Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Dental and postcranial remains (an atlas, carpus and metacarpus elements, and a part of the pelvic girdle) of an embrithopod mammal are described from Bir Om Ali, Tunisia, a new late Eocene locality. The enamel microstructure of a tooth fragment found in association shows 'arsinoitheriid radial enamel', an enamel condition which is characteristic of Arsinoitherium (Arsinoitheriidae, Embrithopoda). Although the postcranial elements slightly differ in size and morphology from those of Arsinoitherium zitteli (late Eocene to early Oligocene), we tentatively refer this new Eocene Tunisian material to that genus. These fossils represent the first known embrithopod from the Eocene of Tunisia.
ISSN: 0899-5362

hal-00903435
https://hal.archives-ouvertes.fr/hal-00903435
DOI : 10.1016/j.jafrearsci.2013.07.010

Éditeur(s) : HAL CCSD SAGE Publications (UK and US)
Résumé : International audience
Genetic approaches have shown that several genes could modify caries susceptibility; AmelogeninX (AMELX) has been repeatedly designated. Here, we hypothesized that AMELX mutations resulting in discrete changes of enamel microstructure may be found in children with a severe caries phenotype. In parallel, possible AMELX mutations that could explain resistance to caries may be found in caries-free patients. In this study, coding exons of AMELX and exon-intron boundaries were sequenced in 399 individuals with extensive caries (250) or caries-free (149) individuals from nine French hospital groups. No mutation responsible for a direct change of amelogenin function was identified. Seven single-nucleotide polymorphisms (SNPs) were found, 3 presenting a high allele frequency, and 1 being detected for the first time. Three SNPs were located in coding regions, 2 of them being non-synonymous. Both evolutionary and statistical analyses showed that none of these SNPs was associated with caries susceptibility, suggesting that AMELX is not a gene candidate in our studied population.
ISSN: 0022-0345

hal-01545481
https://hal.archives-ouvertes.fr/hal-01545481
DOI : 10.1177/0022034513482941