Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
Diesel exhaust particles (DEPs) are common environmental air pollutants primarily affecting the lung. DEPs or chemicals adsorbed on DEPs also exert extra-pulmonary effects, including alteration of hepatic drug detoxifying enzyme expression. The present study was designed to determine whether organic DEP extract (DEPe) may target hepatic drug transporters that contribute in a major way to drug detoxification. Using primary human hepatocytes and transporter-overexpressing cells, DEPe was first shown to strongly inhibit activities of the sinusoidal solute carrier (SLC) uptake transporters organic anion-transporting polypeptides (OATP) 1B1, 1B3 and 2B1 and of the canalicular ATP-binding cassette (ABC) efflux pump multidrug resistance-associated protein 2, with IC50 values ranging from approximately 1 to 20 μg/mL and relevant to environmental exposure situations. By contrast, 25 μg/mL DEPe failed to alter activities of the SLC transporter organic cation transporter (OCT) 1 and of the ABC efflux pumps P-glycoprotein and bile salt export pump (BSEP), whereas it only moderately inhibited those of sodium taurocholate co-transporting polypeptide and of breast cancer resistance protein (BCRP). Treatment by 25 μg/mL DEPe was next demonstrated to induce expression of BCRP at both mRNA and protein level in cultured human hepatic cells, whereas it concomitantly repressed mRNA expression of various transporters, including OATP1B3, OATP2B1, OCT1 and BSEP. Such changes in transporter expression were found to be highly correlated to those caused by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a reference activator of the aryl hydrocarbon receptor (AhR) pathway. This suggests that DEPe, which is enriched in known ligands of AhR like polycyclic aromatic hydrocarbons, alters drug transporter expression via activation of the AhR cascade. Taken together, these data established human hepatic transporters as targets of organic chemicals containing in DEPs, which may contribute to their systemic effects through impairing hepatic transport of endogenous compound or drug substrates of these transporters.
ISSN: 1932-6203

Droits : http://creativecommons.org/licenses/by/
hal-01138535
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01138535
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01138535/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01138535/file/Regulation%20of%20human%20hepatic%20drug.pdf
DOI : 10.1371/journal.pone.0121232

Éditeur(s) : Port-au-Prince [1906?]-1914 Port-au-Prince [1906?]-1914
Résumé : 2b-L/E- 1906-14
HLL Dep HAI 497 F06

LLMC31886

Éditeur(s) : Port-au-Prince [1906?]-1914 Port-au-Prince [1906?]-1914
Résumé : 2b-L/E- 1906-14
HLL Dep HAI 497 F06

LLMC31886

Éditeur(s) : Port-au-Prince, 1917 Port-au-Prince, 1917
Résumé : 1-con-1917
HarLaw Dep HAI 103 F17; Hollis 004570372

LLMC31871

Éditeur(s) : Port-au-Prince [1906?]-1914 Port-au-Prince [1906?]-1914
Résumé : 2b-L/E- 1906-14
HLL Dep HAI 497 F06

LLMC31886

Éditeur(s) : [Port-au-Prince, Imprimerie nationale, 1875] [Port-au-Prince, Imprimerie nationale, 1875]
Résumé : 3-jud-1875?
LAW , Rare; HLL Dep. HAI 397.5 E75

LLMC31930

Éditeur(s) : Port-au-Prince, Impr. de l’état, 1956 Port-au-Prince, Impr. de l’état, 1956
Résumé : 2b-L/E- 1956
Law, Dep., HAI 373.1R F56/AE

LLMC31867

Éditeur(s) : Paris, 1902 Paris, 1902
Résumé : 4-tr-Poujol-1902
HLL Dep. 214 36; Hollis 006812835

LLMC31862

Éditeur(s) : Port-au-Prince [1906?]-1914 Port-au-Prince [1906?]-1914
Résumé : 2b-L/E- 1906-14
HLL Dep HAI 497 F06

LLMC31886

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The heterodimeric L-type amino acid transporter (LAT) 1/ CD98hc is overexpressed in lung cancers with a poor prognosis factor. Factors that contribute to LAT1/CD98hc overexpression in lung cells remain however to be determined, but the implication of atmospheric pollution can be suspected. The present study was therefore designed to analyze the effects of diesel exhaust particle (DEP) extract (DEPe) on LAT1/CD98hc expression in bronchial epithelial BEAS-2B cells. Exposure to DEPe up-regulated LAT1 and CD98hc mRNA levels in a concentration-dependent manner, with DEPe EC50 values (around 0.2 μg/mL) relevant to environmental situations. DEPe concomitantly induced LAT1/CD98hc protein expression and LAT1-mediated leucine accumulation in BEAS-2B cells. Inhibition of the aryl hydrocarbon receptor (AhR) pathway through the use of a chemical AhR antagonist or the siRNA-mediated silencing of AhR expression was next found to prevent DEPe-mediated induction of LAT1/CD98hc, indicating that this regulation depends on AhR, known to be activated by major chemical DEP components like polycyclic aromatic hydrocarbons. DEPe exposure was finally shown to induce mRNA expression and activity of matrix metalloproteinase (MMP)-2 in BEAS-2B cells, in a CD98hc/focal adhesion kinase (FAK)/extracellular regulated kinase (ERK) manner, thus suggesting that DEPe-mediated induction of CD98hc triggers activation of the integrin/FAK/ERK signaling pathway known to be involved in MMP-2 regulation. Taken together, these data demonstrate that exposure to DEPe induces functional overexpression of the amino acid transporter LAT1/CD98h in lung cells. Such a regulation may participate to pulmonary carcinogenic effects of DEPs, owing to the well-documented contribution of LAT1 and CD98hc to cancer development.
ISSN: 0041-008X

hal-01237095
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01237095
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01237095/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01237095/file/Aryl%20hydrocarbon%20receptor-dependent%20up-regulation_accepted.pdf
DOI : 10.1016/j.taap.2015.11.014

Éditeur(s) : Port-au-Prince [1906?]-1914 Port-au-Prince [1906?]-1914
Résumé : 2b-L/E- 1906-14
HLL Dep HAI 497 F06

LLMC31886

Éditeur(s) : Port-au-prince, 1950 Port-au-prince, 1950
Résumé : 4-tr-Lamy-1950
Law, Dep. HAI 696 LAM, Hollis 004455053

LLMC31877
20434026

Éditeur(s) : Port-au-Prince [1906?]-1914 Port-au-Prince [1906?]-1914
Résumé : 2b-L/E- 1906-14
HLL Dep HAI 497 F06

LLMC31886

Éditeur(s) : Port-au-Prince, 1890 Port-au-Prince, 1890
Résumé : 4-tr-Dominique
HLL Dep HAI 991 DOM; Hollis 004570469

LLMC31870

Résumé : Cette septième conférence internationale sur les récifs artificiels et les habitats marins a rassemblé 332 participants de 22 pays du mercredi 6 au lundi 11 octobre 1999, à San Remo, ville de la Riviera italienne proche de la frontière française. La décision de tenir ce congrès en Italie a été prise lors du précédent congrès, à Tokyo, en 1996. En effet, les conférences sur ce sujet ont lieu tous les trois ou quatre ans, ce qui explique l'importance des délégations étrangères non européennes. En effet si les participants italiens étaient logiquement les plus nombreux, plusieurs pays d'Amérique et d'Asie ont envoyé des délégations importantes, notamment, par ordre décroissant, les Etats-Unis (plus de 30 personnes), le Japon (une quinzaine), le Brésil (6 personnes), le Canada. Du côté européen, hors l'Italie, les pays les mieux représentés étaient l'Espagne (10), la Grande Bretagne, la Norvège et le Portugal. La France comptait 3 participants. Quatre pays totalisent les 2/3 des présentations scientifiques: l'Italie, le Japon, l'Espagne et les Etats-Unis. Mais au total, 19 pays présentent des papiers sur les 22 enregistrés. Le programme du congrès était réparti en 6 thèmes: - Fonction et écologie des récifs - Conception et planification - Substrats artificiels - Des plates-formes pétrolières aux récifs artificiels - Aquaculture, dispositifs concentrateurs de poissons (Dep) et pêches - Suivi, restauration de milieux et évaluation En fait, en dehors de la session sur le recyclage des plates formes pétrolières en récifs artificiels, de nombreuses présentations touchaient à plusieurs thèmes à la fois. Pour en simplifier la synthèse, les thèmes ont été regroupés en trois grands domaine de réflexion et d'étude: 1. Ecologie récifale 2.Conception: matériaux, structures, disposition 3. Aménagement: relations avec la pêche, l'aquaculture et le tourisme

Droits : 1999 Ifremer
http://archimer.ifremer.fr/doc/00142/25307/23379.pdf
http://archimer.ifremer.fr/doc/00142/25307/

Éditeur(s) : Port-au-Prince, 1902 Port-au-Prince, 1902
Résumé : 4-tr-Holly
HLL Dep. 76a 131.7

LLMC31875

Éditeur(s) : Port-au-Prince [1906?]-1914 Port-au-Prince [1906?]-1914
Résumé : 2b-L/E- 1906-14
HLL Dep HAI 497 F06

LLMC31886

Éditeur(s) : Port-au-Prince [1906?]-1914 Port-au-Prince [1906?]-1914
Résumé : 2b-L/E- 1906-14
HLL Dep HAI 497 F06

LLMC31886

Éditeur(s) : HAL CCSD American Chemical Society
Résumé : International audience
Semivolatile organic compounds (SVOCs) are ubiquitous contaminants in indoor environments, emanating from different sources and partitioning among several compartments, including the gas phase, airborne particles, and settled dust. Nevertheless, simultaneous measurements in the three compartments are rarely reported. In this study, we investigated indoor concentrations of a wide range of SVOCs in 30 French dwellings. In settled dust, 40 out of 57 target compounds were detected. The highest median concentrations were measured for phthalates and to a lesser extent for bisphenol A, synthetic musks, some pesticides, and PAHs. Di(2-ethylhexyl)phthalate (DEHP) and diisononyl phthalate (DINP) were the most abundant compounds. A total of 34 target compounds were detected both in the gas phase and airborne particles. The highest concentrations were measured for diisobutyl phthalate (DiBP), diethyl phthalate (DEP), dibutyl phthalate (DBP), and synthetic musks in the gas phase and for DEHP, DiBP, DBP, and DINP in the airborne particles. This is the first study on the indoor concentrations of a wide range of SVOCs in settled dust, gas phase, and airborne particles collected simultaneously in each dwelling.
ISSN: 0013-936X

hal-01118577
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01118577
PUBMED : 24588211
DOI : 10.1021/es405269q

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Because territoriality is energetically costly, territorial animals frequently respond less aggressively toneighbours than to strangers, a reaction known as the "dear enemy phenomenon" (DEP). The contrary,the "nasty neighbour effect" (NNE), occurs mainly for group-living species defending resource-basedterritories. We studied the relationships between supercolonies of the pest fire ant Solenopsis saevissimaand eight ant species able to live in the vicinity of its nests plus Eciton burchellii, an army ant predatorof other ants. The workers from all of the eight ant species behaved submissively when confrontedwith S. saevissima (dominant) individuals, whereas the contrary was never true. Yet, S. saevissima weresubmissive towards E. burchellii workers. Both DEP and NNE were observed for the eight ant species, withsubmissive behaviours less frequent in the case of DEP. To distinguish what is due to chemical cues fromwhat can be attributed to behaviour, we extracted cuticular compounds from all of the nine ant speciescompared and transferred them onto a number of S. saevissima workers that were then confronted withuntreated conspecifics. The cuticular compounds from three species, particularly E. burchellii, triggeredgreater aggressiveness by S. saevissima workers, while those from the other species did not.
ISSN: 0376-6357

hal-00913344
https://hal.archives-ouvertes.fr/hal-00913344
https://hal.archives-ouvertes.fr/hal-00913344/document
https://hal.archives-ouvertes.fr/hal-00913344/file/roux_10206.pdf
DOI : 10.1016/j.beproc.2013.04.014