Éditeur(s) : HAL CCSD Bureau de recherches géologiques et minières
Résumé : Pour calculer la probabilité d'un futur séisme partiellement destructeur...
ISSN: 0292-8477

hal-00854040
https://hal.archives-ouvertes.fr/hal-00854040

Éditeur(s) : HAL CCSD Landes Bioscience
Résumé : International audience
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.
Autophagy

hal-00735751
https://hal.archives-ouvertes.fr/hal-00735751
PUBMED : 22966490

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
A dense, local network of 30 geodetic markers covering a 50 × 60 km2 area in the southwestern European Alps (Briançon region) has been temporarily surveyed in 1996, 2006 and 2011 by GPS. The aim is to measure the current deformation in this seismically active area. The study zone is characterized by a majority of extensional and dextral focal mechanisms, along north–south to N160 oriented faults. The combined analysis of the three measurement campaigns over 15 years and up to 16 years of permanent GPS data from the French RENAG network now enables to assess horizontal velocities below 1 mm/year within the local network. The long observation interval and the redundancy of the dense campaign network measurement help to constrain a significant local deformation pattern in the Briançon region, yielding an average E–W extension of 16 ± 11 nanostrain/year. We compare the geodetic deformation field to the seismic deformation rate cumulated over 37 years, and obtain good coherencies both in amplitude and direction. Moreover, the horizontal deformation localized in the Briançon region represents a major part of the Adriatic-European relative plate motion. However, the average uplift of the network in an extensional setting needs the presence of buoyancy forces in addition to plate tectonics.
ISSN: 0264-3707

hal-01119724
https://hal.archives-ouvertes.fr/hal-01119724
DOI : 10.1016/j.jog.2015.02.001

Éditeur(s) : HAL CCSD Elsevier
Résumé : This paper analyzes the effects of pollution permit markets on equilibrium employment in a wage-setting/ price-setting (WS-PS) model. The employment level is determined according to different methods of financing unemployment benefits: a wage tax or the revenue from a pollution permit auction. We show that a permit market weakens the trade unions' market power. Furthermore, whatever the method of financing unemployment benefits, the choice of the pollution cap is always neutral for employment, and the level of employment always increases as the pollution abatement technology becomes more efficient. Depending on the value of the wage tax, the employment level can be higher or lower when unemployment benefits are financed by pollution permits rather than wage tax.
ISSN: 0264-9993

halshs-00866721
https://halshs.archives-ouvertes.fr/halshs-00866721

Éditeur(s) : HAL CCSD
Résumé : In the bay of Aigues-Mortes, the managers of the co astal cities try to preserve the socio-economic and patrimonial stakes against the coastal hazards, such as contamination, storm surge and erosion. In this context, a massive beach nourishment of sand (1 million of m3 for 10km of coastline) was made at the beginning of year 2008 to reduce erosion. The REPBAM project (REchargements et Panaches sédiment aires dans la Baie d'Aigues-Mortes) aims to qualify and quantify by in-situ measurements and numerical modelling: 1. the geomorphological evolution of this modified coast and 2. the impact of the sediment's resuspension on the coastal ecosystems, in particular the one of the Posidonia oceanica seagrass. A numerical modelling "wave/current/sediment" is first implemented for December 2008. Nested and curvilinear grids allow a very high resolution for the beach area but also include the inner shelf where the seagrasses are located. Hydrodynamic and topo-bathymetric measurements were acquired from January to May 2012. Model and measurements results show the same trends during storms: strong currents, seaward migrationof the innerbar, sediment resuspension and turbid on the inner shelf.
Coastal Dynamics 2013
Arcachon, France

hal-00908082
https://hal.archives-ouvertes.fr/hal-00908082