Manioc : Portail | resultats 1 - 5 pour la recherche: Frédéric, Maillard

Hematologic and hemorheological determinants of resting and exercise-induced hemoglobin oxygen desaturation in children with sickle cell disease.
Auteur(s) : Waltz, Xavier Romana, Marc Lalanne-Mistrih, Marie-Laure Machado, Roberto, Lamarre, Yann Tarer, Vanessa Hardy-Dessources, Marie-Dominique Tressieres, Benoit
Auteurs secondaires : Protéines de la membrane érythrocytaire et homologues non-érythroides ; Université des Antilles et de la Guyane (UAG) - Institut National de la Transfusion Sanguine [Paris] (INTS) - Université Paris Diderot - Paris 7 (UPD7) - Université de la Réunion (UR) - Institut National de la Santé et de la Recherche Médicale (INSERM) Adaptations au Climat Tropical, Exercice et Santé (ACTES) ; Université des Antilles et de la Guyane (UAG) Laboratory of Excellence GR-Ex " The red cell : from genesis to death " ; PRES Sorbonne Paris Cité Centre d'investigation clinique Antilles-Guyane ; Institut National de la Santé et de la Recherche Médicale (INSERM) - CH Cayenne Section of Pulmonary, Critical Care Medicine, Sleep and Allergy ; University of Illinois at Chicago (UIC) Service d'Orthopédie et de Traumatologie ; Université des Antilles et de la Guyane (UAG) - CHU Pointe-à-Pitre/Abymes Unité Transversale de la Drépanocytose ; CHU de Pointe-à-Pitre/Abymes Service de Pédiatrie ; Hôpital Ricou - CHU de Pointe-à-Pitre/Abymes

Éditeur(s) : HAL CCSD Ferrata Storti Foundation
Résumé : International audience
The aim of the study was to determine the factors associated with resting and exercise-induced hemoglobin oxygen desaturation. The well-established six-minute walk test was conducted in 107 sickle cell children (50 with sickle hemoglobin C disease and 57 with sickle cell anemia) at steady state. Hemoglobin oxygen saturation was measured before and immediately after the six-minute walk test. Blood samples were obtained on the same day to measure hematologic and hemorheological parameters. Exercise-induced hemoglobin oxygen desaturation was defined as a drop in hemoglobin oxygen saturation of 3% or more at the end of the six-minute walk test compared to resting levels. No children with sickle hemoglobin C disease, but approximately 50% of children with sickle cell anemia showed mild or moderate oxygen desaturation at rest, which was independently associated with the percentage of reticulocytes. Exercise-induced hemoglobin oxygen desaturation was observed in 18% of children with sickle hemoglobin C disease and 34% of children with sickle cell anemia, and was independently associated with the six-minute walk test, acute chest syndrome rate and the strength of red blood cell aggregates in children with sickle cell anemia. No association was found in children with sickle hemoglobin C disease between exercise-induced hemoglobin oxygen desaturation and the measured parameters. Hemoglobin oxygen desaturation at rest was common in children with sickle cell anemia but not in children with sickle hemoglobin C disease, and was mainly associated with greater hemolysis. Physiological strain during exercise and red blood cell aggregation properties may predict the occurrence of exercise-induced hemoglobin oxygen desaturation in children with sickle cell anemia.
ISSN: 0390-6078

inserm-00838989
http://www.hal.inserm.fr/inserm-00838989
http://www.hal.inserm.fr/inserm-00838989/document
http://www.hal.inserm.fr/inserm-00838989/file/Waltz_et_al._Ferrata_Storti_Foundation.pdf
DOI : 10.3324/haematol.2013.083576

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Hematological and hemorheological determinants of the six-minute walk test performance in children with sickle cell anemia.
Auteur(s) : Waltz, Xavier Romana, Marc Hardy-Dessources, Marie-Dominique Lamarre, Yann Divialle-Doumdo, Lydia Petras, Marie Tarer, Vanessa Hierso, Régine
Auteurs secondaires : Protéines de la membrane érythrocytaire et homologues non-érythroides ; Université des Antilles et de la Guyane (UAG) - Institut National de la Transfusion Sanguine [Paris] (INTS) - Université Paris Diderot - Paris 7 (UPD7) - Université de la Réunion (UR) - Institut National de la Santé et de la Recherche Médicale (INSERM) Adaptations au Climat Tropical, Exercice et Santé (ACTES) ; Université des Antilles et de la Guyane (UAG) Laboratory of Excellence GR-Ex "The red cell: from genesis to death" ; PRES Sorbonne Paris Cité Unité Transversale de la Drépanocytose ; Hôpital Ricou - CHU de Pointe-à-Pitre/Abymes Centre de référence maladies rares pour la drépanocytose aux Antilles-Guyane ; Centre Hospitalier et Universitaire de Pointe-à-Pitre Centre d'investigation clinique Antilles-Guyane ; Institut National de la Santé et de la Recherche Médicale (INSERM) - CH Cayenne Service de Pédiatrie ; Centre Hospitalier et Universitaire de Pointe-à-Pitre Institut Universitaire de France (IUF) ; Ministère de l'Éducation nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.)

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Hemorheological risk factors of acute chest syndrome and painful vaso-occlusive crisis in children with sickle cell disease. ; Hemorheological risk factors of acute chest syndrome and painful vaso-occlusive crisis in children with sickle cell disease. : Blood rheology in sickle cell disease
Auteur(s) : Lamarre, Yann Romana, Marc Waltz, Xavier Lalanne-Mistrih, Marie-Laure Tressières, Benoît Divialle-Doumdo, Lydia Hardy-Dessources, Marie-Dominique Vent-Schmidt, Jens
Auteurs secondaires : Protéines de la membrane érythrocytaire et homologues non-érythroides ; Université des Antilles et de la Guyane (UAG) - Institut National de la Transfusion Sanguine [Paris] (INTS) - Université Paris Diderot - Paris 7 (UPD7) - Université de la Réunion (UR) - Institut National de la Santé et de la Recherche Médicale (INSERM) Centre d'investigation clinique Antilles-Guyane ; Institut National de la Santé et de la Recherche Médicale (INSERM) - CH Cayenne Unité Transversale de la Drépanocytose ; CHU de Pointe-à-Pitre/Abymes Service de Pédiatrie ; CHU de Pointe-à-Pitre/Abymes Service d'Orthopédie et de Traumatologie ; Université des Antilles et de la Guyane (UAG) - CHU Pointe-à-Pitre/Abymes

Éditeur(s) : HAL CCSD Ferrata Storti Foundation
Résumé : International audience
BACKGROUND: Little is known about the effects of blood rheology on the occurrence of acute chest syndrome and painful vaso-occlusive crises in children with sickle cell anemia and hemoglobin SC disease. DESIGN AND METHODS: To address this issue, steady-state hemorheological profiles (blood viscosity, red blood cell deformability, aggregation properties) and hematologic parameters were assessed in 44 children with sickle cell anemia and 49 children with hemoglobin SC disease (8-16 years old) followed since birth. Clinical charts were retrospectively reviewed to determine prior acute chest syndrome or vaso-occlusive episodes, and rates of these complications were calculated. RESULTS: Multivariate analysis revealed that: 1) a higher steady-state blood viscosity was associated with a higher rate of vaso-occlusive crises in children with sickle cell anemia, but not in children with hemoglobin SC disease; 2) a higher steady-state red blood cell disaggregation threshold was associated with previous history of acute chest syndrome in children with hemoglobin SC disease and boys with sickle cell anemia. CONCLUSIONS: Our results indicate for the first time that the red blood cell aggregation properties may play a role in the pathophysiology of acute chest syndrome in children with hemoglobin SC disease and boys with sickle cell anemia. In addition, whereas greater blood viscosity is associated with a higher rate of vaso-occlusive crises in children with sickle cell anemia, no association was found in children with hemoglobin SC disease, underscoring differences in the etiology of vaso-occlusive crises between sickle cell anemia and hemoglobin SC disease.
ISSN: 0390-6078

inserm-00849038
http://www.hal.inserm.fr/inserm-00849038
http://www.hal.inserm.fr/inserm-00849038/document
http://www.hal.inserm.fr/inserm-00849038/file/inserm-00849038.pdf
DOI : 10.3324/haematol.2012.066670

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Relationships between systemic vascular resistance, blood rheology and nitric oxide in children with sickle cell anemia or sickle cell-hemoglobin C disease. ; Relationships between systemic vascular resistance, blood rheology and nitric oxide in children with sickle cell anemia or sickle cell-hemoglobin C disease. : Hemodynamics in sickle cell disease
Auteur(s) : Lamarre, Yann Hardy-Dessources, Marie-Dominique Romana, Marc Lalanne-Mistrih, Marie-Laure Waltz, Xavier Petras, Marie Doumdo, Lydia Blanchet-Deverly, Anne
Auteurs secondaires : Protéines de la membrane érythrocytaire et homologues non-érythroides ; Université des Antilles et de la Guyane (UAG) - Institut National de la Transfusion Sanguine [Paris] (INTS) - Université Paris Diderot - Paris 7 (UPD7) - Université de la Réunion (UR) - Institut National de la Santé et de la Recherche Médicale (INSERM) Centre d'investigation clinique Antilles-Guyane ; Institut National de la Santé et de la Recherche Médicale (INSERM) - CH Cayenne Unité Transversale de la Drépanocytose ; CHU de Pointe-à-Pitre/Abymes Service d'Orthopédie et de Traumatologie ; Université des Antilles et de la Guyane (UAG) - CHU Pointe-à-Pitre/Abymes Unité d'explorations cardiovasculaire ; CHU de Pointe-à-Pitre/Abymes Service de Cardiologie ; CHU de Pointe-à-Pitre/Abymes Service de Pédiatrie ; CHU de Pointe-à-Pitre/Abymes The study has been funded by a Projet Hospitalier Recherche Clinique (PHRC) Interregional. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. This work was also supported by European funds and the Conseil Régional de la Guadeloupe (fellowship to YL), as well as Inserm funding. The authors have declared that no competing interests exist.

Éditeur(s) : HAL CCSD IOS Press
Résumé : International audience
Vascular function has been found to be impaired in patients with sickle cell disease (SCD). The present study investigated the determinants of systemic vascular resistance in two main SCD syndromes in children: sickle cell anemia (SCA) and sickle cell-hemoglobin C disease (SCC). Nitric oxide metabolites (NOx), hematological, hemorheological, and hemodynamical parameters were investigated in 61 children with SCA and 49 children with SCC. While mean arterial pressure was not different between SCA and SCC children, systemic vascular resistance (SVR) was greater in SCC children. Although SVR and blood viscosity (ηb) were not correlated in SCC children, the increase of ηb (+18%) in SCC children compared to SCA children results in a greater mean SVR in this former group. SVR was positively correlated with ηb, hemoglobin (Hb) level and RBC deformability, and negatively with NOx level in SCA children. Multivariate linear regression model showed that both NOx and Hb levels were independently associated with SVR in SCA children. In SCC children, only NOx level was associated with SVR. In conclusion, vascular function of SCC children seems to better cope with higher ηb compared to SCA children. Since the occurrence of vaso-occlusive like complications are less frequent in SCC than in SCA children, this finding suggests a pathophysiological link between the vascular function alteration and these clinical manifestations. In addition, our results suggested that nitric oxide metabolism plays a key role in the regulation of SVR, both in SCA and SCC.
ISSN: 1386-0291

inserm-00849031
http://www.hal.inserm.fr/inserm-00849031
http://www.hal.inserm.fr/inserm-00849031/document
http://www.hal.inserm.fr/inserm-00849031/file/2013_Lamarre_-_Relationships_between_SVR_BR_and_NO_in_children_with_sickle_cell_anemia_or_sickle_cell-hemoglobin_C_disease.pdf
DOI : 10.3233/CH-121661

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Incorporation of Biomedical Knowledge in Sickle Cell Disease (SCD) Representations of a Guadeloupe Schooled Population (FWI): Marie-Galante Profile
Auteur(s) : Jérôme, Pruneau Sylvain, Ferez Frédéric, Maillard Jacques, Dumont Ruffié, Sébastien Olivier, Hue
Auteurs secondaires : Adaptations au Climat Tropical, Exercice et Santé (ACTES) ; Université des Antilles et de la Guyane (UAG)

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