Éditeur(s) : HAL CCSD
Résumé : International audience
Background. In a French large population-based case-control study we investigated the dose-response relationship between lung cancer and occupational exposure to diesel motor exhaust (DME), taking into account asbestos exposure. Methods. Exposure to DME was assessed by questionnaire. Asbestos was taken into account through a global indicator of exposure to occupational carcinogens or by a specific JEM. Results. We found a crude dose response relationship with most of the indicators of DME exposure, including with the cumulative exposure index. All results were affected by adjustment for asbestos exposure. The dose response relationships between DME and lung cancer were observed among subjects never exposed to asbestos. Conclusions. Exposure to DME and to asbestos is frequently found among the same subjects, which may explain why dose-response relationships in previous studies that adjusted for asbestos exposure were inconsistent.
Journal of Cancer Epidemiology

hal-01205352
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01205352
DOI : 10.1155/2015/879302
PUBMED : 26425123

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
ISSN: 0007-1048

hal-01679026
https://hal.univ-antilles.fr/hal-01679026
DOI : 10.1111/bjh.14693

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
Growth charts are an essential clinical tool for evaluating a child's health and development. The current French reference curves, published in 1979, have recently been challenged by the 2006 World Health Organization (WHO) growth charts. To evaluate and compare the growth of French children who were born between 1981 and 2007, with the WHO growth charts and the French reference curves currently used. Anthropometric measurements from French children, who participated in 12 studies, were analyzed: 82,151 measurements were available for 27,257 children in different age groups, from birth to 18 years. We calculated and graphically compared mean z-scores based on the WHO and French curves, for height, weight and Body Mass Index (BMI) according to age and sex. The prevalence of overweight using the WHO, the French and International Obesity Task Force definitions were compared. Our population of children was on average 0.5 standard deviations taller than the French reference population, from the first month of life until puberty age. Mean z-scores for height, weight and BMI were closer to zero based on the WHO growth charts than on the French references from infancy until late adolescence, except during the first six months. These differences not related to breastfeeding rates. As expected, the prevalence of overweight depended on the reference used, and differences varied according to age. The WHO growth charts may be appropriate for monitoring growth of French children, as the growth patterns in our large population of French children were closer to the WHO growth charts than to the French reference curves, from 6 months onwards. However, there were some limitations in the use of these WHO growth charts, and further investigation is needed.
ISSN: 1932-6203

hal-01134193
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01134193
DOI : 10.1371/journal.pone.0120806
PUBMED : 25761138
PUBMEDCENTRAL : PMC4356547

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The lower Pleistocene Kritika Member of the Rhodes Formation is composed of predominantly siliciclastic deposits that are sometimes intercalated with hardbottoms formed by drowning of former beachrock beds. A wide variety of sclerobionts occur in this environment, very different from the poorest soft‐bottom populations occurring in other levels of the Kritika Member. The most characteristic, abundant and frequently diverse are the encrusting forms: coralline algae, bivalves, serpulid worms, and bryozoans. Numerous other groups of sessile and vagile organisms are associated with these crust‐forming communities. A number of skeletal organisms (sometimes including zooxanthellate coral colonies) formed small carbonate buildups on top of several beachrock beds. Boring organisms also occur. Evidence for a two‐step deepening succession over the previously formed beachrock is provided by palaeontological and sedimentological data. The rapidly cemented sandy‐conglomeratic beds were first colonised by a relatively shallow‐water (around 20 m) biocoenosis of mostly encrusting organisms. Another association, with encrusting and erect organisms, was later established in a deeper environment (20-40 m). A comparison with Holocene beachrock occurring on the coast of Rhodes was also undertaken. Their submerged part provided habitat for poorer but similar biotas to those occurring in the Kritika Member. The lower Pleistocene beachrock and associated organogenic fossil assemblages indicate repeated drowning episodes during deposition of the Kritika Member and provide help in sequence stratigraphic interpretations of these siliciclastic deposits. Notably, they can be used as indicators of relative sea‐level changes.
ISSN: 0031-0182

hal-00795591
https://hal.archives-ouvertes.fr/hal-00795591
DOI : 10.1016/j.palaeo.2012.09.007

Éditeur(s) : HAL CCSD
Résumé : International audience
10ème Colloque International de l’AFIRSE / 1er Colloque National de l’AFISE – Section Brésilienne, intitulé : « Hétérogénéité, Culture et Education ». Université Fédéral do Rio Grande do Norte
Rio Grande do Norte, Brazil

hal-01613696
https://hal.univ-antilles.fr/hal-01613696

Éditeur(s) : HAL CCSD
Résumé : International audience
Objective The objective of the study was to investigate the joint effect of occupational exposure to asbestos, and tobacco and alcohol consumption, on the risk of laryngeal cancer among men. Methods We used data from a large population-based case–control study conducted in France. We estimated two-way and three-way interactions between asbestos exposure (never vs ever exposed), tobacco consumption ( extless20 vs ≥20 pack-years) and alcohol consumption ( extless5 vs ≥5 drinks per day). The interaction on an additive scale was assessed by estimating the relative excess risk due to interaction (RERI) and the attributable proportion due to interaction, and the interaction on a multiplicative scale was assessed by estimating the multiplicative interaction parameter (ψ). Multiplicative interactions were also assessed using fractional polynomials for alcohol drinking, tobacco smoking and asbestos exposure. Results When compared with light-to-moderate smokers and drinkers never exposed to asbestos, the increase in laryngeal cancer risk was smallest among light-to-moderate drinkers and smokers exposed to asbestos (OR=2.23 (1.08 to 4.60)), and highest among heavy smokers and drinkers ever exposed to asbestos (OR=69.39 (35.54 to 135.5)). We found an additive joint effect between asbestos exposure and alcohol consumption (RERI=4.75 (−4.29 to 11.12)), whereas we observed a more than additive joint effect between asbestos exposure and tobacco consumption (RERI=8.50 (0.71 to 23.81)), as well as between asbestos exposure, and tobacco and alcohol consumption (RERI=26.57 (11.52 to 67.88)). However, our results did not suggest any interaction on a multiplicative scale. Conclusions Our results suggest that asbestos exposure, in combination with tobacco and alcohol exposure, accounted for a substantial number of laryngeal cancer cases. Our findings therefore highlight the need for prevention in activities, such as construction work, where exposure to asbestos-containing materials remains
Occupational and Environmental Medicine

hal-01269904
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01269904
DOI : 10.1136/oemed-2015-102954
PUBMED : 26403532

Éditeur(s) : HAL CCSD Taylor & Francis (Routledge)
Résumé : International audience
This article presents the institutional implications and ideologies in the organisation of a Sports Movement for the disabled, whether a physical or sensory handicap, and focusing particular attention on its development in France, linked with international structures. The emergence and development in France of sports organisations for the disabled is based on a different model from that introduced in England by Guttmann through the Stoke Mandeville Games. From the 1960s, both trends, one supported by physicians and the other by individuals concerned with disabilities, structured the International Movement as a contest of negotiations and competition. The objective of rehabilitating paraplegics put in place at Stoke Mandeville gradually gave way to a sport rational and the integration of all types of disability within the Movement. The desire to unite in a single organisation was the driving force of the Movement in its search for dual recognition, on the one hand, as the representative of all physical and sensory deficiencies and, on the other, by the able-bodied sports councils and, in particular, the International Olympic Committee. However, this raised a number of issues inherent to any deficiency when taking into account its specific peculiarities.
ISSN: 0952-3367

hal-01681857
https://hal.archives-ouvertes.fr/hal-01681857
DOI : 10.1080/09523367.2014.931842

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
ISSN: 0168-583X

hal-01685828
https://hal.univ-antilles.fr/hal-01685828
DOI : 10.1016/0168-583X(88)90188-7

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The present study investigated cerebral and muscle hemoglobin oxygen saturation (tissue oxygen index, TOI) in children with sickle cell anemia (SS), sickle cell hemoglobin C disease (SC) and healthy children (AA). TOI was measured by near-infrared spectroscopy (NIRS) and spectral analysis of the TOI variability was used to assess flowmotion and vasomotion. Arterial oxyhemoglobin saturation (SpO2), hemorheological and hematological parameters were also measured in SS and SC children. Both TOI were lower in SS compared to both AA and SC children, with SC exhibiting lower values than AA children. Cerebral vasomotion expressed in absolute values was enhanced in SS compared to AA and SC children. Muscle vasomotion did not differ between the three groups. Hematocrit, SpO2 and red blood cell deformability were positively associated with cerebral TOI in SS children. We demonstrated that 1) cerebral and muscle TOI were markedly decreased in SS children while the decrease of TOI was milder in SC children, 2) cerebral TOI level was associated with several biological markers in SS children only and 3) cerebral vasomotion was enhanced in SS, possibly to counterbalance the effects of chronic cerebral hypoxia.
ISSN: 1079-9796

inserm-01519106
http://www.hal.inserm.fr/inserm-01519106
http://www.hal.inserm.fr/inserm-01519106/document
http://www.hal.inserm.fr/inserm-01519106/file/2017%2C%20Charlot%20-%20Cerebral%20and%20muscle%20microvascular%20oxygenation%20in%20children%20with%20sickle%20celle%20disease.pdf
DOI : 10.1016/j.bcmd.2017.03.015

Éditeur(s) : HAL CCSD
Résumé : International audience
3ème Congrès International d’Actualité de la Recherche en Education et Formation. Université Victor Segalen Bordeaux II
Bordeaux, France

hal-01613698
https://hal.univ-antilles.fr/hal-01613698

Éditeur(s) : HAL CCSD Geological Society
Résumé : International audience
An integrated stratigraphic study was conducted on the shallow water carbonate platforms of the Guadeloupe archipelago to refine the tectonic evolution of the Lesser Antilles forearc. The carbonate platforms are now dated to the Zanclean-Calabrian interval, and their demise occurred between 1.5 and 1.07 Ma. The precise chronostratigraphy allows dating of the main extensional tectonic events since the late Miocene. An initial episode occurred during the late Miocene, related to the reactivation of inherited N130°E-trending shear zones, and led to the emergence of most parts of the forearc. Subsequently, Zanclean to early Piacenzian carbonate platforms developed in association with a general subsidence of the forearc. During the late Piacenzan, a second extensional episode occurred. At this time La Désirade underwent major uplift and emergence whereas most of the forearc remained submerged. Prior to 1.07 Ma, a third north-south extensional episode occurred and led to the final demise of the carbonate platforms. Thus the forearc was characterized by general subsidence since the early Pliocene interrupted by three main extensional episodes and related differential uplifts. This suggests that the Lesser Antilles subduction is probably erosive north of latitude 15°N since c. 5 Ma, related to aseismic ridge subduction.
ISSN: 0016-7649

hal-01053696
https://hal.archives-ouvertes.fr/hal-01053696
DOI : 10.1144/jgs2013-005

Éditeur(s) : HAL CCSD
Résumé : International audience

Background. Projections of medical demography show a decrease of number of doctors who practice in a rural setting and a low amount of general practitioners’ facilities.

Aim. To explore residents’ career choices and to determine their terms to settle in rural areas.
Methods. Qualitative study by groups interviews in five French cities with total of 33 residents. Thematic analysis was performed using the NVivo® software.
Results. Personal life strongly influenced residents’ career choices with a strong desire of free time. Residents considered working among a team rather than in a traditional group practice. They were interested by a practice in rural setting but countryside perceived as too far from urban centres and lacking of access to services. They also imagined the practice conditions as difficult and solitary. Many residents intended practicing in a “semi-rural” setting, the description of which could match with a significant part of the rural area.
Conclusion. If this declared craze for practice in “semi-rural” setting was confirmed, forecasts for some rural areas could be relativized. Public authorities’ attention should then be focused on rural areas far from urban centres and on territories characterized by lonesome medical practice.

Contexte. Les projections en termes de démographie médicale montrent une diminution du nombre de médecins exerçant en zone rurale, avec un faible nombre d’installations.
Objectif. Explorer les souhaits d’exercice des internes et recueillir leurs conditions pour exercer en zone rurale.
Méthode. Étude qualitative par entretiens collectifs dans cinq villes de France auprès de 33 internes. L’analyse thématique a été réalisée à l’aide du logiciel NVivo®.
Résultats. La vie personnelle influençait fortement les souhaits d’exercice, avec un désir de préserver du temps libre. Les internes envisageaient un exercice en équipe, au-delà de l’exercice de groupe traditionnel. Ils étaient intéressés par l’exercice en milieu rural, mais le territoire rural leur apparaissait sans accès aux services et très éloigné des pôles urbains. Ils se représentaient également des conditions d’exercice difficiles et solitaires. De nombreux internes se projetaient dans un exercice en « semi-rural », dont la description pourrait correspondre à une partie non négligeable de l’espace rural.
Conclusion. Si cet engouement déclaré pour l’exercice en semi-rural venait à se confirmer, ces projections concernant certaines zones rurales pourraient être relativisées. L’attention des pouvoirs publics devrait alors se concentrer sur les zones rurales éloignées des pôles urbains et les territoires marqués par un exercice médical solitaire prédominant.

ISSN: 0998-3953

hal-01654623
https://hal.archives-ouvertes.fr/hal-01654623
OKINA : ua16504

Éditeur(s) : HAL CCSD Taylor & Francis (Routledge)
Résumé : International audience
‘Biological identity’ is the result of interactions between the environment and the genome. These interactions, however, were not taught before 2001. In the French syllabus for 16-year-old students, two of the five sections on genetics deal with biological identity. We analysed the texts and images of the chapters relating to these two sections in the three most commonly used textbooks. The results showed that, using strategies specific to each textbook, all focused predominantly on the genetic determination of the phenotype, and on the idea of the ‘genetic code’. We then analysed the conceptions of 35 trainee Biology teachers, using their answers to a questionnaire. For most of them, psychological identity does not illustrate the notion of biological identity: the Cartesian dualism of body/ soul is very influential. The analysis of the trainee teachers' conceptions showed their poor understanding of genome/ environment interactions and of the process of epigenesis. Fortunately, since 2001, in France genome/ environment interactions have been introduced into the new Biology syllabus.
ISSN: 0021-9266

hal-01537729
https://hal.univ-antilles.fr/hal-01537729
DOI : 10.1080/00219266.2003.9655857

Éditeur(s) : HAL CCSD Société géologique de France
Résumé : Upper Carboniferous heating and melting of the middle orogenic crust associated with the emplacement of syntectonic granitoids are documented in the Upper Gneissic Unit of the Livradois area (central part of the French Massif Central). Crustal melting post-dates peak metamorphism conditions (800-625 degrees C, 10-8 kb) dated at 360 +/- 4 Ma (U-Th-Pb on monazite). The P-T evolution of the metamorphic series indicates that Barrovian metamorphism was followed by a decompression (from 10 +/- 1 kbar to 6 +/- 1 kbar) associated with either a decrease in temperature in the southern part of the series or with an increase in temperature (of about 150 degrees C) in the northern part of the series. This evolution records the first step of the exhumation of the series coeval with granitoids intrusion, of which the emplacements were dated at 315 +/- 4 and 311 +/- 18 Ma (U-Pb on zircon). The final stage of the exhumation is associated with an isobaric cooling of the whole series. Similarity of Ar-40/Ar-39 ages for biotite in the paragneisses (307-300 Ma) and K-feldspar in the granitoids (306-300 Ma) document rapid cooling for this stage. Moreover dextral reverse mylonites, at the border and the northern part of the metamorphic series indicate north-south compression coeval with the unroofing of the series. Youngest Ar-40-Ar-39 ages on K-feldspar (274.6 +/- 5 Ma) combined with normal shearing in mylonites limiting the Carboniferous Brassac-les-Mines basin document the late Carboniferous-early Permian stage of extension coeval with the upwelling of the Velay granitic dome.
EISSN: 1777-5817

hal-00617429
https://hal.archives-ouvertes.fr/hal-00617429
DOI : 10.2113/gssgfbull.182.1.5

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Demographic processes and spatial dispersal of Triatoma dimidiata, a triatomine species vector of Chagas disease, are modeled by integrodifference equations to estimate invasion capacity of this species under different ecological conditions. The application of the theory of orthogonal polynomials and the steepest descent method applied to these equations, allow a good approximation of the abundance of the adult female population and the invasion speed. We show that: (1) under the same mean conditions of demography and dispersal, periodic spatial dispersal results in an invasion speed 2.5 times larger than the invasion speed when spatial dispersal is continuous; (2) when the invasion speed of periodic spatial dispersal is correlated to adverse demographic conditions, it is 34.7% higher as compared to a periodic dispersal that is correlated to good demographic conditions. From our results we conclude, in terms of triatomine population control, that the invasive success of T. dimidiata may be most sensitive to the probability of transition from juvenile to adult stage. We discuss our main theoretical predictions in the light of observed data in different triatomines species found in the literature.
ISSN: 0022-5193

hal-01298098
https://hal-univ-perp.archives-ouvertes.fr/hal-01298098
DOI : 10.1016/j.jtbi.2016.01.017

Éditeur(s) : HAL CCSD
Résumé :   Diplôme : DEA
il s'agit d'un type de produit dont les métadonnées ne correspondent pas aux métadonnées attendues dans les autres types de produit : DISSERTATION
Mon travail de DEA a pour objectif d'analyser la variabilité structurale des couverts forestiers guyanais à partir du signal laser enregistré lors de la campagne aéroportée du BRGM en 1996 (Delor et al., 1998). On s'attachera surtout à construire une démarche méthodologique permettant de caractériser la structure spatiale du signal, afin d'évaluer la faisabilité d'une typologie des peuplements à partir de ces données. Mon travail s'intéresse donc à une caractéristique particulière des peuplements forestiers, vus par le haut : la canopée1. En faisant ce choix, nous faisons l'hypothèse implicite que la canopée apporte des informations pertinentes sur le peuplement forestier sous-jacent. Plusieurs travaux ont en effet permis de donner une signification écologique à la structure de la canopée. Birnbaum (1997) relie les différences structurales entre deux canopées de parcelles forestières à leur stade sylvigénétique ; Dosso (1990) et Paget (1999) ont également démontré que des différences de structure de canopée estimées à partir de photos aériennes pouvaient être corrélées à la structure dendrométrique et floristique du peuplement estimées au sol. Ainsi, la taille des arbres, leur organisation tridimensionnelle, mais aussi la dynamique interne du peuplement (taille et fréquence des trouées) impriment leur empreinte dans le relief de la canopée. La canopée joue également un rôle fonctionnel important dans les échanges gazeux avec l'atmosphère (émission d'O2, absorption de CO2, évapotranspiration) et l'assimilation de l'énergie lumineuse (photosynthèse). A ce titre, sa structure résulte, comme pour beaucoup d'autres surfaces biologiques, de processus biotiques d'auto-organisation.
https://hal.archives-ouvertes.fr/hal-01189532

hal-01189532
https://hal.archives-ouvertes.fr/hal-01189532
PRODINRA : 45820

Éditeur(s) : HAL CCSD
Résumé : International audience
The Chromosome-Centric Human Proteome Project (C-HPP) aims to identify "missing" proteins in the neXtProt knowledgebase. We present an in-depth proteomics analysis of the human sperm proteome to identify testis-enriched missing proteins. Using protein extraction procedures and LC-MS/MS analysis, we detected 235 proteins (PE2-PE4) for which no previous evidence of protein expression was annotated. Through LC-MS/MS and LC-PRM analysis, data mining, and immunohistochemistry, we confirmed the expression of 206 missing proteins (PE2-PE4) in line with current HPP guidelines (version 2.0). Parallel reaction monitoring acquisition and sythetic heavy labeled peptides targeted 36 ≪one-hit wonder≫ candidates selected based on prior peptide spectrum match assessment. 24 were validated with additional predicted and specifically targeted peptides. Evidence was found for 16 more missing proteins using immunohistochemistry on human testis sections. The expression pattern for some of these proteins was specific to the testis, and they could possibly be valuable markers with fertility assessment applications. Strong evidence was also found of four "uncertain" proteins (PE5); their status should be re-examined. We show how using a range of sample preparation techniques combined with MS-based analysis, expert knowledge, and complementary antibody-based techniques can produce data of interest to the community. All MS/MS data are available via ProteomeXchange under identifier PXD003947. In addition to contributing to the C-HPP, we hope these data will stimulate continued exploration of the sperm proteome. © 2016 American Chemical Society.
Journal of Proteome Research

hal-01406074
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01406074
DOI : 10.1021/acs.jproteome.6b00400
PUBMED : 27444420