Éditeur(s) : HAL CCSD
Résumé : International audience
International Journal of GreenhouseGas Control

hal-01314405
https://hal-brgm.archives-ouvertes.fr/hal-01314405

Éditeur(s) : HAL CCSD
Résumé : International audience
INTRODUCTION: The syndrome of combined pulmonary fibrosis and emphysema (CPFE) is characterized by imaging features consisting of the association of centrilobular and/or paraseptal emphysema and pulmonary fibrosis. Virtually all patients are smokers and thus at high risk of developing lung cancer. METHODS: This retrospective multicentre study was conducted by the Groupe d'Etudes et de Recherche sur les Maladies "Orphelines" Pulmonaires (GERM"O"P). RESULTS: A total of 47 patients presenting with lung cancer and CPFE syndrome were identified. All patients were smokers, with a mean of 47 pack-years. A pathological diagnosis of lung cancer was obtained for 38 (81%) patients. Histological type was squamous cell carcinoma in 17 (36%) patients, adenocarcinoma in 14 (30%), non-small-cell lung cancer not otherwise specified in three (6%), small-cell lung cancer in three (6%), and sarcomatoid carcinoma in one (2%). Overall, 20 of the 47 patients could not receive standard-of-care treatment for lung cancer, as per international recommendations or guidelines; this limitation was considered to be directly related to the CPFE syndrome in eight (40%) cases. CONCLUSION: Lung cancer in patients with CPFE syndrome represents a specific entity with a poor prognosis, that further represents the most characteristic and severe model of tobacco-related disease.
Journal of Thoracic Oncology: Official Publication of the International Association for the Study of Lung Cancer

hal-01063912
https://hal.archives-ouvertes.fr/hal-01063912
DOI : 10.1097/JTO.0000000000000209
PUBMED : 25157769

Éditeur(s) : HAL CCSD Springer Verlag
Résumé : International audience
Pituitary adenomas are currently classified by histological, immunocytochemical and numerous ultrastructural characteristics lacking unequivocal prognostic correlations. We investigated the prognostic value of a new clinicopathological classification with grades based on invasion and proliferation. This retrospective multicentric case-control study comprised 410 patients who had surgery for a pituitary tumour with long-term follow-up. Using pituitary magnetic resonance imaging for diagnosis of cavernous or sphenoid sinus invasion, immunocytochemistry, markers of the cell cycle (Ki-67, mitoses) and p53, tumours were classified according to size (micro, macro and giant), type (PRL, GH, FSH/LH, ACTH and TSH) and grade (grade 1a: non-invasive, 1b: non-invasive and proliferative, 2a: invasive, 2b: invasive and proliferative, and 3: metastatic). The association between patient status at 8-year follow-up and age, sex, and classification was evaluated by two multivariate analyses assessing disease- or recurrence/progression-free status. At 8 years after surgery, 195 patients were disease-free (controls) and 215 patients were not (cases). In 125 of the cases the tumours had recurred or progressed. Analyses of disease-free and recurrence/progression-free status revealed the significant prognostic value (p < 0.001; p < 0.05) of age, tumour type, and grade across all tumour types and for each tumour type. Invasive and proliferative tumours (grade 2b) had a poor prognosis with an increased probability of tumour persistence or progression of 25- or 12-fold, respectively, as compared to non-invasive tumours (grade 1a). This new, easy to use clinicopathological classification of pituitary endocrine tumours has demonstrated its prognostic worth by strongly predicting the probability of post-operative complete remission or tumour progression and so could help clinicians choose the best post-operative therapy.
ISSN: 0001-6322

hal-00875723
https://hal.archives-ouvertes.fr/hal-00875723
DOI : 10.1007/s00401-013-1084-y
PUBMED : 23400299

Éditeur(s) : HAL CCSD Lippincott, Williams & Wilkins
Résumé : International audience
OBJECTIVE: In immunocompromised patients, alternative schedules more immunogenic than the standard influenza vaccine regimen are necessary to enhance and prolong vaccine efficacy. We previously reported that the AS03A-adjuvanted 2009 A/H1N1v vaccine yielded a higher short-term immune response than the nonadjuvanted one in HIV-1-infected adults. This study reports the long-term persistence of the immune response. DESIGN AND METHODS: In a prospective, multicenter, randomized, patient-blinded trial, two doses of AS03A-adjuvanted H1N1v vaccine containing 3.75 μg haemagglutinin (n = 155; group A) or nonadjuvanted H1N1v vaccine containing 15 μg haemagglutinin (n = 151; group B), were administered 21 days apart. Haemagglutination inhibition and neutralizing antibodies were assessed 6 and 12 months after vaccination. RESULTS: In group A and B, the seroprotection rates were 83.7 and 59.4% at month 6, and 70.4 and 49.3 at month 12, respectively. In a multivariate analysis, persistence of seroprotection 12 months after vaccination was negatively associated with current smoking (odds ratio = 0.6, P = 0.03) and positively related with the AS03A-adjuvanted H1N1v vaccine (odds ratio = 2.7, P = 0.0002). CONCLUSION: In HIV-1-infected adults, two doses of adjuvanted influenza vaccine induce long-term persistence of immune response up to 1 year after vaccination.
ISSN: 0269-9370

hal-00875148
https://hal.archives-ouvertes.fr/hal-00875148
DOI : 10.1097/QAD.0b013e328359f27a
PUBMED : 23018437

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Fromthe Proterozoic to the Quaternary, the evolution of the Earthwas characterised by recurrent periods of glaciation.However, the margins of many ancient ice-sheets are poorly defined on palaeogeographic reconstructions.The extent and outlines of ancient ice sheets can be better understood through careful documentation ofsediments deposited at the ice-sheet margin. An outstanding example is provided herein based on an end-Ordovician archive in Libya (Tihemboka area, Murzuq Basin). The four sets of structures include: i) subglacialglaciotectonic structures and soft sediment deformations from flowing glacier ice, such as intraformational glacialstriae, intraformational deformation (shear planes, sheath folds), normal microfaults, and large-scaleglaciotectonic folds-and-thrusts; (ii) structures resulting from overpressured subglacial (meltwater) flowssuch as clastic dykes and tunnel valleys; (iii) proglacial depositional structures and facies related to highmagnitudemeltwater floods such as sandstone intraclasts, large-scale bedforms resulting from supercriticalflows, climbing-dune cross-stratification and kettle holes; and (iv) deformation structures resulting from freefloating and nonglacier ice such as ice-keel scours and ice-crystal marks. Such a set of structures points to anice-marginal (essentially continental) depositional setting, and provides an excellent suite of criteria to identifymargins of ancient ice sheets in the stratigraphic record. At a regional scale, a reconstruction through time andspace of the related depositional wedge is proposed. This corresponded to a seismic-scale (N120 m in thickness,40 km in length) ice-marginal wedge in front of an essentially warm-based ice-sheet inducing concomitantlarge-scale glaciotectonic deformation, glacial basin and tunnel valley downcuttings. The related ice-front wasassociated with high-energy meltwater flows feeding a network of deeply incised proglacial channels downstreamand, beyond them, a fluvioglacial deltaic system. Shallow ice-marginal permafrost most likely affectedthe depositional wedge. At a larger scale, the Tihemboka ice-marginal wedge is interpreted as related to a stillstandperiod over the Gondwana platform, developed over an estimated interval of a few thousands of years.Based on these data, the conditions that arose in a particularly favourable context for the development, the preservationand the identification of ice-marginal wedges in the geological record are reviewed. Significantmeltwater-derived sediment deposition and aggradation in an accommodation space resulting either frompreglacial inheritance, glacial downcuttings and/or glacio-isostatic lithospheric flexure, or active tectonic subsidence(>1 Myr) are required for their formation and subsequent preservation.
ISSN: 0012-8252

insu-01184739
https://hal-insu.archives-ouvertes.fr/insu-01184739
DOI : 10.1016/j.earscirev.2015.06.006

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
OBJECTIVES: Tracheobronchial stenosis (TBS) is noted in 12-23% of patients with granulomatosis with polyangiitis (GPA), and includes subglottic stenosis and bronchial stenosis. We aimed to analyse the endoscopic management of TBS in GPA and to identify factors associated with the efficacy of endoscopic interventions. METHODS: We conducted a French nationwide retrospective study that included 47 patients with GPA-related TBS. RESULTS: Compared with patients without TBS, those with TBS were younger, more frequently female and had less frequent kidney, ocular and gastrointestinal involvement and mononeuritis multiplex. Endoscopic procedures included 137 tracheal and 50 bronchial interventions, mainly endoscopic dilatation, local steroid injection and conservative laser surgery, and less frequently stenting. After the first endoscopic procedure, the cumulative incidence of endoscopic treatment failure was 49% at 1 year, 70% at 2 years and 80% at 5 years. Factors significantly associated with a higher cumulative incidence of treatment failure were a shorter time from GPA diagnosis to endoscopic procedure [hazard ratio (HR) 1.08 (95% CI 1.01, 1.14); P = 0.01] and a bronchial stenosis [HR 1.96 (95% CI 1.28, 3.00); P = 0.002]. A prednisone dose ≥30 mg/day at the time of the procedure was associated with a lower cumulative incidence of treatment failure [HR 0.53 (95% CI 0.31, 0.89); P = 0.02]. CONCLUSION: TBS represents severe and refractory manifestations with a high rate of restenosis. High-dose systemic CSs at the time of the procedure and increased time from GPA diagnosis to bronchoscopic intervention are associated with a better event-free survival. In contrast, bronchial stenoses are associated with a higher rate of restenosis than subglottic stenosis.
ISSN: 1462-0324

hal-01155105
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01155105
DOI : 10.1093/rheumatology/kev129
PUBMED : 26001634

Éditeur(s) : HAL CCSD
Résumé : International audience
A CO 2 migration field laboratory for testing of monitoring methods has been established in the glaciofluvial-glaciomarine Holocene deposits of the Svelvik ridge, near Oslo. A shallow CO 2 injection experiment was conducted in September 2011 in which approximately 1700 kg of CO 2 was injected at 18 m depth below surface. The objectives of this experiment were to (i) detect and, where possible, quantify migrated CO 2 concentrations, (ii) evaluate the sensitivity of the monitoring tools and (iii) study the impact of the vadose zone on measurements. This paper describes the injection, discusses the joint interpretation of the results and suggests some recommendations for further work.
The 7th Trondheim CCS Conference
Trondheim, Norway

hal-01314396
https://hal-brgm.archives-ouvertes.fr/hal-01314396
https://hal-brgm.archives-ouvertes.fr/hal-01314396/document
https://hal-brgm.archives-ouvertes.fr/hal-01314396/file/1-s2.0-S1876610214008704-main.pdf
DOI : 10.1016/j.egypro.2014.07.008