Éditeur(s) : Université des Antilles Études caribéennes
Résumé : Le débat théorique sur les migrations et la famille connait une ambivalence allant du postulat de la migration comme une logique « individualiste » et de distanciation de la famille à celui de la migration vue comme une stratégie de survie portée par le réseau familial. C’est dans le but de contribuer à ce débat que le présent texte aborde l’analyse du processus migratoire sous l’angle des stratégies déployées par les migrants « Hloua » de la côte béninoise. Quatre dimensions ont particulièrement retenu notre attention : la prise de décision, le financement et l’organisation du voyage, l'intégration dans le milieu d’accueil, et les rapports maintenus avec le milieu d'origine.L’analyse s’appuie sur les récits de migration collectés auprès de migrants de retour ou de membres de familles restés au village, ceci dans le cadre d’une enquête plus large sur la pauvreté et les stratégies de survie dans le milieu de la pêche artisanale (Avloh, Ayiguinnou et Agoué) au Bénin. Cette analyse de récit a été complétée par des analyses de type quantitatif sur la fréquence des recours pour l’organisation et la prise de décision, la fréquence de recours pour l’insertion résidentielle et professionnelle, et le montant des envois de fonds. Les résultats montrent la place centrale du réseau familial le long du processus migratoire depuis la prise de décision, l’organisation du voyage, le « confiage » de la femme et des enfants du migrant, à l’établissement résidentiel et l’insertion professionnelle dans le milieu d’accueil. Ce réseau organise et structure efficacement le phénomène migratoire en intervenant lors des étapes décisives. Cependant, une fois insérés, les rapports maintenus avec le réseau familial se limitent pour la plupart à une solidarité affective, caractérisée par des contacts téléphoniques ou transferts de message et quelques envois de fonds largement en deçà des attentes. Ce qui fait dire de plus en plus que le migrant diminue le capital social de la famille sans pour autant y contribuer de façon substantielle sur le plan financier : Un paradoxe qui pourrait bien trouver son explication dans les recherches futures sous une perspective dynamique des migrations.
The theoretical debate on migration and family is ambivalent. Migration can be seen from an “individualist’’ and distant logic of the family or, on the other hand, migration can be viewed as a strategy of survival for the family network. It is in the objective of contributing to this debate, the present article will analyze the migration process from a migrant strategy perspective, more specifically from the perspective of the “Hloua” migrants off the Benin coast. Four dimensions are of particular interest: the decision making process, the cost and organization of the trip, integration in the host community and the maintenance of relations with the host community. Within a large scale research on poverty and the strategies of survival of artisan fishing (Avloh, Ayiguinnou et Agoué) in Bénin, the present analysis is based on migration stories collected from returning migrants or from family members still living in the village. This story analysis has been completed with quantitative analyses on the frequency of the use of organization and decision making, the frequency of the use of residential and professional insertion, and the amount of remittances. The results show the central place of family ties during the migratory process from the start of the decision making process, the travel planning, the entrusting of the women and children of the migrant, to the residential establishment and the professional insertion in the host society. This network organizes and structures efficiently the migratory phenomenon by intervening during the decisive steps. However, once inserted, the connections maintained with the family network are limited for the majority to an affective solidarity characterized by telephone contacts or message transfers, and sometimes remittances sent back largely lower to the family’s expectations. This results more and more in the migrant diminishing the social capital of the family without always contributing in some substantially way on the financial side. A paradox which could find its explanation in future researches under a perspective of migrations’ dynamics.
Bénin

Droits : info:eu-repo/semantics/openAccess
urn:doi:10.4000/etudescaribeennes.5785
http://journals.openedition.org/etudescaribeennes/5785

Éditeur(s) : HAL CCSD BioMed Central
Résumé : International audience
Cell proliferation is a hallmark of cancer and depends on complex signaling networks that are chiefly supported by protein kinase activities. Therapeutic strategies have been used to target specific kinases but new methods are required to identify combined targets and improve treatment. Here, we propose a small interfering RNA genetic screen and an integrative approach to identify kinase networks involved in the proliferation of cancer cells. The functional siRNA screen of 714 kinases in HeLa cells identified 91 kinases implicated in the regulation of cell growth, most of them never being reported in previous whole-genome siRNA screens. Based on gene ontology annotations, we have further discriminated between two classes of kinases that, when suppressed, result in alterations of the mitotic index and provoke cell-cycle arrest. Extinguished kinases that lead to a low mitotic index mostly include kinases implicated in cytosolic signaling. In contrast, extinguished kinases that result in a high mitotic index mostly include kinases implicated in cell division. By mapping hit kinases in the PhosphPOINT phosphoprotein database, we generated scale-free networks consisting of 449 and 661 protein-protein interactions for kinases from low MI and high MI groups, respectively. Further analyses of the kinase interactomes revealed specific modules such as FER- and CRKL-containing modules that connect three members of the epidermal growth factor receptor (EGFR) family, suggesting a tight control of the mitogenic EGF-dependent pathway. Based on experimental studies, we confirm the involvement of these two kinases in the regulation of tumor cell growth. Based on a combined approach of large kinome-wide siRNA screens and ontology annotations, our study identifies for the first time two kinase groups differentially implicated in the control of cell proliferation. We further demonstrate that integrative analysis of the kinase interactome provides key information which can be used to facilitate or optimize target design for new therapeutic strategies. The complete list of protein-protein interactions from the two functional kinase groups will provide a useful database for future investigations.
ISSN: 1471-2164

hal-01118475
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01118475
DOI : 10.1186/1471-2164-15-1169
PUBMED : 25540073

Éditeur(s) : Université des Antilles Études caribéennes
Résumé : Sur l'île de Bali, en Indonésie, paradis touristique et culturel, aujourd'hui en proie à un développement trop rapide, les rizières en terrasses constituent une véritable marque de fabrique du paysage local. La campagne autour de Jatiluwih est désormais le site naturel phare récemment reconnu par l'Unesco. Ses fameuses rizières représentent aussi un parfait exemple du fonctionnement des subak balinais, ces systèmes d’irrigation et de gestion de l’eau qui sont traditionnellement ancrés dans la culture balinaise. Ici, culture et agriculture sont intrinsèquement liées, et de plus en plus menacées. Cet article traite du présent et du devenir de la riziculture, patrimonialisée ou non, face à un essor du tourisme qui tous les jours s'affirme plus massif que culturel. Un défi majeur pour les Balinais qui souhaiteraient que leur paradis ne soit pas perdu mais préservé.
On the island of Bali, in Indonesia, a touristic and cultural heaven, nowadays confronted with a too fast development, the typical rice fields form a real distinguishable brand of the local landscape. The countryside around Jatiluwih become now the main natural site recently approved by UNESCO. Its famous rice fields also represent a perfect case of the Balinese system named Subak, a traditional water network deeply rooted in the local culture. Here, culture and agriculture are strongly tied together, but always more threatened these days. This contribution discuss the present and the future of the rice culture, whether put in heritage or not, in the context of a tourism growth which everyday looks more mass than cultural oriented. A major challenge for the Balinese who would prefer to see their paradise not lost but better preserved.
Bali
Indonésie

Droits : info:eu-repo/semantics/openAccess
urn:doi:10.4000/etudescaribeennes.6957
http://journals.openedition.org/etudescaribeennes/6957

Résumé : Les graphes définis à partir de structures algébriques possèdent d’excellentes propriétés de symétries particulièrement intéressantes. L’exemple le plus flagrant est la notion de graphe de Cayley qui s’est révélée très riche non seulement du point de vue théorique mais aussi pratique par ses applications à de nombreux domaines incluant l’architecture des réseaux ou les machines parallèles. Néanmoins, la régularité des graphes de Cayley se révèle parfois être une limite étant donné qu’ils sont toujours sommet-transitifs et donc en particulier non pertinents pour générer des réseaux semiréguliers.Cette observation a motivé, en 2005, la définition d’une nouvelle classe de graphes définis à partir d’un groupe, appelés G-graphes. Ils possèdent aussi de nombreuses propriétés de régularité mais de manière moins restrictive.Cette thèse propose un nouveau regard sur cette classe de graphes par une approche plutôt orientée recherche opérationnelle alors que la grande majorité des études précédentes est dominée par des approches essentiellement algébriques. Nous-nous sommes alors intéressés à plusieurs questions :— La caractérisation des G-graphes : nous proposons des améliorations par rapport aux précédents résultats.— Identifier des classes de graphes comme des G-graphes grâce à des isomorphismes ou en utilisant le théorème de caractérisation.— Etudier la structure et les propriétés de ces graphes, en particulier pour de possibles applications aux réseaux : colorations semi-régulières, symétries et robustesse.— Une approche algorithmique pour la reconnaissance de cette classe avec notamment un premier exemple de cas polynomial lorsque le groupe est abélien.
Interactions between graph theory and group theory have already led to interesting results for both domains. Graphs defined from algebraic groups have highly symmetrical structure giving birth to interesting properties. The most famous example is Cayley graphs, which revealed to be particularly interesting both from a theoretical and a practical point of view due to their applications in several domains including network architecture or parallel machines. Nevertheless, the regularity of Cayley graphs is also a limit as they are always vertex-transitive and therefore not relevant to generate semi-regular networks. This observation motivated the definition, in 2005, of a new family of graphs defined from a group, called G-graphs. They also have many regular properties but are less restrictive. These graphs are in particular semi-regular k-partite, with a chromatic number k directly given in the group representation and they can be either transitive or not.This thesis proposes a new insight into this class of graphs using an approach based on operational research while most of previous studies have been so far dominated by algebraic approaches. Then, the thesis addresses different kind of questions:— Characterizing G-graphs: we propose improvements of previous results.— Identifying some classes of graphs as G-graphs through isomorphism or using the characterization theorem.— Studying the structure and properties of these graphs, in particular for possible applications to networks: semi-regular coloring, symmetries and robustness.— Algorithmic approach for recognizing this class with a first example of polynomial case when the group is abelian.

http://www.theses.fr/2014AGUY0787/document

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
Defining homologous genes is important in many evolutionary studies but raises obvious issues. Some of these issues are conceptual and stem from our assumptions of how a gene evolves, others are practical, and depend on the algorithmic decisions implemented in existing software. Therefore, to make progress in the study of homology, both ontological and epistemological questions must be considered. In particular, defining homologous genes cannot be solely addressed under the classic assumptions of strong tree thinking, according to which genes evolve in a strictly tree-like fashion of vertical descent and divergence and the problems of homology detection are primarily methodological. Gene homology could also be considered under a different perspective where genes evolve as ``public goods,'' subjected to various introgressive processes. In this latter case, defining homologous genes becomes a matter of designing models suited to the actual complexity of the data and how such complexity arises, rather than trying to fit genetic data to some a priori tree-like evolutionary model, a practice that inevitably results in the loss of much information. Here we show how important aspects of the problems raised by homology detection methods can be overcome when even more fundamental roots of these problems are addressed by analyzing public goods thinking evolutionary processes through which genes have frequently originated. This kind of thinking acknowledges distinct types of homologs, characterized by distinct patterns, in phylogenetic and nonphylogenetic unrooted or multirooted networks. In addition, we define `` family resemblances'' to include genes that are related through intermediate relatives, thereby placing notions of homology in the broader context of evolutionary relationships. We conclude by presenting some payoffs of adopting such a pluralistic account of homology and family relationship, which expands the scope of evolutionary analyses beyond the traditional, yet relatively narrow focus allowed by a strong tree-thinking view on gene evolution.
ISSN: 0737-4038

hal-01544794
https://hal.archives-ouvertes.fr/hal-01544794
DOI : 10.1093/molbev/mst228

Éditeur(s) : HAL CCSD
Résumé : International audience
The digital world authentic parallel organisation which deeply transforms the classical art organisation held by institutions, galleries, and collectors and that, mainly in the field of contempory art. Through a series of interviews, it reveals a lack of knowledge of this creative and collective energy and a protective reaction against these self appointed experts. The case of the photographer Alain Laboile whose recent fame comes out social network permits to better understand the resistance from official circles. We can say consequently that they resist to any legitimation witch ignore them.
C’est une véritable organisation parallèle des internautes qui se met en place et qui change en profondeur les instances de légitimation traditionnelles du milieu de l’art contemporain sans que les élites ne s’en aperçoivent véritablement ou ne consentent à l'accepter. Les entretiens que nous avons menés auprès des institutions, des galeristes et des collectionneurs, ont mis en évidence une méconnaissance de cette énergie créatrice et collective et une réaction de protection contre ces intrus d’une expertise autodidacte. Le cas du photographe Alain Laboile, dont la notoriété soudaine est née des réseaux sociaux, permet de mieux cerner les résistances des circuits officiels à une légitimation qui les contourne.
Les écosystèmes numériques et la démocratisation informationnelle : Intelligence collective, Développement durable, Interculturalité, Transfert de connaissances
Schoelcher, France

hal-01258283
https://hal.univ-antilles.fr/hal-01258283
https://hal.univ-antilles.fr/hal-01258283/document
https://hal.univ-antilles.fr/hal-01258283/file/Nicole%20DENOIT.pdf

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
Epigenetics is most often reduced to chromatin marking in the current literature, whereas this notion was initially defined in a more general context. This restricted view ignores that epigenetic memories are in fact more robustly ensured in living systems by steady-state mechanisms with permanent molecule renewal. This misconception is likely to result from misleading intuitions and insufficient dialogues between traditional and quantitative biologists. To demystify dynamic epigenetics, its most famous image, a Waddington landscape and its attractors, are explicitly drawn. The simple example provided, is sufficient to highlight the main requirements and characteristics of dynamic gene networks, underlying cellular differentiation, de-differentiation and trans-differentiation.
ISSN: 0248-4900

inserm-00920766
http://www.hal.inserm.fr/inserm-00920766
http://www.hal.inserm.fr/inserm-00920766/document
http://www.hal.inserm.fr/inserm-00920766/file/Dynamic_Epigenetics.pdf
PUBMED : 24111561

Éditeur(s) : HAL CCSD Oxford University Press
Résumé : International audience
The epigenetic events imposed during germline reprogramming and affected by harmful exposure can be inherited and transferred to subsequent generations via gametes inheritance. In this study, we examine the transgenerational effects promoted by widely used herbicide atrazine (ATZ). We exposed pregnant outbred CD1 female mice and the male progeny was crossed for three generations with untreated females. We demonstrate here that exposure to ATZ affects meiosis, spermiogenesis and reduces the spermatozoa number in the third generation (F3) male mice. We suggest that changes in testis cell types originate from modified transcriptional network in undifferentiated spermatogonia. Importantly, exposure to ATZ dramatically increases the number of transcripts with novel transcription initiation sites, spliced variants and alternative polyadenylation sites. We found the global decrease in H3K4me3 occupancy in the third generation males. The regions with altered H3K4me3 occupancy in F3 ATZ-derived males correspond to altered H3K4me3 occupancy of F1 generation and 74% of changed peaks in F3 generation are associated with enhancers. The regions with altered H3K4me3 occupancy are enriched in SP family and WT1 transcription factor binding sites. Our data suggest that the embryonic exposure to ATZ affects the development and the changes induced by ATZ are transferred up to three generations.
ISSN: 0305-1048

hal-01477213
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01477213
DOI : 10.1093/nar/gkw840
PUBMED : 27655631

Éditeur(s) : HAL CCSD Springer Verlag (Germany)
Résumé : International audience
The Michaelis-Menten enzymatic reaction is sufficient to perceive many subtleties of network modeling, including the concentration and time scales separations, the formal equivalence between bulk phase and single-molecule approaches, or the relationships between single-cycle transient probabilities and steady state rates. Twelve methods proposed by different authors and yielding the same famous Michaelis-Menten equation, are selected here to illustrate the kinetic and probabilistic use of rate constants and to review basic techniques for handling them. Finally, the general rate of an ordered multistep reaction, of which the Michaelis-Menten reaction is a particular case, is deduced from a Markovian approach.
ISSN: 0259-9791

hal-00920806
https://hal-univ-rennes1.archives-ouvertes.fr/hal-00920806
https://hal-univ-rennes1.archives-ouvertes.fr/hal-00920806v2/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-00920806/file/12MM.pdf
ARXIV : 1312.5468

Éditeur(s) : HAL CCSD Springer Verlag (Germany)
Résumé : International audience
The Michaelis-Menten enzymatic reaction is sufficient to perceive many subtleties of network modeling, including the concentration and time scales separations, the formal equivalence between bulk phase and single-molecule approaches, or the relationships between single-cycle transient probabilities and steady state rates. Seven methods proposed by different authors and yielding the same famous Michaelis-Menten equation, are selected here to illustrate the kinetic and probabilistic use of rate constants and to review basic techniques for handling them. Finally, the general rate of an ordered multistep reaction, of which the Michaelis-Menten reaction is a particular case, is deduced from a Markovian approach.
Journal of Mathematical Chemistry

hal-00920806
https://hal-univ-rennes1.archives-ouvertes.fr/hal-00920806
https://hal-univ-rennes1.archives-ouvertes.fr/hal-00920806/document
ARXIV : 1312.5468
DOI : 10.1007/s10910-013-0237-5