Éditeur(s) : HAL CCSD American Physiological Society
Résumé : Full text: http://jn.physiology.org/content/88/3/1475
International audience
The contribution of voltage-gated calcium channels (VGCC) to the development of cultured embryonic cockroach brain neurons was assessed using pharmacological agents. VGCC currents were recorded using the patch-clamp technique and were found to be blocked dose-dependently by micromolar concentrations of mibefradil. The activation and inactivation properties of the calcium channels enable a sizeable calcium current to flow at rest (about -30 and -20 mV in high-potassium culture media). As expected, the cytoplasmic-free calcium concentration was found to rise when the extracellular potassium concentration was raised from 3 to 15 and 30 mM. The effects of VGCC blockers and calcium chelators were different in fresh and in mature cultures in which the neurons were connected to each other to form a defined network. In fresh cultures, the two non-selective VGCC blockers (verapamil and mibefradil) induced a dose-dependent cell death that was proportional to their blocking effect on I(Ba). This effect could not be prevented by addition of fetal calf serum to the culture medium. A similar effect was obtained using intra- or extracellular calcium chelating agents (10 microM BAPTA-AM or 10 mM EGTA). Quite unexpectedly, blockade of the P/Q-like (omega-Aga WA-sensitive) component of the calcium current by 500 nM of omega-AgaTx IVA had no lethal effect, suggesting that the corresponding channels are not involved in the survival mechanism. As expected from their lack of effect on I(Ba), isradipine, nifedipine, and omega-CgTx GVIA did not induce cell death. When the neurons started growing neurites, their sensitivity to calcium channel blockade by mibefradil decreased, indicating a correlation between neurite outgrowth and resistance to calcium depletion. In mature cultures, the neurons became resistant to mibefradil, verapamil, and BAPTA-AM. However, these agents, as well as omega-AgaTx IVA, had a significant inhibitory effect on the increase in diameter of the connectives that linked adjacent clusters of neurons. This effect has been shown to result, in the case of mibefradil, from an inhibition of neurite outgrowth characterized by a significant reduction of the number of primary neurites and secondary branchings but not to a significant modification of the diameter of individual neurites. These results support the view that, as in vertebrates, calcium influx through VGCC plays an important role in survival and neurite outgrowth of cultured embryonic insect neurons. The differential contribution of the P/Q-like and R-like (omega-Aga WA-sensitive) calcium channels in these processes is discussed.
ISSN: 0022-3077

hal-00982287
https://hal.archives-ouvertes.fr/hal-00982287
DOI : 10.1152/jn.00749.2001
PUBMED : 12205168

Éditeur(s) : HAL CCSD Canadian Education Association
Résumé : International audience
ISSN: 0013-1253

hal-01658927
https://hal.univ-antilles.fr/hal-01658927
https://hal.univ-antilles.fr/hal-01658927/document
https://hal.univ-antilles.fr/hal-01658927/file/Vers%20une%20implication%20de%20l%27apprenant%20article%20revue%20Education%20CANADA.pdf

Éditeur(s) : HAL CCSD
Résumé : 6 pages
In a Spiking Neural Networks (SNN), spike emissions are sparsely and irregularly distributed both in time and in the network architecture. Since a current feature of SNNs is a low average activity, efficient implementations of SNNs are usually based on an Event-Driven Simulation (EDS). On the other hand, simulations of large scale neural networks can take advantage of distributing the neurons on a set of processors (either workstation cluster or parallel computer). This article presents DAMNED, a large scale SNN simulation framework able to gather the benefits of EDS and parallel computing. Two levels of parallelism are combined: Distributed mapping of the neural topology, at the network level, and local multithreaded allocation of resources for simultaneous processing of events, at the neuron level. Based on the causality of events, a distributed solution is proposed for solving the complex problem of scheduling without synchronization barrier.
https://hal.archives-ouvertes.fr/hal-00015137

hal-00015137
https://hal.archives-ouvertes.fr/hal-00015137
https://hal.archives-ouvertes.fr/hal-00015137v2/document
https://hal.archives-ouvertes.fr/hal-00015137/file/hal_damned.pdf
ARXIV : cs.NE/0512018

Éditeur(s) : HAL CCSD IAIMTE
Résumé : no abstract
ISSN: 1567-6617

hal-01360225
https://hal.archives-ouvertes.fr/hal-01360225

Éditeur(s) : HAL CCSD Human Kinetics
Résumé : International audience
The purpose of the present experiment was to examine whether the use of self-handicapping strategies influences participants' anxiety levels before athletic performance. Seventy-one competitive basketball players participated in the study. A repeated measures design was used, such that state cognitive and somatic anxiety intensity and direction were measured before and after participants were given the opportunity to self-handicap. Overall, participants reported their cognitive anxiety to be more facilitating after they had the opportunity to self-handicap. Thus, participants who were given the opportunity to self-handicap (i.e., use claimed and behavioral self-handicaps), reported greater increases in perceptions of cog-nitive anxiety as facilitating their performance. This study shows the importance of looking at anxiety direction, and not just anxiety intensity, when examining self-handicapping's effects on anxiety. Implications for sport psychologists are proposed.
ISSN: 1543-2793

Droits : info:eu-repo/semantics/OpenAccess
hal-01343255
https://hal.univ-antilles.fr/hal-01343255
https://hal.univ-antilles.fr/hal-01343255/document
https://hal.univ-antilles.fr/hal-01343255/file/TSP%2007-54.%20Final%20Manuscript.Self-handicapping%20and%20Anxiety%20in%20Sport%20HAL.pdf
DOI : 10.1123/tsp.22.3.304

Éditeur(s) : HAL CCSD
Résumé : International audience
This paper focuses on the study of the influence of a newly implemented mechanism on a Pittsburgh-like classifier system. The Adapted Pittsburgh Classifier System is a learning classifier system that uses genetic algorithms to evolve its ruleset. The new mechanism discussed is inspired from Wilson work on the eXtended Classifier System (XCS): it allows the concerned LCS to adapt its rule set when facing a new signal by modifying an existing rule. This mechanism is called covering mechanism due to the fact that the rule is covered up by a new rule which is sensitive to this new signal. Effects of this covering mechanism are first measured on the performances of APCS on well known multi-step environments: maze-type environments (Woods 101 and E2). In addition, further measures presented in this paper indicate that we could possibly rely on the behavior of this covering mechanism to automate the research of a correct cognitive capacity needed by the APCS to solve a given multistep problem.
2008 Eighth International Conference on Hybrid Intelligent Systems
Barcelone, Spain

hal-00520608
https://hal.archives-ouvertes.fr/hal-00520608
DOI : 10.1109/HIS.2008.105

Éditeur(s) : HAL CCSD Editeur :1022 [SUISSE] : Association de la revue [petite] enfance
Résumé : International audience
En Martinique, comme dans d'autres régions francophones/créolophones, les adultes éduquent et instruisent les enfants en langue française. Ils tendent toutefois, par leurs propres conduites langagières en présence des tout petits, à lever le voile sur l'emploi de la langue créole qu'ils tiennent tant à proscrire au contact des enfants. Cette contradiction dans les conduites langagières des adultes est rapidement repérée par les enfants qui saisissent progressivement les interdits et la dimension confidentielle relatifs à l'emploi du créole, en faisant notamment la part des fréquents échanges créolophones entre adultes et de l'emploi exclusif du français par ces mêmes adultes lorsqu'ils s'adressent à eux. Au contact de son milieu familial et/ou dans les collectivités qu'il fréquente, le tout petit a un rapport plus ou moins direct avec la langue créole qu'emploient des adultes (conversations entendues) ou certains pairs de son entourage. Il surprend par moments ses locuteurs référents lors de l'introduction spontanée d'expressions en créole dans leurs énoncés. Ce n'est qu'au moment de l'intégration des règles liées aux pratiques langagières établies dans le cadre de son éducation que s'instaure une pudeur relative au parler créole en présence des adultes. Dès sa dernière année de crèche (2ans1/2 – 3 ans) et sa première année d'école, il commence à maîtriser le parler français, tout en intériorisant les contradictions des adultes de son entourage. Les distorsions langagières se sont ainsi déplacées d'un espace intersubjectif (entre l'enfant et l'adulte) à un espace intra subjectif (chez l'enfant lui-même) où le jeune locuteur a commencé à s'autocensurer dans ses pratiques langagières, se conformant aux exigences monolingues de l'école où il s'instruit. L'activité du tout petit se situe aussi bien au niveau de la production d'actes langagiers que dans sa position de sujet entendant les productions de ses interlocuteurs, c'est-à-dire que le point de départ de l'investissement personnel de la langue entendue se situe au niveau de l'écoute pratiquée par le locuteur en puissance, le point d'élaboration de cet investissement se manifestant à travers la mise en oeuvre des éléments recueillis durant l'écoute.
ISSN: 1422-8874

Droits : info:eu-repo/semantics/OpenAccess
hal-01658926
https://hal.univ-antilles.fr/hal-01658926
https://hal.univ-antilles.fr/hal-01658926/document
https://hal.univ-antilles.fr/hal-01658926/file/Les%20enfants%20au%20contact%20de%20la%20langue%20proscrite%20RPES.pdf

Éditeur(s) : HAL CCSD
Résumé : International audience
https://hal.univ-antilles.fr/hal-01658929

Droits : info:eu-repo/semantics/OpenAccess
ISBN : 9782955045008
hal-01658929
https://hal.univ-antilles.fr/hal-01658929
https://hal.univ-antilles.fr/hal-01658929/document
https://hal.univ-antilles.fr/hal-01658929/file/LA%20CONSTRUCTION%20INTERACTIVE%20DES%20%20SAVOIR-FAIRE%20%20%20LIVRE%20UNIVERSITAIRE.pdf

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
BACKGROUND: A prospective study of infectious encephalitis was conducted in France in 2007. In total, 253 patients were enrolled with a proven etiological diagnosis for 52%. The cohort of surviving patients with encephalitis was assessed for sequelae and impairment 3 years after enrollment. METHODS: Patients, their family, and general practitioners (GPs) were interviewed by phone to document persisting symptoms, return to work, and past and current leisure activities, with standardized questionnaires. The IQCODE (Informant Questionnaire on Cognitive Decline in the Elderly) was completed with relatives. The global outcome was determined in all patients with the Glasgow outcome scale. RESULTS: In 2010, 20 patients (10%) were unavailable for follow-up, 2 (1%) were excluded, and 18 (9%) had died since hospital discharge. Data were available for 167 survivors and 9 patients whose death was related to the encephalitis. The outcome was favorable in 108 of 176 patients (61%) (71 with complete resolution), 31 (18%) were mildly impaired, 25 (14%) were severely impaired, and 3 (1%) were in a vegetative state. The most frequent symptoms were difficulty concentrating (42%), behavioral disorders (27%), speech disorders (20%), and memory loss (19%). Fifteen of 63 patients (24%) previously employed were still unable to resume work. Long-term outcome was significantly associated with comorbid conditions, age, level of education, and the causative agent of encephalitis. CONCLUSIONS: Most patients with encephalitis experienced a favorable outcome 3 years after hospital discharge. However, minor to severe disability persists in a high number of cases with consequences for everyday life. Physical and mental impairment should be evaluated in all patients with encephalitis, and neuropsychological rehabilitation implemented whenever needed.
ISSN: 1058-4838

hal-00875190
https://hal.archives-ouvertes.fr/hal-00875190
DOI : 10.1093/cid/cis226
PUBMED : 22460967

Éditeur(s) : HAL CCSD L'Harmattan
Résumé : International audience
Apprendre dans un certain contexte, apprendre en prenant appui sur le contexte, apprendre en dépit de décalages contextuels : voilà ce que questionnent les approches contextualisées dans l’enseignement, l’apprentissage, la médiation et la socialisation. Dans ce cadre, la contextualisation didactique, telle que nous la définissons, se fixe trois objectifs : identifier et analyser les paramètres contextuels en jeu dans l’interaction apprenant-acquisitions ; proposer des ajustements ainsi que des reconstructions des processus didactiques et de médiation afin de réduire les inadaptations contextuelles ; évaluer les effets des approches contextualisées mises en œuvre.Cet ouvrage collectif, dans la suite de Contextualisations didactiques : approches théoriques (L’Harmattan, 2013) et de Contextes, effets de contexte et didactique des langues (L’Harmattan, 2014), s’articule autour de ces trois objectifs en questionnant l’adaptation contextuelle de certains dispositifs, les facilitations ou résistances engendrées par les effets de contextes, ainsi que les impacts de supports d’enseignement en relation avec le contexte.
https://hal.univ-antilles.fr/hal-01529540

ISBN : 978-2-243-07837-3
hal-01529540
https://hal.univ-antilles.fr/hal-01529540

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
: In non-mammalian vertebrates, serotonin (5-HT)-producing neurons exist in the paraventricular organ (PVO), a diencephalic structure containing cerebrospinal fluid (CSF)-contacting neurons exhibiting 5-HT or dopamine (DA) immunoreactivity. Because the brain of the adult teleost is known for its neurogenic activity supported, for a large part, by radial glial progenitors, this study addresses the origin of newborn 5-HT neurons in the hypothalamus of adult zebrafish. In this species, the PVO exhibits numerous radial glial cells (RGCs) whose somata are located at a certain distance from the ventricle. To study relationships between RGCs and 5-HT CSF-contacting neurons, we performed 5-HT immunohistochemistry in transgenic tg(cyp19a1b-GFP) zebrafish in which RGCs are labelled with GFP under the control of the cyp19a1b promoter. We show that the somata of the 5-HT neurons are located closer to the ventricle than those of RGCs. RGCs extend towards the ventricle cytoplasmic processes that form a continuous barrier along the ventricular surface. In turn, 5-HT neurons contact the CSF via processes that cross this barrier through small pores. Further experiments using proliferating cell nuclear antigen or 5-bromo-2'-deoxyuridine indicate that RGCs proliferate and give birth to 5-HT neurons migrating centripetally instead of centrifugally as in other brain regions. Furthermore, treatment of adult zebrafish with tryptophan hydroxylase inhibitor causes a significant decrease in the number of proliferating cells in the PVO, but not in the mediobasal hypothalamus. These data point to the PVO as an intriguing region in which 5-HT appears to promote genesis of 5-HT neurons that accumulate along the brain ventricles and contact the CSF.
ISSN: 0953-816X

inserm-00866212
http://www.hal.inserm.fr/inserm-00866212
DOI : 10.1111/ejn.12348
PUBMED : 23981075

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Maternal affective disorders are frequently treated with selective serotonin reuptake inhibitor medications (SSRIs); with up to 10% of women being prescribed these medications during pregnancy. Infant development depends on the early serotonergic environment, which is altered by perinatal SSRIs, raising concern about how these medications affect neural outcomes. While clinical and preclinical research suggests an impact of SSRIs on the developing brain, more research is needed to determine the effects on neuroplasticity, the serotonergic system, and the hypothalamic-pituitary-adrenal axis in neural regions mediating behavior. The current work investigated the effects of the SSRI, fluoxetine, on the serotonergic system in the prefrontal cortex (PFC) during pre-adolescence, and changes to synaptic markers and glucocorticoid receptor density in the cingulate cortex (medial PFC) of pre-adolescent and adult Sprague-Dawley male and female rats. To model aspects of Perinatal Depression and maternal anxiety, pre-gestational maternal stress was used resulting in male and female offspring from 4 groups: 1) control, 2) perinatal fluoxetine exposed, 3) pre-gestational maternal stress exposed, and 4) pre-gestational maternal stress + fluoxetine. Perinatal fluoxetine prevented the effects of maternal stress on 5-HT levels and 5-HT turnover ratio in the PFC of pre-adolescent offspring, particularly in females. However, pre-gestational stress reduced synaptophysin and PSD-95 densities in the cingulate cortex, effects that were more pronounced in males. Interestingly, perinatal fluoxetine exposure reduced GR density in adult males in this same brain area. Together, results show differential effects of perinatal SSRIs and pre-gestational maternal stress on neurodevelopment in the PFC of males and females.
ISSN: 0028-3908

hal-01647158
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01647158
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01647158/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01647158/file/Gemmel%20-%20Perinatal%20fluoxetine%20prevents%20the%20effect.pdf
DOI : 10.1016/j.neuropharm.2017.10.009

Éditeur(s) : HAL CCSD Frontiers
Résumé : International audience
The generation of handwriting is a complex neuromotor skill requiring the interaction of many cognitive processes. It aims at producing a message to be imprinted as an ink trace left on a writing medium. The generated trajectory of the pen tip is made up of strokes superimposed over time. The Kinematic Theory of rapid human movements and its family of lognormal models provide analytical representations of these strokes, often considered as the basic unit of handwriting. This paradigm has not only been experimentally confirmed in numerous predictive and physiologically significant tests but it has also been shown to be the ideal mathematical description for the impulse response of a neuromuscular system. This latter demonstration suggests that the lognormality of the velocity patterns can be interpreted as reflecting the behavior of subjects who are in perfect control of their movements. To illustrate this interpretation, we present a short overview of the main concepts behind the Kinematic Theory and briefly describe how its models can be exploited, using various software tools, to investigate these ideal lognormal behaviors. We emphasize that the parameters extracted during various tasks can be used to analyze some underlying processes associated with their realization. To investigate the operational convergence hypothesis, we report on two original studies. First, we focus on the early steps of the motor learning process as seen as a converging behavior toward the production of more precise lognormal patterns as young children practicing handwriting start to become more fluent writers. Second, we illustrate how aging affects handwriting by pointing out the increasing departure from the ideal lognormal behavior as the control of the fine motricity begins to decline. Overall, the paper highlights this developmental process of merging toward a lognormal behavior with learning, mastering this behavior to succeed in performing a given task, and then gradually deviating from it with aging.
ISSN: 1664-1078

hal-01098124
https://hal.archives-ouvertes.fr/hal-01098124
DOI : 10.3389/fpsyg.2013.0094

Éditeur(s) : HAL CCSD
Résumé : International audience
OBJECTIVE: To analyze complications of endoscopic transsphenoidal surgery (ETS) for nonfunctioning pituitary macroadenomas (NFPAs).ăMETHODS: A retrospective study of 300 NFPAs was performed. Complications and factors that could influence these complications were analyzed.ăRESULTS: Visual and pituitary functions worsened in 2.4% and 13.7% of cases, respectively. Postoperative diabetes insipidus was permanent in 6.2% of cases. Postoperative meningitis occurred in 3.3% of patients. Meningitis was strongly associated with intraoperative cerebrospinal fluid (CSF) leaks (P = 0.01), postoperative CSF leaks (P = 0.0001), and operation times longer than 1 hour (P = 0.023). Detection of Staphylococcus aureus and preoperative treatment with mupirocin in the nostrils did not impact the occurrence of meningitis. Two patients with meningitis died (unique causes of death). Postoperative CSF leaks occurred in 2.7% of cases and were associated with intraoperative CSF leaks (P = 0.007) and permanent diabetes insipidus (P = 0.028). The rate of CSF leak decreased from 4% to 0.8% (P = 0.048) after we moved from a soft to hard reconstruction of the sella. The rate of postoperative epistaxis decreased from 6.7% to 1.25% after we stopped using monopolar coagulation (P = 0.013).ăCONCLUSIONS: ETS permits a wide view, allowing good conditions for a satisfactory resection in the majority of NFPAs. Some pitfalls of endoscopy can lead to complications that improve with modification of the operative technique (i.e., CSF leak and postoperative epistaxis). This study confirms an acceptable rate of complications associated with ETS.
World Neurosurgery

hal-01474296
https://hal.archives-ouvertes.fr/hal-01474296
DOI : 10.1016/j.wneu.2016.02.059
PUBMED : 26902781

Éditeur(s) : HAL CCSD
Résumé : From the protolanguage born with Homo erectus, the modern human language of Homo sapiens has naturally diversified into tonal, stress-timed, or syllable-timed languages, although the definition of the syllable has yet to be established. Thus for a French speaker, the transition from a language punctuated by the syllable to a language punctuated by the lexical stress will be a delicate point in learning oral English. For this purpose, we recommend the implementation of a reprogramming of the articulatory gesture in the brains as evidenced by articulatory phonology. Through the arched beam, Broca's area of the French-speaking learner will inhibit the French-related data to send to Wernicke's area new information regarding the reception / production of oral English.
A partir du protolangage né avec Homo erectus, le langage humain moderne d'Homo sapiens s'est naturellement diversifié en langues tonales, accentuelles, ou syllabiques, bien que la définition de la syllabe reste encore à établir. Ainsi pour un francophone, le passage d'une langue rythmée par la syllabe à une langue rythmée par l'accent lexical sera un point délicat de l'apprentissage de l'anglais oral. Pour ce faire, nous préconisons la mise en place d'une reprogrammation de la gestuelle articulatoire telle qu'elle a pu être mise en évidence par la phonologie articulatoire. Par le biais du faisceau arqué, l'aire de Broca de l'apprenant francophone inhibera les données liées au français pour envoyer à l'aire de Wernicke de nouvelles informations quant à la réception / production de l'anglais oral. Mots clés : neurodidactique, anglais oral, phonologie articulatoire, aires du langage, mémoire procédurale et à long terme. Abstract: From the protolanguage born with Homo erectus, the modern human language of Homo sapiens has naturally diversified into tonal, stress-timed, or syllable-timed languages, although the definition of the syllable has yet to be established. Thus for a French speaker, the transition from a language punctuated by the syllable to a language punctuated by the lexical stress will be a delicate point in learning oral English. For this purpose, we recommend the implementation of a reprogramming of the articulatory gesture in the brains as evidenced by articulatory phonology. Through the arched beam, Broca's area of the French-speaking learner will inhibit the French-related data to send to Wernicke's area new information regarding the reception / production of oral English.
https://hal.archives-ouvertes.fr/hal-01626540

hal-01626540
https://hal.archives-ouvertes.fr/hal-01626540
https://hal.archives-ouvertes.fr/hal-01626540/document
https://hal.archives-ouvertes.fr/hal-01626540/file/Neurodidactique%20%20Comment%20le%20cerveau%20d%27un%20apprenant%20francophone%20peut-il%20se%20programmer%20sur%20une%20langue%20accentuelle..pdf

Éditeur(s) : HAL CCSD Springer Verlag
Résumé : no abstract
ISSN: 0256-2928

hal-01360229
https://hal.archives-ouvertes.fr/hal-01360229

Éditeur(s) : HAL CCSD
Résumé : International audience
The Sigma-Lognormal model of the Kinematic Theory of rapid human movements allows us to represent on-line signatures with an analytical neuromuscular model. It has been successfully used in the past to generate synthetic signatures in order to improve the performance of an automatic verification system. In this paper, we attempt for the first time to build a verification system based on the model parameters themselves. For describing individual lognormal strokes, we propose eighteen features which capture cognitive psychomotor characteristics of the signer. They are matched by means of dynamic time warping to derive a dissimilarity measure for signature verification. Promising initial results are reported for an experimental evaluation on the SUSIG visual sub-corpus, which contains some of the most skilled forgeries currently available for research.
17th Biennial Conference of the International Graphonomics Society
Pointe-à-Pitre, Guadeloupe

hal-01165871
https://hal.univ-antilles.fr/hal-01165871
https://hal.univ-antilles.fr/hal-01165871/document
https://hal.univ-antilles.fr/hal-01165871/file/IGS_2015_submission_11.pdf

Éditeur(s) : HAL CCSD Springer Verlag
Résumé : no abstract
ISSN: 0090-6905

hal-01360230
https://hal.archives-ouvertes.fr/hal-01360230

Éditeur(s) : HAL CCSD Frontiers
Résumé : International audience
Estrogens can induce rapid, short-lived physiological and behavioral responses, in addition to their slow, but long-term, effects at the transcriptional level. To be functionally relevant, these effects should be associated with rapid modulations of estrogens concentrations. 17β-estradiol is synthesized by the enzyme aromatase, using testosterone as a substrate, but can also be degraded into catechol-estrogens via hydroxylation by the same enzyme, leading to an increase or decrease in estrogens concentration, respectively. The first evidence that aromatase activity (AA) can be rapidly modulated came from experiments performed in Japanese quail hypothalamus homogenates. This rapid modulation is triggered by calcium-dependent phosphorylations and was confirmed in other tissues and species. The mechanisms controlling the phosphorylation status, the targeted amino acid residues and the reversibility seem to vary depending of the tissues and is discussed in this review. We currently do not know whether the phosphorylation of the same amino acid affects both aromatase and/or hydroxylase activities or whether these residues are different. These processes provide a new general mechanism by which local estrogen concentration can be rapidly altered in the brain and other tissues.
ISSN: 1662-4548

Droits : http://creativecommons.org/licenses/by/
hal-01142062
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01142062
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01142062/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01142062/file/fnins-09-00083.pdf
PUBMED : 25852459

Éditeur(s) : HAL CCSD
Résumé : International audience
An investigation of the eye and hand movement during the task of signature simulation was conducted. Three subjects' eye movements and hand movements were recorded using an eye-tracker and a digitizing tablet while they simulated signatures. The study revealed that eye gaze most frequently shifted within less than 17 msec of a pen velocity minimum. It is thought that the cognitive processes overseeing this movement control and the limitations of the visuomotor buffer could play an important role in the behaviour of simulating signatures and signature simulation quality.
17th Biennial Conference of the International Graphonomics Society
Pointe-à-Pitre, Guadeloupe

hal-01166493
https://hal.univ-antilles.fr/hal-01166493
https://hal.univ-antilles.fr/hal-01166493/document
https://hal.univ-antilles.fr/hal-01166493/file/IGS_2015_submission_35.pdf