Éditeur(s) : AIHP-GEODE : Archéologie Industrielle, Histoire, Patrimoine/Géographie- Développement Environnement de la Caraïbe
Extrait de : "Rimed gran moun. Plantes et usages au fil du temps" : séminaire, le 15 décembre 2012. Université des Antilles et de la Guyane
Description : Cette deuxième tranche de débat est l'occasion d'insister sur la recherche moléculaire. Il est question de prolonger la réflexion sur la gossypitrine présentée dans l'exposé de Frantz François-Haugrin. La question des usages et pratiques en matière de médecine traditionnelle revient également. La médecine créole est présentée comme complément de la médecine académique. Suite au débat, Françoise Pagney clôture le séminaire sur les plantes aromatiques médicinales.
Siècle(s) traité(s) : 21
Droits : CC-BY-NC-ND - Attribution - Pas d'utilisation commerciale - Pas de modification
Permalien : http://www.manioc.org/fichiers/V13017
V13017

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The Dien Bien Phu (DBP) Fault strikes nearly perpendicular to the general tectonic framework, separating northwest Vietnam into two compartments. The DBP and Muong Lay granites are exposed respectively east and west of the fault. The U/Pb age of 277 ± 2 Ma obtained for the Muong Lay granite is similar to the age of the Chieng Khuong complex exposed within the Song Ma structure east of the DBP Fault. These two magmatic intrusions are considered as belonging to a same tectonic structure related to the subduction of the Song Ma Ocean under the Indochina Block during the Indosinian orogeny. The DBP Fault with a total post Permian dextral offset of 30-40 km shifts the Song Ma Suture. It could then be connected to the Ailao Shan-Shuanggou suture to the north. The undeformed DBP granite gave a U/Pb age of 230 ± 1 Ma sealing the Indosinian deformation on the fault. The Ladinian-Carnian activity of the fault is confirmed by the 40Ar/39Ar (biotite) age of 228 ± 4 Ma obtained from the paragneiss forming the fault zone. A geodynamic model is proposed to describe the various tectonic phases recorded by on the DBP Fault. It associates field data, stratigraphic observations, and geochronology analyses (U/Pb, Ar/Ar, fission tracks). Following the Late Triassic exhumation of the granite and the end of the Indosinian orogeny marked by the Norian unconformity, the granite was buried under Jurassic and Lower Cretaceous sediments. A strong cooling event during the early Late Cretaceous (100 Ma) is associated with the reactivation of the DBP Fault and the accommodation of a southward thrusting of the Song Da terrane onto the Truong Son Belt. This newly recognised tectonic phase could be associated to the subduction of the Paleo-Pacific plate under the Indochina Block. No data are available yet to constrain the Tertiary evolution of the DBP system. However, the Tertiary deformation is likely similar to the Cretaceous one.
ISSN: 1342-937X

insu-01015379
https://hal-insu.archives-ouvertes.fr/insu-01015379
DOI : 10.1016/j.gr.2013.07.018

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Archives of Cardiovascular Diseases Supplements
Strasbourg, France

hal-01118035
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01118035
DOI : 10.1016/S1878-6480(14)71283-2

Éditeur(s) : HAL CCSD
Résumé : International audience
Estrogen receptor alpha (ERα) has been recognized now for several decades as playing a key role in reproduction and exerting functions in numerous nonreproductive tissues. In this review, we attempt to summarize the in vitro studies that are the basis of our current understanding of the mechanisms of action of ERα as a nuclear receptor and the key roles played by its two activation functions (AFs) in its transcriptional activities. We then depict the consequences of the selective inactivation of these AFs in mouse models, focusing on the prominent roles played by ERα in the reproductive tract and in the vascular system. Evidence has accumulated over the two last decades that ERα is also associated with the plasma membrane and activates non-nuclear signaling from this site. These rapid/nongenomic/membrane-initiated steroid signals (MISS) have been characterized in a variety of cell lines, and in particular in endothelial cells. The development of selective pharmacological tools that specifically activate MISS and the generation of mice expressing an ERα protein impeded for membrane localization have begun to unravel the physiological role of MISS in vivo. Finally, we discuss novel perspectives for the design of tissue-selective ER modulators based on the integration of the physiological and pathophysiological roles of MISS actions of estrogens.
Physiological Reviews

hal-01533249
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01533249
DOI : 10.1152/physrev.00024.2016
PUBMED : 28539435

Éditeur(s) : HAL CCSD Elsevier
Résumé : In Vietnam, recent studies demonstrated that the Kon Tum Massif was part of the Indosinian mountain system, together with the Truong Son Belt. One sector of the Kon Tum Massif (Song Ba valley) is a granulite facies terrain for which Ar–Ar and U–Pb ages cluster around 245–250 Ma. In the area of Song Bien river, also metamorphosed under granulite facies conditions, Ar–Ar ages of 410 Ma are displayed by biotite. In this study, U–Pb dating of monazite and zircon has been used to understand the reason for these two groups of ages, taking into account the metamorphic mineral assemblages related to granulite facies metamorphism in the two districts. For granulites of Song Ba valley, ages of 245–250 Ma are confirmed from monazites. In the Song Bien district, ages of 465–470 Ma displayed by monazites are interpreted to correspond to the metamorphic climax. Zircons from one of these samples record the age of anatexis that has affected the granulitic rocks. The younger age recorded in the Song Ba valley is considered to reflect high temperature related to charnockitic intrusions emplaced near the end of the Indosinian orogeny, overprinting the earlier formed granulites and resetting the U–Pb and Ar–Ar ages. For the first time, two HT events are dated in the Kon Tum Massif, one occurring during the Ordovician and the other during the Permo-Triassic.
ISSN: 0743-9547

hal-00404975
https://hal.archives-ouvertes.fr/hal-00404975
DOI : 10.1016/j.jseaes.2007.01.005

Éditeur(s) : HAL CCSD European Centre for Disease Prevention and Control
Résumé : International audience
In 2002, the French Food Safety Agency drew attention to the lack of information on the prevalence of human cryptosporidiosis in the country. Two years later, the ANOFEL Cryptosporidium National Network (ACNN) was set up to provide public health authorities with data on the incidence and epidemiology of human cryptosporidiosis in France. Constituted on a voluntary basis, ACNN includes 38 hospital parasitology laboratories (mainly in university hospitals). Each laboratory is engaged to notify new cases of confirmed human cryptosporidiosis, store specimens (e.g. stools, duodenal aspirates or biopsies) and related clinical and epidemiological data, using data sheet forms. From January 2006 to December 2009, 407 cryptosporidiosis cases were notified in France and 364 specimens were collected. Of the notified cases, 74 were children under four years of age, accounting for 18.2%. HIV-infected and immunocompetent patients represented 38.6% (n=157) and 28% (n=114) of cases, respectively. A marked seasonal pattern was observed each year, with increased number of cases in mid to late summer and the beginning of autumn. Genotyping of 345 isolates from 310 patients identified C. parvumin 168 (54.2%) cases, C. hominis in 113 (36.4%) and other species in 29 (9.4%), including C. felis (n=15), C. meleagridis (n=4), C. canis (n=4), Cryptosporidium chipmunk genotype (n=1), Cryptosporidium rabbit genotype (n=1) and new Cryptosporidium genotypes (n=4). These data represent the first multisite report of laboratory-confirmed cases of cryptosporidiosis in France.
ISSN: 1560-7917

hal-00926813
https://hal-unilim.archives-ouvertes.fr/hal-00926813
PUBMED : 20739000

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : The First International Orogenic Lherzolite Conference was held in Montpellier, France, in 1990 (Menzies et al., 1991Go). Subsequent Orogenic Lherzolite Conferences were held in Granada, Spain in 1995, Pavia, Italy in 1999 and Samani, Japan in 2002. A vital aspect of all these meetings was the opportunity to visit nearby exposures of mantle peridotites: to date, participants have visited Lherz in France; Baldissero, Balmuccia, Erro Tobio, Finero, Lanzo and Liguria in Italy; Ronda in Spain; Beni Bousera in Morocco; and Horoman in Hokkaido, Japan. Peer-reviewed papers from all four conferences were published in the Journal of Petrology in 1991, 2001 and 2004 and, in one instance, in Chemical Geology in 1996.
ISSN: 0022-3530

hal-00496489
https://hal.archives-ouvertes.fr/hal-00496489
DOI : 10.1093/petrology/egp098

Éditeur(s) : HAL CCSD Springer Verlag
Résumé : International audience
Pituitary adenomas are currently classified by histological, immunocytochemical and numerous ultrastructural characteristics lacking unequivocal prognostic correlations. We investigated the prognostic value of a new clinicopathological classification with grades based on invasion and proliferation. This retrospective multicentric case-control study comprised 410 patients who had surgery for a pituitary tumour with long-term follow-up. Using pituitary magnetic resonance imaging for diagnosis of cavernous or sphenoid sinus invasion, immunocytochemistry, markers of the cell cycle (Ki-67, mitoses) and p53, tumours were classified according to size (micro, macro and giant), type (PRL, GH, FSH/LH, ACTH and TSH) and grade (grade 1a: non-invasive, 1b: non-invasive and proliferative, 2a: invasive, 2b: invasive and proliferative, and 3: metastatic). The association between patient status at 8-year follow-up and age, sex, and classification was evaluated by two multivariate analyses assessing disease- or recurrence/progression-free status. At 8 years after surgery, 195 patients were disease-free (controls) and 215 patients were not (cases). In 125 of the cases the tumours had recurred or progressed. Analyses of disease-free and recurrence/progression-free status revealed the significant prognostic value (p < 0.001; p < 0.05) of age, tumour type, and grade across all tumour types and for each tumour type. Invasive and proliferative tumours (grade 2b) had a poor prognosis with an increased probability of tumour persistence or progression of 25- or 12-fold, respectively, as compared to non-invasive tumours (grade 1a). This new, easy to use clinicopathological classification of pituitary endocrine tumours has demonstrated its prognostic worth by strongly predicting the probability of post-operative complete remission or tumour progression and so could help clinicians choose the best post-operative therapy.
ISSN: 0001-6322

hal-00875723
https://hal.archives-ouvertes.fr/hal-00875723
DOI : 10.1007/s00401-013-1084-y
PUBMED : 23400299

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
In northeastern Vietnam, the major tectonic episode responsible for nappes emplacement is Triassic. These allochtonous structures are intruded by granitic melts. Two post-tectonic massifs showing no sign of deformation have been dated by the LA-ICPMS zircon U-Pb techniques. Dating reveals a multiphase history with zircon cores showing evidence of Proterozoic magmatism. The emplacement of the Phia Bioc granite intrusive in allochtonous units is 248-245 Ma, an age which assesses a younger limit for the major nappes tectonic. This tectonic could be synchronous of the tectonometamorphic strike-slip faulting events (250-245 Ma) defined in the Truong Son Belt as the Indosinian orogen. The Phia Bioc intrusion is probably linked with the intra-plate magmatism of the Emeishan Large Igneous Province or with magma- tism associated with the Paleotethys closure. The age of the Phia Oac granite intrusion in displaced units is much younger, at 87.3 ± 1.2 Ma. This granite is probably linked to the magmatic activity produced dur- ing the Paleo-Pacific plate subduction under the SE Asia continental plate during the Mesozoic. Although the Cenozoic Red River fault system is close to these two plutons, this last thermotectonic episode has not been strong enough to disturb the U/Pb system. Zircons rims do not show any Tertiary magmatic or meta- morphic overprint.
ISSN: 0743-9547

hal-00681725
https://hal.archives-ouvertes.fr/hal-00681725
DOI : 10.1016/j.jseaes.2011.12.012

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The biogeochemistry of sulfur and carbon during early-diagenetic processes within organic-rich marine mangrove sediments was studied in the “Manche à Eau” lagoon, Guadeloupe, West Indies. These sediments are characterized by a total organic carbon content (TOC) mostly above 11 wt%, δ13CTOC below − 25‰ VPDB and C/Nmolar ratios exceeding 15. Rates of mangrove-derived organic carbon accumulation vary between ~ 200 and 400 gOC·m− 2·yr− 1, with highest rates at the shore of the lagoon. On the lagoon border, where colorless filamentous sulfur-oxidizing bacteria colonize the sediments, active sulfate reduction within the upper 20 cm, with a net removal rate of ~ 0.5 μmol·cm− 3·d− 1, is assumed to be essentially driven by organic carbon oxidation. This is expressed by relatively low apparent sulfur isotope fractionation (34εnet = − 33‰) and a gentle δ18O/δ34Ssulfate apparent slope of 0.36 ± 0.03 (2s). Further inside the lagoon, in the absence of sulfur-oxidizing bacteria, higher apparent sulfur isotope fractionation and a steeper δ18O/δ34Ssulfate slope (0.67 ± 0.20) suggest an overall lower sulfate removal rate that may be coupled to minor sulfur disproportionation. Spatial and vertical variation in sulfur cycling, reflected by oxygen and sulfur isotopic characteristics, seem to be mainly controlled by unsteady to relatively steady organic matter deposition and its reactivity. In all sediments, δ34S values of pyrite are positively correlated with the TOC/TS ratio and negatively correlated with δ13CTOC; suggesting a primary control of the quantity and quality of organic matter on the pyrite isotope records, despite potential iron-limiting conditions for the most active sites. Our results provide insights into the role of organic carbon input on sulfur cycling; stimulating sulfate reduction and in turn the presence of sulfur-oxidizing microbial mats, resulting in an intense cycling of both carbon and sulfur in these marine mangrove sediments.
ISSN: 0009-2541

hal-01507696
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01507696
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01507696/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01507696/file/Cr%C3%A9mi%C3%A8re%20et%20al.%20-%20Sulfur%20diagenesis%20under%20rapid%20accumulation%20of%20orga.pdf
DOI : 10.1016/j.chemgeo.2017.02.017

Éditeur(s) : HAL CCSD
Résumé : International audience
Up-to-date estimates of the health outcomes of preterm children are needed for assessing perinatal care, informing parents, making decisions about care, and providing evidence for clinical guidelines. To determine survival and neonatal morbidity of infants born from 22 through 34 completed weeks' gestation in France in 2011 and compare these outcomes with a comparable cohort in 1997. The EPIPAGE-2 study is a national, prospective, population-based cohort study conducted in all maternity and neonatal units in France in 2011. A total of 2205 births (stillbirths and live births) and terminations of pregnancy at 22 through 26 weeks' gestation, 3257 at 27 through 31 weeks, and 1234 at 32 through 34 weeks were studied. Cohort data were collected from January 1 through December 31, 1997, and from March 28 through December 31, 2011. Analyses for 1997 were run for the entire year and then separately for April to December; the rates for survival and morbidities did not differ. Data are therefore presented for the whole year in 1997 and the 8-month and 6-month periods in 2011. Survival to discharge and survival without any of the following adverse outcomes: grade III or IV intraventricular hemorrhage, cystic periventricular leukomalacia, severe bronchopulmonary dysplasia, retinopathy of prematurity (stage 3 or higher), or necrotizing enterocolitis (stages 2-3). A total of 0.7% of infants born before 24 weeks' gestation survived to discharge: 31.2% of those born at 24 weeks, 59.1% at 25 weeks, and 75.3% at 26 weeks. Survival rates were 93.6% at 27 through 31 weeks and 98.9% at 32 through 34 weeks. Infants discharged home without severe neonatal morbidity represented 0% at 23 weeks, 11.6% at 24 weeks, 30.0% at 25 weeks, 47.5% at 26 weeks, 81.3% at 27 through 31 weeks, and 96.8% at 32 through 34 weeks. Compared with 1997, the proportion of infants surviving without severe morbidity in 2011 increased by 14.4% (P < .001) at 25 through 29 weeks and 6% (P < .001) at 30 through 31 weeks but did not change appreciably for those born at less than 25 weeks. The rates of antenatal corticosteroid use, induced preterm deliveries, cesarean deliveries, and surfactant use increased significantly in all gestational-age groups, except at 22 through 23 weeks. The substantial improvement in survival in France for newborns born at 25 through 31 weeks' gestation was accompanied by an important reduction in severe morbidity, but survival remained rare before 25 weeks. Although improvement in survival at extremely low gestational age may be possible, its effect on long-term outcomes requires further studies. The long-term results of the EPIPAGE-2 study will be informative in this regard.
ISSN: 2168-6211

hal-01258705
http://hal.univ-brest.fr/hal-01258705
PUBMED : 25621457
DOI : 10.1001/jamapediatrics.2014.3351

Résumé : Le Brésil et la France partagent une frontière commune sur plus de 700 kilomètres, via la Guyane, région monodépartementale d’Outre-Mer française, et l’Amapá, Etat de la République fédérative du Brésil. Réalité socio-spatiale en marges à toutes les échelles malgré le différentiel socio-économique fort qu’elle marque, la frontière franco-brésilienne est devenue, depuis les années 1990, une interface politique, support de la relance des relations internationales franco-brésiliennes et des relations entre Guyane et Amapá.La thèse pose la question de cet écart en se concentrant sur la partie estuarienne de la frontière fluviale de l’Oyapock, autour des bourgs riverains de Saint-Georges (Guyane française) et d’Oiapoque (Brésil), entre lesquels un pont binational d’envergure est en construction, malgré leur rattachement routier à la marge aux polarités régionales de Cayenne et de Macapá.
Brazil and France share a common border of over 700 km via French Guiana, a French Overseas monodepartmental region, and Amapá, State of the Federal Republic of Brazil. Socio-spatial margin at all scales despite the strong socio-economic differential it marks, the Franco-Brazilian border has become since the 1990s a political interface, support for the revival of the Franco-Brazilian international relations and of the relations between French Guiana and Amapá. The thesis raises the question of this gap, focusing on the estuarine portion of the border river of the Oyapock, around the towns of Saint-Georges (French Guiana) and Oiapoque (Brazil) ; a significant bi-national bridge is under construction between these two towns, despite their road connection as margins to the regional polarities of Cayenne and Macapá.
Brasil e França compartilham uma fronteira comum com mais de 700 km através da Guiana Francesa, Região monodepartamental ultramarina francesa, e do Amapá, Estado da República Federativa do Brasil. Realidade sócio-espacial à margem a todas as escalas, apesar do forte diferencial sócio-econômico que a marca, a fronteira franco-brasileira tornou-se, desde os anos 90, uma interface política, suporte para a retomada das relações internacionais franco-brasileiras e das relações entre a Guiana Francesa e o Amapá. A tese expõe a questão deste desnível, centrando-se na porção estuarina da fronteira fluvial do Oiapoque, ao redor das pequenas cidades de Saint-Georges (Guiana Francesa) e de Oiapoque (Brasil), entre as quais uma ponte binacional de grande porte está em construção, apesar da ligação rodoviária delas como margens aos pólos regionais de Caiena e Macapá.

http://www.theses.fr/2012AGUY0504/document

Éditeur(s) : HAL CCSD
Congrès de la Société Française de Mycologie Médicale
Poitiers, France

hal-00676567
https://hal.archives-ouvertes.fr/hal-00676567

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
While the populations of large herbivores are being depleted in many tropical rainforests, the importance of their trophic role in the ecological functioning and biodiversity of these ecosystems is still not well evaluated. This is due to the outstanding plant diversity that they feed upon and the inherent difficulties involved in observing their elusive behaviour. Classically, the diet of elusive tropical herbivores is studied through the observation of browsing signs and macroscopic analysis of faeces or stomach contents. In this study, we illustrate that the original coupling of classic methods with genetic and ethnobotanical approaches yields information both about the diet diversity, the foraging modalities and the potential impact on vegetation of the largest terrestrial mammal of Amazonia, the lowland tapir. The study was conducted in the Guianan shield, where the ecology of tapirs has been less investigated. We identified 92 new species, 51 new genera and 13 new families of plants eaten by tapirs. We discuss the relative contribution of our different approaches, notably the contribution of genetic barcoding, used for the first time to investigate the diet of a large tropical mammal, and how local traditional ecological knowledge is accredited and valuable for research on the ecology of elusive animals.
ISSN: 1932-6203

halsde-00676374
https://hal.archives-ouvertes.fr/halsde-00676374
DOI : 10.1371/journal.pone.0025850
PUBMED : 21991372

Éditeur(s) : HAL CCSD Oxford University Press (OUP): Policy A1 - Oxford Open Option C
Résumé : International audience
BACKGROUND: Infections of renal grafts with Candida species can induce life-threatening complications in the recipient. METHODS: A 9-year retrospective study involving all of the transplant centers in France was designed to determine the incidence, origin, characteristics, and outcome of graft-site candidiasis that occurred after kidney transplantation. Yeasts cultured from preservation or drainage solutions and graft specimens were recorded. RESULTS: Among 18,617 kidney grafts, 18 recipients corresponding to 12 donors developed culture-confirmed graft-site candidiasis (incidence, 1 case per 1000 grafts) a median of 25 days after the graft procedure. Clinical presentations included 14 cases of renal arteritis (13 were complicated by aneurysm), 1 urinoma, 2 graft site abscesses, and 1 surgical site infection. Candida albicans was involved in 13 cases. A unique C. albicans genotype or a single rare Candida species was involved in each episode. Together with the clinical history, these findings demonstrate that organ contamination followed by transmission to the recipient occurred during recovery. Therapeutic management varied from simple monitoring in 1 case to a combination of surgery (nephrectomy in 9 cases and arterial bypass in 9 cases) and antifungal therapy (14 cases). Overall, 3 of 18 kidney transplant recipients died, and 9 had their graft surgically removed. CONCLUSION: Graft-transmitted candidiasis that ends most often in fungal arteritis is associated with high morbidity and mortality after kidney transplantation and is related to organ contamination during recovery in the donor.
Clinical Infectious Diseases

hal-00676313
https://hal.archives-ouvertes.fr/hal-00676313
DOI : 10.1086/595688
PUBMED : 19090753

Éditeur(s) : HAL CCSD Wiley Open Access
Résumé : International audience
Estetrol (E4) is a natural estrogen with a long half-life produced only by the human fetal liver during pregnancy. The crystal structures of the estrogen receptor α (ERα) ligand-binding domain bound to 17β-estradiol (E2) and E4 are very similar, as well as their capacity to activate the two activation functions AF-1 and AF-2 and to recruit the coactivator SRC3. In vivo administration of high doses of E4 stimulated uterine gene expression, epithelial proliferation, and prevented atheroma, three recognized nuclear ERα actions. However, E4 failed to promote endothelial NO synthase activation and acceleration of endothelial healing, two processes clearly dependent on membrane-initiated steroid signaling (MISS). Furthermore, E4 antagonized E2 MISS-dependent effects in endothelium but also in MCF-7 breast cancer cell line. This profile of ERα activation by E4, uncoupling nuclear and membrane activation, characterizes E4 as a selective ER modulator which could have medical applications that should now be considered further.
ISSN: 1757-4676

hal-01118028
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01118028
PUBMED : 25214462
PUBMEDCENTRAL : PMC4287935
DOI : 10.15252/emmm.201404112