Éditeur(s) : HAL CCSD
Résumé : International audience
Extreme rainfall events can trigger numerous landslides in mountainous areas and a prolonged increase of river sediment load. The resulting mass transfer at the Earth surface in turn induces stress changes at depth, which could be sufficient to trigger shallow earthquakes. The 2009 Morakot typhoon represents a good case study as it delivered 3 m of precipitation in 3 days and caused some of the most intense erosion ever recorded. Analysis of seismicity time-series before and after the Morakot typhoon reveals a systematic increase of shallow (i.e. 0-15 km of depth) earthquake frequency in the vicinity of the areas displaying a high spatial density of landslides. This step-like increase in frequency lasts for at least 2-3 years and does not follow an Omori-type aftershock sequence. Rather, it is associated to a step change of the Gutenberg-Richter b-value of the earthquake catalog. Both changes occurred in mountainous areas of southwest Taiwan, where typhoon Morakot caused extensive landsliding. These spatial and temporal correlations strongly suggest a causal relationship between the Morakot-triggered landslides and the increase of earthquake frequency and their associated b-value. We propose that the progressive removal of landslide materials from the steep mountain landscape by river sediment transport acts as an approximately constant increase of the stress rate with respect to pre-typhoon conditions, and that this in turn causes a step-wise increase in earthquake frequency. To test this hypothesis, we investigate the response of a rate-and-state fault to stress changes using a 2-D continuum elasto-dynamic model. Consistent with the results of Ader et al. (2013), our preliminary results show a step-like increase of earthquake frequency in response to a step-like decrease of the fault normal stress. We also investigate the sensitivity of the amplitude and time-scale of the earthquake frequency increase to the amplitude of the normal stress change and to rheological parameters. Our study offers new insights on the potential influence of extreme erosional events on the short-time scale dynamics of faults and earthquakes.
American Geophysical Union Fall Meeting 2016
San Francisco, United States

insu-01416987
https://hal-insu.archives-ouvertes.fr/insu-01416987

Éditeur(s) : HAL CCSD
Résumé : International audience
This article describes the educational ideologies observed between 2010 and 2015 among the Wayana-Apalaï – an indigenous community living in the French Guiana rainforest - and their influence on local educational styles, training priorities and strategies of social success. The results of our fieldwork show that the dynamics of national and global integration have succeeded in transforming local educational ideologies - especially those linked to the Amazon ecosystem - by introducing new criteria of success and assigning a leading educative role to formal schooling.
En este texto, se describen los caracteres propios a la ideología educativas de los Wayana-Apalaï, una comunidad indígena que vive en el sector amazónico de la Guayana francesa, así como los estilos educativos, las prioridades de formación y las representaciones sociales del éxito que caracterizan a esta comunidad. Los resultados de las observaciones realizadas entre 2010 y 2015 en el marco de esta investigación muestran que las dinámicas de integración nacional y global están logrando transformar las ideologías educativas locales – y, sobre todo, los aspectos más vinculados con el ecosistema amazónico-mediante la introducción de nuevos criterios de éxito y asignando un papel protagónico a la educación escolar.
Revista Kavilando

Droits : info:eu-repo/semantics/OpenAccess
hal-01587174
https://hal.archives-ouvertes.fr/hal-01587174
https://hal.archives-ouvertes.fr/hal-01587174/document
https://hal.archives-ouvertes.fr/hal-01587174/file/ALI%2C%20M.%20et%20AILINCAI%2C%20R.%20%282017%29.%20La%20ideolog%C3%ADa%20educativa%20de%20los%20Wayana-Apala%C3%AF%20de%20la%20Guyana%20francesa.pdf

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
Basal cell carcinoma (BCC) is the commonest tumor in human. About 70% sporadic BCCs bear somatic mutations in the PATCHED1 tumor suppressor gene which encodes the receptor for the Sonic Hedgehog morphogen (SHH). PATCHED1 germinal mutations are associated with the dominant Nevoid Basal Cell Carcinoma Syndrome (NBCCS), a major hallmark of which is a high susceptibility to BCCs. Although the vast majority of sporadic BCCs arises exclusively in sun exposed skin areas, 40 to 50% BCCs from NBCCS patients develop in non photo-exposed skin. Since overwhelming evidences indicate that microenvironment may both be modified by- and influence the- epithelial tumor, we hypothesized that NBCCS fibroblasts could contribute to BCCs in NBCCS patients, notably those developing in non photo-exposed skin areas. The functional impact of NBCCS fibroblasts was then assessed in organotypic skin cultures with control keratinocytes. Onset of epidermal differentiation was delayed in the presence of primary NBCCS fibroblasts. Unexpectedly, keratinocyte proliferation was severely reduced and showed high levels of nuclear P53 in both organotypic skin cultures and in fibroblast-led conditioning experiments. However, in spite of increased levels of senescence associated β-galactosidase activity in keratinocytes cultured in the presence of medium conditioned by NBCCS fibroblasts, we failed to observe activation of P16 and P21 and then of bona fide features of senescence. Constitutive extinction of P53 in WT keratinocytes resulted in an invasive phenotype in the presence of NBCCS fibroblasts. Finally, we found that expression of SHH was limited to fibroblasts but was dependent on the presence of keratinocytes. Inhibition of SHH binding resulted in improved epidermal morphogenesis. Altogether, these data suggest that the repertoire of diffusible factors (including SHH) expressed by primary NBCCS fibroblasts generate a stress affecting keratinocytes behavior and epidermal homeostasis. Our findings suggest that defects in dermo/epidermal interactions could contribute to BCC susceptibility in NBCCS patients.
ISSN: 1932-6203

Droits : http://creativecommons.org/licenses/by/
hal-01257867
http://hal.upmc.fr/hal-01257867
http://hal.upmc.fr/hal-01257867/document
http://hal.upmc.fr/hal-01257867/file/journal.pone.0145369.pdf
DOI : 10.1371/journal.pone.0145369

Éditeur(s) : HAL CCSD
Résumé : International audience
The Alboran Domain, situated at the western end of the Mediterranean subduction system, is characterized by theRonda Peridotites, one of the world largest exposures of sub-continental mantle. Using U-Pb (LA-ICP-MS) and Ar-Ar dating, we precisely dated two tectonic events associated with the Tertiary exhumation of the Ronda Peridotites.First, shearing along the Crust-Mantle Extensional Shear Zone caused, at ca. 22.5 Ma, mantle exhumation, localpartial melting in the deep crust and coeval cooling in the upper crust. Second, the Ronda Peridotites Thrusttriggered the final crustal emplacement of the peridotites onto the continental crust at ca. 21 Ma, as testified bygranitic intrusions in the thrust hanging-wall. The tectonic evolution of the western Alboran Domain is thereforecharacterized by a fast switch from a continental lithosphere extension in a backarc setting, with sub-continentalmantle exhumation, to a rift inversion by thrusting driven by shortening of the subduction upper plate
European Geosciences Union General Assembly 2017
Vienne, Austria

insu-01510393
https://hal-insu.archives-ouvertes.fr/insu-01510393

Éditeur(s) : HAL CCSD
Résumé : National audience
Epidemiological researches in the field of DOHaD are in favor of a role of early environment, including chemical (pesticides), physical (air pollution), nutritional or psychosocial environment, on child and adult health. Disentangling the different factors of environment that may affect health, especially over time, and identifying critical periods of exposure remains a major challenge. The biological mechanisms involved remain elusive in human beings. Nevertheless, it seems that whatever the nature of the exposure, epigenetic mechanisms are currently discussed to explain how the environment may alter biological systems over time.
Les résultats épidémiologiques dans le domaine de la DOHaD (developmental origins of health and disease) sont en faveur d’un rôle de l’environnement précoce sur la santé immédiate mais aussi future, qu’il s’agisse de l’environnement physique, chimique, nutritionnel ou encore psychosocial. Faire la part des différents facteurs de l’environnement susceptibles de modifier la santé, notamment sur le long terme, et des périodes critiques d’exposition reste un enjeu majeur. De même, les multiples mécanismes biologiques impliqués restent encore, pour une grande part, à identifier chez l’homme. Il semble néanmoins que, quelle que soit la nature de l’exposition considérée, des mécanismes épigénétiques sont actuellement évoqués pour expliquer comment l’environnement est susceptible de modifier des systèmes biologiques sur le long terme.
Médecine Sciences: M/S

hal-01274219
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01274219
DOI : 10.1051/medsci/20163201005
PUBMED : 26850603

Éditeur(s) : Paris : Bloud et Gay
Résumé : Publication du Comité «  L'effort de la France et de ses alliés »
Siècle(s) traité(s) : 20
Droits : Domaine public
Provenance : Ville de Pointe-à-Pitre. Réseau des bibliothèques
Permalien : http://www.manioc.org/patrimon/PAP11175
PAP11175

Éditeur(s) : HAL CCSD
Résumé : International audience
EGU General Assembly
Vienne, Austria

insu-01091973
https://hal-insu.archives-ouvertes.fr/insu-01091973