Manioc : Portail | resultats 1 - 20 pour la recherche: Roux, Virginie

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Purpose: Active surveillance is a treatment option for favorable risk prostate cancer. However, data are missing on populations of African descent. We evaluated the safety and benefit of active surveillance in an African Caribbean cohort with favorable risk prostate cancer. Materials and Methods: Between 2005 and 2016, a single center, prospective cohort study was performed in Guadeloupe, French West Indies, including patients on active surveillance who had low risk prostate cancer (prostate specific antigen 10 ng/ml or less and Gleason score 6 or less) or favorable intermediate risk prostate cancer (prostate specific antigen 10 to 20 ng/ml, Gleason score 3 + 4 or less and life expectancy less than 10 years). Treatment was recommended in case of grade progression, increased tumor volume, prostate cancer doubling time less than 36 months or patient wish. Overall survival, disease specific survival and duration of active surveillance were calculated with the KaplanMeier method. Multivariate analysis was performed using the Cox proportional hazards model to identify predictors of active surveillance termination. Results: A total of 234 patients with a median age of 64 years were enrolled in study. Median followup was 4 years (IQR 2.3-5.5). Overall survival at 30 months, 5 years and 10 years was 99.5%, 98.5% and 90.7%, respectively. Disease specific survival at 30 months, and 5 and 10 years was 100%. At 30 months, 5 years and 10 years 72.7%, 52.6% and 40.4% of patients, respectively, remained untreated and on active surveillance. Age (HR 0.96 per additional year, 95% CI 0.93-0.99) and prostate specific antigen density (HR 1.52 per additional 0.1 ng/ml, 95% CI 1.20-1.89) were found to be independent predictors of active surveillance termination. Conclusions: Active surveillance is safe and beneficial for highly selected African Caribbean patients. It seems to be feasible for patients at low risk and intermediate favorable risk. Prostate specific antigen density could help better select these patients.
ISSN: 0022-5347

hal-01519251
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01519251
DOI : 10.1016/j.juro.2016.12.047
PUBMED : 27993665

| Plus

Histoire générale des Antilles. Tome cinquième et deuxième de la deuxième série
Auteur(s) : Dessalles, Adrien (1809-1870)
Année de publication :

| Plus

Flore pittoresque et médicale des Antilles ou histoire naturelle des plantes usuelles des colonies françaises, anglaises, espagnoles et portugaises. Tome quatrième
Auteur(s) : Descourtilz, Michel Etienne (1777-1835)
Auteurs secondaires : Descourtilz, Jean Théodore (1798-1855)
Année de publication :

| Plus

Histoire philosophique et politique des établissemens et du commerce des Européens dans les deux Indes. Tome neuvième
Auteur(s) : Raynal, Guillaume-Thomas (1713-1796)
Année de publication :

| Plus

Statistique générale et particulière de la France et de ses colonies avec une nouvelle description topographique, physique, agricole, politique, industrielle et commerciale T.7
Auteur(s) : Herbin de Halle, Pierre Etienne (1772-18..) Peuchet, Jacques (1758-1830)
Auteurs secondaires : Poirson, Jean-Baptiste (1760-1831) Tardieu, Jean Baptiste Pierre (1746-1816)
Année de publication :

| Plus