Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
Diagnosis of toxoplasmic encephalitis (TE) in patients with AIDS is not straightforward because clinicians rely initially on an empiric diagnosis based on clinical and radiographic improvement to specific anti-Toxoplasma gondii therapy. There is therefore a need for biological tools to improve the diagnosis of TE, especially in tropical areas where this diagnosis is likely to be underestimated. The use of PCR testing in blood samples for the diagnosis of TE has been limited by its poor sensitivity in the studies conducted in Europe. In tropical South America, the results of PCR sensitivity in blood samples were controversial. Considering that T. gondii strains from tropical South America have substantial genetic and pathogenic differences with those from USA and Europe, it is therefore important to re-evaluate the performance of the PCR assay in blood samples for the diagnosis of TE in AIDS patients from this region. Our results showed that the only interest of PCR would be in the most severe forms of TE with altered consciousness because PCR is more likely to be positive. We also provided important genotyping data on T. gondii strains isolated in human cases of toxoplasmosis in the Caribbean and in South America.
ISSN: 1935-2727

hal-01503761
https://hal-unilim.archives-ouvertes.fr/hal-01503761
https://hal-unilim.archives-ouvertes.fr/hal-01503761/document
https://hal-unilim.archives-ouvertes.fr/hal-01503761/file/journal.pntd.0004790.pdf
DOI : 10.1371/journal.pntd.0004790

Éditeur(s) : HAL CCSD
Résumé : International audience
This paper shows the information criteria (IC) performances in feature selection framework. Feature selection aims to select a representative subset among a wide set of features. We apply this approach to classify an hand segmented image. The performance is tested using various feature selection schemes (SFS, SBS, SFFS and SBFS) to select the candidate subsets. The accuracy of the approach is based on a good quality of the joint probability density approximation of the combined features. They are obtained using histogram optimized thanks to the adaptive arithmetic coding principles. Our approach is tested on different reference data. The subsets quality is evaluated using correct classification rate computed on multiple classifiers. Results show stability and convergence properties of this tool and its ability to select representative subsets (in the sense that the subset of feature is a good characterization of the classes in which the data belong). Information Criteria could be used for feature selection as a good alternative to other criteria.
CISP Proceedings
Shangay, China

hal-00634749
https://hal.archives-ouvertes.fr/hal-00634749

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
In French Guiana, severe cases of toxoplasmosis in immunocompetent patients are associated with atypical strains of Toxoplasma gondii linked to a wild neotropical rainforest cycle and a higher genetic diversity than usually observed for T. gondii isolates from anthropized environment. This raises the question of the impact of anthropization of the natural environment, on genetic diversity and on the population structure of T. gondii. However, few data are available on strains circulating in the anthropized areas from French Guiana. Seropositive animals originating mainly from anthropized sub-urban areas and punctually from wild environment in French Guiana were analyzed for T. gondii isolation and genotyping. Thirty-three strains were obtained by bioassay in mice and compared with 18 previously reported isolates chiefly originating from the Amazon rainforest. The genotyping analysis performed with 15 microsatellite markers located on 12 different chromosomes revealed a lower genetic diversity in the anthropized environment. Results were analyzed in terms of population structure by clustering methods, Neighbor-joining trees reconstruction based on genetic distances, F(ST,) Mantel's tests and linkage disequilibrium. They clearly showed a genetic differentiation between strains associated to the anthropized environment and those associated to the wild, but with some inbreeding between them. The majority of strains from the anthropized environment were clustered into additional lineages of T. gondii that are common in the Caribbean. In conclusion the two environmental populations "wild" and "anthropized" were genetically well differentiated. The anthropization of the environment seems to be accompanied with a decreased diversity of T. gondii associated with a greater structure of the populations. We detected potential interpenetration and genetic exchanges between these two environmental populations. As a higher pathogenicity in human of "wild" genotypes has been described, the interpenetration of both environments leads to hybridization between strains that may be at risk for human health.
ISSN: 1567-1348

pasteur-00654105
https://hal-riip.archives-ouvertes.fr/pasteur-00654105
https://hal-riip.archives-ouvertes.fr/pasteur-00654105/document
https://hal-riip.archives-ouvertes.fr/pasteur-00654105/file/Mercier_et_al_IGE2011.pdf
DOI : 10.1016/j.meegid.2011.05.003

Éditeur(s) : HAL CCSD Nature Publishing Group
Résumé : International audience
Necroptosis is a programmed cell death pathway that has been shown to be of central pathophysiological relevance in multiple disorders (hepatitis, brain and cardiac ischemia, pancreatitis, viral infection and inflammatory diseases). Necroptosis is driven by two serine threonine kinases, RIPK1 (Receptor Interacting Protein Kinase 1) and RIPK3, and a pseudo-kinase MLKL (Mixed Lineage Kinase domain-Like) associated in a multi-protein complex called necrosome. In order to find new inhibitors for use in human therapy, a chemical library containing highly diverse chemical structures was screened using a cell-based assay. The compound 6E11, a natural product derivative, was characterized as a positive hit. Interestingly, this flavanone compound: inhibits necroptosis induced by death receptors ligands TNF-α (Tumor Necrosis Factor) or TRAIL (TNF-Related Apoptosis-Inducing Ligand); is an extremely selective inhibitor, among kinases, of human RIPK1 enzymatic activity with a nM Kd; has a non-ATP competitive mode of action and a novel putative binding site; is weakly cytotoxic towards human primary blood leukocytes or retinal pigment epithelial cells at effective concentrations; protects human aortic endothelial cells (HAEC) from cold hypoxia/reoxygenation injury more effectively than necrostatin-1 (Nec-1) and Nec-1s. Altogether, these data demonstrate that 6E11 is a novel potent small molecular inhibitor of RIPK1-driven necroptosis.
ISSN: 2045-2322

hal-01616456
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01616456
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01616456/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01616456/file/s41598-017-12788-4.pdf
DOI : 10.1038/s41598-017-12788-4

Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : International audience
o abstract
ISSN: 0755-4982

hal-01187124
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01187124
PUBMED : 26206702
DOI : 10.1016/j.lpm.2015.06.001

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Aims: The aims of this study were to compare short-and long-term outcomes for clinical T2N0 oesophageal cancer with analysis of (i) primary surgery (S) versus neoadjuvant therapy plus surgery (NS), (ii) squamous cell carcinoma and adenocarcinoma subsets; and (iii) neoadjuvant chemoradiotherapy versus neoadjuvant chemotherapy.Methods: Data were collected from 30 European centres from 2000 to 2010. Among 2944 included patients, 355 patients (12.1%) had cT2N0 disease; 285 (S) and 70 (NS), were compared in terms of short-and long-term outcomes. Propensity score matching analyses were used to compensate for differences in baseline characteristics.Results: No significant differences between the groups were shown in terms of in hospital morbidity and mortality. Nodal disease was observed in 50% of S-group at the time of surgery, with 20% pN2/N3. Utilisation of neoadjuvant therapy was associated with significant tumour downstaging as reflected by increases in pT0, pN0 and pTNM stage 0 disease, this effect was further enhanced with neoadjuvant chemoradiotherapy. After adjustment on propensity score and confounding factors, for all patients and subset analysis of squamous cell and adenocarcinoma, neoadjuvant therapy had no significant effect upon survival or recurrence (overall, loco-regional, distant or mixed) compared to surgery alone. There were no significant differences between neoadjuvant chemotherapy and chemoradiotherapy in short-or long-term outcomes.Conclusion: The results of this study suggest that a surgery alone treatment approach should be recommended as the primary treatment approach for cT2N0 oesophageal cancer despite 50% of patients having nodal disease at the time of surgery.
ISSN: 0959-8049

hal-01666517
https://hal.univ-lorraine.fr/hal-01666517
DOI : 10.1016/j.ejca.2015.11.024

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Toxoplasma gondii is highly virulent in New World monkeys, but despite numerous outbreaks observed in captive populations there are few reports of molecular characterization of strains. In this article, we describe two outbreaks of toxoplasmosis that occurred in 2001 and 2006 in an outdoor captive breeding colony of squirrel monkeys (Saimiri sciureus) kept by the Institut Pasteur in French Guiana. A microsatellite DNA analysis of the biological samples collected in the 2001 and 2006 outbreaks showed that two different Toxoplasma strains were involved. The 2001 strain exhibited a type II genotype whereas the 2006 strain showed a combination of type I, type III and atypical alleles. Infection could be related to oocysts contaminating water or food, or to ingestion of rats by monkeys. In 2006, a second episode was observed 3 weeks after the first, and was believed to be related to direct contamination by tachyzoites of bronchopulmonary origin from dying monkeys of the first event. During both outbreaks, a total of 50 monkeys died and none recovered spontaneously, confirming the virulence of both type II and non-type II Toxoplasma strains in New World monkeys.
ISSN: 0304-4017

hal-00408048
https://hal.archives-ouvertes.fr/hal-00408048
DOI : 10.1016/j.vetpar.2009.04.004
PUBMED : 19423226

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
ISSN: 0012-8252

hal-01671832
https://hal-univ-rochelle.archives-ouvertes.fr/hal-01671832
DOI : 10.1016/j.earscirev.2016.12.005

Éditeur(s) : HAL CCSD
Résumé : International audience
This work proposes an original approach using mutual information and Pareto curve jointly for feature selection. Mutual information is used to estimate dependency criterion between features and classes and redundancy criterion between features taken two by two. Unlike some studies, these criteria are used simultaneously to compute Pareto curve and determine the optimal feature sets. This approach is tested on more reference data. Several clustering algorithms are used to compute classification accuracy. The obtained results show the importance of our tools and its ability to select the best feature sets that give the better description.
GRETSI Proceedings
Bordeaux, France

hal-00602260
https://hal.archives-ouvertes.fr/hal-00602260

Éditeur(s) : HAL CCSD Presses Universitaires de France
Résumé : ISBN 2-13-056651-9
Les jeunes enfants sont confrontés dès leur plus jeune âge à un environnement sémiotique où l'image et l'icône sont très présents, par le biais de leurs jouets, de leurs livres d'images, des dessins animés, et d'écrits nombreux ... Grâce à cette iconicité très stéréotypée, ils acquièrent rapidement une culture du signe iconique, apportée par l'adulte sans que celui-ci ait nécessairement conscience du contenu ainsi transmis. Par ailleurs, l'environnement scriptural de l'adulte fait lui-même une part très large à l'icône en général et au pictogramme en particulier. On sait que le pictogramme est un signe qui, malgré son caractère iconique et son apparence simple, voire simpliste, est souvent difficile à interpréter correc­tement par les adultes et que les erreurs en ce domaine sont plus fréquentes qu'on ne le croit. Le recours aux savoirs du « lecteur », aux stéréotypes scriptovisuels qu'il connaît, à son expérience, est nécessaire pour l'interprétation mais en même temps source d'erreurs. En effet, la compréhension de ces signes, loin de relever d'un réalisme naïf permettant de voir la « chose » à travers son image, requiert une compétence sémiotique et le recours à des interprétants externes, qui sont à la fois du domaine du contexte (entour du signe), et de celui de l'intertexte polysémiotique constitué par une culture intériorisé. Or le rôle de ces interprétants externes est tel que le recours à d'autres interprétants que ceux que l'émetteur du signe avait en vue peut conduire à des interprétations nettement divergentes à la lecture. Dès lors, nous nous demandons comment ces signes sont perçus par les enfants et plus particulièrement par les enfants pré-lecteurs, comment ceux-ci parviennent, ou non, à les sémiotiser, à les décrypter, à les interpréter. Nous avons donc proposé à des enfants fréquentant l'école (maternelle ou élémentaire) une série de pictogrammes. Il s'agit, en leur demandant simplement ce qu'ils comprennent, d'interroger leurs connaissances en matière de signe iconique et la manière dont ils arrivent à les réinvestir pour cons­truire du sens. Par ce biais, nous nous interrogeons également sur la manière dont ces enfants perçoivent ces signes qui ne leur sont pas spécifiquement destinés (voire pas du tout dans le cas de la signalisation routière, des pictogrammes « de gare », ou des modes d'emploi ...) mais qu'ils perçoivent cependant. Nous tentons enfin par là d'explorer la lisibilité de notre environnement scriptural « à hau­teur d'enfant ».
Les âges de la vie : Sémiotique de la culture et du temps

hal-00330427
https://hal.archives-ouvertes.fr/hal-00330427

Éditeur(s) : HAL CCSD Archéo-Logis/CDERAD CDERAD éd
Résumé : pdf disponible en tant que "tiré à part" électronique à usage scientifique privé
La Montagne Pelée doit sa renommée à la nuée ardente du 8 mai 1902 qui détruisit la ville de Saint-Pierre. Bien avant cette date, ses éruptions avaient perturbé la vie des premiers martiniquais. L'étude du peuplement amérindien de l'île se doit de prendre en compte la dimension volcanique. L'analyse de cinq sites localisés sur le pourtours de la Montagne Pelée montre l'interstratification des niveaux d'occupation et de couches éruptives. Nous avons cherché à distinguer et à dater les épisodes volcaniques contemporains de l'occupation précolombienne et tenté de percevoir leur influence sur la vie des populations. On conçoit mieux aujourd'hui la dynamique et la chronologie de ce peuplement précolombien de la Martinique.
ISSN: 1629-5226
Goudet, France

halshs-00004045
https://halshs.archives-ouvertes.fr/halshs-00004045
https://halshs.archives-ouvertes.fr/halshs-00004045/document
https://halshs.archives-ouvertes.fr/halshs-00004045/file/Martinique2002.pdf

Éditeur(s) : HAL CCSD
Résumé : International audience
The paper deals with iterative schemes for finding a zero of a maximal monotone operator. A combination of the auxiliary principle with the Tikhonov method is considered. Under some assumptions the sequence generated by such an iterative scheme is shown to converge to a solution of the problem that is required to satisfy an associated variational inequality
Lecture notes in economics and mathematical systems

hal-00773198
https://hal.univ-antilles.fr/hal-00773198

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
ISSN: 1935-2727

hal-00921369
https://hal-unilim.archives-ouvertes.fr/hal-00921369
DOI : 10.1371/journal.pntd.0001802
PUBMED : 23145185

Éditeur(s) : HAL CCSD European Centre for Disease Prevention and Control
Résumé : International audience
In 2002, the French Food Safety Agency drew attention to the lack of information on the prevalence of human cryptosporidiosis in the country. Two years later, the ANOFEL Cryptosporidium National Network (ACNN) was set up to provide public health authorities with data on the incidence and epidemiology of human cryptosporidiosis in France. Constituted on a voluntary basis, ACNN includes 38 hospital parasitology laboratories (mainly in university hospitals). Each laboratory is engaged to notify new cases of confirmed human cryptosporidiosis, store specimens (e.g. stools, duodenal aspirates or biopsies) and related clinical and epidemiological data, using data sheet forms. From January 2006 to December 2009, 407 cryptosporidiosis cases were notified in France and 364 specimens were collected. Of the notified cases, 74 were children under four years of age, accounting for 18.2%. HIV-infected and immunocompetent patients represented 38.6% (n=157) and 28% (n=114) of cases, respectively. A marked seasonal pattern was observed each year, with increased number of cases in mid to late summer and the beginning of autumn. Genotyping of 345 isolates from 310 patients identified C. parvumin 168 (54.2%) cases, C. hominis in 113 (36.4%) and other species in 29 (9.4%), including C. felis (n=15), C. meleagridis (n=4), C. canis (n=4), Cryptosporidium chipmunk genotype (n=1), Cryptosporidium rabbit genotype (n=1) and new Cryptosporidium genotypes (n=4). These data represent the first multisite report of laboratory-confirmed cases of cryptosporidiosis in France.
ISSN: 1560-7917

hal-00926813
https://hal-unilim.archives-ouvertes.fr/hal-00926813
PUBMED : 20739000

Éditeur(s) : HAL CCSD American Society for Microbiology
Résumé : International audience
Summary: The apicomplexan parasite Toxoplasma gondii was discovered a little over 100 years ago, but knowledge of its biological life cycle and its medical importance has grown in the last 40 years. This obligate intracellular parasite was identified early as a pathogen responsible for congenital infection, but its clinical expression and the importance of reactivations of infections in immunocompromised patients were recognized later, in the era of organ transplantation and HIV infection. Recent knowledge of host cell-parasite interactions and of parasite virulence has brought new insights into the comprehension of the pathophysiology of infection. In this review, we focus on epidemiological and diagnostic aspects, putting them in perspective with current knowledge of parasite genotypes. In particular, we provide critical information on diagnostic methods according to the patient's background and discuss the implementation of screening tools for congenital toxoplasmosis according to health policies.
ISSN: 0893-8512

hal-00696903
https://hal.archives-ouvertes.fr/hal-00696903
https://hal.archives-ouvertes.fr/hal-00696903/document
https://hal.archives-ouvertes.fr/hal-00696903/file/Epidemiologysur and_Diagnostic-accepted.pdf
DOI : 10.1128/CMR.05013-11

Éditeur(s) : HAL CCSD
Résumé : From the protolanguage born with Homo erectus, the modern human language of Homo sapiens has naturally diversified into tonal, stress-timed, or syllable-timed languages, although the definition of the syllable has yet to be established. Thus for a French speaker, the transition from a language punctuated by the syllable to a language punctuated by the lexical stress will be a delicate point in learning oral English. For this purpose, we recommend the implementation of a reprogramming of the articulatory gesture in the brains as evidenced by articulatory phonology. Through the arched beam, Broca's area of the French-speaking learner will inhibit the French-related data to send to Wernicke's area new information regarding the reception / production of oral English.
A partir du protolangage né avec Homo erectus, le langage humain moderne d'Homo sapiens s'est naturellement diversifié en langues tonales, accentuelles, ou syllabiques, bien que la définition de la syllabe reste encore à établir. Ainsi pour un francophone, le passage d'une langue rythmée par la syllabe à une langue rythmée par l'accent lexical sera un point délicat de l'apprentissage de l'anglais oral. Pour ce faire, nous préconisons la mise en place d'une reprogrammation de la gestuelle articulatoire telle qu'elle a pu être mise en évidence par la phonologie articulatoire. Par le biais du faisceau arqué, l'aire de Broca de l'apprenant francophone inhibera les données liées au français pour envoyer à l'aire de Wernicke de nouvelles informations quant à la réception / production de l'anglais oral. Mots clés : neurodidactique, anglais oral, phonologie articulatoire, aires du langage, mémoire procédurale et à long terme. Abstract: From the protolanguage born with Homo erectus, the modern human language of Homo sapiens has naturally diversified into tonal, stress-timed, or syllable-timed languages, although the definition of the syllable has yet to be established. Thus for a French speaker, the transition from a language punctuated by the syllable to a language punctuated by the lexical stress will be a delicate point in learning oral English. For this purpose, we recommend the implementation of a reprogramming of the articulatory gesture in the brains as evidenced by articulatory phonology. Through the arched beam, Broca's area of the French-speaking learner will inhibit the French-related data to send to Wernicke's area new information regarding the reception / production of oral English.
https://hal.archives-ouvertes.fr/hal-01626540

hal-01626540
https://hal.archives-ouvertes.fr/hal-01626540
https://hal.archives-ouvertes.fr/hal-01626540/document
https://hal.archives-ouvertes.fr/hal-01626540/file/Neurodidactique%20%20Comment%20le%20cerveau%20d%27un%20apprenant%20francophone%20peut-il%20se%20programmer%20sur%20une%20langue%20accentuelle..pdf

Éditeur(s) : HAL CCSD
Résumé : International audience
This paper introduces the information criteria in feature selection framework. Information criteria are integrated in feature selection scheme to select subset candidates. The accuracy of the proposed approach is based on the quality of the probability density approximations of these features. They are obtained using histograms optimized thanks to the adaptive arithmetic coding principles. Tests on simulated data and references are made. Multiple classifiers are used. The correct classification rate shows, the importance of this tools and its ability to select a best subsets. Generally, the subsets produce a good characterization of classes which the data belong.
TAIMA Proceedings

hal-00634754
https://hal.archives-ouvertes.fr/hal-00634754

Éditeur(s) : HAL CCSD
Résumé : International audience
European Geosciences Union General Assembly April-2013
Vienne, Austria

hal-01134025
https://hal.archives-ouvertes.fr/hal-01134025

Éditeur(s) : HAL CCSD Centers for Disease Control and Prevention
Résumé : International audience
From 1998 through 2006, 44 cases of severe primary toxoplasmosis were observed in French Guiana in immunocompetent adults. Toxoplasma gondii isolates exhibited an atypical multilocus genotype. Severe disease in humans may result from poor host adaptation to neotropical zoonotic strains of T. gondii circulating in a forest-based cycle.
ISSN: 1080-6040

hal-00406549
https://hal.archives-ouvertes.fr/hal-00406549
PUBMED : 19331765

Éditeur(s) : HAL CCSD Lavoisier
Résumé : National audience
ISSN: 0765-0019

hal-00509496
https://hal.archives-ouvertes.fr/hal-00509496