Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
TMPRSS2/ERG fusion resulting in ERG overexpression occurs in 30 to 50% of prostate cancer (PCa) in Caucasian patients, but its prognostic relevance remains controversial. In the present study, we investigated ERG expression in all stages of PCa progression, and evaluated the prognostic impact of ERG status in clinically localized PCa (CLC) and in castration resistant disease (CRPC). ERG and AR expressions were evaluated by immunohistochemistry on tissue microarrays containing samples of high grade PIN (n = 57), CLC surgically treated (n = 299, including 185 Caucasians and 114 African-Caribbeans), metastases (n = 17), and CRPC (n = 41). In Caucasians, ERG expression significantly increased from high grade PIN (17.5%) to pT2 (27%) and pT3 CLC (43%), then to metastases (53%). In CLC, stainings for ERG and AR were correlated, and ERG expression was less frequent in African-Caribbeans compared to Caucasians (11.5% vs. 33%). In Caucasians CLC, ERG was associated with longer recurrence free survival, after adjusting for classical prognostic markers. In CRPC, ERG was expressed in 29% of cases, and was associated with a longer overall survival. Our results confirm that ERG expression is less frequent in PCa from patients of African descent. Although ERG expression increases during PCa natural history, positive ERG status is associated with better outcome in both CLC and CRPC. This paradox could be explained in part by the fact that ERG expression is AR dependant, then ERG positive cancers are likely to progress in a rich androgen environment, with a better response to androgen suppression.
ISSN: 0270-4137

hal-01118555
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01118555
DOI : 10.1002/pros.22863
PUBMED : 25175352

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
A network of 54 survey GPS sites, 28 continuous GPS stations and three absolute gravity (AG) observation sites have been set up in the Alborz mountain range to quantify the present-day kinematics of the range. Our results allow us to accurately estimate the motion of the South Caspian block (SCB) for the first time, and indicate rotation of the SCB relative to Eurasia, accounting for the left lateral motion in the Alborz range. In light of these new results, it clearly appears that deformation rates vary along the range, the eastern part accommodating mainly left lateral strike slip (2 mm yr(-1) south of the range and 5 mm yr(-1) north of the range) with a very low range normal shortening rate on the Khazar thrust fault (similar to 2 mm yr(-1)), and the western part accommodating range normal shortening (similar to 6 mm yr-1) on the Khazar thrust fault with a left lateral component of similar to 2 mm yr(-1) north of the range and 1 mm yr(-1) south of the range. These present-day kinematics agree with geomorphologic estimated slip rates, but not the long-term deformation, corroborating the idea that the kinematics of the range have changed recently due to the change of SCB motion.;Modelling of the interseismic deformation suggests a deep locking depth on the central-western segment of the Khazar fault (similar to 30 km) in agreement with the Baladeh earthquake rupture and aftershock ranging between 10 and 30 km. Given this unusual deep locking depth and the 34 degrees dip of the thrust, a large part of the Alborz range is located above the seismically coupled part of the fault. Based on our AG measurements this part of the range seems to uplift at a rate of 1-5 mm yr(-1), in agreement with terrace uplift.
ISSN: 0956-540X

hal-00617146
https://hal.archives-ouvertes.fr/hal-00617146
https://hal.archives-ouvertes.fr/hal-00617146v2/document
https://hal.archives-ouvertes.fr/hal-00617146/file/djamour2010.pdf
DOI : 10.1111/j.1365-246X.2010.04811.x