Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
Anthropogenic impacts are increasingly affecting the world's oceans. Networks of marine protected areas (MPAs) provide an option for increasing the ecological and economic benefits often provided by single MPAs. It is vital to empirically assess the effects of MPA networks and to prioritize the monitoring data necessary to explain those effects. We summarize the types of MPA networks based on their intended management outcomes and illustrate a framework for evaluating whether a connectivity network is providing an outcome greater than the sum of individual MPA effects. We use an analysis of an MPA network in Hawai'i to compare networked MPAs to non-networked MPAs to demonstrate results consistent with a network effect. We assert that planning processes for MPA networks should identify their intended outcomes while also employing coupled field monitoring-simulation modeling approaches, a powerful way to prioritize the most relevant monitoring data for empirically assessing MPA network performance.
ISSN: 1932-6203

Droits : http://creativecommons.org/licenses/by/
hal-01341695
https://hal-univ-perp.archives-ouvertes.fr/hal-01341695
https://hal-univ-perp.archives-ouvertes.fr/hal-01341695/document
https://hal-univ-perp.archives-ouvertes.fr/hal-01341695/file/journal.pone.0102298.PDF
DOI : 10.1371/journal.pone.0102298

Éditeur(s) : HAL CCSD Springer Verlag
Résumé : International audience
The implication of oxidative stress as primary mechanism inducing doxorubicin (DOX) cardiotoxicity is still questionable as many in vitro studies implied supra-clinical drug doses or unreliable methodologies for reactive oxygen species (ROS) detection. The aim of this study was to clarify whether oxidative stress is involved in compliance with the conditions of clinical use of DOX, and using reliable tools for ROS detection. We examined the cytotoxic mechanisms of 2 μM DOX 1 day after the beginning of the treatment in differentiated H9c2 rat embryonic cardiac cells. Cells were exposed for 2 or 24 h with DOX to mimic a single chronic dosage or to favor accumulation, respectively. We found that apoptosis was prevalent in cells exposed for a short period with DOX: cells showed typical hallmarks as loss of anchorage ability, mitochondrial hyperpolarization followed by the collapse of mitochondrial activity, and nuclear condensation. Increasing the exposure period favored a shift to necrosis as the cells preferentially exhibited early DNA impairment and nuclear swelling. In either case, measuring the fluorescence lifetime of 1-pyrenebutyric acid or the intensities of dihydroethidium or amplex red showed a consistent pattern in ROS production which was a slight increased level far from representative of an oxidative stress. Moreover, pre-treatment with dexrazoxane provided a cytoprotective effect although it failed to detoxify ROS. Our data support that oxidative stress is unlikely to be the primary mechanism of DOX cardiac toxicity in vitro.
ISSN: 0300-8177

hal-01285736
https://hal-univ-perp.archives-ouvertes.fr/hal-01285736
DOI : 10.1007/s11010-016-2653-x

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The Dahomey belt in Togo and Benin is an important segment of the larger West Gondwana Orogen. Here, we review the geodynamic evolution of the Dahomey belt and discuss new U–Pb and Lu–Hf zircon data in light of similar data previously acquired on the geologically related Northern Borborema Province, in NE Brazil. Eighteen samples from different tectonic settings and regions within the belt were collected for zircon isotopic investigation. Passive margin deposits of the Atacora Structural Unit and lower units of the Volta Basin have detrital zircon signatures compatible with the flanking West Africa Craton. The arc-related magmatism resulted from the east-dipping subduction of the Goiás-Pharusian oceanic lithosphere and is represented by a variety of granitoids emplaced in the Benino-Nigerian Shield between 670 and 610 Ma. These granitoids were mainly sourced from crustal reservoirs with subordinate juvenile input. Detrital zircon ages from syn-orogenic deposits in Benino-Nigerian Shield suggest that arc development could have started as early as 780 Ma. The main period of melting in the internal part of the belt, the Benino-Nigerian Shield, is related to crustal thickening and occurs only ca. 30 m.y. after initiation of the continental collision, marked by the ca. 610 Ma ultra-high pressure (UHP) metamorphism recorded at Lato Hills. Foreland development represented by the upper units of the Volta basin developed soon after continental collision and persisted with the development of the west-verging thrust front synchronously with the main period of crustal melting due to collision at ca. 580 Ma. The subvertical Transbrasiliano Lineament in South America, that corresponds to the Kandi Lineament in Africa, provides a present-day fit between NW Africa and NE Brazil. Restoration of the movement of the Transbrasiliano-Kandi Lineament (strike-slip plate boundary) places the Dahomey belt and Borborema Province (NE Brazil) along the same section of the West Gondwana Orogen. This configuration would explain some of the misfits previously discussed in the literature and aligns the UHP eclogites in Togo and NE Brazil.
ISSN: 0301-9268

hal-01358584
https://hal.archives-ouvertes.fr/hal-01358584
DOI : 10.1016/j.precamres.2016.01.032