Éditeur(s) : HAL CCSD BioMed Central
Résumé : ICARE Study Group
International audience
BackgroundPopulation attributable risks (PARs) are useful tool to estimate the burden of risk factors in cancer incidence. Few studies estimated the PARs of oral cavity cancer to tobacco smoking alone, alcohol drinking alone and their joint consumption but none performed analysis stratified by subsite, gender or age. Among the suspected risk factors of oral cavity cancer, only PAR to a family history of head and neck cancer was reported in two studies. The purpose of this study was to estimate in France the PARs of oral cavity cancer to several recognized and suspected risk factors, overall and by subsite, gender and age.MethodsWe analysed data from 689 oral cavity cancer cases and 3481 controls included in a population-based case–control study, the ICARE study. Unconditional logistic regression models were used to estimate odds ratios (ORs), PARs and 95 % confidence intervals (95 % CI).ResultsThe PARs were 0.3 % (95 % CI −3.9 %; +3.9 %) for alcohol alone, 12.7 % (6.9 %–18.0 %) for tobacco alone and 69.9 % (64.4 %–74.7 %) for their joint consumption. PAR to combined alcohol and tobacco consumption was 74 % (66.5 %–79.9 %) in men and 45.4 % (32.7 %–55.6 %) in women. Among suspected risk factors, body mass index 2 years before the interview <25 kg.m−2, never tea drinking and family history of head and neck cancer explained 35.3 % (25.7 %–43.6 %), 30.3 % (14.4 %–43.3 %) and 5.8 % (0.6 %–10.8 %) of cancer burden, respectively. About 93 % (88.3 %–95.6 %) of oral cavity cancers were explained by all risk factors, 94.3 % (88.4 %–97.2 %) in men and only 74.1 % (47.0 %–87.3 %) in women.ConclusionOur study emphasizes the role of combined tobacco and alcohol consumption in the oral cavity cancer burden in France and gives an indication of the proportion of cases attributable to other risk factors. Most of oral cavity cancers are attributable to concurrent smoking and drinking and would be potentially preventable through smoking or drinking cessation. If the majority of cases are explained by recognized or suspected risk factors in men, a substantial number of cancers in women are probably due to still unexplored factors that remain to be clarified by future studies.
ISSN: 1471-2407

Droits : http://creativecommons.org/licenses/by/
hal-01258466
http://hal.upmc.fr/hal-01258466
http://hal.upmc.fr/hal-01258466/document
http://hal.upmc.fr/hal-01258466/file/BMCC.pdf
DOI : 10.1186/s12885-015-1841-5

Éditeur(s) : HAL CCSD
Résumé : International audience
The Transbaikal region extends over several hundreds of kilometres east of the Baikal Rift System. It is characterized by a number of sub-parallel Mesozoic grabens or half grabens generally filled with late Jurassic to Early Cretaceous clastic sediments interbedded with coal layers (1). Similar basins occur on an even larger area spanning from the Transbaikal region down to Korea implying a large-scale extensional process affecting most of the Amuria plate during the Mesozoic. In the Transbaikal region, the normal faults controlling the edges of the Mesozoic basins are generally superimposed to Palaeozoic ductile shear zones implying a strong localisation of the extensional deformation on inherited structures. Recent studies, associated to our own fieldwork demonstrated that some of the faults were again activated (2), still as extensional faults, during the Tertiary or Quaternary, and that some of them are presently active. The closure of the Mongol-Okhotsk ocean separating the Siberian plate from the Amurian block during the Mesozoic corresponds to a major event in the growth process of the East Asian continent. The oceanic suture zone is situated on the southern edge of the Transbaikal region and its roughly SW-NE direction is parallel to the basins (3). The timing of the closure of the Mongol-Okhotsk ocean is still highly debated: while sedimentological and tectonic data suggest that the oceanic closure and the following collision occurred in early Middle Jurassic (4), paleomagnetic studies advocate for a Early Cretaceous collision (5). Furthermore, several other questions remain on the localization, the size and the fate of the relief that most probably formed during the collision between the Amuria block and the Siberian craton. In order to answer those questions we used low temperature thermochronology data associated to tectonic, sedimentology and palinology to investigate the evolution of the Transbaikal grabens from Mesozoic to Present. Tectonic and thermochronology data provide evidences of exhumation and erosion along the eastern edge of the Siberian craton during the Middle Jurassic as well as a potential continuum of deformation between the Mesozoic extension and the initiation of the Baikal Rift System (6). Sedimentology and palinology reveals that the sediments deposited in the Transbaikal basin did not registered large-scale compressive deformation during or after their Late Jurassic - Early Cretaceous deposition and that they do not correspond to the dismantling of a strong compressive relief.
Geophysical Research Abstracts
Vienne, Austria

insu-00810487
https://hal-insu.archives-ouvertes.fr/insu-00810487

Éditeur(s) : HAL CCSD Nature Publishing Group
Résumé : International audience
The etiology of congenital heart defect (CHD) combines environmental and genetic factors. So far, there were studies reporting on the screening of a single gene on unselected CHD or on familial cases selected for specific CHD types. Our goal was to systematically screen a proband of familial cases of CHD on a set of genetic tests to evaluate the prevalence of disease-causing variant identification. A systematic screening of GATA4, NKX2-5, ZIC3 and Multiplex ligation-dependent probe amplification (MLPA) P311 Kit was setup on the proband of 154 families with at least two cases of non-syndromic CHD. Additionally, ELN screening was performed on families with supravalvular arterial stenosis. Twenty-two variants were found, but segregation analysis confirmed unambiguously the causality of 16 variants: GATA4 (1 x), NKX2-5 (6 x), ZIC3 (3 x), MLPA (2 x) and ELN (4 x). Therefore, this approach was able to identify the causal variant in 10.4% of familial CHD cases. This study demonstrated the existence of a de novo variant even in familial CHD cases and the impact of CHD variants on adult cardiac condition even in the absence of CHD. This study showed that the systematic screening of genetic factors is useful in familial CHD cases with up to 10.4% elucidated cases. When successful, it drastically improved genetic counseling by discovering unaffected variant carriers who are at risk of transmitting their variant and are also exposed to develop cardiac complications during adulthood thus prompting long-term cardiac follow-up. This study provides an important baseline at dawning of the next-generation sequencing era.
ISSN: 1018-4813

hal-01404211
https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01404211
DOI : 10.1038/ejhg.2015.105
PUBMED : 26014430