Éditeur(s) : CRPLC : Centre de Recherche sur les Pouvoirs Locaux dans la Caraïbe CRPLC : Centre de Recherche sur les Pouvoirs Locaux dans la Caraïbe
Extrait de : Conférence : L'alliance Athena, le 4 décembre 2014. Université des Antilles et de la Guyane
Description : Françoise Thibault présente ici le numérique comme facteur de dialogue quand on sait l'utiliser.
Siècle(s) traité(s) : 21
Droits : CC-BY-NC-ND - Attribution - Pas d'utilisation commerciale - Pas de modification
Permalien : http://www.manioc.org/fichiers/V15131
V15131
V15131

Éditeur(s) : CRPLC : Centre de Recherche sur les Pouvoirs Locaux dans la Caraïbe
Siècle(s) traité(s) : 21
Droits : CC-BY-NC-ND - Attribution - Pas d'utilisation commerciale - Pas de modification
Permalien : http://www.manioc.org/fichiers/V15129
V15129

Éditeur(s) : HAL CCSD CNRS-Editions
Résumé : The links between education and technology had existed for a long time before the emergence of the socalled information and communication technologies. Their analysis comes within several fields of research such as computer science, education and cognitive sciences in addition to information and communication sciences (ICS),... ICS have obvious assets to speak for themselves: their interdisciplinary approaches enable them to connect the technical, social, semiotic and political levels. Besides, the goals and methods of information sciences fully intersect with those of communication sciences.
Les liens entre éducation et technique, bien antérieurs à l'apparition des «technologies de l'information et de la communication» (Tic), relèvent de plusieurs disciplines: informatique, sciences de l'éducation, sciences de la cognition et Sic... Les Sic ont des atouts: leurs approches interdisciplinaires permettent d'articuler les niveaux technique, social, sémiotique, politique et les objets et méthodes des sciences de l'information rejoignent pleinement ceux des sciences de la communication
ISSN: 0767-9513

edutice-00260703
https://edutice.archives-ouvertes.fr/edutice-00260703
https://edutice.archives-ouvertes.fr/edutice-00260703/document
https://edutice.archives-ouvertes.fr/edutice-00260703/file/HERMES_2004_38_191.pdf

Éditeur(s) : HAL CCSD CNRS-Editions
Résumé : Toute l'histoire des techniques de communication est intimement liée à l'histoire de l'éducation. Avant le cahier, la craie et le tableau, on savait, dans l'antiquité, recourir à diverses techniques pour construire des dispositifs socio-techniques susceptibles de faciliter l'apprentissage (Marrou, 1948). Les possibilités offertes par l'image et ses moyens successifs de diffusion ont été de même fondamentales dans la diffusion des connaissances. Ce fut d'abord l'image artisanale (vitraux et enluminures utilisés pour l'édification...). Puis l'image imprimée dès le début du seizième siècle (planches, éclatés, cartes...) et l'image projetée (de la lanterne magique aux diapositives). A partir du vingtième siècle, l'image audiovisuelle et la production industrielle (photographie, radio, cinéma, télévision...) ont croisé les systèmes éducatifs comme l'ont fait depuis une vingtaine d'années les techniques de numérisation des documents (sonores, iconiques et graphiques), les logiciels d'apprentissage, de simulation et de production, la transmission à travers des réseaux numériques, et les nouvelles formes de documents informatisés (hypertexte, écrit sur écran...)...
ISSN: 0767-9513

Droits : info:eu-repo/semantics/OpenAccess
edutice-00001307
https://edutice.archives-ouvertes.fr/edutice-00001307
https://edutice.archives-ouvertes.fr/edutice-00001307/document
https://edutice.archives-ouvertes.fr/edutice-00001307/file/hermes_SIC.pdf

Éditeur(s) : HAL CCSD
Résumé : International audience
BACKGROUND AND AIM: The impact of basal core promoter (BCP) and precore (PC) mutants of the hepatitis B virus (HBV) on liver disease severity remains controversial. The aim of the present study was to screen BCP and PC mutations in 252 HBV surface antigen (HBsAg) positive carriers in France and to assess relationships between these mutations and severe fibrosis. METHODS: Direct sequencing of the precore/core gene was used to detect A1762T/G1764A and G1757A mutations in the BCP and G1896A and G1899A mutations in the PC region. RESULTS: The prevalences of A1762T/G1764A, G1757A, G1896A, and G1899A mutations were 34.1%, 38.7%, 54.9%, and 29.3% (P < 0.001), respectively. The independent predictors of severe fibrosis (>/=F3 Metavir) were older age (P < 0.001), male gender (P = 0.012), elevated alanine aminotransferase (P < 0.001), and the double A1762T/G1764A mutant with no other mutations (P = 0.011). Interestingly, the association of the G1899A mutation with the double A1762T/G1764A mutant significantly counteracted the deleterious effect of the sole double A1762T/G1764A mutant (odds ratio [OR] = 0.28 vs. OR = 3.55, respectively, P = 0.028). CONCLUSIONS: Patients with the A1762T/G1764A mutation have a higher risk of severe fibrosis. The G1899A mutation is a protective factor against severe fibrosis that counteracted the deleterious effect of the A1762T/G1764A mutation. Finally, host phenotypic and HBV genotypic markers independently predict fibrosis severity.
Journal of gastroenterology and hepatology

hal-01477209
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01477209
DOI : 10.1111/jgh.13338
PUBMED : 26992056

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
Growth charts are an essential clinical tool for evaluating a child's health and development. The current French reference curves, published in 1979, have recently been challenged by the 2006 World Health Organization (WHO) growth charts. To evaluate and compare the growth of French children who were born between 1981 and 2007, with the WHO growth charts and the French reference curves currently used. Anthropometric measurements from French children, who participated in 12 studies, were analyzed: 82,151 measurements were available for 27,257 children in different age groups, from birth to 18 years. We calculated and graphically compared mean z-scores based on the WHO and French curves, for height, weight and Body Mass Index (BMI) according to age and sex. The prevalence of overweight using the WHO, the French and International Obesity Task Force definitions were compared. Our population of children was on average 0.5 standard deviations taller than the French reference population, from the first month of life until puberty age. Mean z-scores for height, weight and BMI were closer to zero based on the WHO growth charts than on the French references from infancy until late adolescence, except during the first six months. These differences not related to breastfeeding rates. As expected, the prevalence of overweight depended on the reference used, and differences varied according to age. The WHO growth charts may be appropriate for monitoring growth of French children, as the growth patterns in our large population of French children were closer to the WHO growth charts than to the French reference curves, from 6 months onwards. However, there were some limitations in the use of these WHO growth charts, and further investigation is needed.
ISSN: 1932-6203

hal-01134193
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01134193
DOI : 10.1371/journal.pone.0120806
PUBMED : 25761138
PUBMEDCENTRAL : PMC4356547

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The parasitic life cycle of Leishmania includes an extracellular promastigote stage that occurs in the gut of the insect vector. During that period, the sucrose metabolism and more specifically the first glycosidase of this pathway are essential for growth and survival of the parasite. We investigated the expression of the invertase BfrA in the promastigote and amastigote stages of three parasite species representative of the three various clinical forms and of various geographical areas, namely Leishmania major, L. donovani and L. braziliensis. Thereafter, we cloned, overexpressed and biochemically characterized this invertase BfrA from L. major, heterologously expressed in both Escherichia coli and L. tarentolae. For all species, expression levels of BfrA mRNA were correlated to the time of the culture and the parasitic stage (promastigotes > amastigotes). BfrA exhibited no activity when expressed as a glycoprotein in L. tarentolae but proved to be an invertase when not glycosylated, yet owing low sequence homology with other invertases from the same family. Our data suggest that BfrA is an original invertase that is located inside the parasite. It is expressed in both parasitic stages, though to a higher extent in promastigotes. This work provides new insight into the parasite sucrose metabolism
ISSN: 0008-6215

hal-01187142
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01187142
DOI : 10.1016/j.carres.2015.07.001
PUBMED : 26279524