Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
In this study, we report the cloning of three transcripts for leptin receptor in the European sea bass, a marine teleost of economic interest. The two shortest variants, generated by different splice sites, encode all functional extracellular and intracellular domains but missed the transmembrane domain. The resulting proteins are therefore potential soluble binding proteins for leptin. The longest transcript (3605 bp), termed sblepr, includes all the essential domains for binding and transduction of the signal. Thus, it is proposed as the ortholog for the human LEPR gene, the main responsible for leptin signalling. Phylogenetic analysis shows the sblepr clustered within the teleost leptin receptor group in 100% of the bootstrap replicates. The neuroanatomical localization of sblepr expressing cells has been assessed by in situ hybridization in brains of sea bass of both sexes during their first sexual maturation. At histological level, the distribution pattern of sblepr expressing cells in the brain shows no clear differences regarding sex or reproductive season. Transcripts of the sblepr have a widespread distribution throughout the forebrain and midbrain until the caudal portion of the hypothalamus. A high hybridization signal is detected in the telencephalon, preoptic area, medial basal and caudal hypothalamus and in the pituitary gland. In a more caudal region, sblepr expressing cells are identified in the longitudinal torus. The expression pattern observed for sblepr suggests that in sea bass, leptin is very likely to be involved in the control of food intake, energy reserves and reproduction
ISSN: 0016-6480

hal-01290500
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01290500
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01290500/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01290500/file/Leptin%20receptor%20gene%20in%20the%20European%20sea%20bass%20postprint.pdf
DOI : 10.1016/j.ygcen.2016.03.017

Éditeur(s) : HAL CCSD
Résumé : International audience
The aim of this study was to examine the heart rate (HR) response to Olympic windsurfing competition and to check if there was any correlation between racing HR, performance, and the variables measured during laboratory maximal exercise. Ten elite windsurfers [age: 20.93 (3.46) years; height: 178.10 (6.34) cm; body mass: 66.79 (5.90) kg] performed a laboratory maximal oxygen consumption (VO2max) trial and national windsurf competitions wearing a HR monitor. One hundred and forty-three individual races were examined. Racing HR was expressed as a percentage of (1) HRmax (maximal treadmill HR) and (2) HRreserve (HRmax)HRrest). The performance (racing classification: RC, which is inversely proportional to performance) was significantly correlated to the racing HR response in both light wind (LW): LW)RC=)0.12(%HRreserve)+13.03; r=)0.71, r2=0.50, p<0.001, and medium wind (MW): MW)RC=)0.11(%HRreserve)+10.99; r=)0.66, r2=0.43, p<0.001. The results showed similar correlations between performance and %HRmax. Post racing lactate concentration was higher in LW compared to MW [7.14 (0.21) and 5.18 (2.02) mmolÆl)1, respectively]. There was a negative correlation between the highest racing HR (%HRreserve) of each athlete and the second ventilatory threshold expressed as a percentage of VO2max (r=-0.71, p<0.05). To summarize, this study showed that light and medium wind Olympic windsurfing performances are highly dependent on the capacity of the athlete to maintain a high HR for long periods of time. Furthermore, windsurfing is highly dependent on the athlete's physical fitness level as shown by the correlations between racing HRs and laboratory physiological variables.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

hal-00720564
https://hal.univ-antilles.fr/hal-00720564
https://hal.univ-antilles.fr/hal-00720564/document
https://hal.univ-antilles.fr/hal-00720564/file/Chamari_Wind_surf_and_Heart_rat.pdf

Éditeur(s) : HAL CCSD
Résumé : International audience
The French West Indies (F.W.I.) were French colonies with a specific legal frame until 1946 when they became French departments. Since that time the legal frame in force concerning archaeological heritage protection is exactly the same than in metropolitan France. In this system all the laws relating to cultural heritage are grouped in the "Code du Patrimoine" (Heritage code), which contains several topics such as archives, museums, archaeology and historic monuments. Some articles refer to the Penal Code, the Code of Urban Development, the Environmental Code or the Mining Code. These laws are supplemented by various decrees that define the applying conditions for different areas: rescue archeology (decree 2004-490), INRAP , advisory bodies, the content of the field reports, penal provisions, etc ... The heritage laws have been created in 1917 (Historic Monuments) and 1941 (archaeology). The law on rescue archeology is in force only since 2001 and is an application of the European Convention of Malta (1992). However, the implementation of the regulation and of the institutions in charge of is application in the French West Indies is fairly recent. In this presentation after a general presentation of the archaeological heritage protection French system we will focus on the different aspects of is application in F.W.I.: difficulties linked to the application of a system suited for metropolitan France, the level of the French West Indian people implication in the archaeological heritage protection and the future perspectives.
The Archaeology of the Netherlands Antilles and Aruba, 16th Annual Meeting of the European Association of Archaeologists
Den Haag, France

Droits : info:eu-repo/semantics/OpenAccess
hal-00960161
https://hal.univ-antilles.fr/hal-00960161
https://hal.univ-antilles.fr/hal-00960161/document
https://hal.univ-antilles.fr/hal-00960161/file/European_rules_american_.pdf

Éditeur(s) : HAL CCSD
Résumé : International audience
Industrial use of aniline is increasing worldwide with production estimated to surpass 5.6 million metric tons in 2016. Exposure to aniline occurs via air, diet and water augmenting the risk of exposing a large number of individuals. Early observations suggest that aniline is metabolised to paracetamol/acetaminophen, likely explaining the omnipresence of low concentrations of paracetamol in European populations. This is of concern as recent studies implicate paracetamol as a disrupter of reproduction. Here we show through steroidogenic profiling that exposure to aniline led to increased levels of the Δ4 steroids, suggesting that the activity of CYP21 was decreased. By contrast, paracetamol decreased levels of androgens likely through inhibition of CYP17A1 activity. We confirm that aniline in vivo is rapidly converted to paracetamol by the liver. Intrauterine exposure to aniline and paracetamol in environmental and pharmaceutical relevant doses resulted in shortening of the anogenital distance in mice, a sensitive marker of fetal androgen levels that in humans is associated with reproductive malformations and later life reproductive disorders. In conclusion, our results provide evidence for a scenario where aniline, through its conversion into anti-androgenic paracetamol, impairs male reproductive development
Toxicological Sciences: An Official Journal of the Society of Toxicology

hal-01187305
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01187305
DOI : 10.1093/toxsci/kfv179
PUBMED : 26259604

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
BACKGROUND: HIV cohort collaborations, which pool data from diverse patient cohorts, have provided key insights into outcomes of antiretroviral therapy (ART). However, the extent of, and reasons for, between-cohort heterogeneity in rates of AIDS and mortality are unclear. METHODS: We obtained data on adult HIV-positive patients who started ART from 1998 without a previous AIDS diagnosis from 17 cohorts in North America and Europe. Patients were followed up from 1 month to 2 years after starting ART. We examined between-cohort heterogeneity in crude and adjusted (age, sex, HIV transmission risk, year, CD4 count and HIV-1 RNA at start of ART) rates of AIDS and mortality using random-effects meta-analysis and meta-regression. RESULTS: During 61 520 person-years, 754/38 706 (1.9%) patients died and 1890 (4.9%) progressed to AIDS. Between-cohort variance in mortality rates was reduced from 0.84 to 0.24 (0.73 to 0.28 for AIDS rates) after adjustment for patient characteristics. Adjusted mortality rates were inversely associated with cohorts' estimated completeness of death ascertainment [excellent: 96-100%, good: 90-95%, average: 75-89%; mortality rate ratio 0.66 (95% confidence interval 0.46-0.94) per category]. Mortality rate ratios comparing Europe with North America were 0.42 (0.31-0.57) before and 0.47 (0.30-0.73) after adjusting for completeness of ascertainment. CONCLUSIONS: Heterogeneity between settings in outcomes of HIV treatment has implications for collaborative analyses, policy and clinical care. Estimated mortality rates may require adjustment for completeness of ascertainment. Higher mortality rate in North American, compared with European, cohorts was not fully explained by completeness of ascertainment and may be because of the inclusion of more socially marginalized patients with higher mortality risk.
ISSN: 0300-5771

hal-00875138
https://hal.archives-ouvertes.fr/hal-00875138
DOI : 10.1093/ije/dys164
PUBMED : 23148105

Éditeur(s) : HAL CCSD Wiley
Résumé : The evolutionary potential of long-lived species, such as forest trees, is fundamental for their local persistence under climate change (CC). Genome–environment association (GEA) analyses reveal if species in heterogeneous environments at the regional scale are under differential selection resulting in populations with potential preadaptation to CC within this area. In 79 natural [i]Fagus sylvatica[/i] populations, neutral genetic patterns were characterized using 12 simple sequence repeat (SSR) markers, and genomic variation (144 single nucleotide polymorphisms (SNPs) out of 52 candidate genes) was related to 87 environmental predictors in the latent factor mixed model, logistic regressions and isolation by distance/environmental (IBD/IBE) tests. SSR diversity revealed relatedness at up to 150m intertree distance but an absence of large-scale spatial genetic structure and IBE. In the GEA analyses, 16 SNPs in 10 genes responded to one or several environmental predictors and IBE, corrected for IBD, was confirmed. The GEA often reflected the proposed gene functions, including indications for adaptation to water availability and temperature. Genomic divergence and the lack of large-scale neutral genetic patterns suggest that gene flow allows the spread of advantageous alleles in adaptive genes. Thereby, adaptation processes are likely to take place in species occurring in heterogeneous environments, which might reduce their regional extinction risk under CC
ISSN: 0028-646X

hal-01309135
https://hal.archives-ouvertes.fr/hal-01309135
PRODINRA : 343710
DOI : 10.1111/nph.13809

Éditeur(s) : HAL CCSD American Geophysical Union (AGU)
Résumé : International audience
The Calabro-Peloritan belt constitutes the eastward termination of the southern segment of the Alpine Mediterranean belt. This orogenic system was built up during the convergence between the Eurasian and the African plates, roughly directed North-South since the Upper Cretaceous. It was subsequently fragmented during the opening of the Western Mediterranean basins since Oligocene times. The curved shape of the Calabro-Peloritan belt was acquired during the opening of the Tyrrhenian basin since Tortonian. The origin, kinematics and significance of the Calabro-Peloritan tectonic pile are still debated. Our data in the Aspromonte Massif of Southern Calabria reveal an Alpine history marked by two main superimposed kinematic regimes. (i) A first phase corresponds to the piling up of basement nappes with a top-to-the-SE vergence, i.e in a direction orthogonal to the belt trend and towards the Adriatic foreland. This external vergence is similar to what is observed in both Northeastern Sicily and Northern Calabria. In Sicily, the age of nappe piling is Alpine, as evidenced by pinched slices of Mesozoïc sediments. In the Aspromonte Massif, thrusting age is less constrained. Our data suggest remnants of late Hercynian structuration before the Alpine stacking. (ii) A second phase corresponds to the thinning of the continental crust, dated at around 30 Ma by both geochronological and stratigraphical data. This extension is mainly localized on two low-angle detachment contacts, with top-to-the-NE displacement. The lower one corresponds to the reworking of the former main nappe contact. The upper one is a large detachment fault cutting across the pile from upper sedimentary levels down to metamorphic basement. Extension of similar Alpine age and similar internal vergence has been already recognized in other parts of the Calabro-Peloritan Arc: in the basement nappes of Northeastern Sicily and in the ophiolitic units of Northern Calabria. Coming back to the original geometry and position of the Calabro-Peloritan belt, before its bending and the opening of the Liguro-Provençal and Tyrrhenian basins, we evidence a homogeneous Oligocene NE-SW extension all along the Calabro-Peloritan segment of the Alpine Mediterranean belt. This tectonometamorphic history is best explained within the framework of the continuous Tertiary westward dipping subduction of the Tethyan oceanic domain below the European active margin and the progressive eastward retreat of the Apennine trench since Oligocene times.
ISSN: 0278-7407

hal-00283182
https://hal.archives-ouvertes.fr/hal-00283182
https://hal.archives-ouvertes.fr/hal-00283182/document
https://hal.archives-ouvertes.fr/hal-00283182/file/Heymes_et_al_2008.pdf
DOI : 10.1029/2007TC002157

Résumé : This report which is one of final parts of the European project Pace-Net, makes a reminder of the starting points of this project, the setting up of the network further to four meetings: that of the kick off meeting in Nouméa in 2010, then a first workshop in Brisbane in 2011, one second in Brussels in 2012 and the closing seminar in Suva in March, 2013. We propose in conclusion a set of recommendations appropriate to the themes of the project which join the Pacific – Europe collaboration perspectives at the horizon 2020.
Ce rapport qui est une des pièces finales du projet européen Pace-Net fait un rappel des bases de départ de ce projet, du montage du réseau suite à quatre réunions : celle de lancement à Nouméa en 2010, un premier atelier à Brisbane en 2011, une second à Bruxelles en 2012 et le séminaire de clôture à Suva en mars 2013. On propose en conclusion un ensemble de recommandations propres aux thématiques du projet qui s’inscrivent dans la collaboration Pacifique Europe à l’horizon 2020.

Droits : Pace-Net Network - All rights reserved
http://archimer.ifremer.fr/doc/00204/31487/29897.pdf
http://archimer.ifremer.fr/doc/00204/31487/

Résumé : Nous traiterons successivement des circonstances de l'émergence du Panama depuis la période précolombienne, les premières expéditions espagnoles à la recherche d'un détroit vers les Indes, de l'indépendance du Panama. Dans la première partie, nous traiteront de l'Isthme du Panama comme terre de passage et de son Canal de1880 à 1914, du rêve séculaire à la réalité où, successivement, nous étudierons son destin français, sa position entre intérêts français et aspirations américaines. Les États-Unis et le Panama nous conduiront à traiter de l'installation des Américains, la construction du Canal (1904-1914) ; les traités Carter-Torrijos, entre compromis et ambiguïtés. La deuxième partie traitera des stratégies de développement du Panama; l'importance des facteurs socioéconomiques et la dynamique des structures sociopolitiques seront mises en exergue. L'intégration des Antillais de Guadeloupe et de Martinique dans le cercle communautaire panaméen de 1914 à nos jours. Àcet égard, nous traiterons des apports de la culture antillaise dans la représentation panaméenne, un brassage culturel. En troisième lieu, leur contribution à l'essor de la nation. Il s'agira ici d'étudier les arts et la culture, la musique et les danses, la littérature et la linguistique de même que les revendications culturelles des minorités ethniques. Enfin, nous orienterons nos recherches sur la question de l'unité panaméenne à l'aube du Ille millénaire, l'organisation des diverses communautés et l'installation européenne au Panama.
We will successively deal with the circumstances of the emergence of Panama since the pre-Colum bian period, the first Spanish shipping expeditions in search of a strait towards India, and the independence of Panama. ln the first part, we shall deal with the Isthmus of Panama as a land of passage and with its Channel from 1880 to 1914, from the secular dream to reality where, successively, we shall study its French fate, its position in regards to French interests and American aspiration. The relationship between the United States and Panama will lead us to deal with the settling of the Americans, the construction of the Channel (1904-1914), the "Carter-Torrijos" treaties, between compromises and ambiguities. The second part will deal with strategies of development for Panama; the importance of socioeconomic factors and the dynamics of the sociopolitical structures will be highlighted. The integration of the people of Guadeloupe and Martinique in the Panamanian community circle from 1914 to nowadays. In this respect, we shall treat contributions of the French West Indian culture within the Panamanian representation; the cultural admixture. In the third part, their contribution at the development of the Panamanian nation. The issue will be to study arts and culture, music and dances, Iiterature and Iinguistics as weil as the cultural demands from ethnic minorities. Finally, we shall direct our researches towards the question of Panamanian unity at the dawn of the third millennium, the organization of the diverse communities and the European settling in Panama

http://www.theses.fr/2010AGUY0393/document

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
In this paper we investigate finite-frequency effects in crustal tomography. We developed an inversion procedure based on an exact numerical computation of the sensitivity kernels. In this approach we compute the 3D travel-time sensitivity kernels by using (1) graph theory and an additional bending to estimate accurately both rays and travel-times between source/receiver and diffraction points and (2) paraxial ray theory to estimate the amplitude along theses rays. We invert both the velocity and the hypocentre parameters, using these so-called banana-doughnut kernels and the LSQR iterative solver. We compare the ray-theoretical and the finite-frequency tomography to image the intermediate structures beneath the Gulf of Corinth (Greece), which has long been recognized as the most active continental rifting zone in the Mediterranean region. Our dataset consists of 451 local events with 9233 P- firstarrival times recorded in the western part of the Gulf (Aigion area) in the framework of the 3F-Corinth European project. Previous tomographic images showed a complex velocity crustal model and a low-dip surface that may accommodate the deformation. Accurate velocity models will help to better constrain the rifting process, which is still a subject of debate. The main results of this study show that finite-frequency tomography improves crustal tomographic images by providing better resolved images of the 3D complicated velocity structure. Because the kernels spread the information over a volume, finite-frequency tomography results in a sharpening of layer boundaries as we observed for the shallower part of the crust (down to 5 km depth) beneath the Gulf of Corinth.
ISSN: 0016-8025

insu-00354702
https://hal-insu.archives-ouvertes.fr/insu-00354702
DOI : 10.1111/j.1365-2478.2007.00683.x

Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : International audience
The seismological study of recent seismic crises near Oleron Island confirms the coexistence of an extensional deformation and a transtensive regime in the Atlantic margin of France, which is different from the general western European stress field corresponding to a strike-slip regime. We argue that the switch of the principal stress axes σ1/σ2 in a NW-SE vertical plane is linked with the existence of crustal heterogeneities. Events of magnitude larger than 5 sometimes occur along the Atlantic margin of France, such as the 7 September 1972 (ML = 5.2) earthquake near Oleron island and the 30 September 2002 (ML = 5.7) Hennebont event in Brittany. To test the mechanism of local strain localization, we model the deformation of the hypocentral area of the Hennebont earthquake using a 3D thermo-mechanical finite element code. We conclude that the occurrence of moderate earthquakes located in limited parts of the Hercynian shear zones (as the often reactivated swarms near Oleron) could be due to local reactivation of pre-existing faults. These sporadic seismic ruptures are favoured by stress concentration due to rheological heterogeneities.
ISSN: 1631-0713

hal-00936220
https://hal.archives-ouvertes.fr/hal-00936220
DOI : 10.1016/j.crte.2013.07.004

Éditeur(s) : HAL CCSD
Résumé : National audience
Crustal-scale models for the Pyrenees based on ECORS reflection profileshave around 20 years now. In recent years, new understandingswere gained on the reconstruction to the preorogenic times, namelya scenario of extreme crustal attenuation and mantle exhumation ; inturn, this has implications on the interpretation of the present-day structure,as new models for the chain must consider feedbacks between themid-Cretaceous hyperextension and the Pyrenean inversion. On the WcentralPyrenean traverse, the southern part comprises 3 S-vergent basementthrust units, the Lakora, Gavarnie and Guarga units, flanked by thedetached cover of the Jaca piggyback basin and the Ebro basin, wherethe Mesozoic is thin and Late Cretaceous-Tertiary synorogenic carbonateand detrital sequences record a southward depocenter migration.To the N, the Chaînons Béarnais belt (CB) is a system of Jurassic to LowerCretaceous carbonate anticline ridges separated by synclines withthick Albian-Cenomanian flysch, covered to the north by Upper Cretaceousflysch sequences. The CB is thrust southwards together with theLakora thrust unit and northwards onto the Aquitaine basin. CB foldinglargely results from the rising and squeezing of diapirs initiated duringthe Jurassic-Early Cretaceous extension. Pieces of crust and mantle liftedin the diapirs attest that the CB derive from a Cretaceous domainof hyperextended continental crust and exhumed mantle. Moho reflectionsin the ECORS-Arzaq profile constrain the present deep structure.Restoration leads to a Mesozoic cover detachment over the N-Iberianand S-European margins. Inversion began by subduction of the exhumedmantle and folding and pop-up thrusting of the CB cover onto themargins. From the mid-late Eocene onwards, continental collision wasaccommodated by wedging and thrust stacking in the Iberian crust, involvingthe piggyback formation of S-vergent basement thrusts in theupper crust, and the northward subduction of the lower crust.
24 ème Réunion des sciences de la Terre 2014
Pau, France

insu-01080831
https://hal-insu.archives-ouvertes.fr/insu-01080831

Éditeur(s) : American Geophysical Union
Résumé : [1] A multiproxy integrated chronological framework, based on oxygen and carbon stable isotope stratigraphy, biostratigraphy (foraminifera and nannoplankton bioevents and foraminifer assemblage-based climate cyclicity), magnetostratigraphy, sapropel stratigraphy, and C-14 AMS radiometric dates, has been achieved for borehole PRAD1-2, collected in 185.5 m water depth in the central Adriatic. This work was carried out within the European Community project Profiles across Mediterranean Sedimentary Systems (PROMESS1). The 71.2 m long borehole spans a time interval between late MIS 11 and MIS 1 (the last 370 ka), showing a chronological resolution of 500 and 250 years per cm during interglacial and glacial intervals, respectively. At present, this record is the most expanded and continuous marine record available for the Adriatic Basin. Several orbital cycles can be recognized in the PRAD1-2 record: the 100 ka glacial-interglacial fluctuations and the 23 ka precession-related cycles, which in turn control the deposition of sapropel layers. An integrated analysis of short-term oscillations within the Last Glaciation interval (MIS 4-MIS 2) allowed the identification of the Adriatic signature of Dansgaard-Oeschger events, showing the potential to achieve a more refined chronostratigraphic framework for the top part of the PRAD1-2 record. Finally, the age model obtained by this study allowed the chronological integration of the main foraminifera bioevents detected in the borehole as well as of the volcanoclastic layers present in the upper part of the record. Despite its proximal location, PRAD1-2 presents a continuous record and shows the potential to be consistently correlated both with deep-sea and continental records in the Mediterranean region and beyond.
Geochemistry Geophysics Geosystems (1525-2027) (American Geophysical Union), 2008 , Vol. 9 , P. NIL_107-NIL_127

Droits : 2008 American Geophysical Union
http://archimer.ifremer.fr/doc/2008/publication-3605.pdf
DOI:10.1029/2007GC001713
http://archimer.ifremer.fr/doc/00000/3605/

Éditeur(s) : HAL CCSD American Geophysical Union
Résumé : International audience
We have investigated the seismic anisotropy from SKS and SKKS wave splitting along a N-S profile perpendicular to the Pyrenean mountain belt. The line crossed the North Pyrenean Fault (NPF), which probably represents the plate boundary between the European and the Iberian plates. We observed large delay times δt (1.3 to 1.5 s) and uniform fast polarization directions ϕ (N100E) at three stations located on the Iberian plate. On the other hand, δt are smaller (0.5–1.0 s) and the ϕ scattered at stations located north of the NPF. The small scale variability, the relation with surface geology and the correlation of the δt with lithospheric thickness suggest that the anisotropy could be predominantly of lithospheric origin. However, an asthenospheric contribution cannot be ruled out. In the North Pyrenean Zone, an important thermal event before the Pyrenean compression has likely erased the former mantle fabric. The observed anisotropy is then likely related to the Pyrenean orogeny. On the Iberian plate, our splitting parameters are similar to those obtained at two stations located on Hercynian structures in Central Spain. This suggests that two contributions are likely superposed to that of the Pyrenean built up: one related to the Hercynian orogeny and the other one related to the rotation of the Iberian plate.
ISSN: 0094-8276

hal-01389118
http://hal.univ-reunion.fr/hal-01389118
http://hal.univ-reunion.fr/hal-01389118/document
http://hal.univ-reunion.fr/hal-01389118/file/barruol_pyr_GRL1995.pdf
DOI : 10.1029/94GL03225

Éditeur(s) : World Aquaculture Society, Aquaculture 2006
Résumé : Oysters are among the most familiar of all marine invertebrate taxa. However our knowledge of oyster phylogeny and systematics is fragmentary. This is principally due to the plastic growth patterns of these animals, which result in a wide range of overlapping, ecophenotypic variants that greatly reduce the value of analysis based on shell morphology. Besides that, many intentional or accidental anthropogenic transfers have emphasised this situation. In several cases of misclassification or misidentification of oysters, DNA molecular data, have provided valuable new insights on the tracing of introductions or more generally on the phylogeographic relationships between oyster species. We will illustrate this issue with recent case studies from our lab on several flat and cupped oysters: (1) the Crassostrea gigas – Crassostrea angulata couple of Asian species and their successive introductions in Europe, (2) the new species of cupped oysters, Crassostrea honkongensis, described in Hong-Kong and very divergent from the species Crassostrea gigas it was initially supposed to be, (3) the mangrove oyster Crassostrea gasar that was shown not only to be present along the coasts of Western Africa but also along the Atlantic coasts of South America, and (4) the geographic disjunction between Ostreola stentina, described in the Mediterranean Sea, and the genetically closely related species Ostrea aupouria (from New Zealand) and Ostreola equestris (from Mexico Gulf/Atlantic). At the intra specific level, we will focus on one of the main documented case in Europe, the flat oyster, Ostrea edulis. It is a marine bivalve whose natural geographical distribution ranges along the European Atlantic coast from Norway to Morocco, in addition to the Mediterranean and Black Sea. Studies of allozymes, microsatellites and mitochondrial differentiation over the whole range concluded that a significant divergence existed between Mediterranean and Atlantic populations, together with an isolation-by-distance pattern. However, the average mitochondrial haplotypic diversity displayed a high among populations variance, reflecting smaller effective population size in some locations. Additionally, a ten-fold quantitative difference was observed in the same study in Fst between the mitochondrial and the nuclear genomes, which could be due to sex biased differential reproductive success between males and females. In order to further document this hypothesis, two experiments at the population level were conducted. First, brooding females were sampled in a wild population and the number of males fertilizing a given female estimated. Then, parentage analyses were achieved under experimental conditions: successive mass spawnings were collected from a population of potential genitors kept in hatchery, whose genotypes were known, in order to infer a posteriori the relative contribution of each genitor. Moreover, we aimed to better understand the reproduction dynamics of this species. Several patterns of spawning could be distinguished: unique, successive or extended in time. The different parental contributions and reproductive behaviors observed in these experiments are discussed in the context of the hypothesis of a variance in the reproductive success of males and females and consequences in local and temporal reduced effective population sizes.

Droits : info:eu-repo/semantics/openAccess
http://archimer.ifremer.fr/doc/2006/acte-3475.pdf
http://archimer.ifremer.fr/doc/00000/3475/

Résumé : This report makes the synthesis of the works and the results acquired thanks to the development of the project Pace-Net (2010-2013) registered in the 7th framework program of the European Commission aiming to create a scientific and technological network between Europe and the Pacific in front of main common stakes. These concern the biodiversity and the environmental management, the climate change, the energy, the water, the agriculture and the forest, the natural risks, the fisheries and aquaculture and the trans-cutting approaches
Ce rapport effectue la synthèse des travaux et des résultats acquis à la faveur du développement du projet Pace-Net (2010-2013) inscrit dans le 7 ème programme cadre de la Commission Européenne et visant à faire naître un réseau scientifique et technologique entre l'Europe et le Pacifique face aux grands enjeux posés. Ceux-ci concernent la biodiversité et la gestion environnementale, le changement climatique, l’énergie, l’eau, l’agriculture et la forêt, les risques naturels, la pêche et de l’aquaculture et les approches intégratrices.

Droits : Pace-Net Network - All rights reserved
http://archimer.ifremer.fr/doc/00204/31488/29898.pdf
http://archimer.ifremer.fr/doc/00204/31488/

Résumé : As the emergence of new vibriosis in the European Atlantic coasts has been associated with mass mortalities of molluscs cuasing important economic losses, the project obectives are to provide knowledge and operational tools to evaluate the impact of vibriosis on farmed japenese oyster Crassostrea gigas. Facing the diversity of Vibrio species associated to bivalve disease outbreaks, the difficulties of identification and the detemrination of their pathogenic abilities we propose a double approach to correlate phenotype/geneotype of a bacteria with risk of disease : 1) by genotyping we will evaluate if specific strains are associated with disease. 2) by evaluating likely virulence mechanisms implicated in pathogenesis, we will characterise the genes involved. Therefore, new diagnostic test should be used in an epizootiological study to evaluate the importance of these emerging pathogens in farmed bivalves and will be supplied for further exploitation in aquaculture.
Les vibrioses sont les infections bactériennes les plus courantes chez les espèces marines d'intérêt aquacole. Certaines espèces sont pathogènes et ont été associées à d'importantes pertes économiques pour l'industrie aquacole dans le monde. L'objectif principal de mon projet de recherche est de développer des outils diagnostiques pertinents permettant d'évaluer l'impact des vibrioses dans des élevages d'huîtres creuses Crassostrea gigas. Le problème majeur est l'extraordinaire diversité des espèces appartenant à ce genre bactérien, compliquant considérablement leur caractérisation en terme de spéciation et de virulence. Nous développons une double approche pour corréler le phénotype et le génotype de pathogènes potentiels par : 1) une clarification taxonomique des souches de vibrions nous déterminons si certaines espèces sont systématiquement associées à de maladies; 2) une caractérisation des mécanismes de virulence, nous recherchons les gènes supports de la pathogénie. Les marqueurs génétiques ou de virulence mis au point pourront alors être utilisés pour une étude épidémiologique de ces maladies.

Droits : info:eu-repo/semantics/openAccess
http://archimer.ifremer.fr/doc/2004/these-3699.pdf
http://archimer.ifremer.fr/doc/00000/3699/

Éditeur(s) : HAL CCSD BMJ Publishing Group
Résumé : International audience
We read with interest the report by Desrosiers et al 1 on the association between maternal occupational exposure to organic solvents and some birth defects. Their case-control study examined occupational exposure to three classes of solvents (chlorinated, aromatic and Stoddard) and found one association--between neural tube defects (mainly spinal bifida) and maternal occupational exposure to chlorinated solvents, but no association with the other solvent classes or with oral clefts. In their discussion, the authors noted that previous findings on maternal occupational exposure to solvents and oral clefts were from European, mainly French, populations and they hypothesised that the inconsistency between their results and these previous studies might be due to different exposure profiles (eg, intensity and solvent formulation). Although this explanation is plausible, another explanation must be discussed: differences in the definition of exposure. Our research team conducted four of the five studies with positive results cited by Desrosiers et al.2-5 All four were population based and included, in addition to the solvent classes considered by Desrosiers et al, oxygenated solvents, for example, alcohols or glycol ethers. Exposure limited to only oxygenated solvents appears to be very frequent among working women: more than half of the solvent exposure group in Chevrier et al 4 were exposed only to that solvent class. Because previous studies found an increased risk of oral clefts to be associated principally with that specific exposure, failure to consider this association could explain the negative findings for oral clefts. Moreover, women who were exposed only to oxygenated solvents are included in the reference ('non-exposed') group here, which would result in underestimating associations with chlorinated and petroleum solvents. For both these reasons, we believe that the failure to consider oxygenated solvents led to underestimating the risk estimates for oral clefts.
ISSN: 1351-0711

hal-00875943
https://hal.archives-ouvertes.fr/hal-00875943
DOI : 10.1136/oemed-2012-100999
PUBMED : 22843438

Éditeur(s) : EURAQUA 1992
Résumé : Aquaculture is an important part of the Common Fisheries Policy. Indeed, the Community incentives policy for the farming of sea or fresh water fish, shellfish and molluscs must contribute to supplying the Common Market with fisheries products and to reducing the chronic negative trade balance in this area. The collection of statistics on the economic and social aspects of Aquaculture in the European Community is not a straightforward process. [NOT CONTROLLED OCR]

Droits : info:eu-repo/semantics/openAccess
http://archimer.ifremer.fr/doc/1992/acte-4280.pdf
http://archimer.ifremer.fr/doc/00000/4280/

Éditeur(s) : HAL CCSD WB Saunders
Résumé : International audience
: The apicomplexan parasite Toxoplasma gondii was discovered a little over one hundred years ago and was soon recognized as a pathogen responsible for congenital infection. But detailed understanding of its epidemiology emerged only after 1970 with the discovery of its life cycle. In the last ten years, high resolution molecular tools have allowed the characterization of various strain types with different virulence patterns, and current studies are exploring the distribution of these different genotypes. In parallel, sophisticated diagnostic tools have been developed and awareness of disease burden has led some European countries with high prevalence rates to implement screening of pregnant women. In this article, the screening options and therapies used to prevent congenital toxoplasmosis are dissected in the light of recent data from cohort studies and other epidemiological data.
ISSN: 0163-4453

hal-00875492
https://hal.archives-ouvertes.fr/hal-00875492
https://hal.archives-ouvertes.fr/hal-00875492/document
https://hal.archives-ouvertes.fr/hal-00875492/file/Robert-Gangneux_-_It_is_not_only_the_cat_that_did_it_-_how_to_prevent_and_treat_congenital_toxoplasmosis_HAL.d.pdf
DOI : 10.1016/j.jinf.2013.09.023