Éditeur(s) : [s.n.] [s.n.] ( [Fort de France] )
Résumé : Original in the files of the Archives of Martinique, F. W. I.
Martinique

AJD5614
001723104

Éditeur(s) : [s.n.] [s.n.] ( [Fort de France] )
Résumé : Original in the files of the Archives of Martinique, F. W. I.
Martinique

001723104
AJD5614

Éditeur(s) : [s.n.] [s.n.] ( [Fort de France] )
Résumé : Original in the files of the Archives of Martinique, F. W. I.
Martinique

AJD5614
001723104

Résumé : Original manuscript records in the Archives of Martinique, F.W.I.

001907368
AJY2793

Éditeur(s) : [s.n.] [s.n.] ( [Fort de France] )
Résumé : Original in the files of the Archives of Martinique, F. W. I.
Martinique

001723104
AJD5614

Éditeur(s) : [s.n.] [s.n.] ( [Fort de France] )
Résumé : Original in the files of the Archives of Martinique, F. W. I.
Martinique

AJD5614
001723104

Résumé : Original manuscript records in the Archives of Martinique, F.W.I.

001907368
AJY2793

Résumé : Original manuscript records in the Archives of Martinique, F.W.I.

001907368
AJY2793

Résumé : Original manuscript records in the Archives of Martinique, F.W.I.

001907368
AJY2793

Résumé : Original manuscript records in the Archives of Martinique, F.W.I.

001907368
AJY2793

Éditeur(s) : [s.n.] [s.n.] ( [Fort de France] )
Résumé : Original in the files of the Archives of Martinique, F. W. I.
Martinique

AJD5614
001723104

Éditeur(s) : [s.n.] [s.n.] ( [Fort de France] )
Résumé : Original in the files of the Archives of Martinique, F. W. I.
Martinique

AJD5614
001723104

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
Diagnosis of toxoplasmic encephalitis (TE) in patients with AIDS is not straightforward because clinicians rely initially on an empiric diagnosis based on clinical and radiographic improvement to specific anti-Toxoplasma gondii therapy. There is therefore a need for biological tools to improve the diagnosis of TE, especially in tropical areas where this diagnosis is likely to be underestimated. The use of PCR testing in blood samples for the diagnosis of TE has been limited by its poor sensitivity in the studies conducted in Europe. In tropical South America, the results of PCR sensitivity in blood samples were controversial. Considering that T. gondii strains from tropical South America have substantial genetic and pathogenic differences with those from USA and Europe, it is therefore important to re-evaluate the performance of the PCR assay in blood samples for the diagnosis of TE in AIDS patients from this region. Our results showed that the only interest of PCR would be in the most severe forms of TE with altered consciousness because PCR is more likely to be positive. We also provided important genotyping data on T. gondii strains isolated in human cases of toxoplasmosis in the Caribbean and in South America.
ISSN: 1935-2727

hal-01503761
https://hal-unilim.archives-ouvertes.fr/hal-01503761
https://hal-unilim.archives-ouvertes.fr/hal-01503761/document
https://hal-unilim.archives-ouvertes.fr/hal-01503761/file/journal.pntd.0004790.pdf
DOI : 10.1371/journal.pntd.0004790

Éditeur(s) : HAL CCSD BioMed Central
Résumé : International audience
Background: HCV treatment uptake has drastically increased in HIV-HCV coinfected patients in France since direct-acting antiviral (DAA) treatment approval, resulting in HCV cure in 63% of all HIV-HCV patients by the end of 2015. We investigated the impact of scaling-up DAA on HCV prevalence in the whole HIV population and in various risk groups over the next 10 years in France using a transmission dynamic compartmental model.Methods: The model was based on epidemiological data from the French Dat’AIDS cohort. Eight risk groups wereconsidered, including high-risk (HR) and low-risk (LR) men who have sex with men (MSM) and male/female heterosexuals,intra-venous drug users, or patients from other risk groups. The model was calibrated on prevalence and incidence dataobserved in the cohort between 2012 and 2015.Results: On January 1, 2016, 156,811 patients were registered as infected with HIV in France (24,900 undiagnosedpatients) of whom 7938 (5.1%) had detectable HCV-RNA (722 undiagnosed patients). Assuming a treatmentcoverage (TC) rate of 30%/year (i.e., the observed rate in 2015), model projections showed that HCV prevalenceamong HIV patients is expected to drop to 0.81% in 2026. Sub-analyses showed a similar decrease of HIV-HCVprevalence in most risk groups, including LR MSM. Due to higher infection and reinfection rates, predicted prevalencein HR MSM remained stable from 6.96% in 2016 to 6.34% in 2026. Increasing annual TC rate in HR MSM to 50/70%would decrease HCV prevalence in this group to 2.35/1.25% in 2026. With a 30% TC rate, undiagnosed patients wouldaccount for 34% of HCV infections in 2026.Conclusions: Our model suggests that DAA could nearly eliminate coinfection in France within 10 years for most riskgroups, including LR MSM. Elimination in HR MSM will require increased TC.
ISSN: 1741-7015

Droits : info:eu-repo/semantics/OpenAccess
inserm-01685739
http://www.hal.inserm.fr/inserm-01685739
http://www.hal.inserm.fr/inserm-01685739/document
http://www.hal.inserm.fr/inserm-01685739/file/2017%2C%20Virlogeux%20-%20Modeling%20HIV-HCV%20coinfection.pdf
DOI : 10.1186/s12916-017-0979-1

Résumé : Original manuscript records in the Archives of Martinique, F.W.I.

001907368
AJY2793

Éditeur(s) : [s.n.] [s.n.] ( [Fort de France] )
Résumé : Original in the files of the Archives of Martinique, F. W. I.
Martinique

001723104
AJD5614

Éditeur(s) : [s.n.] [s.n.] ( [Fort de France] )
Résumé : Original in the files of the Archives of Martinique, F. W. I.
Martinique

AJD5614
001723104

Éditeur(s) : [s.n.] [s.n.] ( [Fort de France] )
Résumé : Original in the files of the Archives of Martinique, F. W. I.
Martinique

001723104
AJD5614

Résumé : Original manuscript records in the Archives of Martinique, F.W.I.

001907368
AJY2793

Résumé : Original manuscript records in the Archives of Martinique, F.W.I.

001907368
AJY2793