Éditeur(s) : HAL CCSD Lippincott, Williams & Wilkins
Résumé : International audience
ISSN: 1044-3983

hal-00875980
https://hal.archives-ouvertes.fr/hal-00875980
DOI : 10.1097/EDE.0b013e318246073e
PUBMED : 22317818

Éditeur(s) : HAL CCSD Springer Verlag
Résumé : International audience
Bone Morphogenetic Protein 9 (BMP9) has been recently found to be the physiological ligand for the activin receptor-like kinase 1 (ALK1), and to be a major circulating vascular quiescence factor. Moreover, a soluble chimeric ALK1 protein (ALK1-Fc) has recently been developed and showed powerful anti-tumor growth and anti-angiogenic effects. However, not much is known concerning BMP9. This prompted us to investigate the human endogenous sources of this cytokine and to further characterize its circulating form(s) and its function. Analysis of BMP9 expression reveals that BMP9 is produced by hepatocytes and intrahepatic biliary epithelial cells. Gel filtration analysis combined with ELISA and biological assays demonstrate that BMP9 circulates in plasma (1) as an unprocessed inactive form that can be further activated by furin a serine endoprotease, and (2) as a mature and fully active form (composed of the mature form associated with its prodomain). Analysis of BMP9 circulating levels during mouse development demonstrates that BMP9 peaks during the first 3 weeks after birth and then decreases to 2 ng/mL in adulthood. We also show that circulating BMP9 physiologically induces a constitutive Smad1/5/8 phosphorylation in endothelial cells. Taken together, our results argue for the role of BMP9 as a hepatocyte-derived factor, circulating in inactive (40%) and active (60%) forms, the latter constantly activating endothelial cells to maintain them in a resting state.
ISSN: 1420-682X

hal-00681969
https://hal.archives-ouvertes.fr/hal-00681969
DOI : 10.1007/s00018-011-0751-1
PUBMED : 21710321

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Background: While it is known that cancer risk is related to area-level socioeconomic status, the extent to which these inequalities are explained by contextual effects is poorly documented especially for head and neck cancer. Methods: A case-control study, ICARE, included 2415 head and neck cancer cases and 3555 controls recruited between 2001 and 2007 from 10 French regions retrieved from a general cancer registry. Individual socioeconomic status was assessed using marital status, highest educational level and occupational social class. Area-level socioeconomic status was assessed using the French version of the European Deprivation Index (EDI). The relationship between both individual and area-based socioeconomic level and the risk of head and neck cancer was assessed by multilevel analyses. Results: A higher risk for head and neck cancer was found in divorced compared with married individuals (OR = 2.14, 95% CI = 1.78-2.57), for individuals with a basic school-leaving qualification compared with those with higher education (OR = 4.55 95% CI = 3.72-5.57), for manual workers compared with managers (OR = 4.91, 95% CI = 3.92-6.15) and for individuals living in the most deprived areas compared with those living in the most affluent ones (OR = 1.98, 95% CI = 1.64-2.41). The influence of area-level socioeconomic status measured by EDI remained after controlling for individual socioeconomic characteristics (OR = 1.51; 95% confidence interval: 1.23-1.85, p-value = 0.0003). Conclusions: The role of individual socioeconomic status in the risk of head and neck cancer is undeniable, although contextual effects of deprived areas also increase the susceptibility of individuals developing the disease. (C) 2017 Elsevier Ltd. All rights reserved.
ISSN: 1368-8375

hal-01578588
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01578588
DOI : 10.1016/j.oraloncology.2017.06.014
PUBMED : 28688682

Éditeur(s) : HAL CCSD
Résumé : International audience
Metamorphic soles correspond to m to 500m thick tectonic slices welded beneath most of the large-scale ophiolites.They typically show a steep inverted metamorphic structure where the pressure and temperature conditions ofcrystallization increase upward (from 500100ºC at 0.50.2 GPa to 800100ºC at 1.00.2 GPa), with isogradssubparallel to the contact with the overlying ophiolitic peridotite. The proportion of mafic rocks in metamorphicsoles also increases from the bottom (meta-sediments rich) to the top (approaching the ophiolite peridotites). Thesesoles are interpreted as the result of heat transfer from the incipient mantle wedge toward the nascent slab (associatedwith large-scale fluid transfer and possible shear heating) during the first My of intra-oceanic subduction(as indicated by radiometric ages). Metamorphic soles provide therefore major constraints on early subductiondynamics (i.e. thermal structure, fluid migration and rheology along the nascent slab interface).We present a detailed structural and petrological study of the metamorphic sole from 4 major cross-sections alongthe Oman ophiolite. We show precise pressure–temperature estimates obtained by pseudosection modelling andEBSD measurements performed on both the garnet-bearing and garnet-free high-grade sole. Results allow quantificationof the micro-scale deformation and highlight differences in pressure–temperature–deformation conditionsbetween the 4 different locations, showing that the inverted metamorphic gradient through the sole is not continuousin all locations.Based on these new constraints, we suggest a new tectonic–petrological model for the formation of metamorphicsoles below ophiolites. This model involves the stacking of several homogeneous slivers of oceanic crust leadingto the present-day structure of the sole. In this view, these thrusts are the result of rheological contrasts between thesole and the peridotite as the plate interface progressively cools down. These slivers later underwent several stagesof retrogression (partly mediated by ascending fluids from the slab) from amphibolite- to prehnite/pumpellite-faciesconditions.
Geophysical Research Abstracts
Vienne, Austria

insu-01309369
https://hal-insu.archives-ouvertes.fr/insu-01309369

Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : 14 pages
International audience
Central Africa hosts the world's second largest tropical forest after the Amazonian basin. However, as compared to its Amazonian counterpart, the Central Africa forests receive much less rain (∼1500 mm/year in mean spread over two rainy seasons in March-May and September-November, and two dry seasons). They also experience a slower deforestation rate, so that the main threat for the next decades might come from climate variations. Nonetheless, their response to the annual cycle of solar radiation and rainfall/clouds is still poorly known. Analysing high resolution remote sensing data of Enhanced Vegetation Index, rainfall, cloudiness, and solar radiation for a target region located between 0 and 5°N and 12–19°E, we explore the climatic drivers of the forests greenness mean annual cycle. Three main points emerge; first, the diurnal cycle is a key-scale for understanding the mean annual cycles of rainfall and incoming solar radiation at surface, then how climate shapes the greenness mean annual evolution; second, neither the two dry seasons nor the two rainy seasons resemble each other in terms of cloud cover, solar radiation and rainfall, and their links with greenness levels; third, whereas the first rainy season (March-May) appears optimal for greenness especially because of favorable light conditions, water availability is the main controlling factor during the main dry season and at the start of the first vegetative season (February). Regarding the little dry season (mid-June-mid-August) and the second rainy season (September-October), light availability might be the main limiting factor. These findings pave the way for further studies of the climate interannual variability and change impacts on the Central Africa forests, taking into account time-scale interactions.
ISSN: 0168-1923

hal-01309565
https://hal.archives-ouvertes.fr/hal-01309565
DOI : 10.1016/j.agrformet.2016.04.005

Éditeur(s) : HAL CCSD
Résumé : International audience
The Heliosat-II method was developed to process Meteosat satellite images in order to assess the solar irradiation at surface. It is modified for its use with GOES satellite images in order to estimate the solar irradiation over French Guiana.Modifications include a change in the calibration formula, in the calculation of the cloud albedo, and in the values of the Linke turbidity factor. These modifications allow the improvement of the performances of the Heliosat-II model in Intertropical zones in French Guiana. The outcomes were compared to coincident measurements of hourly irradiation performed by ground stations.The results show that the use of the maximum apparent albedo as the cloud albedo (ρcmax), along with a fixed value of the Linke turbidity factor produces the best results; the bias was less than 23.61 Wh/m2 (5% of the mean value of the measurements) overall, and the RMSE was less than 109.39 W/m2 (24%) overall when using hourly values. In the case of daily means, the RMSE drops to less than 10.08 W/m2 (10%) overall, whereas the overall bias remains unchanged, as expected. The model performs better in clear skies than in cloudy skies. The results suggest that the Linke turbidity factor used in the Heliosat-II method does not reproduce well the attenuation of the solar radiation in French Guiana. The results were compared to those obtained from Heliosat II method and Meteosat images (HelioClim-3 database) and we found a better accuracy for GOES satellite data, which exhibits smaller viewing angle. The use of the Heliosat II method with GOES images allows assessment of the SSI with a good accuracy and high temporal and spatial resolutions.
Canadian Journal of Remote Sensing

meteo-01304576
https://hal-meteofrance.archives-ouvertes.fr/meteo-01304576
DOI : 10.1080/07038992.2015.1040876

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
ISSN: 0014-2956

hal-01680530
https://hal.univ-antilles.fr/hal-01680530
DOI : 10.1111/j.1432-1033.2004.04156.x

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
Most kimberlites contain abundant dunitic nodules. These are centimetre-sized, rounded and multi-grained assemblages of xenocrystic olivine with a wide range of compositions (Fo83 to Fo94). The absence of orthopyroxene and other mantle minerals and the range of olivine compositions have been attributed to reaction between mantle peridotite and (proto)kimberlitic fluid or melt, but the timing of the reaction is a subject of debate. In a kimberlite from the Kangamiut region of Greenland, nodule cores are surrounded by fine-grained outer margins with near-constant Fo contents (∼Fo88) but highly variable minor element contents (e.g. 500–2500 ppm Ni). These margins crystallized from the kimberlite melt and we show that their compositions can be explained by crystallization of olivine alone, if a high partition coefficient for Ni between melt and olivine (DNi > 20) is assumed. Orthopyroxene assimilation is not required, removing the constraint that its dissolution occurred during ascent of the kimberlite magma. Within some nodules, in addition to the usual core-to-margin gradients, we observe asymmetric compositional changes (variable Fo but near-constant minor element contents) across mobile grain boundaries. These changes document fluid percolation at the grain scale that occurred during dynamic recrystallization in the deforming lithospheric mantle. We note that chemical gradients associated with mobile grain boundaries are observed in olivines that cover the entire compositional range of the nodules, and propose that fluid-assisted dynamic recrystallization took place in dunite that was already compositionally heterogeneous. Reaction between peridotite and protokimberlitic melt or fluid and dissolution of orthopyroxene thus occurred within the lithospheric mantle, immediately (a few days) prior to the ascent of the kimberlite melt and the entrainment of the dunite nodules. We propose that the grain boundary zones probably mimic, at a fine scale, the fluid–peridotite interaction that caused, at a larger scale, orthopyroxene dissolution and formation of compositionally diverse olivine in kimberlites.
ISSN: 0022-3530

hal-01277963
https://hal.archives-ouvertes.fr/hal-01277963
DOI : 10.1093/petrology/egv054

Éditeur(s) : HAL CCSD
Résumé : National audience
Epidemiological researches in the field of DOHaD are in favor of a role of early environment, including chemical (pesticides), physical (air pollution), nutritional or psychosocial environment, on child and adult health. Disentangling the different factors of environment that may affect health, especially over time, and identifying critical periods of exposure remains a major challenge. The biological mechanisms involved remain elusive in human beings. Nevertheless, it seems that whatever the nature of the exposure, epigenetic mechanisms are currently discussed to explain how the environment may alter biological systems over time.
Les résultats épidémiologiques dans le domaine de la DOHaD (developmental origins of health and disease) sont en faveur d’un rôle de l’environnement précoce sur la santé immédiate mais aussi future, qu’il s’agisse de l’environnement physique, chimique, nutritionnel ou encore psychosocial. Faire la part des différents facteurs de l’environnement susceptibles de modifier la santé, notamment sur le long terme, et des périodes critiques d’exposition reste un enjeu majeur. De même, les multiples mécanismes biologiques impliqués restent encore, pour une grande part, à identifier chez l’homme. Il semble néanmoins que, quelle que soit la nature de l’exposition considérée, des mécanismes épigénétiques sont actuellement évoqués pour expliquer comment l’environnement est susceptible de modifier des systèmes biologiques sur le long terme.
Médecine Sciences: M/S

hal-01274219
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01274219
DOI : 10.1051/medsci/20163201005
PUBMED : 26850603

Éditeur(s) : HAL CCSD Elsevier
Résumé : Field isolates of Toxoplasma gondii in Europe and North America have been grouped into three clonal lineages that display different virulence in mice. Whether the genetic structure of the parasite is related to clinical expression in humans has not yet been demonstrated. We developed an enzyme-linked immunosorbent assay which uses lineage-specific, polymorphic polypeptides derived from the dense granule antigens, GRA5 and GRA6. Our goal was to compare serotypical patterns observed in asymptomatic versus symptomatic (ocular disease and severe infection in human immunodeficiency virus (HIV)-positive patients) infections among patients from Europe and South America. Independent of the clinical presentation of the disease, serotypes differed according to geographical origin, with a homogeneous distribution of serotype II in Europe and of serotypes I and III in South America. We conclude that GRA5-GRA6 serotyping is an interesting tool to study serotype prevalence in populations but it is not an accurate marker of pathogenicity of Toxoplasma infection in humans.
ISSN: 1286-4579

hal-00306841
https://hal.archives-ouvertes.fr/hal-00306841
DOI : 10.1016/j.micinf.2008.04.001
PUBMED : 18539501

Éditeur(s) : HAL CCSD American Society for Microbiology
Résumé : International audience
Toxoplasmosis is a life-threatening infection in immunocompromised patients (ICPs). The definite diagnosis relies on parasite DNA detection, but the incidence and burden of disease are ill-known in HIV-negative patients. A three-year retrospective study was conducted in 15 reference laboratories from the network of the French National Reference Center for Toxoplasmosis, to record the frequency of Toxoplasma DNA detection in ICPs, to review the molecular methods used for diagnosis and the prevention measures implemented in transplant patients. During the study period, out of 31,640 PCR performed in ICPs, 610 were positive (323 patients). Blood (n=337), cerebrospinal fluid (n=101) and aqueous humor (n=100) samples were more frequently positive. Chemoprophylaxis schemes in transplant patients differed between centers. PCR follow-up of allogeneic hematopoietic stem-cell transplant (allo-HSCT) patients was implemented in 8/15 centers. Data from 180 patients (13 centers) were further analyzed regarding clinical setting and outcome. Only 68/180 (38%) patients were HIV+; the remaining 62% consisted in 72 HSCT, 14 solid-organ transplants, and 26 miscellaneous immunodeficiencies. Cerebral toxoplasmosis and disseminated toxoplasmosis were most frequently observed in HIV and transplant patients, respectively. Of 72 allo-HSCT patients with a positive PCR, 23 were asymptomatic; all were diagnosed in centers performing systematic blood PCR follow-up, and received specific treatment. Overall survival of allo-HSCT patients at two months was better in centers with PCR follow-up than in other centers (p<0.01). This study provides updated data on the frequency of toxoplasmosis in HIV-negative ICPs and suggests that regular PCR follow-up of allo-HSCT patients could guide pre-emptive treatment and improve outcome.
ISSN: 0095-1137

hal-01134189
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01134189
DOI : 10.1128/JCM.03282-14
PUBMED : 25762774

Éditeur(s) : HAL CCSD
Résumé : International audience
Understanding subduction rheology in both space and time has been a challenge since the advent of plate tectonics.We herein focus on "subduction infancy", which corresponds to the first 0-2 My immediately following subductionnucleation, when a newly born slab penetrates into the overriding plate mantle and heats up.The only remnants of this critical, yet elusive, geodynamic step are thin metamorphic soles, commonly found beneathpristine, 100-1000 km long portions of oceanic lithosphere emplaced on top of continents (i.e. ophiolites).In this study, we show how, during subduction infancy, transient mechanical properties of both the mantle and crustacross the subduction plate interface (during 100s ky) control and hinder the penetration of tectonic plates intothe mantle, and how this results in strong peaks of resistance and even slicing of their surface — leaving behindthin, chopped-off metamorphic slivers (i.e. metamorphic soles).These findings constrain the mechanical behaviour of the subduction plate interface (with implications for couplingprocesses and earthquake generation) as well as the properties of the crust and mantle. They also highlight the roleof fluids in enabling subduction to overcome this early resistance.
Geophysical Research Abstracts
Vienne, Austria

insu-01309386
https://hal-insu.archives-ouvertes.fr/insu-01309386

Éditeur(s) : HAL CCSD Copernicus Publications on behalf of the European Geosciences Union
Résumé : International audience
During the GWADASEIS cruise (Lesser Antilles volcanic arc, February–March 2009) a very high resolution (VHR) seismic-reflection survey was performed in order to constrain Late Quaternary to Present faulting. The profiles we obtained evidence frequent " ponding " of reworked sediments in the deepest areas, similar to the deposition of Mediterranean " homogenites ". These bodies are acoustically transparent (few ms t.w.t. thick) and are often deposited on the hanging walls of dominantly normal faults, at the base of scarps. Their thickness appears sufficient to compensate (i.e. bury) co-seismic scarps between successive earthquakes, resulting in a flat and horizontal sea floor through time. In a selected area (offshore Montserrat and Nevis islands), piston coring (4 to 7 m long) was dedicated to a sedimento-logical analysis of the most recent of these particular layers. It corresponds to non-stratified homogenous calcareous silty sand (reworked calcareous plankton and minor volcanoclas-tics). This layer can be up to 2 m thick, and overlies fine-grained hemipelagites. The upper centimeters of the latter represent the normal RedOx water/sediment interface. 210 Pb and 137 Cs activities lack in the massive sands, while a normal profile of unsupported 210 Pb decrease is observed in the hemipelagite below, together with a 137 Cs peak corresponding to the Atmospheric Nuclear Experiments (1962). The RedOx level was thus capped by a recent instantaneous major sedimentary event considered as post-1970 AD; candidate seismic events to explain this sedimentary deposits are either the 16 March 1985 earthquake or the 8 October 1974 one (M w = 6.3 and M w = 7.4, respectively). This leads to consider that the syntectonic sedimentation in this area is not continuous but results from accumulation of thick homogen-ites deposited after the earthquakes (as observed in the following weeks after Haiti January 2010 event, McHugh et al., 2011). The existence of such deposits suggests that, in the area of study, vertical throw likely results from cu-mulated effects of separated earthquakes rather than from aseismic creep. Examination of VHR profiles shows that all major co-seismic offsets are recorded in the fault growth sequence and that co-seismic offsets can be precisely estimated. By using a sedimentation rate deduced from 210 Pb decrease curve (0.5 mm yr −1) and taking into account minor reworking events detected in cores, we show that the Redonda system may have been responsible for five > M 6 events during the last 34 000 yr. The approach presented in this work differs from fault activity analyses using displaced sets of isochronous surfaces and postulating co-seismic offsets. Combining VHR seismic imagery and coring we can decipher co-seismic vs. slow continuous displacement, and thus actually estimate the amplitude and the time distribution of major co-seismic offsets.
Natural Hazards and Earth System Science

insu-01585969
https://hal-insu.archives-ouvertes.fr/insu-01585969
https://hal-insu.archives-ouvertes.fr/insu-01585969/document
https://hal-insu.archives-ouvertes.fr/insu-01585969/file/nhess-12-1755-2012-beck.pdf
DOI : 10.5194/nhess-12-1755-2012

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
No major earthquake occurred in North Chile since the 1877 Mw 8.6 subduction earthquake that produced a huge tsunami. However, geodetic measurements conducted over the last decade in this area show that the upper plate is actually deforming, which reveals some degree of locking on the subduction interface. This accumulation of elastic deformation is likely to be released in a future earthquake. Because of the long elapsed time since 1877 and the rapid accumulation of deformation (thought to be 6-7 cm yr−1), many consider this area is a mature seismic gap where a major earthquake is due and seismic hazard is high. We present a new Global Positioning System (GPS) velocity field, acquired between 2008 and 2012, that describes in some detail the interseismic deformation between 18°S and 24°S. We invert for coupling distribution on the Nazca-South America subduction interface using elastic modelling. Our measurements require that, at these latitudes, 10 to 12 mm yr−1 (i.e. 15 per cent of the whole convergence rate) are accommodated by the clockwise rotation of an Andean block bounded to the East by the subandean fold-and-thrust belt. This reduces the accumulation rate on the subduction interface to 56 mm yr−1 in this area. Coupling variations on the subduction interface both along-strike and along-dip are described. We find that the North Chile seismic gap is segmented in at least two highly locked segments bounded by narrow areas of weak coupling. This coupling segmentation is consistent with our knowledge of the historical ruptures and of the instrumental seismicity of the region. Intersegment zones (Iquique, Mejillones) correlate with high background seismic rate and local tectonic complexities on the upper or downgoing plates. The rupture of either the Paranal or the Loa segment alone could easily produce a Mw 8.0-8.3 rupture, and we propose that the Loa segment (from 22.5°S to 20.8°S) may be the one that ruptured in 1877.
ISSN: 0956-540X

hal-00941279
https://hal.archives-ouvertes.fr/hal-00941279
DOI : 10.1093/gji/ggt183

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
Moore proposes in his Comment (Moore, 2017) that marginal zones in olivine grains in kimberlites (Fig. 1a) are produced by crystallization from kimberlite melt. He suggests that the chemical zones observed in these marginal zones (inner transition zones and outer margins, illustrated in his fig. 1) result from abrupt changes in distribution coefficients during crystallization. He proposes that the transition zones, characterized by variable Fo at constant and high Ni contents, are produced by crystallization with high KdFe–Mg (= 0·45) and low DNi (= 4) whereas the margins, characterized by a sharp drop in Ni content at nearly constant Fo (Fig. 1b), are produced by crystallization with higher DNi owing to a sudden change in physical conditions of crystallization (P,...
ISSN: 0022-3530

hal-01685633
https://hal.archives-ouvertes.fr/hal-01685633
DOI : 10.1093/petrology/egx013

Éditeur(s) : HAL CCSD
Résumé : International audience
Metamorphic soles correspond to m to 500 m thick highly strained metamorphic rock units found beneath myloniticbanded peridotites at the base of large-scale ophiolites, as exemplified in Oman. Metamorphic soles aremainly composed of metabasalts deriving from the downgoing oceanic lithosphere and metamorphosed up togranulite-facies conditions by heat transfer from the mantle wedge. Pressure–temperature peak conditions areusually estimated at 1.00.2 GPa and 800100ºC. The absence of HP–LT metamorphism overprint implies thatmetamorphic soles have been formed and exhumed during subduction infancy. In this view, metamorphic soleswere strongly deformed during their accretion to the mantle wedge (corresponding, now, to the base of the ophiolite).Therefore, metamorphic soles and banded peridotites are direct witnesses of the dynamics of early subductionzones, in terms of thermal structure, fluid migration and rheology evolution across the nascent slab interface.Based on fieldwork and EBSD analyses, we present a detailed (micro–) structural study performed on samplescoming from the Sumeini window, the better-preserved cross-section of the metamorphic sole of Oman. Largedifferences are found in the deformation (CPO, grain size, aspect ratio) of clinopyroxene, amphibole and plagioclase,related to mineralogical changes linked with the distance to the peridotite contact (e.g., hardening due to theappearance of garnet and clinopyroxene).To model the incipient slab interface in laboratory, we carried out 5 hydrostatic annealing and simple-shear experimentson Griggs solid-medium apparatus. Deformation experiments were conducted at axial strain rates of 10-6s-1. Fine-grained amphibolite was synthetized by adding 1 wt.% water to a (Mid-Ocean Ridge) basalt powder asa proxy for the metamorphic sole (amphibole + plagioclase + clinopyroxene garnet assemblage). To synthetizegarnet, 2 experiments were carried out in hydrostatic conditions and with deformation at 800C with confiningpressure of 2 GPa. Another simple-shear experiment has been carried out at 800C and 1 GPa with fined-grainednatural garnet. With the aim of mimicking the early slab interface (between the metamorphic sole and bandedperidotites at the base of the ophiolite), 2 simple-shear deformation experiments with 2 layers have been carriedout at 800C and confining pressure of 1 GPa. The bottom layer was made of hydrated basalt powder and the toplayer was made of olivine.Fined-grained garnet-free amphibolite is significantly weaker than dunite but the appearance of harder mineralsin the amphibolite (garnet and clinopyroxene) has major implications on its rheological evolution. These resultsallow liking field observations of strain localization at the interface to the metamorphic sole formation
European Geosciences Union General Assembly 2016
Vienne, Austria

insu-01309394
https://hal-insu.archives-ouvertes.fr/insu-01309394

Éditeur(s) : HAL CCSD American College of Physicians
Résumé : International audience
BACKGROUND: Most clinical guidelines recommend that AIDS-free, HIV-infected persons with CD4 cell counts below 0.350 × 10(9) cells/L initiate combined antiretroviral therapy (cART), but the optimal CD4 cell count at which cART should be initiated remains a matter of debate. OBJECTIVE: To identify the optimal CD4 cell count at which cART should be initiated. DESIGN: Prospective observational data from the HIV-CAUSAL Collaboration and dynamic marginal structural models were used to compare cART initiation strategies for CD4 thresholds between 0.200 and 0.500 × 10(9) cells/L. SETTING: HIV clinics in Europe and the Veterans Health Administration system in the United States. PATIENTS: 20, 971 HIV-infected, therapy-naive persons with baseline CD4 cell counts at or above 0.500 × 10(9) cells/L and no previous AIDS-defining illnesses, of whom 8392 had a CD4 cell count that decreased into the range of 0.200 to 0.499 × 10(9) cells/L and were included in the analysis. MEASUREMENTS: Hazard ratios and survival proportions for all-cause mortality and a combined end point of AIDS-defining illness or death. RESULTS: Compared with initiating cART at the CD4 cell count threshold of 0.500 × 10(9) cells/L, the mortality hazard ratio was 1.01 (95% CI, 0.84 to 1.22) for the 0.350 threshold and 1.20 (CI, 0.97 to 1.48) for the 0.200 threshold. The corresponding hazard ratios were 1.38 (CI, 1.23 to 1.56) and 1.90 (CI, 1.67 to 2.15), respectively, for the combined end point of AIDS-defining illness or death. Limitations: CD4 cell count at cART initiation was not randomized. Residual confounding may exist. CONCLUSION: Initiation of cART at a threshold CD4 count of 0.500 × 10(9) cells/L increases AIDS-free survival. However, mortality did not vary substantially with the use of CD4 thresholds between 0.300 and 0.500 × 10(9) cells/L.
ISSN: 0003-4819

hal-00875307
https://hal.archives-ouvertes.fr/hal-00875307
PUBMED : 21502648
DOI : 10.7326/0003-4819-154-8-201104190-00001

Éditeur(s) : HAL CCSD
Résumé : International audience
Understanding subduction rheology in both space and time has been a challenge since the advent of plate tectonics. We herein focus on "subduction infancy", that is the first ~1-5 My immediately following subduction nucleation, when a newly born slab penetrates into the upper plate mantle and heats up. The only remnants of this critical yet elusive geodynamic step are thin metamorphic soles, commonly found beneath pristine, 100-1000 km long portions of oceanic lithosphere emplaced on continents (i.e., ophiolites).Through the (i) worldwide compilation of pressure-temperature conditions of metamorphic sole formation augmented by pseudosection thermodynamic modeling, (ii) calculations of the viscosity of materials along the plate interface and (iii) generic numerical thermal models, we provide a conceptual model of dynamic plate interface processes during subduction infancy (and initiation s.l.).We show in particular how major rheological switches across the subduction interface control slab penetration, and the formation of metamorphic soles. Due to the downward progression of hydration and weakening of the mantle wedge with cooling, the lower plate (basalt, sediment) and the upper plate (mantle wedge) rheologies equalize and switch over a restricted temperature-time-depth interval (e.g., at ~800°C and ~1 GPa, during 0.1-2 My, for high-temperature metamorphic sole formation). These switches result in episodes of maximum interplate mechanical coupling, thereby slicing the top of the slab and welding pieces (basalt, sediment) to the base of the mantle wedge. Similar mechanical processes likely apply for the later, deeper accretion and exhumation of high-temperature oceanic eclogites in serpentinite mélanges, or for the accretion of larger tectonic slices.This model provides constraints on the effective rheologies of the crust and mantle and general understanding, at both rock and plate scale, for accretion processes and early slab dynamics.
AGU Fall Meeting 2015
San Francisco, United States

insu-01242103
https://hal-insu.archives-ouvertes.fr/insu-01242103

Éditeur(s) : HAL CCSD Lippincott, Williams & Wilkins
Résumé : PURPOSE OF REVIEW: Malaria represents one of the most important selective factors affecting human populations. Several inherited diseases of red blood cells lead to resistance at the erythrocytic stage. Among patients who experience hereditary elliptocytosis related to mutations of erythrocyte membrane proteins, molecular studies have shown the prevalence of particular spectrin mutations in patients from black ethnic extraction, leading one to question the selection of new malaria-resistant genes. RECENT FINDINGS: Prospective epidemiological and molecular studies in West Africa have confirmed the prevalence (between 0.6 and 1.6%) of particular spectrin mutations related to hereditary elliptocytosis. These studies have also revealed the frequency of alpha-spectrin chain polymorphisms, associated in cis with elliptocytogenic spectrin mutations and defining particular spectrin allele haplotypes. Culture studies of Plasmodium falciparum in elliptocytes bearing such elliptocytogenic alleles of spectrin showed that these alleles are supplementary genetic factors of malaria resistance in vitro. SUMMARY: Certain instances of spectrin mutations or polymorphisms have not yet been shown to constitute new factors of innate resistance to malaria in vivo. Epidemiological surveys of hereditary elliptocytosis and parasite culture studies, however, have argued that the relationships between parasite and spectrin-based skeleton should be examined more closely and the molecular interactions between parasite ligands and particular spectrin chain domains should be characterized.
ISSN: 1065-6251

inserm-00128119
http://www.hal.inserm.fr/inserm-00128119
http://www.hal.inserm.fr/inserm-00128119/document
http://www.hal.inserm.fr/inserm-00128119/file/Dhermy_et_al_figures.pdf
DOI : 10.1097/MOH.0b013e3280d21afd

Éditeur(s) : HAL CCSD European Geosciences Union
Résumé : International audience
The seasonal climate drivers of the carbon cycle in tropical forests remain poorly known, although these forests account for more carbon assimilation and storage than any other terrestrial ecosystem. Based on a unique combination of seasonal pan-tropical data sets from 89 experimental sites (68 include aboveground wood productivity measurements and 35 litter productivity measurements), their associated canopy photosynthetic capacity (enhanced vegetation index, EVI) and climate, we ask how carbon assimilation and aboveground allocation are related to climate seasonality in tropical forests and how they interact in the seasonal carbon cycle. We found that canopy photosynthetic capacity seasonality responds positively to precipitation when rainfall is < 2000 mm yr(-1) (water-limited forests) and to radiation otherwise (light-limited forests). On the other hand, independent of climate limitations, wood productivity and litterfall are driven by seasonal variation in precipitation and evapotranspiration, respectively. Consequently, light-limited forests present an asynchronism between canopy photosynthetic capacity and wood productivity. First-order control by precipitation likely indicates a decrease in tropical forest productivity in a drier climate in water-limited forest, and in current light-limited forest with future rainfall < 2000 mm yr(-1).
ISSN: 1726-4170

hal-01557759
https://hal.univ-lorraine.fr/hal-01557759
https://hal.univ-lorraine.fr/hal-01557759/document
https://hal.univ-lorraine.fr/hal-01557759/file/bg-13-2537-2016.pdf
DOI : 10.5194/bg-13-2537-2016