Éditeur(s) : Association YES YOU CAN Formations CRILLASH : Centre de Recherches Interdisciplinaires en Lettres, Langues, Arts et Sciences Humaines
Extrait de : "La variation linguistique" : journée d'étude, le 27 avril 2018. Université des Antilles
Description : Élodie Martin, Professeure à l'Université des Antilles, met au coeur de son intervention la relation entre l'anglais et le français. Pour ce faire, elle présente un plan d'exposé grâce auquel elle développe d'abord la notion de lexicalisation et son lien étroit avec la variation lexicale. Puis, elle analyse le vocabulaire relatif aux réseaux sociaux et établit une classification des différents types d'emprunts que l'on doit audit vocabulaire.

Droits : CC-BY-NC-ND - Attribution - Pas d'utilisation commerciale - Pas de modification
Permalien : http://www.manioc.org/fichiers/V18148
V18148

Éditeur(s) : HAL CCSD Nature Publishing Group
Résumé : International audience
Treacher Collins/Franceschetti syndrome (TCS; OMIM 154500) is a disorder of craniofacial development belonging to the heterogeneous group of mandibulofacial dysostoses. TCS is classically characterized by bilateral mandibular and malar hypoplasia, downward-slanting palpebral fissures, and microtia. To date, three genes have been identified in TCS:,TCOF1, POLR1D, and POLR1C. We report a clinical and extensive molecular study, including TCOF1, POLR1D, POLR1C, and EFTUD2 genes, in a series of 146 patients with TCS. Phenotype-genotype correlations were investigated for 19 clinical features, between TCOF1 and POLR1D, and the type of mutation or its localization in the TCOF1 gene. We identified 92/146 patients (63%) with a molecular anomaly within TCOF1, 9/146 (6%) within POLR1D, and none within POLR1C. Among the atypical negative patients (with intellectual disability and/or microcephaly), we identified four patients carrying a mutation in EFTUD2 and two patients with 5q32 deletion encompassing TCOF1 and CAMK2A in particular. Congenital cardiac defects occurred more frequently among patients with TCOF1 mutation (7/92, 8%) than reported in the literature. Even though TCOF1 and POLR1D were associated with extreme clinical variability, we found no phenotype-genotype correlation. In cases with a typical phenotype of TCS, 6/146 (4%) remained with an unidentified molecular defect.
ISSN: 1098-3600

hal-01134364
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01134364
DOI : 10.1038/gim.2015.29
PUBMED : 25790162

Éditeur(s) : HAL CCSD Inter Research
Résumé : International audience
The main objective of the VULSACO (VULnerability of SAndy COasts to climate change and anthropic pressure) project was to investigate present day and potential future vulnerability of sandy coasts at the 2030 horizon, i.e. on a time scale related to climate variability. The method, based on a multidisciplinary approach bringing together geologists, geographers, physicists, social psychologists, engineers and stakeholders, was structured around 4 axes: field data analysis; numerical modelling; analysis of governance and stakeholder perceptions; and development of vulnerability indexes. This approach was designed to investigate vulnerability at a local scale and was applied to 4 contrasting beaches located in France: Sète Lido (Mediterranean Sea), Truc Vert and La Tresson beaches (Atlantic Ocean), and Dewulf (English Channel). The results focus on decadal and multi-annual beach trends at the Truc Vert beach site. There is almost no trend in beach volume at Truc Vert beach, although there is a variation in this parameter on a cycle of 2 to 3 yr, with variations related to wave energy and probably to indexes of climate variability. Numerical modelling identified the sensitivity of beach responses to changes in wave height and direction, especially in terms of subtidal morphology and the potential development of shoreline instability. Together with the observed offshore wave angle at the Biscay Buoy, these model results suggest that a potential change in wave angle due to climate variability could significantly modify the bars' morphology. The combination of data analysis and numerical modelling contributed to the development of vulnerability indexes designed for sandy coasts, which take into account climate-dependant variables such as waves. This allowed the differentiation of the sites in terms of vulnerability to erosion: Sète Lido and Truc Vert beach were the most and least vulnerable sites, respectively. These indexes help in identifying the dominant components of beach vulnerability, and provide potential for the study of how anthropogenic factors affect vulnerability. The study of stakeholder perceptions and decision-making with regard to climate-related risk also highlighted potential anthropogenic effects on beach vulnerability, and identified possible site-specific outcomes.
ISSN: 0936-577X

hal-00843946
https://hal-brgm.archives-ouvertes.fr/hal-00843946
DOI : 10.3354/cr01153

Éditeur(s) : Actes du Colloque CARHAMB'AR CARtographie des HAbitats Marins Benthiques : de l'Acquisition à la Restitution Ifremer – Centre de Bretagne, 26‐28 mars 2013

Droits : 2013 Ifremer, Agence des Aires Marines Protégées
http://archimer.ifremer.fr/doc/00185/29672/28044.pdf
http://archimer.ifremer.fr/doc/00185/29672/

Éditeur(s) : HAL CCSD Rockefeller University Press
Résumé : International audience
Accumulation of type I collagen fibrils in tumors is associated with an increased risk of metastasis. Invadosomes are F-actin structures able to degrade the extracellular matrix. We previously found that collagen I fibrils induced the formation of peculiar linear invadosomes in an unexpected integrin-independent manner. Here, we show that Discoidin Domain Receptor 1 (DDR1), a collagen receptor overexpressed in cancer, colocalizes with linear invadosomes in tumor cells and is required for their formation and matrix degradation ability. Unexpectedly, DDR1 kinase activity is not required for invadosome formation or activity, nor is Src tyrosine kinase. We show that the RhoGTPase Cdc42 is activated on collagen in a DDR1-dependent manner. Cdc42 and its specific guanine nucleotide-exchange factor (GEF), Tuba, localize to linear invadosomes, and both are required for linear invadosome formation. Finally, DDR1 depletion blocked cell invasion in a collagen gel. Altogether, our data uncover an important role for DDR1, acting through Tuba and Cdc42, in proteolysis-based cell invasion in a collagen-rich environment.
ISSN: 0021-9525

hal-01118481
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01118481
PUBMED : 25422375
DOI : 10.1083/jcb.201404079
PUBMEDCENTRAL : PMC4242841