Éditeur(s) : Trinidad Guardian Trinidad Guardian
North America -- Trinidad and Tobago -- Caribbean -- Trinidad -- Port of Spain
Caribbean

UF00078602

Éditeur(s) : Impr. de l'État Impr. de l'État ( Port-au-Prince, Haïti )
Résumé : Title from PDF t.p. (LLMC Digital, viewed on Sept. 7, 2010).
At head of title: République d'Haïti. Département de l'intérieur. Services de l'immigration et des passeports.
"Elie Lescot, président de la République"--P. 1.
"En vigueur le er février 1945."
Haiti
Haïti

662530930

Éditeur(s) : HAL CCSD BioMed Central
Résumé : International audience
BACKGROUND: Estrogen receptors (ER) α and β are found in both women and men in many tissues, where they have different functions, including having roles in cell proliferation and differentiation of the reproductive tract. In addition to estradiol (E2), a natural hormone, numerous compounds are able to bind ERs and modulate their activities. Among these compounds, phytoestrogens such as isoflavones, which are found in plants, are promising therapeutics for several pathologies. Glyceollins are second metabolites of isoflavones that are mainly produced in soybean in response to an elicitor. They have potentially therapeutic actions in breast cancer by reducing the proliferation of cancer cells. However, the molecular mechanisms driving these effects remain elusive. METHODS: First, to determine the proliferative or anti-proliferative effects of glyceollins, in vivo and in vitro approaches were used. The length of epithelial duct in mammary gland as well as uterotrophy after treatment by E2 and glyceollins and their effect on proliferation of different breast cell line were assessed. Secondly, the ability of glyceollin to activate ER was assessed by luciferase assay. Finally, to unravel molecular mechanisms involved by glyceollins, transcriptomic analysis was performed on MCF-7 breast cancer cells. RESULTS: In this study, we show that synthetic versions of glyceollin I and II exert anti-proliferative effects in vivo in mouse mammary glands and in vitro in different ER-positive and ER-negative breast cell lines. Using transcriptomic analysis, we produce for the first time an integrated view of gene regulation in response to glyceollins and reveal that these phytochemicals act through at least two major pathways. One pathway involving FOXM1 and ERα is directly linked to proliferation. The other involves the HIF family and reveals that stress is a potential factor in the anti-proliferative effects of glyceollins due to its role in increasing the expression of REDD1, an mTORC1 inhibitor. CONCLUSION: Overall, our study clearly shows that glyceollins exert anti-proliferative effects by reducing the expression of genes encoding cell cycle and mitosis-associated factors and biomarkers overexpressed in cancers and by increasing the expression of growth arrest-related genes. These results reinforce the therapeutic potential of glyceollins for breast cancer.
ISSN: 1478-811X

hal-01560288
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01560288
DOI : 10.1186/s12964-017-0182-1
PUBMED : 28666461

AAA5652
http://ufdc.ufl.edu/UF00003811/00001

Éditeur(s) : Florida International University. Department of African New World Studies. Florida International University. Department of African New World Studies.
North America -- Trinidad and Tobago -- Caribbean
Caribbean

Éditeur(s) : Trinidad Guardian Trinidad Guardian
North America -- Trinidad and Tobago -- Caribbean -- Trinidad -- Port of Spain
Caribbean

UF00085476

Éditeur(s) : HAL CCSD
Résumé : International audience
The present study was conducted to assess the effects of Cd exposure on estrogen signaling in the zebrafish brain, as well as the potential protective role of Zn against Cd-induced toxicity. For this purpose, the effects on transcriptional activation of the estrogen receptors (ERs), aromatase B (Aro-B) protein expression and molecular expression of related genes were examined in vivo using wild-type and transgenic zebrafish embryos. For in vitro studies, an ER-negative glial cell line (U251MG) transfected with different zebrafish ER subtypes (ERα, ERβ1 and ERβ2) was also used. Embryos were exposed either to estradiol (E2), Cd, E2+Cd or E2+Cd+Zn for 72 h and cells were exposed to the same treatments for 30 h. Our results show that E2 treatment promoted the transcriptional activation of ERs and increased Aro-B expression, at both the protein and mRNA levels. Although exposure to Cd, does not affect the studied parameters when administered alone, it significantly abolished the E2-stimulated transcriptional response of the reporter gene for the three ER subtypes in U251-MG cells, and clearly inhibited the E2 induction of Aro-B in radial glial cells of zebrafish embryos. These inhibitory effects were accompanied by a significant downregulation of the expression of esr1, esr2a, esr2b and cyp19a1b genes compared to the E2-treated group used as a positive control. Zn administration during simultaneous exposure to E2 and Cd strongly stimulated zebrafish ERs transactivation and increased Aro-B protein expression, whereas mRNA levels of the three ERs as well as the cyp19a1b remained unchanged in comparison with Cd-treated embryos. In conclusion, our results clearly demonstrate that Cd acts as a potent anti-estrogen in vivo and in vitro, and that Cd-induced E2 antagonism can be reversed, at the protein level, by Zn supplement.
Journal of Applied Toxicology

Droits : info:eu-repo/semantics/OpenAccess
hal-01274217
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01274217
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01274217/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01274217/file/Inhibitory%20effect%20of%20Cadmium%20on%20estrogen_accepted.pdf
DOI : 10.1002/jat.3285

Éditeur(s) : Himalayan Academy Himalayan Academy ( United States )
Résumé : (Funding) Support for the development of the technical infrastructure and partner training provided by the United States Department of Education TICFIA program.
(Acquisition) This article is published in Hinduism Today http://www.hinduismtoday.com and is shared by the author Vidyaratha Kissoon email vidyak1 (at) gmail dot com. The author Vidyaratha Kissoon has proposed the following corrections to the PDF version. Some corrections have been made in the print version and in the online edition. Errata Sheet for "Guyana's Hindus face Gay Quandary" Page 60 1) The caption on the photograph should be "Activists from the Caribbean at a human rights advocacy workshop in Guyana in August 2010" - 2) The line "After being ruled by the Dutch, the Spanish and finally the British ... " should read "After being ruled by the Dutch and the British".. 3) The line 'Revisions and amendments to the constitution are relatively common' to 'Revisions and amendments to the constitution are necessary to achieving this nationhood' 4) The phrase "Congress of Guyana" should be changed to "Parliament of Guyana" Page 61 4) The line "Hindu institutions were mostly absent from the 2001 debate except for a joint statement issued by a few organisations.." should read "Hindu institutions were mostly absent from the 2003 debate except for a joint multifaith statement which included a few organisations .." 6) The comments by Former UN Secretary General Kofi Annan - referred to laws like those in Guyana (the British colonial Caribbean) 7) The last sentence should read "Freedom of worship is ... and each of the main groups has national holidays [Christmas, Easter, Diwali, Phagwah, Eid ul Adha, Youman Nabi] Page 62 8) The line "Pandit Dhanesar was not able.. " to "Pandit Dhanesar did not provide any specific reference in the Vedas. In Guyana, many Pandits sustain traditions a mix of oral and written traditions" 9) The line "Active in helping the gay and lesbian communities, he advocates acceptance." should read "He advocates acceptance .. " The corrected version of the article appears online at http://hinduismtoday.com/modules/smartsection/item.php?itemid=5172

Droits : All rights reserved by the source institution.

Éditeur(s) : Trinidad Guardian Trinidad Guardian
North America -- Trinidad and Tobago -- Caribbean -- Trinidad -- Port of Spain
Caribbean

UF00085487

Éditeur(s) : Trinidad Guardian Trinidad Guardian
North America -- Trinidad and Tobago -- Caribbean -- Trinidad -- Port of Spain
Caribbean

UF00085483

Éditeur(s) : Trinidad Guardian Trinidad Guardian
North America -- Trinidad and Tobago -- Caribbean -- Trinidad -- Port of Spain
Caribbean

UF00078589

Éditeur(s) : Trinidad Guardian Trinidad Guardian
North America -- Trinidad and Tobago -- Caribbean -- Trinidad -- Port of Spain
Caribbean

UF00085486

Éditeur(s) : Trinidad Guardian Trinidad Guardian
North America -- Trinidad and Tobago -- Caribbean -- Trinidad -- Port of Spain
Caribbean

UF00078613

Résumé : Address to the Economics Society of the University of the West Indies, Jamaica, 19th February, 1963 /by Eric Williams
Subject-Top.Trm: Economic assistance. West Indies

Droits : All rights reserved by the source institution.
20905243
21716198

Résumé : Photograph of Watercolor painting
St. Croix, USVI
Estate Sion Farm

Droits : All rights reserved by the source institution.
http://ufdc.ufl.edu/AA00013492/00001

Éditeur(s) : Trinidad Guardian Trinidad Guardian
North America -- Trinidad and Tobago -- Caribbean -- Trinidad -- Port of Spain
Caribbean

UF00085478

Éditeur(s) : Trinidad Guardian Trinidad Guardian
North America -- Trinidad and Tobago -- Caribbean -- Trinidad -- Port of Spain
Caribbean

UF00078611

Éditeur(s) : Trinidad Guardian Trinidad Guardian
North America -- Trinidad and Tobago -- Caribbean -- Trinidad -- Port of Spain
Caribbean

UF00078594

Éditeur(s) : Trinidad Guardian Trinidad Guardian
North America -- Trinidad and Tobago -- Caribbean -- Trinidad -- Port of Spain
Caribbean

UF00078617

Éditeur(s) : London : Printed for John Stockdale London : Printed for John Stockdale
Résumé : Errata: p. [1], following the Preface (i.e., p. xxiv).
A⁴( -A4) b-d⁴ B-2D⁴ 2E² 2F-2I⁴.
The verso of sig. Dd4 is numbered 208-212.
Includes bibliographical references.
This item is part of the West Indies collection.
Has bookplate inside front cover: "Port Elizabeth Public Library, George Owen Smith Collection, 1892".
Spine repaired with leather stamped with gilt; hinges repaired with marbled paper.
Full leather over boards; gilt decorations on covers; marbled endpapers.

Droits : All rights to images are held by the respective holding institution. This image is posted publicly for non-profit educational uses, excluding printed publication. For permission to reproduce images and/or for copyright information contact Special Collections & University Archives, University of Central Florida Libraries, Orlando, FL 32816 phone (407) 823-2576, email: speccoll@mail.ucf.edu
UCF Special Collections Bryant - 5th Floor -- F1923.E26 1797
DP0003441