Éditeur(s) : HAL CCSD
Résumé : Food-grade dairy propionibacteria release beneficial short chain fatty acids (SCFAs), folic acid and cobalamin. They induce apoptosis via the mitochondrial death pathway. We investigated their synergy with drugs used in gastric and colorectal cancer.Fermented milk containing propionibacteria and SCFAS acetate and propionate, as well as its cell-free supernatant, induced apoptosis in gastric HGT-1 and colic HT-29. Characterization of cells revealed apoptosis induction evidenced by chromatin condensation, DNA laddering, emergence of a subG1 population, phosphatidylserine exposure at the plasma membrane outer leaflet and cytochrome c release. Interestingly, the fermented milk was shown to potentiate the cytotoxic effect of molecules used in cancer chemotherapy, camptothecin and TRAIL (TNF Related Apoptosis Inducing Ligand).These results open new perspectives in the field of colon cancer cells prevention and/or treatment. Such a fermented product, or the propionibacterium alone, may be proposed as a food supplement to enhance the effects of anticancer treatments.
Les bactéries propioniques laitières produisent des acides gras volatils (AGV), acide folique et cobalamine, composés bénéfiques. Elles induisent l’apoptose via la voie mitochondriale. Nous avons recherché leur synergie avec des drogues utilisées dans le cancer gastrique ou colique.Un lait fermenté contenant des bactéries propioniques et les AGVs propionate et acétate a induit l’apoptose de cellules gastriques HGT-1 et coliques HT-29. L’étude des cellules a révélé l’induction de l’apoptose : condensation de la chromatine, fragmentation de l’ADN, l’émergence d’une population subG1, l’externalisation des phosphatidylserines et le relargage du cytochrome c. De manière intéressante, le lait fermenté a potentialisé les effets cytotoxiques de molécules utilisées en chimiothérapie, camptothécine et TRAIL (TNF Related Apoptosis Inducing Ligand).Ces résultats ouvrent de nouvelles perspectives dans le domaine du traitement ou de la prévention des cancers digestifs. Un tel produit fermenté, ou les propionibactéries seules, pourrait être proposé comme supplément alimentaire pour augmenter l’efficacité de traitements anti-cancéreux.
5. Colloque Intenational Molécules & Ingrédients Santé
Quimper, France

hal-01204307
https://hal.archives-ouvertes.fr/hal-01204307
PRODINRA : 261444

Éditeur(s) : HAL CCSD Thieme Publishing
Résumé : International audience
We evaluated the eff ects of the fl uid replacement strategy on core temperature, heart rate and urine osmolality during a 27-km trail run in tropical climate. 20 well-trained runners completed a 27-km trail race in tropical conditions. They were acclimatized to these conditions. Heart rate was monitored every 5 s, while core temperature and perceived thermal and comfort sensations were recorded before, at the 11 th km, and just after the end of the race. Water intake, urine osmolality and body mass were measured before and after the race. Core temperature and the scores of perceived thermal and comfort sensations were signifi cantly higher at the 11 th km and at the end of the race compared to before the race, but not at the 11 th km compared to before the race. No participant exhibited dehydration as assessed by urine osmolality. The less the trail runners weighed, the greater the heat retention was. The less hot they felt at the end of the race, the more they lost water, and the better the performance was. The fastest runners were able to tolerate a greater variation in core temperature between the beginning and the end of the trail race with lower water intake.
ISSN: 0172-4622

hal-01152345
https://hal.univ-antilles.fr/hal-01152345
DOI : 10.1055/s-0033-1349108

Éditeur(s) : HAL CCSD Nature Publishing Group
Résumé : International audience
Hepatocyte death is a central event during liver disease progression, in which immune cells play key roles by activating members of the Tumor Necrosis Factor Receptor Superfamily (TNFRSF), including TNFR1 (TNFRSF1A), Fas (TNFRSF6) and TRAIL-R2 (TNFRSF10B). Receptor Interacting Protein Kinase 1 (RIPK1) emerged as a signaling node downstream of these receptors. In the case of TNFR1, RIPK1 has been demonstrated to paradoxically serve as a scaffold to promote the survival of hepatocytes and as a kinase to kill them. To evaluate whether RIPK1 also protects hepatocytes from death in response to FasL or TRAIL, we took advantage of liver parenchymal cell-specific Ripk1 knockout mice (Ripk1 (LPC-KO)). We found that Ripk1 (LPC-KO) mice, as well as primary hepatocytes derived from them, were more susceptible to Fas-mediated apoptosis than their respective WT counterparts. Fas-induced hepatocyte death was independent of TNF-α signaling. Interestingly, while TRAIL administration did not induce hepatitis in Ripk1 (LPC-KO) mice or in their WT counterparts, its combination with IFN-γ only induced TNF-α dependent apoptosis in the Ripk1 (LPC-KO) mice. Together, our data demonstrate the protective role of RIPK1 downstream of Fas and highlight the general protective function of RIPK1 in hepatocytes exposed to inflammatory conditions, where TNF-α, FasL and/or TRAIL are present.
ISSN: 2045-2322

hal-01579612
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01579612
DOI : 10.1038/s41598-017-09789-8
PUBMED : 28835677

Éditeur(s) : American Geophysical Union
Résumé : Magmatism associated with subducting plate edges or slab tears has been suggested in the southern Okinawa Trough. The cross back-arc volcanic trail, which consists of a cluster of about 70 seamounts, is located above a Ryukyu slab tear lying along the 123.3°E meridian. In November 2003, more than 3300 earthquakes recorded in this area by 15 ocean bottom seismometers and surrounding land stations during a period of 12 days were used to determine the three-dimensional Vp and Vs velocity structures and Vp/Vs ratios. A mantle inflow characterized by low Vp and Vs and high Vp/Vs passing through the slab tear is imaged. The fluid and/or melt component is rising obliquely from the slab tear in the directions of the cross back-arc volcanic trail, the northern slope of the southern Okinawa Trough and to north of Iriomote Island. The asthenospheric intake is also imaged by an inclined chip-like high Vp/Vs and low Vp and Vs body dipping northerly, which might be linked to the slab retreat. West of the slab tear, most of the earthquakes are located around low Vp and Vs and high Vp/Vs bodies, which suggests that the seismicity is related to magmatic and/or fluid activities. East of it, earthquakes are concentrated in an area characterized by high Vp and Vs velocities and low Vp/Vs, suggesting that the magma chamber is absent beneath the axial part of the trough and that normal faulting is the main factor controlling the seismicity.
Journal of Geophysical Research ( JGR ) - Solid earth (0148-0227) (American Geophysical Union), 2007-08 , Vol. 112 , N. B8 , P. NIL_13-NIL_32

Droits : 2007 AGU
http://archimer.ifremer.fr/doc/2007/publication-3032.pdf
DOI:10.1029/2006JB004703
http://archimer.ifremer.fr/doc/00000/3032/

Résumé : The slides were taken on collecting trips sponsored by the William L. Bryant Foundation, where books, music and art indigenous to the regions were gathered. The are organized by geographical location.
Three men including Walter W. S. Cook, wearing khaki shorts and shirt, walk along a sandy path on the coast of Nicholls Town, a town in northeastern Andros, Bahamas. Two of these men were companions of William Junior Bryant during Bryant’s trips to Andros and New Providence in 1946. A boat can be seen on land along with several buildings. Slide labeled Nicolls Town Andros Mar. '46.
Bahamas -- North America -- Nicholls Town, Andros

Droits : All rights reserved by the source institution.
CFM1972_01a
Sheet 6:8

Éditeur(s) : Université des Antilles Études caribéennes
Résumé : Tout en étant une des régions les plus pauvres du Pérou, le sud andin est la destination touristique nationale par excellence où se trouve le sanctuaire archéologique de Machu Picchu, un des sites du patrimoine mondial les plus prisés au monde. Le boom du développement touristique des années 1990 à rapidement transformé la région de Cuzco en une destination écotouristique et de tourisme culturel. Cette étude présente le développement du tourisme dans la région en général, ainsi que les effets sur quelques communautés spécifiques s’étant intégrées au système touristique international grâce au développement du chemin de l’inca, une randonnée de quatre jours servant de porte d’entrée à Machu Picchu. Les hommes des communautés paysannes des hauts plateaux andins avoisinant Ollantaytambo ont été sollicités pour transporter l’équipement nécessaire au service des randonneurs étrangers. Ces habitants représentaient une main d’œuvre accessible, abordable, voire exploitable, capable physiquement de transporter des poids lourds en haute altitude. Aujourd’hui, la Fédération des Porteurs Daniel Estrada est composée de 6200 porteurs provenant de différentes communautés de la vallée. Essentiellement quechuas, ces communautés rurales marginalisés survivent sur des terres arides ; leur niveau d’éducation ne dépasse souvent pas le primaire ; les villages ne disposent pas d’eau potable, de services d’égouts, d’électricité, de téléphone, d’accès à des services de santé ; les habitations sont faites d’adobe. Étant donné la vulnérabilité de ces populations, l’intégration à un système offrant de nouvelles possibilités de revenus s’avérait souhaitable, malgré les conditions d’emploi déplorables.
While one of the poorest regions of Peru, the Andean south is a national tourist destination and the site of the archaeological sanctuary and one of the most popular sites in the world, Machu Picchu. The boom of tourism development in the 1990s quickly transformed the Cuzco region to an ecotourism and cultural tourism destination. This paper presents the development of tourism in the region in general, as well as the effects for some communities as they are integrated into the international tourism system through the development of the Inca Trail, a four-day hike which leads to Machu Picchu. Men in the peasant communities in the Andean highlands surrounding Ollantaytambo are asked to carry the equipment needed by foreign hikers during the ascent. These people represent an available and affordable workforce, physically capable of carrying heavy weight at high altitudes. Today, the Daniel Estrada Federation of Carriers is composed of 6200 carriers from different communities in the valley. Mainly Quechua, these marginalized rural populations survive in an arid environment; their education often does not exceed the primary level; the villages lack drinking water, sewage services, electricity, telephones, and access to health services; and the houses are made of adobe. Given the vulnerability of these populations, the integration of a system offering new revenue opportunities proved desirable, in spite of the deplorable employment conditions.
Pérou

Droits : info:eu-repo/semantics/openAccess
urn:doi:10.4000/etudescaribeennes.6550
http://journals.openedition.org/etudescaribeennes/6550

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Glioblastoma (GB), the most frequent primary tumor of the central nervous system, remains one of the most lethal human cancers despite intensive researches. Current paradigm in the study of GB has been focused on inter-patient variability and on trying to isolate new classification elements or prognostic factors. Here, using ICPL, a technique for protein relative quantification by mass spectrometry, we investigated protein expression between the four regions of GB on clinically relevant biopsies from 5 patients. We identified 584 non-redundant proteins and 31 proteins were found to be up-regulated in the tumor region compared to the peri-tumoral brain tissue, among which, 24 proteins belong to an interaction network linked to 4 biological processes. The core of this network is mainly constituted of interactions between beta-actin (ACTB) with heat shock proteins (HSP90AA1, HSPA8) and 14-3-3 proteins (YWHAZ, YWHAG, YWHAB). A cluster of three isoforms of the sodium pump α-subunit (ATP1A1, ATP1A2, ATP1A3) was also identified outside this network. The differential expression observed for ACTB and 14-3-3γ was further validated by western blot and/or immunohistochemistry. Our study confirms the identity of previously proposed molecular targets, highlights several functional processes altered in GB such as energy metabolism and synaptic transmission and could thus provide added value to new therapeutic trails.
ISSN: 1874-3919

hal-00877756
https://hal.archives-ouvertes.fr/hal-00877756
DOI : 10.1016/j.jprot.2012.04.034
PUBMED : 22575386

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
Here we show that Daceton armigerum, an arboreal myrmicine ant whose workers are equipped with hypertrophied trap-jaw mandibles, is characterized by a set of unexpected biological traits including colony size, aggressiveness, trophobiosis and hunting behavior. The size of one colony has been evaluated at ca. 952,000 individuals. Intra- and interspecific aggressiveness were tested and an equiprobable null model used to show how D. armigerum colonies react vis-à-vis other arboreal ant species with large colonies; it happens that D. armigerum can share trees with certain of these species. As they hunt by sight, workers occupy their hunting areas only during the daytime, but stay on chemical trails between nests at night so that the center of their home range is occupied 24 hours a day. Workers tend different Hemiptera taxa (i.e., Coccidae, Pseudococcidae, Membracidae and Aethalionidae). Through group-hunting, short-range recruitment and spread-eagling prey, workers can capture a wide range of prey (up to 94.12 times the mean weight of foraging workers).
ISSN: 1932-6203

hal-00825759
https://hal.archives-ouvertes.fr/hal-00825759
https://hal.archives-ouvertes.fr/hal-00825759/document
https://hal.archives-ouvertes.fr/hal-00825759/file/Dejean2012_TheEcology.pdf
DOI : 10.1371/journal.pone.0037683

Résumé : Herbácea anual, rastrera o ascendente, de tallos ligeramente angulosos. Zarcillos simples o ramificados. Hojas pubescentes, dentadas, con 5 a 7 lóbulos agudos u obtusos. Flores unisexuales, axilares, solitarias; corola amarillo-anaranjada de hasta 15 cm. Fruto globoso, a veces cilíndrico, piriforme o cónico, verde, amarillo o anaranjado, frecuentemente sulcado.
Herbacée annuelle, rampante ou ascendante, à tiges légèrement anguleuses. Vrilles simples ou ramifiées. Feuilles pubescentes, dentées, avec 3 à 5 lobes aigus ou obtus. Fleurs axillaires, solitaires; corolle orangée de 6 à 8 cm. Fruit arrondi, parfois cylindrique, piriforme ou conique, jaunâtre ou orangé.
Annual herbaceous, trailing vine. Stem slightly woody, rounded or slightly 5-angled; tendrils coiling and branching; leaves simple, shallowly lobed, pubescent 20 x 30 cm, petiole 12-30 cm long; flowers unisexual, solitary, petals yellowish-orange, up to 15 cm long; fruits dull in colour, globose, sometimes cylindrical or pyriform, at least 15cm long, often with rounded ridges.
Originaria de América tropical, ampliamente cultivada en regiones tropicales y subtropicales.
Originaire d’;Amérique tropicale, cultivée dans les régions tropicales et subtropicales, subspontanée.
Native to tropical America, widely cultivate

http://www.tramil.net/fototeca/plant34

Éditeur(s) : HAL CCSD Nature Publishing Group
Résumé : International audience
Necroptosis is a programmed cell death pathway that has been shown to be of central pathophysiological relevance in multiple disorders (hepatitis, brain and cardiac ischemia, pancreatitis, viral infection and inflammatory diseases). Necroptosis is driven by two serine threonine kinases, RIPK1 (Receptor Interacting Protein Kinase 1) and RIPK3, and a pseudo-kinase MLKL (Mixed Lineage Kinase domain-Like) associated in a multi-protein complex called necrosome. In order to find new inhibitors for use in human therapy, a chemical library containing highly diverse chemical structures was screened using a cell-based assay. The compound 6E11, a natural product derivative, was characterized as a positive hit. Interestingly, this flavanone compound: inhibits necroptosis induced by death receptors ligands TNF-α (Tumor Necrosis Factor) or TRAIL (TNF-Related Apoptosis-Inducing Ligand); is an extremely selective inhibitor, among kinases, of human RIPK1 enzymatic activity with a nM Kd; has a non-ATP competitive mode of action and a novel putative binding site; is weakly cytotoxic towards human primary blood leukocytes or retinal pigment epithelial cells at effective concentrations; protects human aortic endothelial cells (HAEC) from cold hypoxia/reoxygenation injury more effectively than necrostatin-1 (Nec-1) and Nec-1s. Altogether, these data demonstrate that 6E11 is a novel potent small molecular inhibitor of RIPK1-driven necroptosis.
ISSN: 2045-2322

hal-01616456
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01616456
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01616456/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01616456/file/s41598-017-12788-4.pdf
DOI : 10.1038/s41598-017-12788-4

Éditeur(s) : HAL CCSD American Geophysical Union (AGU)
Résumé : International audience
Sandbox experiments, using a two-dimensional and a three-dimensional approach, are used to study the deformation of margins in response to seamount subduction. Successive mechanisms of deformation are activated during the subduction of conical seamounts. First, reactivation of the frontal thrusts and compaction of the accretionary wedge is observed. Then, back thrusting and, conjugate strike-slip faulting develops above the leading slope of the subducted seamount. The basal d6collement is deflected upward in the wake of the subducting high, and a large shadow zone develops behind the seamount trailing slope. Consequently, frontal accretion is inhibited and part of the frontal margin is dragged into the subduction zone. When the main d6collement returns to its basal level in the wake of the seamount, the margin records a rapid subsidence and a new accretionary wedge develops, closing the margin reentrant. The sediments underthrusted in the wake of the seamount into the shadow zone, are underplated beneath the rear part of the accretionary wedge. Substantial shortening and thickening of the deformable seaward termination of the upper plate basement, associated with basal erosion is observed. Seamount subduction induces significant material transfer within the accretionary wedge, favors large tectonic erosion of the frontal margin and thickening of the rear part of the margin. The subduction and underplating of relatively undeformed, water-ladden sediments, associated with fluid expulsion along the fractures affecting the margin could modify the fluid pressure along the basal ddcollement. Consequently, significant variations of the effective basal friction and local mechanical coupling between the two plates could be expected around the subducting seamount.
ISSN: 0278-7407

hal-01261523
https://hal.archives-ouvertes.fr/hal-01261523
https://hal.archives-ouvertes.fr/hal-01261523/document
https://hal.archives-ouvertes.fr/hal-01261523/file/Dominguez2000-Tectonics.pdf
DOI : 10.1029/1999TC900055

Éditeur(s) : HAL CCSD Magnolia Press
Résumé : International audience
The genus Notomicrus Sharp, 1882 is recorded from Guadeloupe for the first time. Examination of recently collected material revealed the presence of four species, of which three are described as new species so far endemic to Guadeloupe. Notomicrus sabrouxi sp. n. is akin to the continental Neotropical species N. gracilipes Sharp, 1882 and N. traili Sharp, 1882. Notomicrus chailliei sp. n. and N. femineus sp. n. are sibling species which diverge from each other by 3.4% of observed distance in cytochrome oxidase 1 sequences. The latter species seems to be comprised of only females, and is suspected to reproduce by obligate parthenogenesis. The fourth species is N. sharpi Balfour-Browne, 1939. These species are morphologically described notably through scanning electron microscopy study, and data on their distribution in the Guadeloupe archipelago and habitat preferences are presented and discussed.
ISSN: 1175-5326

hal-01544477
https://hal.archives-ouvertes.fr/hal-01544477

Résumé : Les attines sont des fourmis champignonnistes dans la zone allant des Etats-Unis à l'Argentine en passant par la Caraïbe. Les dégâts causés par ces ravageurs sont considérables et estimés à plusieurs millions de dollars par an. Elles sont de ce fait considérées comme l'un des premiers fléaux de l'agriculture de la zone (Cameron & Riggs, 1985 ; Fowler et al., 1986). En Guadeloupe, la "fourmi manioc" (Acromyrmexoctospinosus Reich) cause de nombreux dommages, aussi bien pour l'agriculture que dans les milieux naturels. Les dégâts occasionnés par ces fourmis ont nécessité l'utilisation de pesticides de synthèse. pour tenter de les combattre. La dangerosité de ces substances pour les milieux naturels et anthropisés ainsi que pour la santé publique est un contexte favorable à l'exploration de nouvelles pistes telles que l'utilisation de plantes à usages phytosanitaires. L'objet principal de cette thèse consiste à savoir si on peut déceler à partir de l'ethnopharmacologieTRAMIL des usages permettant de combattre cette fourmi et son symbiote fongique, Leucocoprinuss 'gongylophorus (Heim) MoeIler. Les protocoles retenus et présentés dans ce travail permettent d'observer les effets des usages de plantes choisis sur la survie et le comportement des insects et sur la croissance du symbiote. Ils ont été sélectionnés pour leur potentialité à mettre en évidence les différents types d'effets des extraits végétaux (insecticide par contact, insectifuge, toxique par ingestion, fongistatique ou fongicide). Six usages traditionnels issus de cinq plantes sont testés sur la fourmi: Mammea americana L., Nerium oleander L., Nicotiana tabacum L., Rollinia mucosa (Jacq.) Baill. et Trichilia pallida Sw. Cinq autres usages traditionnels sont testés sur le champignon : Allium cepa L., Allium sativum L., Lycopersicom esculentum Mill., Manihot esculenta Crantz et Senna alata (L.) Roxb. Les resultants obtenus permettent de dégager quelques pistes de lutte intéressantes contre ce ravageur.
Leaf-cutting ants are fungus-growing ants.Their geographie distribution ranges from southern United States to northern Argentina, incIuding the West Indies, Economic losses due to these ants were estimated at several million dollars per year. The latter statement makes they are considered as one of the most important pest species of the agricultural productions (Cameron & Riggs, 1985 ; Fowler et al., 1986). In (Guadeloupe, the most important invasive pest species which caused important losses in forests, gardens and field crops is 'cassava ant' (Acromyrmex octospinosus Reich). These huge losses required to use, synthetic chemical pesticides to control these leaf-cutting ants, the consequence of which is, irreversible' injuries on environment and on human health. As a matter of fact, this situation has prompted an increasing interest in alternative methods for pest control like plants with pesticide used. The main objective of this thesis is to know if traditional ethnopharmacological TRAMIL uses could help to fight against this ant and against the symbiotic fungus, Leucocoprinus gongylophorus (Heim) . Moeller. Methods used and presented in this work aIIowed to observe effects of selected plant uses on mortality and insect's behavior. The protocols performed were selected for their potentiality to detect the different types of insecticidal effects (contact toxicity, repellent effect, toxicity by ingestion, fungicidal or fungistatic). Six traditional plant uses of five plants were tested on the ant : Mammea americana L., Nerium oleander L., Nicotiana tabacum L.,Rollinia mucosa (Jacq) Baill. and Trichilia pallida Sw.Five other plants uses were tested on the fungus:Allium cepa L.,Lycopersicon esculentum Mill.,Manihot esculenta Crantz and Senna alata (L.) Roxb.The obtained résults provide us with some interesting trails to fight against this pest.

http://www.theses.fr/2011AGUY0469/document