Éditeur(s) : HAL CCSD American Diabetes Association
Résumé : International audience
OBJECTIVE: To compare incidences and risk factors for diabetes using seven definitions, with combinations of pharmacological treatment, fasting plasma glucose (FPG) ≥7.0 mmol/L, and HbA(1c) ≥6.5%. RESEARCH DESIGN AND METHODS: Participants aged 30-65 years from the Data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) cohort were followed for 9 years. RESULTS: More men had incident diabetes as defined by FPG ≥7.0 mmol/L and/or treatment than by HbA(1c) ≥6.5% and/or treatment: 7.5% (140/1,867) and 5.3% (99/1,874), respectively (P < 0.009); for women incidences were similar: 3.2% (63/1,958) and 3.4% (66/1,954). Known risk factors predicted diabetes for almost all definitions. Among those with incident diabetes by FPG alone versus HbA(1c) alone, there were more men (78 vs. 35%), case patients were 8 years younger, and fewer were alcohol abstainers (12 vs. 35%) (all P < 0.005). A diabetes risk score discriminated well between those with and without incident diabetes for all definitions. CONCLUSIONS: In men, FPG definitions yielded more incident cases of diabetes than HbA(1c) definitions, in contrast with women. An FPG-derived risk score remained relevant for HbA(1c)-defined diabetes.
Diabetes Care

inserm-00739799
http://www.hal.inserm.fr/inserm-00739799
http://www.hal.inserm.fr/inserm-00739799/document
DOI : 10.2337/dc10-1581
PUBMED : 21346181

Éditeur(s) : HAL CCSD Elsevier
Résumé : Differentiation of the Earth's mantle and formation of continental and oceanic crust occur principally through partial melting and extraction of basaltic melt. Among the mantle rocks occurring at the Earth's surface, as tectonically-emplaced massifs, abyssal peridotites or xenoliths, the harzburgites (< 5% clinopyroxene) are widely considered as refractory mantle residues left after extraction of a basaltic component. In contrast, the most fertile lherzolites (15% clinopyroxene) are generally regarded as pristine mantle, only weakly affected by partial melting. In this paper we present new convergent structural and geochemical data from the Lherz massif, the type-locality of lherzolite, indicating that the lherzolites from Lherz do not represent pristine mantle. Detailed structural mapping clearly shows that the lherzolites are secondary rocks formed at the expense of the harzburgites. Variations of major, minor and trace elements through the harzburgite–lherzolite contacts indicate that the lherzolites were formed through a refertilization process involving interaction of refractory, lithospheric mantle with upwelling asthenospheric partial melts. Combined with previously published indications of refertilization in orogenic peridotites, our new observations in Lherz suggest that most lherzolite massifs represent secondary (refertilized) rather than pristine mantle. Together with geochemical data on mantle xenoliths, this indicates that melt transport and melt-rock reaction play a key role on the rejuvenation and erosion of the lithospheric mantle.
ISSN: 0012-821X

hal-00406433
https://hal.archives-ouvertes.fr/hal-00406433
DOI : 10.1016/j.epsl.2007.05.026

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
Growth charts are an essential clinical tool for evaluating a child's health and development. The current French reference curves, published in 1979, have recently been challenged by the 2006 World Health Organization (WHO) growth charts. To evaluate and compare the growth of French children who were born between 1981 and 2007, with the WHO growth charts and the French reference curves currently used. Anthropometric measurements from French children, who participated in 12 studies, were analyzed: 82,151 measurements were available for 27,257 children in different age groups, from birth to 18 years. We calculated and graphically compared mean z-scores based on the WHO and French curves, for height, weight and Body Mass Index (BMI) according to age and sex. The prevalence of overweight using the WHO, the French and International Obesity Task Force definitions were compared. Our population of children was on average 0.5 standard deviations taller than the French reference population, from the first month of life until puberty age. Mean z-scores for height, weight and BMI were closer to zero based on the WHO growth charts than on the French references from infancy until late adolescence, except during the first six months. These differences not related to breastfeeding rates. As expected, the prevalence of overweight depended on the reference used, and differences varied according to age. The WHO growth charts may be appropriate for monitoring growth of French children, as the growth patterns in our large population of French children were closer to the WHO growth charts than to the French reference curves, from 6 months onwards. However, there were some limitations in the use of these WHO growth charts, and further investigation is needed.
ISSN: 1932-6203

hal-01134193
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01134193
DOI : 10.1371/journal.pone.0120806
PUBMED : 25761138
PUBMEDCENTRAL : PMC4356547

Éditeur(s) : HAL CCSD BioMed Central
Résumé : International audience
ISSN: 2047-217X

hal-01429002
https://hal.archives-ouvertes.fr/hal-01429002
DOI : 10.1186/s13742-016-0118-5