Éditeur(s) : Pub. by J.B. Smith & Co. Pub. by J.B. Smith & Co. ( Philadelphia (No. 610 Chestnut Street) )
Résumé : (Statement of Responsibility) by Daniel Defoe ; two volumes in one.
Gilt, decorative spine with title: Robinson Crusoe.
Undated reissue of Lovett, R.W. Robinson Crusoe, 458 and NUC pre- 1956, 0118338 (v. 136, p. 598) both of which are dated 1859.
Col. front.: Sinclair's Lith. Probably Thomas S. Sinclair, a lithographer active in Philadelphia from the 1840s.
All pages have fancy ruled frame.
Parts I and II of Robinson Crusoe. Part II originally published under title: Farther adventures of Robinson Crusoe.
(Funding) Preservation and Access for American and British Children's Literature, 1870-1889 (NEH PA-50860-00).
United States -- Pennsylvania -- Philadelphia

Droits : This item is presumed to be in the public domain. The University of Florida George A. Smathers Libraries respect the intellectual property rights of others and do not claim any copyright interest in this item. Users of this work have responsibility for determining copyright status prior to reusing, publishing or reproducing this item for purposes other than what is allowed by fair use or other copyright exemptions. Any reuse of this item in excess of fair use or other copyright exemptions may require permission of the copyright holder. The Smathers Libraries would like to learn more about this item and invite individuals or organizations to contact The Department of Special and Area Studies Collections (special@uflib.ufl.edu) with any additional information they can provide.
27866802

Éditeur(s) : Thomas Y. Crowell & Co. Thomas Y. Crowell & Co. ( New York )
Résumé : (Statement of Responsibility) by Daniel De Foe ; including a memoir of the author and an essay on his writings.
(Citation/Reference) Lovett, R.W. Robinson Crusoe,
Spine title: Robinson Crusoe; caption title, p. 253: Further adventures of Robinson Crusoe.
Ill. signed GHT; engraved by W.J.L., W.L. Thomas, and Wentworth.
Date from Lovett citation below.
Parts I and II of Robinson Crusoe. Part II originally published under title: Farther adventures of Robinson Crusoe.
United States -- New York -- New York
United States -- Massachusetts -- Boston

Droits : This item is presumed to be in the public domain. The University of Florida George A. Smathers Libraries respect the intellectual property rights of others and do not claim any copyright interest in this item. Users of this work have responsibility for determining copyright status prior to reusing, publishing or reproducing this item for purposes other than what is allowed by fair use or other copyright exemptions. Any reuse of this item in excess of fair use or other copyright exemptions may require permission of the copyright holder. The Smathers Libraries would like to learn more about this item and invite individuals or organizations to contact The Department of Special and Area Studies Collections (special@uflib.ufl.edu) with any additional information they can provide.
01276545

Éditeur(s) : Printed for T. Cadell and W. Davies W. Blackwood Printed for T. Cadell and W. Davies ( London (Strand) ) W. Blackwood ( Edinburgh )
Résumé : (Citation/Reference) NUC pre-1956,
(Statement of Responsibility) embellished with engravings from designs by Thomas Stothard.
Caption title, v. 2: Further adventures of Robinson Crusoe.
"Printed by A. and R. Spottiswoode, Printers Street, London" -- V. 1, verso of half-title p., v.2, leaf opposite t.p.
Plates engraved by C. Heath, printed by B. McQueen.
Probably the samae as Lovett, R. W. Robinson Crusoe, 247, although Lovett states that the plates for this edition were re-engraved by a James Heath.
Parts I and II of Robinson Crusoe. Part II originally published under title: Farther adventures of Robinson Crusoe.
England -- London
Scotland -- Edinburgh

Droits : This item is presumed to be in the public domain. The University of Florida George A. Smathers Libraries respect the intellectual property rights of others and do not claim any copyright interest in this item. Users of this work have responsibility for determining copyright status prior to reusing, publishing or reproducing this item for purposes other than what is allowed by fair use or other copyright exemptions. Any reuse of this item in excess of fair use or other copyright exemptions may require permission of the copyright holder. The Smathers Libraries would like to learn more about this item and invite individuals or organizations to contact The Department of Special and Area Studies Collections (special@uflib.ufl.edu) with any additional information they can provide.
63956309

Éditeur(s) : Printed at the Shakespeare Press, by W. Nicol, for John Major Printed at the Shakespeare Press, by W. Nicol, for John Major ( London (Fleet St.) )
Résumé : (Citation/Reference) Lovett, R.W. Robinson Crusoe,
(Citation/Reference) NUC pre-1956
(Citation/Reference) Osborne Coll.,
(Statement of Responsibility) with introductory verses by Bernard Barton ; and illustrated with numerous engravings from drawings by George Cruikshank expressly designed for this edition.
"The text ... is restored in this edition by a careful collation with the early copies of both parts of the work." -- Pref. signed J.M. [i.e. John Major]
Caption title, v. 2: Farther adventures of Robinson Crusoe.
Frontispiece engraved by Augs. Fox (v.1) and W. Raddon (v.2); other engravers include Gorway, J. Jackson, Slader, and Thos. Williams.
Part I and II of Robinson Crusoe. Part II originally published under the title: Farther adventures of Robinson Crusoe.
England -- London

Droits : This item is presumed to be in the public domain. The University of Florida George A. Smathers Libraries respect the intellectual property rights of others and do not claim any copyright interest in this item. Users of this work have responsibility for determining copyright status prior to reusing, publishing or reproducing this item for purposes other than what is allowed by fair use or other copyright exemptions. Any reuse of this item in excess of fair use or other copyright exemptions may require permission of the copyright holder. The Smathers Libraries would like to learn more about this item and invite individuals or organizations to contact The Department of Special and Area Studies Collections (special@uflib.ufl.edu) with any additional information they can provide.
001801246
29632426
AJM5007

Éditeur(s) : Bickers & Son Bickers & Son ( London (I Leiscester Square) )
Résumé : (Citation/Reference) NUC pre-1956,
(Citation/Reference) Smith, R.D.H. Crusoe 250,
(Statement of Responsibility) by Daniel De Foe [sic] ; with a memoir of the author and twelve illustrations in permanent photography by T. Stothard, R.A.
Variant of Lovett, R.W. Robinson Crusoe, 636, which has an additional New York imprint and a blank verso on the half title p. This copy has on verso of half title: Ballantyne Press, Ballantyne, Hanson and Co., Edinburgh and London.
Parts I and II of Robinson Crusoe.
(Funding) Preservation and Access for American and British Children's Literature, 1870-1889 (NEH PA-50860-00).
England -- London
Scotland -- Edinburgh
England -- London
Scotland -- Edinburgh

Droits : This item is presumed to be in the public domain. The University of Florida George A. Smathers Libraries respect the intellectual property rights of others and do not claim any copyright interest in this item. Users of this work have responsibility for determining copyright status prior to reusing, publishing or reproducing this item for purposes other than what is allowed by fair use or other copyright exemptions. Any reuse of this item in excess of fair use or other copyright exemptions may require permission of the copyright holder. The Smathers Libraries would like to learn more about this item and invite individuals or organizations to contact The Department of Special and Area Studies Collections (special@uflib.ufl.edu) with any additional information they can provide.
001814129
30836226
AJN8034
http://ufdc.ufl.edu/UF00026212/00001

Éditeur(s) : David Bogue David Bogue ( London (86 Fleet St.) )
Résumé : (Citation/Reference) NUC pre-1956
(Statement of Responsibility) With illustrations by Thomas Stothard, R.A. engraved by Charles Heath.
Spine title: Robinson Crusoe.
Caption title, p. 321: Farther adventures of Robinson Crusoe.
Variant of Lovett, R.W. Robinson Crusoe, 386.
Parts I and II of Robinson Crusoe. Part II originally published under title: Farther adventures of Robinson Crusoe.
(Funding) Preservation and Access for American and British Children's Literature, 1870-1889 (NEH PA-50860-00).
England -- London
England -- Chiswick

Droits : This item is presumed to be in the public domain. The University of Florida George A. Smathers Libraries respect the intellectual property rights of others and do not claim any copyright interest in this item. Users of this work have responsibility for determining copyright status prior to reusing, publishing or reproducing this item for purposes other than what is allowed by fair use or other copyright exemptions. Any reuse of this item in excess of fair use or other copyright exemptions may require permission of the copyright holder. The Smathers Libraries would like to learn more about this item and invite individuals or organizations to contact The Department of Special and Area Studies Collections (special@uflib.ufl.edu) with any additional information they can provide.
06056847
11030289

Éditeur(s) : Cassell, Petter & Galpin Cassell, Petter & Galpin ( London, Paris, New York )
Résumé : (Statement of Responsibility) as related by himself, by Daniel Defoe ; with upwards of one hundred illustrations.
Spine and cover title: Robinson Crusoe; half title: The life and adventures of Robinson Crusoe.
Date based on imprint information. Cassell Petter & Galpin opened a Paris office in 1871 and the above form of publisher's name was used from 1858 to 1878. Cf. Brit. literary pub. houses, 1820-1880.
Some ill. drawn by P. Justyne, R.P. Leitch, T. Macquoid, AP, and GHT George Houseman Thomas; some engraved by T. Bolton, Butterworth & Heath, T. Cobb, J. Cooper, W.J. Linton, R.S. Marriott, Morgan, Pearson, W.L. Thomas, and F. Wentworth.
Cowper's verse, p. xiii-xiv.
Publisher's advertisement (4 p.) at end.
Half title p. and front. included in pre-paging.
All pages (1-394) in decorative borders.
Parts I and II Robinson Crusoe. Pt. II originally published under title: Farther adventures of Robinson Crusoe.
England -- London
France -- Paris
United States -- New York -- New York

Droits : This item is presumed to be in the public domain. The University of Florida George A. Smathers Libraries respect the intellectual property rights of others and do not claim any copyright interest in this item. Users of this work have responsibility for determining copyright status prior to reusing, publishing or reproducing this item for purposes other than what is allowed by fair use or other copyright exemptions. Any reuse of this item in excess of fair use or other copyright exemptions may require permission of the copyright holder. The Smathers Libraries would like to learn more about this item and invite individuals or organizations to contact The Department of Special and Area Studies Collections (special@uflib.ufl.edu) with any additional information they can provide.
28050571

Éditeur(s) : For Thomas Kelly For Thomas Kelly ( London (No. 17 Paternoster-Row) )
Résumé : Spine title: Robinson Crusoe.
Variant of Lovett, R.W. Robinson Crusoe, 222, but not listed as a reissue.
Added ill. t.p. with imprint: Published by Thomas Kelly, Paternoster Row, June 27 1818.
On t.p.: Two volumes in one.
Plates have legend: London Pubd Oct. 18 1817-Jan. 24 1818 by T. Kelly, Paternoster Row.
Parts I and II of Robinson Crusoe. Part II originally published under title: Farther adventures of Robinson Crusoe.
(Statement of Responsibility) by Daniel Defoe.
England -- London

Droits : This item is presumed to be in the public domain. The University of Florida George A. Smathers Libraries respect the intellectual property rights of others and do not claim any copyright interest in this item. Users of this work have responsibility for determining copyright status prior to reusing, publishing or reproducing this item for purposes other than what is allowed by fair use or other copyright exemptions. Any reuse of this item in excess of fair use or other copyright exemptions may require permission of the copyright holder. The Smathers Libraries would like to learn more about this item and invite individuals or organizations to contact The Department of Special and Area Studies Collections (special@uflib.ufl.edu) with any additional information they can provide.
27566787

Éditeur(s) : A.L. Burt A.L. Burt ( New York )
Résumé : (Citation/Reference) NUC pre-1956, suppl. 0015750 (v. 716, p. 458)
(Statement of Responsibility) from the original in words of one syllable by Mary A. Schwacofer ; illustrated.
Spine title: Robinson Crusoe.
"Copyright 1895 by The Cassell Publishing Co."--T.p. verso.
Some ill. by Gordon Browne, Macquoid, GHT; some engraved by R.S. Marriott and W.L. Thomas.
Publisher's advertisement for Burt's series of one syllable books (1 p.) at end. Crusoe is listed.
Parts I and II of Robinson Crusoe, retold.
United States -- New York -- New York

Droits : This item is presumed to be in the public domain. The University of Florida George A. Smathers Libraries respect the intellectual property rights of others and do not claim any copyright interest in this item. Users of this work have responsibility for determining copyright status prior to reusing, publishing or reproducing this item for purposes other than what is allowed by fair use or other copyright exemptions. Any reuse of this item in excess of fair use or other copyright exemptions may require permission of the copyright holder. The Smathers Libraries would like to learn more about this item and invite individuals or organizations to contact The Department of Special and Area Studies Collections (special@uflib.ufl.edu) with any additional information they can provide.
01440205
001819899

Éditeur(s) : Printed at the Shakespeare Press, by W. Nicol, for John Major Printed at the Shakespeare Press, by W. Nicol, for John Major ( London (Fleet St.) )
Résumé : (Citation/Reference) Lovett, R.W. Robinson Crusoe,
(Citation/Reference) NUC pre-1956
(Citation/Reference) Osborne Coll.,
(Statement of Responsibility) with introductory verses by Bernard Barton ; and illustrated with numerous engravings from drawings by George Cruikshank expressly designed for this edition.
"The text ... is restored in this edition by a careful collation with the early copies of both parts of the work." -- Pref. signed J.M. [i.e. John Major]
Caption title, v. 2: Farther adventures of Robinson Crusoe.
Frontispiece engraved by Augs. Fox (v.1) and W. Raddon (v.2); other engravers include Gorway, J. Jackson, Slader, and Thos. Williams.
Part I and II of Robinson Crusoe. Part II originally published under the title: Farther adventures of Robinson Crusoe.
England -- London

Droits : This item is presumed to be in the public domain. The University of Florida George A. Smathers Libraries respect the intellectual property rights of others and do not claim any copyright interest in this item. Users of this work have responsibility for determining copyright status prior to reusing, publishing or reproducing this item for purposes other than what is allowed by fair use or other copyright exemptions. Any reuse of this item in excess of fair use or other copyright exemptions may require permission of the copyright holder. The Smathers Libraries would like to learn more about this item and invite individuals or organizations to contact The Department of Special and Area Studies Collections (special@uflib.ufl.edu) with any additional information they can provide.
001801246
29632426
AJM5007

Éditeur(s) : Chatto & Windus Chatto & Windus ( London ( Piccadilly ) )
Résumé : (Statement of Responsibility) by Daniel Defoe.
(Citation/Reference) Lovett, R.W. Robinson Crusoe,
Spine title: Robinson Crusoe.
"The text ... is restored in this edition by a careful collation with the early copies of both parts of the work."--Pref., signed John Major.
Some ill. engraved by Gorway, J. Jackson, and Thos. Williams. 9.4.
"A poet's memorial of Robinson Crusoe," Bernard Barton, p. -xii.
Distinctive red cover with title in rustic style letters, Robinson Crusoe; coastline of island on right; line of footprints on left and illustrated by George Cruikshank .
Parts I and II of Robinson Crusoe.
England -- London

Droits : This item is presumed to be in the public domain. The University of Florida George A. Smathers Libraries respect the intellectual property rights of others and do not claim any copyright interest in this item. Users of this work have responsibility for determining copyright status prior to reusing, publishing or reproducing this item for purposes other than what is allowed by fair use or other copyright exemptions. Any reuse of this item in excess of fair use or other copyright exemptions may require permission of the copyright holder. The Smathers Libraries would like to learn more about this item and invite individuals or organizations to contact The Department of Special and Area Studies Collections (special@uflib.ufl.edu) with any additional information they can provide.
SN01269
10369979

Éditeur(s) : D. Lothrop and Co. D. Lothrop and Co. ( Boston )
Résumé : (Statement of Responsibility) by Daniel Defoe ; with sixteen illustrations by Thomas Stothard, R.A.
(Citation/Reference) Lovett, R.W. Robinson Crusoe,
Spine and half-title: Robinson Crusoe; caption title, p. 289: Farther adventures of Robinson Crusoe.
Introd. (p. -xii) signed Austin Dobson.
Ill. engraved by C. Heath.
Series from verso of half-title p. and cover.
Contains reproduction of original t.p.: The life and strange surprising adventures of Robinson Crusoe, of York. Mariner ... Written by himself. London, Printed for W. Taylor, 1719.
Front. is included in the pre-paging.
Includes publisher's advertisements (<16> p.) at end.
Parts I and II of Robinson Crusoe.
United States -- Massachusetts -- Boston.

Droits : This item is presumed to be in the public domain. The University of Florida George A. Smathers Libraries respect the intellectual property rights of others and do not claim any copyright interest in this item. Users of this work have responsibility for determining copyright status prior to reusing, publishing or reproducing this item for purposes other than what is allowed by fair use or other copyright exemptions. Any reuse of this item in excess of fair use or other copyright exemptions may require permission of the copyright holder. The Smathers Libraries would like to learn more about this item and invite individuals or organizations to contact The Department of Special and Area Studies Collections (special@uflib.ufl.edu) with any additional information they can provide.
16836239
22014561

Éditeur(s) : Lee and Shepard Lee and Shepard ( Boston (10 Milk St.) )
Résumé : Some ill. by R.P. Leitch and T. MacQuoid; engraving by Butterworth & Heath, W.J. Linton, R.S. Marriott, Morison, W.L. Thomas, Wentworth, and Williamson.
Originally published as The Children's Robinson Crusoe by Mrs. Eliza Farrar in 1830.
This edition omits "most of the chapter relating to the early life of the hero, and condenses the rest of the volume." It is adapted "to the use of schools ... by simplifying many words and reducing the length of sentences. With these exceptions, the editor has taken few liberties with the text of Mrs. Farrar."--P. 3.
Based upon part I of Daniel Defoe's Robinson Crusoe.
Publisher's advertisement p. 4 of cover.
(Statement of Responsibility) by a Lady ; edited and adapted by William T. Adams.
United States of America -- Massachusetts -- Boston

Droits : This item is presumed to be in the public domain. The University of Florida George A. Smathers Libraries respect the intellectual property rights of others and do not claim any copyright interest in this item. Users of this work have responsibility for determining copyright status prior to reusing, publishing or reproducing this item for purposes other than what is allowed by fair use or other copyright exemptions. Any reuse of this item in excess of fair use or other copyright exemptions may require permission of the copyright holder. The Smathers Libraries would like to learn more about this item and invite individuals or organizations to contact The Department of Special and Area Studies Collections (special@uflib.ufl.edu) with any additional information they can provide.
SN01270
27081349

Éditeur(s) : s. Babcock s. Babcock ( New Haven )
Résumé : (Funding) Preservation and Access for American and British Children's Literature, 1870-1889 (NEH PA-50860-00).
United States -- Connecticut -- New Haven

Droits : This item is presumed to be in the public domain. The University of Florida George A. Smathers Libraries respect the intellectual property rights of others and do not claim any copyright interest in this item. Users of this work have responsibility for determining copyright status prior to reusing, publishing or reproducing this item for purposes other than what is allowed by fair use or other copyright exemptions. Any reuse of this item in excess of fair use or other copyright exemptions may require permission of the copyright holder. The Smathers Libraries would like to learn more about this item and invite individuals or organizations to contact The Department of Special and Area Studies Collections (special@uflib.ufl.edu) with any additional information they can provide.
00946998

Éditeur(s) : Thomas Richardson Robert Sears and Co. Thomas Richardson ( Derby ) Robert Sears and Co. ( London (53 Paternoster Row) )
Résumé : (Citation/Reference) NUC pre-1956,
(Citation/Reference) Osborne Coll.,
(Statement of Responsibility) with a coloured engraving.
Robert Sears listed at above address from 1835-1837. Cf. Todd, W.B. Directory of printers and others in allied trades ..., 1972.
"Printed by Thomas Richardson, Derby."--P. 12.
Series from publisher's listing on p. 4 of cover.
Variant of Lovett, R.W. Robinson Crusoe, 338, which gives a date of 184- and an imprint as above omitting 'Robert'.
Illustration hand-colored.
Part I of Robinson Crusoe, retold.
England -- Derby
England -- London

Droits : This item is presumed to be in the public domain. The University of Florida George A. Smathers Libraries respect the intellectual property rights of others and do not claim any copyright interest in this item. Users of this work have responsibility for determining copyright status prior to reusing, publishing or reproducing this item for purposes other than what is allowed by fair use or other copyright exemptions. Any reuse of this item in excess of fair use or other copyright exemptions may require permission of the copyright holder. The Smathers Libraries would like to learn more about this item and invite individuals or organizations to contact The Department of Special and Area Studies Collections (special@uflib.ufl.edu) with any additional information they can provide.
27698232

Éditeur(s) : Edward C. Biddle Edward C. Biddle ( Philadelphia (6 South Fifth Street) )
Résumé : Part I of Defoe's Robinson Crusoe, retold and abridged.
Added illustrated t.p.: Robinson Crusoe for the young; same spine title.
Variant of NUC Pre-1956 0118262 and of Lovett, R.W. Robinson Crusoe, 356. Frontispiece opposite added t.p.; dark brown cloth, blind stamped cover decoration and illustration; gilt spine title with gilt illustration.
Vignette illustrations (every 4th page) engraved by Mumford.
(Funding) Preservation and Access for American and British Children's Literature, 1870-1889 (NEH PA-50860-00).
United States -- Pennsylvania -- Philadelphia

Droits : This item is presumed to be in the public domain. The University of Florida George A. Smathers Libraries respect the intellectual property rights of others and do not claim any copyright interest in this item. Users of this work have responsibility for determining copyright status prior to reusing, publishing or reproducing this item for purposes other than what is allowed by fair use or other copyright exemptions. Any reuse of this item in excess of fair use or other copyright exemptions may require permission of the copyright holder. The Smathers Libraries would like to learn more about this item and invite individuals or organizations to contact The Department of Special and Area Studies Collections (special@uflib.ufl.edu) with any additional information they can provide.
26897893

Éditeur(s) : HAL CCSD Landes Bioscience
Résumé : International audience
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.
Autophagy

hal-00735751
https://hal.archives-ouvertes.fr/hal-00735751
PUBMED : 22966490

Éditeur(s) : HAL CCSD American Association for the Advancement of Science
Résumé :  
Amazon forests are a key but poorly understood component of the global carbon cycle. If, as anticipated, they dry this century, they might accelerate climate change through carbon losses and changed surface energy balances. We used records from multiple long-term monitoring plots across Amazonia to assess forest responses to the intense 2005 drought, a possible analog of future events. Affected forest lost biomass, reversing a large long-term carbon sink, with the greatest impacts observed where the dry season was unusually intense. Relative to pre-2005 conditions, forest subjected to a 100-millimeter increase in water deficit lost 5.3 megagrams of aboveground biomass of carbon per hectare. The drought had a total biomass carbon impact of 1.2 to 1.6 petagrams (1.2 × 1015 to 1.6 × 1015 grams). Amazon forests therefore appear vulnerable to increasing moisture stress, with the potential for large carbon losses to exert feedback on climate change.
ISSN: 0036-8075

hal-01032111
https://hal.archives-ouvertes.fr/hal-01032111
DOI : 10.1126/science.1164033

Éditeur(s) : HAL CCSD
Résumé : International audience
The search for safe antimalarial compounds acting against asexual symptom-responsible stages and sexual transmission-responsible forms of Plasmodium species is one of the major challenges in malaria elimination programs. So far, among current drugs approved for human use, only primaquine has transmission-blocking activity. The discovery of small molecules targeting different Plasmodium falcip-arum life stages remains a priority in antimalarial drug research. In this context, several independent studies have recently reported antiplasmodial and transmission-blocking activities of commonly used stains, dyes and fluorescent probes against P. falciparum including chloroquine-resistant isolates. Herein we have studied the antimalarial activities of dyes with different scaffold and we report that the triar-ylmethane dye (TRAM) Brilliant green inhibits the growth of asexual stages (IC 50 2 mM) and has exflagellation-blocking activity (IC 50 800 nM) against P. falciparum reference strains (3D7, 7G8) and chloroquine-resistant clinical isolate (Q206). In a second step we have investigated the antiplasmodial activities of two polysulfonated triarylmethane food dyes. Green S (E142) is weakly active against P. falciparum asexual stage (IC 50 x 17 mM) whereas Patent Blue V (E131) is inactive in both antimalarial assays. By applying liquid chromatography techniques for the culture supernatant analysis after cell washings and lysis, we report the detection of Brilliant green in erythrocytes, the selective uptake of Green S (E142) by infected erythrocytes, whereas Patent Blue V (E131) could not be detected within non-infected and 3D7-infected erythrocytes. Overall, our results suggest that two polysulfonated food dyes might display different affinity with transporters or channels on infected RBC membrane.
International journal for parasitology. Drugs and drug resistance

Droits : http://creativecommons.org/licenses/by-nc-sa/
pasteur-01614675
https://hal-pasteur.archives-ouvertes.fr/pasteur-01614675
https://hal-pasteur.archives-ouvertes.fr/pasteur-01614675/document
https://hal-pasteur.archives-ouvertes.fr/pasteur-01614675/file/Leba%20LJ-article%20colorant-version%20publiee.pdf
DOI : 10.1016/j.ijpddr.2017.07.002

Éditeur(s) : HAL CCSD Oxford University Press
Résumé : International audience
The BioMart Community Portal (www.biomart.org) is a community-driven effort to provide a unified interface to biomedical databases that are distributed worldwide. The portal provides access to numerous database projects supported by 30 scientific organizations. It includes over 800 different biological datasets spanning genomics, proteomics, model organisms, cancer data, ontology information and more. All resources available through the portal are independently administered and funded by their host organizations. The BioMart data federation technology provides a unified interface to all the available data. The latest version of the portal comes with many new databases that have been created by our ever-growing community. It also comes with better support and extensibility for data analysis and visualization tools. A new addition to our toolbox, the enrichment analysis tool is now accessible through graphical and web service interface. The BioMart community portal averages over one million requests per day. Building on this level of service and the wealth of information that has become available, the BioMart Community Portal has introduced a new, more scalable and cheaper alternative to the large data stores maintained by specialized organizations.
ISSN: 0305-1048

hal-01146849
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01146849
DOI : 10.1093/nar/gkv350
PUBMED : 25897122