Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
In 2008 a fatal case of primary amoebic meningoencephalitis, due to the amoeboflagellate Naegleria fowleri, occurred in Guadeloupe, French West Indies, after a child swam in a bath fed with geothermal water. In order to improve the knowledge on free-living amoebae in this tropical part of France, we investigated on a monthly basis, the presence of Naegleria spp. in the recreational baths, and stream waters which feed them. A total of 73 water samples, 48 sediments and 54 swabs samples were collected from 6 sampling points between June 2011 and July 2012. The water samples were filtered and the filters transferred to non-nutrient agar plates seeded with a heat-killed suspension of Escherichia coli while sediment and swab samples were placed directly on these plates. The plates were incubated at 44°C for the selective isolation of thermophilic Naegleria. To identify the Naegleria isolates the internal transcribed spacers, including the 5.8S rDNA, were amplified by polymerase chain reaction and the sequence of the PCR products was determined. Thermophilic amoebae were present at nearly all collection sites. The pathogenic N. fowleri was the most frequently encountered thermophilic species followed by N. lovaniensis. The concentration of N. fowleri was rather low in most water samples, ranging from 0 to 22 per liter. Sequencing revealed that all N. fowleri isolates belonged to a common Euro-American genotype, the same as detected in the human case in Guadeloupe. These investigations need to be continued in order to counsel the health authorities about prevention measures, because these recreational thermal baths are used daily by local people and tourists.
ISSN: 1932-6203

pasteur-00782031
https://hal-riip.archives-ouvertes.fr/pasteur-00782031
https://hal-riip.archives-ouvertes.fr/pasteur-00782031/document
https://hal-riip.archives-ouvertes.fr/pasteur-00782031/file/article_naegleria_plos_one.pdf
DOI : 10.1371/journal.pone.0054414

Résumé : Aux Antilles, la faible fréquence des coronaropathies pourrait être liée à des facteurs génétiques, ethniques et/ou une distribution spécifique des facteurs de risque cardio-vasculaire (FDRCV). Les propriétés l'ANP (Atrial Natriuretic Peptide) et l'influence de certains polymorphismes de son gène, fréquents dans les populations d'ascendance Africaine pourraient également être en cause. L'analyse des dossiers de 638 patients coronariens consécutifs a mis en évidence une forte prévalence de l'hypertension artérielle et du diabète dans cette population et révélé des différences significatives dans la prévalence des FDRCV entre Afro-Caribéens (AC), Caucasiens et descendants de migrants Indiens. L'analyse angiographique de 420 patients AC a révélé que le diabète était le FDRCV le plus fortement lié à la sévérité des lésions coronaires alors l'obésité apparaissait comme un facteur protecteur. La transfection in vitro, de cellules musculaires lisses artérielles par une construction adénovirale porteuse du gène de l'ANP a entrainé une inhibition de la prolifération et de la migration cellulaire de 31 % et 25% respectivement. In vivo, cet effet s'est traduit par une réduction de 25% de la formation néotimale et de 28% du rapport intima/média dans un modèle d'hyperplasie de carotide de rat. Dans étude transversale incluant 210 sujets diabétiques AC nous avons mis en évidence une association entre le polymorphisme rs5065 (22381>C) du gène de l'ANP et l'existence d'une coronaropatbie. Dans cette étude, l'odds ratio de la présence d'une coronaropathie chez les porteurs de l'allèle mineur de cette mutation (TC/CC) était de 0,50 (0,26- 0,96; P = 0,038).
In Guadeloupe and Martinique, the low frequency ofcoronary artery disease (CAD) could be related to genetic or ethniefactors and/or specifie distribution ofcardiovascular risk factors (CRFs). Atrial Natriuretic Peptide (ANP) properties and influence of sorne of ANP gene polymorphism that are frequent in populations of African descent could also be involved in CAD occurrence. We retrospectively studied 638 consecutive patients with documented CAO and found a high prevalence of hypertension and diabetes in this population. This study also demonstrated significant differences in the prevalence of CRFs between Afro-Caribbean (AC), Caucasians and Indians migrants. The angiographie analysis of420 patients revealed that in AC, diabetes emerged as the strongest CFR related to the severity ofcoronary lesions while obesity appeared as a protective factor. After transfection by an adenoviral construct carrying the ANP gene, vascular smooth muscle cell proliferation stimulated by 10% fetal calf serum was reduced by 31% and migration by 25%. In vivo, in rat carotid artery model ofvascular injury, neointima formation and intima/media ratio was reduced by 25% and 28% respectively. In a cross-sectional study inc1uding 210 AC diabetics we found an association between rs5065 (22381> C) polymorpbism and the presence of coronary artery disease suggesting that the minor allele could have a protective effect against CAD. The odds ratio for the presence ofCAD in carriers ofthe minor allele ofthis mutation (TC / CC) was 0.50 (0.26-0.96, P = 0.038).

http://www.theses.fr/2012AGUY0553/document

Éditeur(s) : HAL CCSD PeerJ
Résumé : International audience
Coral reefs are in decline across the globe as a result of overexploitation, pollution, disease and, more recently, climate change. The impacts of changes in coral cover on associated fish communities can be difficult to predict because of the uneven dependence of reef fish species on corals for food, shelter or the three-dimensional structure they provide. We compared live coral cover, reef fish community metrics, and their associations in two surveys of the lagoon of the remote atoll of Mataiva (French Polynesia) carried out 31 years apart. In contrast to the general pattern of decreasing coral cover reported for many parts of the Indo-Pacific region, live coral cover increased 6–7 fold at Mataiva between 1981 and 2012, and fish density nearly doubled. The stable overall reef fish species richness belied a significant shift in community structure. There was little overlap in community composition across years, and fish assemblages in 2012 were more homogeneous in composition than they were in 1981. Changes in species abundance were not clearly related to species-specific reliance on corals. The strong positive relationships between live coral cover and fish diversity and abundance noted in 1981, when coral cover rarely exceeded 10%, were no longer present in 2012, when coral cover rarely fell below this value. The most parsimonious explanation for these contrasting relationships is that, over the combined range of coral cover observed in the 1981 and 2012 snapshots, there is a rapidly asymptotic relationship between coral and fish. Our results, and other data from the south and west Pacific, suggest that fish diversity and abundance might accumulate rapidly up to a threshold of approximately 10% live coral cover. Such a relationship would have implications for our expectations of resistance and recovery of reef fish communities facing an increasingly severe regime of coral reef disturbances.
ISSN: 2167-8359

Droits : http://creativecommons.org/licenses/by/
hal-01135589
https://hal.archives-ouvertes.fr/hal-01135589
https://hal.archives-ouvertes.fr/hal-01135589/document
https://hal.archives-ouvertes.fr/hal-01135589/file/2015_02_26_more_coral_more_fish.pdf
DOI : 10.7717/peerj.745

Éditeur(s) : HAL CCSD
Résumé : International audience
At the time of the collision with India (55Ma), the southern margin of Asia was a composite continental domainresulting from an already long history of successive accretions of different terranes having different rheologies.Knowledge about the structure, composition and thermal state of the Tibetan lithosphere through time is thusfundamental to understand the respective contributions of pre-Cenozoïc and Cenozoïc tectonics in the building ofthe Plateau to its present-day elevations.We focused on the boundary between the Qiangtang terrane to the south, and the Songpan-Ganze terrane to thenorth.We jointly studied deep crustal xenoliths and associated (ultra-)potassic magmatism from the Eocene basinsof Nangqian and Xialaxiu (Qinghai Province, China), north of the Qiangtang terrane. The aims were to retrievethe composition and the thermal state of the lower crust during Eocene times, to study the behavior of the lowercrust and lithospheric mantle of the Eastern Qiangtang terrane and the adjacent Songpan-Ganze terrane at the timeof the collision, and the link with the magmatic activity.Crustal xenoliths are of two types: biotite-rich, amphibole bearing metasediments; and garnet-bearing quartzofeldspathicgneisses. Such assemblages are typical of very high-grade amphibolite and granulite faciesmetamorphism; further study should allow us to quantify the pressures and temperatures those rocks experienceduntil the time they were sampled by their host lavas.Major element geochemistry places the c.a. 51-49 Ma (Spurlin et al., 2005) Xialaxiu volcanic field in a fairlydifferentiated (SiO265-70 wt%) high-K field of the calc-alcaline series. Trace element analysis suggests a strongcrustal contamination of the primary mantellic melts. C.a. 38-37 Ma (Spurlin et al., 2005) Nangqian magmaticbodies span across the alkaline series, with high to extreme (K2O6wt%) values. Complex major and traceelement patterns, coupled with high-resolution microprobe data on pyroxene xenocrysts, suggest that enrichmentoccurred at the source by metasomatism of the lithospheric mantle.Further work will precise which mechanisms could have accounted for such a metasomatism of the mantle beneaththe Northern Qiangtang terrane during Eocene, and whether the lower crust had an autochtonous or allochtonousnature.
Geophysical Research Abstracts
Vienne, Austria

insu-01308919
https://hal-insu.archives-ouvertes.fr/insu-01308919

Éditeur(s) : HAL CCSD
Résumé : 32 pages
Wind energy production is very sensitive to instantaneous wind speed fluctuations. Thus rapid variation of wind speed due to changes in the local meteorological conditions can lead to electrical power variations of the order of the nominal power output. In small grids, as they exist for example on some islands in the French West Indies, such fluctuations can cause instabilities in case of intermediate power shortages. To palliate these difficulties, it is essential to identify and characterize the wind speed distributions. This allows to anticipate the eventuality of power shortage or power surge. Therefore, it is of interest to categorize wind speed fluctuations into distinct classes and to estimate the probability of a distribution to belong to a class. This paper presents a method for classifying wind speed histograms by estimating a finite mixture of Dirichlet distributions. The SAEM algorithm that we use provides a fine distinction between wind speed distribution classes. It's a new nonparametric method for wind speed sequences classification. However, we show that the wind speed distributions in each class correspond to specific Gram- Charlier densities.
https://hal.archives-ouvertes.fr/hal-00319608

hal-00319608
https://hal.archives-ouvertes.fr/hal-00319608
https://hal.archives-ouvertes.fr/hal-00319608v2/document
https://hal.archives-ouvertes.fr/hal-00319608/file/Article_dirichlet.pdf
ARXIV : 0810.4422

Résumé : Les risques naturels majeurs constituent une menace plus ou moins récurrente pour la plupart des populations de la planète. Les catastrophes naturelles sont à la fois sources et révélatrices d’inégalités sociales et environnementales, dans le monde, mais aussi sur le territoire de la République française. Les Antilles françaises sont très fréquemment, et très lourdement frappées par les aléas naturels. La réponse en matière de gestion des crises, et, en amont, en matière de prévention, ne nous semble pas à la hauteur des défis, et des besoins des populations. C’est la raison pour laquelle nous nous interrogeons, à travers la présente thèse, sur la place de la solidarité et de l’égalité, dans le régime juridique des risques naturels majeurs. C’est une préoccupation doctrinale majeure, inscrite dans la constitution. La recherche du lien entre droit des risques naturels majeurs et justice sociale et environnementale est l’objet de la présente étude, s’agissant de la réponse juridique à la préoccupation des populations et catégories défavorisées, qui s’avèrent a priori les plus atteintes par les catastrophes naturelles. Les limites des textes, l’insuffisance des moyens, ainsi que les pratiques locales, facteurs d’aggravation des vulnérabilités, le laxisme des pouvoirs publics nationaux et territoriaux, l’absence de culture de risque et l’esprit « kokagneur » des populations (avec des différences de comportement entre la Guadeloupe et la Martinique), toutes ces considérations rendent illusoire la détermination proclamée des pouvoirs publics de résoudre les problèmes de risques naturels majeurs. Des voies d’un renforcement de la solidarité sont proposées. Cette contribution à la recherche sur les risques ambitionne d’apporter aux acteurs, une vision transversale de la problématique des risques naturels, par l’analyse du régime juridique confronté à une exigence de justice sociale et environnementale. Les Antilles françaises servent de support à cette étude.
Major natural hazards are more or less recurring threat for most people in the world. Natural disasters are both sources and revealing social and environmental inequalities in the world, but also in the French Republic. The French West Indies are very frequently and strongly hit by natural hazards. The answer in terms of crisis management, and beforehand, in terms of prevention, doesn’t seem to be up to the population’s challenges and needs. This is why we wonder, in this thesis, about the place of solidarity and equality in the legal system of major natural hazards. This is a major doctrinal concern in the constitution. The research of the relationship between major natural hazards law and environmental and social justice is the subject of this study, concerning the legal answer to the concerns of the underprivileged people and categories, which prove to be a priori the most struck by natural disasters. The limits of the legislation, inadequate resources and local practices, vulnerabilities worsening factor, the laxity of the national and territorial public authorities, the lack of risk culture and the "kokagneur" spirit of the populations (with behavior differences between Guadeloupe and Martinique), all these considerations make unreal the government’s proclaimed determination to solve the major natural hazards issues. Ways to strengthen solidarity are proposed. This contribution to risks research aims to bring to the players an interdisciplinary view of natural hazards issues, through the analysis of the legal system confronted with the requirement of social and environmental justice. The French West Indies are used as research support.

http://www.theses.fr/2015AGUY0824/document

Résumé : En occupant un espace social privilégié, la médecine traditionnelle et les diverses pratiques qui y sont liées, sont de moins en moins marginalisées, de plus en plus admises comme ressources et la société leur devient du même coup permissive. La tolérance sociale est relativement forte ». Cette lecture de la situation de la médecine traditionnelle et de sa réception dans la société est celle de l’anthropologue et médecine martiniquais M. Yoyo. Elle évoque la réalité de la médecine créole dans l’espace antillais et dit l’intérêt que lui portent ceux qui en font usage.L’objectif de cette recherche est de poser la question de la transmission du savoir médicinal en contexte martiniquais : transmission des tradipraticiens vers les profanes ; transmission entre professionnels de cette médecine. Autrement dit comment se fait l’apprentissage si apprentissage il y a, de ce savoir traditionnel, jalousement gardé par ceux qui l’exercent ? La dimension magico-religieuse de ce savoir influe-t-elle sur sa transmission ? Quel est le rôle de la famille dans l’éducation et la transmission de ces pratiques ? Quelle est la connaissance profane accessible à tous et que détiennent certaines familles ? Celle-ci répond-elle aux attentes de la médecine traditionnelle et comment les familles procèdent-elles à sa transmission ? Quelle contribution l’institution scolaire apporte-t-elle à la sauvegarde de ce patrimoine ? Ce questionnement nous amène à nous interroger sur les pratiques en matière de médecine des Martiniquais et à considérer la coexistence entre savoir traditionnel et savoir rationnel dit moderne.On ne peut faire l’économie de ces analyses si on veut appréhender de façon objective le problème de la transmission de la médecine créole, de sa sauvegarde par – et pour – les générations montantes, en raison de l’aspect mémoriel de cette pratique thérapeutique mais également en raison de son efficacité et du potentiel important qu’elle représente pour la santé dans les années qui viennent.
By occupying a privileged social space, traditional medicine and the diverses practices related to the field are less and less marginalized, more and more accepted as resources, thus society is gradually becoming more tolerant towards those practices. The social tolerance is relatively strong”. This perception of the present situation of traditional medicine and of its reception in society is proposed by M. Yoyo, French anthropologist and physician from Martinique. It speaks of the reality of traditional medicine in the west Indians context and highlights the positive affects on those who make use of it. The objective of this research is to explore the question of the transmission of medicinal knowledge within the confines of Martinique: transmission by traditionalists towards nonprofessionals as well as transmission among professionals in the fields of medicine. In other words, what learning, if any, still exists of this traditional knowledge faithfully kept by those practiced it? To what extent does the magical-religious experience influence the transmission of this knowledge? What is the role of the family in the education and the transmission of those practices? How much of this profane knowledge is accessible to all and to what extent is it practiced by families? Does the latter respond to the demands of traditional medicine? How do families proceed with the process of transmission. What contribution does the school make towards preserving this tradition ? The above questions provoke reflection on the medicinal practices of the people of Martinique and of the possible coexistence of traditional knowledge and modern or rational knowledge. These questions are inevitable if we want to progress with objectivity in the transmission of Creole medicine and of its preservation for future generations, as a form of safeguarding the memory of this therapeutic practice. However, they also help to focus on the level of its effectiveness and the potential importance that it represents in ensuring a healthy environment in the coming years.

http://www.theses.fr/2015AGUY0865/document

Résumé : Mondialisation et cultures populaires à Barbade et Trinidad (musique, Carnaval et danse) La culture caribéenne subit de plus en plus les assauts de la mondialisation. Et la question qui se pose concerne l'impact de la mondialisation sur la culture dans la région, c'est-à- dire le passage de la culture ethnique à la mondialisation. Au cours des siècles, le Caribéen, ce métis culturel, cet individu s'est façonné au contact d'influences diverses . Il faut attendre les années 1970 pour que la Barbade et Trinidad se forgent une nouvelle identité sous l'influence du Black Power venu des Etats - Unis et du mouvement Rastafari issu de la Jamaïque. Par ailleurs, l'influence de la télévision et de la musique américaine combinée aux migrations et aux effets de la mondialisation constitue des éléments majeurs à la formation de cette nouvelle identité. Aujourd 'hui après plus de cinquante ans d'indépendance, il y a une timide appréciation de la culture locale. Timide , parce qu'à radio, on entend plus de la musique internationale (américaine, anglais) que de musique locale (calypso, soca) saufpendant le Carnaval de Trinidad et le Crop Over de Barbade. Ce que regrettent les calypsoniens qui reprochent aux radios locales de ne diffuser cette musique que pendant cette période. De la musique caribéenne, les . jeunes de Barbade et de Trinidad plébiscitentures le reggae, la dancehall, le raggasoca, la musique soca. En fait, le calypso correspond à un moment de la vie. A Trinidad, la musique indienne joue un rôle important qui correspond à la population du pays. La musique de Rihanna, l'icône du moment n'a rien de caribéen. Mais son succès phénoménal à Barbade et ailleurs permet de mieux appréhender les facettes de l'identité caribéenne, en général et en particulier, celle de Barbadien et du Trinidadien. De nos jours, les nouvelles technologies accentuent les effets de la mondialisation et contribuent à l'émergence d'une « décréolisation » pour reprendre les termes de G. Létang et d'une nouvelle identité..
Globalization and popular cultures in Barbados and Trinidad Caribbean culture is under the influence ofglobalization. The question is here the impact ofglobalization on the culture in the region . Through centuries the Caribbean man has been made through different cultures. We must wait for the years 1970 to see Barbados and Trinidad which have been made a new identity under the influence of Black Power and the Rastafari movement coming from Jamaica. After more than 50 years ofindependence, there is a shy appreciation oflocal culture . There is more international music than calypso. In Trinidad the Indian music plays an important role corresponding ta the population of the country The new technologies increase the effect of the globalization. It constitutes the rise of the "decreolisation movement".

http://www.theses.fr/2013AGUY0681/document

Éditeur(s) : HAL CCSD Springer Verlag
Résumé : International audience
Purpose Human papillomavirus (HPV) is known to play a role in the development of head and neck squamous cell carcinomas (HNSCC) and to date, no study has reported on the association between oral HPV infection and HNSCC in the Caribbean. The objective was to determine the prevalence of oral HPV infection in the French West Indies (FWI), overall and by HPV genotype, among HNSCC cases and healthy population controls. Method We used data from a population-based case-control study conducted in the FWI. The prevalence of oral HPV was estimated separately among 100 HNSCC cases (mean age 59 years) and 308 population controls (mean age 57 years). Odds ratios (OR) and 95% confidence intervals (CI) were estimated using a logistic regression adjusting for age, sex, tobacco, and alcohol consumption, to assess the association between oral HPV infection and HNSCC. Results Prevalence of oral HPV infections was 26% in controls (30% in men and 14% in women) and 36% in HNSCC cases (36% in men, 33% in women). HPV52 was the most commonly detected genotype, in cases and in controls. The prevalence of HPV16, HPV33, and HPV51 was significantly higher in cases than in controls (p = 0.0340, p = 0.0472, and 0.0144, respectively). Oral infection with high-risk HPV was associated with an increase in risk of HNSCC (OR 1.99, 95% CI 0.95-4.15). HPV16 was only associated with oropharyngeal cancer (OR 16.01, 95% CI 1.67-153.64). Conclusion This study revealed a high prevalence of oral HPV infection in this middle-aged Afro-Caribbean population, and a specific distribution of HPV genotypes. These findings may provide insight into HNSCC etiology specific to the FWI.
ISSN: 0957-5243

hal-01659247
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01659247
DOI : 10.1007/s10552-017-0966-z
PUBMED : 28948421