. RESULTS: Sequences were obtained for 506 patients. Sequencing was successful in 45%, 80% and 96% of samples with VL of 51-500, 501-1000 and >1000 copies/mL, respectively. Resistance or possible resistance to at least one ARV was observed in 59% of samples. Overall, 0.9% of samples contained viruses resistant to all drugs belonging to at least three drug classes. All resistance prevalence rates were significantly lower in 2009 than in 2004. CONCLUSION: In France, where 86% of patients were receiving combination antiretroviral therapy in 2009, only 15.0% of patients had a VL >50 copies/mL, suggesting that only 8.9% of treated patients could potentially transmit resistant viruses. Only 0.08% of patients harboured viruses fully resistant to at least three antiretroviral drug classes. Further studies are needed to determine whether resistance continues to decline over time.
ISSN: 0305-7453

hal-00875092
https://hal.archives-ouvertes.fr/hal-00875092
DOI : 10.1093/jac/dkt033
PUBMED : 23404192