Éditeur(s) : HAL CCSD Universidad de Malaga
Résumé : International audience
The development of information systems follows a long and complex process in which various actors are involved. We report an experiment in which we observe the evolution of the analysis model of an information system through 15 successive versions. We use indicators on the underlying concept lattices built by applying Relational Concept Analysis (RCA) to each version. RCA is an extension of FCA which groups entities based on characteristics they share, including links to other entities. It here helps in analyzing their evolution. From this experience, we establish recommendations to monitor and verify the proper evolution of the analysis process.
CLA'2012: 9th International Conference on Concept Lattices and Applications
Fuengirola (Málaga), Spain

ISBN : 978-84-695-5252-0
lirmm-00743886
http://hal-lirmm.ccsd.cnrs.fr/lirmm-00743886
http://hal-lirmm.ccsd.cnrs.fr/lirmm-00743886/document

Éditeur(s) : HAL CCSD Landes Bioscience
Résumé : International audience
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.
Autophagy

hal-00735751
https://hal.archives-ouvertes.fr/hal-00735751
PUBMED : 22966490

Éditeur(s) : HAL CCSD Institute of Physics
Résumé : International audience
ISSN: 0957-4484

hal-01674723
https://hal-umontpellier.archives-ouvertes.fr/hal-01674723
DOI : 10.1088/1361-6528/aa9c07

Résumé : With resolution 3 067 (XXVIII), November 16th, 1973, the UN General Assembly decided the organization of a 3rd Conference on marine legislation which first session, "organization and proceedings", was held in New York City from December 3rd to December 14th, 1973 and whose second session, "in-depth questions", will be held in Caracas for 10 weeks between June 20th and August 29th, 1974. In reality, the decision dates back to a resolution 2 750 C (XXV), November 17th, 1970, and stems from a number of consultations carried out by the Secretary-General demonstrating that "the idea of a general-interest conference on marine legislation was largely supported". Why did it appear necessary to totally review marine legislation, 15 years after the Geneva Conferences of 1958 and 1960? This is what we will try to explain in analysing the causes of such an evolution and drawing its general tendencies, before focusing on the current situation at the opening of the conference and the future perspectives.
Par une résolution 3067 (XXVIII) du 16 Novembre 1973, l'Assemblée Générale des Nations Unies décidait la convocation d'une 3ème Conférence sur le droit de la mer dont la première session d'organisation et de procédure a eu lieu à New York du 3 au 14 Décembre 1973 et dont la deuxième session, "aux fins de traiter des questions de fond", se tiendra à Caracas pendant 10 semaines du 20 Juin au 29 Août 1974. En réalité, la décision de principe remonte B une résolution 2750 C (XXV) du 17 Décembre 1970, et résulte de consultations entreprises par le Secrétaire Général indiquant que "l'idée de convoquer une Conférence de portée générale sur le droit de la mer recueillait un large appui". Pourquoi est-il apparu nécessaire de procéder à une révision totale du droit de la mer, 15 ans après les Conférences de Genève de 1958 et 1960 ? C'est ce que nous allons essayer d'expliquer en analysant les causes d'une telle évolution et en dégageant les tendances qui se manifestent avant d'examiner la situation telle quel le se présente à l'ouverture de la Conférence et les perspectives d'avenir. [OCR NON CONTRÔLE]

Droits : info:eu-repo/semantics/openAccess
http://archimer.ifremer.fr/doc/1974/rapport-4794.PDF
http://archimer.ifremer.fr/doc/00000/4794/

Éditeur(s) : HAL CCSD
Résumé : International audience
We assessed whether maternal employment during pregnancy - overall and in selected occupational sectors - is associated with birth weight, small for gestational age (SGA), term low birth weight (LBW), length of gestation, and preterm delivery in a population-based birth cohort design. We used data from >200 000 mother-child pairs enrolled in 13 European birth cohorts and compared employed versus non-employed women. Among employees, we defined groups of occupations representing the main sectors of employment for women where potential reproductive hazards are considered to be present. The comparison group comprised all other employed women not included in the occupational sector being assessed. We performed meta-analyses of cohort-specific estimates and explored heterogeneity. Employees had a lower risk of preterm delivery than non-employees [adjusted odds ratio (OR adj) 0.86, 95% confidence interval (95% CI) 0.81-0.91]. Working in most of the occupational sectors studied was not associated with adverse birth outcomes. Being employed as a nurse was associated with lower risk SGA infants (OR adj0.91, 95% CI 0.84-0.99) whereas food industry workers had an increased risk of preterm delivery (OR adj1.50, 95% CI 1.12-2.02). There was little evidence for heterogeneity between cohorts. This study suggests that, overall, employment during pregnancy is associated with a reduction in the risk of preterm birth and that work in certain occupations may affect pregnancy outcomes. This exploratory study provides an important platform on which to base further prospective studies focused on the potential consequences of maternal occupational exposures during pregnancy on child development.
Scandinavian journal of work, environment & health

Droits : info:eu-repo/semantics/OpenAccess
hal-01151621
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01151621
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01151621/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01151621/file/Maternal%20occupation%20during%20pregnancy_supplementary%20material.pdf
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01151621/file/Maternal%20occupation%20during%20pregnancy_accepted.pdf

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The Borborema Province of northeastern Brazil is divided into three main domains: northern, central, and southern. Several U-Pb zircon ages of plutons and orthogneisses became available in the recent years in the central and northern domains, but similar results are scarce in the southern domain. This study reports U-Pb dates for single zircon grains from one orthogneiss (Jupi orthogneiss) and two plutons (Cachoeirinha syenitic pluton and Cabanas granite) south of the East Pernambuco shear zone system (EPSZ). The results provide geochronological constraints on the timing of deformation and magmatism in this part of the southern domain and allow correlations with the central domain. The Jupi orthogneiss was emplaced and deformed during development of the regional flat-lying foliation. A Pb-206/U-238 weighted apparent mean age of 606 +/- 8 Ma is interpreted as the crystallization age of the protolith of the orthogneiss and consequently the age of high-grade Brasiliano metamorphism. The NNE-trending Cachoeirinha pluton is only locally affected by strike-slip deformation, whereas the ENE-trending Cabanas granite is intensely affected by deformation related to the EPSZ. The 587 8 Ma and 573 4 Ma ages of the Cachoeirinha pluton and Cabanas granite, respectively, bracket the main period of activity of the EPSZ. Tectonomagmatic activity in the study area is similar to the age of Brasiliano events in the central domain, north of the EPSZ. In addition, xenocrystic zircons in the Jupi orthogneiss and Cabanas granite are interpreted as inherited from Paleoproterozoic source rocks, suggesting the presence of widespread reworked old crust in the southern domain, similar to the central domain. These results support the idea that the central and southern domains belonged to the same crustal block before the onset of the Brasiliano orogeny.
ISSN: 0895-9811

hal-00411394
https://hal.archives-ouvertes.fr/hal-00411394
DOI : 10.1016/j.jsames.2007.06.003

Éditeur(s) : HAL CCSD SciTePress
Résumé : International audience
Data integration and knowledge capitalization combine data and information coming from different data sources designed by different experts having different purposes. In this paper, we propose to assist the underlying model merging activity. For close models made by experts of various specialities, we partially automate the identification of a Greatest Common Model (GCM) which is composed of the common concepts (core concepts) of the different models. Our methodology is based on Formal Concept Analysis which is a method of data analysis based on lattice theory. A decision tree allows to semi-automatically classify concepts from the concept lattices and assist the GCM extraction. We apply our approach on the EIS-Pesticide project, an environmental information system which aims at centralizing knowledge and information produced by different specialized teams.
ICEIS 2012: 14th International Conference on Enterprise Information Systems
Wroclaw, Poland

lirmm-00727009
https://hal-lirmm.ccsd.cnrs.fr/lirmm-00727009