Éditeur(s) : HAL CCSD European Geosciences Union (EGU) European Geosciences Union
Résumé : The Moroccan Mediterranean coast is located in one of the area's most vulnerable to extreme weather events or tsunami hazards. The objective of this research is to reconstruct the historical extreme submersion-event record using sea-induced deposits preserved in coastal lagoon. The Nador lagoon is the largest Moroccan lagoon (115 km2). It is located along the western Mediterranean, which has a high cyclogenetic character and is exposed to tsunamis from the Alboran Sea. The sandy barrier which separates the lagoon from the Mediterranean Sea is marked by much overwash, which indicate how intensely it has been exposed to the adverse sea events through history. Using the UWITEC© gravity coring platform, an undisturbed MC4.5 core (1.15 m long) was successfully sampled in the studied lagoon. To identify extreme sea events, a multi-proxy approach was applied combining sedimentological and geochemical data. Three paleoevents were identified; all of them are concentrated over the last 500 years, and the most recent event corresponds to the 1889 storm. For the others deposits, it is difficult to determine exactly their origin; however, the high frequency of storm events over the relevant period and the absence of historical tsunamis evidence is more in favor of the meteorological origin.
ISSN: 1561-8633

hal-01146451
https://hal.archives-ouvertes.fr/hal-01146451
DOI : 10.5194/nhess-15-203-2015

Éditeur(s) : HAL CCSD Landes Bioscience
Résumé : International audience
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.
Autophagy

hal-00735751
https://hal.archives-ouvertes.fr/hal-00735751
PUBMED : 22966490