Éditeur(s) : HAL CCSD
Résumé : International audience
Selective serotonin reuptake inhibitor medications (SSRIs) are the first lines of treatment for maternal affective disorders, and are prescribed to up to 10% of pregnant women. Concern has been raised about how perinatal exposure to these medications affect offspring neurobehavioral outcomes, particularly those related to social interactions, as recent research has reported conflicting results related to autism spectrum disorder (ASD) risk in children prenatally exposed to SSRIs. Therefore, the aim of this work was to investigate the effects of perinatal exposure to the SSRI fluoxetine on social play behaviors and the hypothalamic pituitary adrenal system, using a model of pre-gestational maternal stress. We also investigated synaptic proteins in the CA2, CA3, and dentate gyrus of the hippocampus, as well as number of immature neurons in the granule cell layer, as both measures of plasticity in the hippocampus have been linked to social behaviors. In pre-adolescent male and female Sprague-Dawley rat offspring, main findings show that perinatal fluoxetine prevents the negative effect of maternal stress on sibling play behavior. However, perinatal fluoxetine increased social aggressive play with a novel conspecific in both sexes and decreased time grooming a novel conspecific in males only. Perinatal fluoxetine also increased serum corticosteroid binding globulin levels, 5-HT levels in the hippocampus, and pre-synaptic density assessed via synaptophysin in the dentate gyrus. Social interaction was significantly correlated with changes in plasticity in the CA2 region of the hippocampus. Pre-gestational maternal stress exposure resulted in significantly decreased rates of hippocampal neurogenesis and synaptophysin density in the dentate gyrus of pre-adolescent males, but not females. Together, these results further characterize the role of perinatal SSRIs, maternal stress prior to conception, and sex/gender on developing social behaviors and related plasticity in the hippocampus of pre-adolescent offspring.
Psychoneuroendocrinology

hal-01579611
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01579611
DOI : 10.1016/j.psyneuen.2017.07.480
PUBMED : 28735226

Éditeur(s) : HAL CCSD BioMed Central
Résumé : International audience
Background: Adolescent obesity is prevalent in Pacific region ethnic groups (European, Melanesian and Polynesian) living in both urban and rural areas. Although body perception is an important factor of weight gain or loss, little is known about the body self-perceptions of Pacific region adolescents. This study therefore evaluated adolescent perceptions of body weight according to ethnicity (European, Melanesian or Polynesian), socioeconomic status (low, intermediate or high) and living area (rural or urban) in New Caledonia.Methods: Sociodemographic and anthropomorphic data from 737 adolescents (351 boys and 386 girls) with ages ranging from 11 to 16 years were collected and analysed. The International Obesity Task Force (IOTF) standards were used to define weight status as normal-weight, underweight or overweight/obese. Weight perception was assessed from detailed questionnaires, with adolescents rating their own weight with the following descriptors: 'about the right weight', 'too heavy', or 'too light'.Results: Results showed that only 8.5% of normal-weight adolescents (7% boys and 10% girls) identifying themselves as ‘too heavy’. Normal-weight Melanesian adolescents were less likely than their European counterparts to assess themselves as too heavy (OR = 0.357). However, half the overweight/obese adolescents underestimated their weight status (53% boys and 48% girls). Weight misperception was associated with ethnicity, socioeconomic status and living area, with gender-specific differences.Conclusions: The results of this study suggest that these sociodemographic factors should be taken into account when designing public health policies and health education school programmes in New Caledonia and, more broadly, the Pacific regio
ISSN: 1471-2458

Droits : info:eu-repo/semantics/OpenAccess
hal-01678909
https://hal.univ-antilles.fr/hal-01678909
https://hal.univ-antilles.fr/hal-01678909/document
https://hal.univ-antilles.fr/hal-01678909/file/Misperception%20of%20weight%20status%20in%20the%20pacific-%20preliminary%20findings%20in%20rural%20and%20urban%2011-%20to%2016-year-olds%20of%20New%20Caledonia%20Ste%CC%81phane%20Frayon%20et%20al%202017.pdf
DOI : 10.1186/s12889-016-3982-0

Éditeur(s) : HAL CCSD BMJ Publishing Group
Résumé : International audience
OBJECTIVES: Social position and social mobility are associated with cancer incidence and mortality, yet little is known about their association with mediating factors such as occupational exposures to carcinogens. Our aim was to assess the association between the type of professional trajectory and multiple occupational exposure profiles. METHOD: Data were extracted from the Giscop93 study (n = 1 009), which is a cohort of cancer patients with (mainly) respiratory tumours. Job histories were reconstructed through interview, then a multi-disciplinary expert group examined the probability of occupational exposure to a list of 54 potentially carcinogenic agents. The typology of professional trajectories was built based on employment stability, employment continuity, job qualification trend, and multiple skills through Multiple Correspondence Analysis followed by Ascending Hierarchical Classification. Association with multiple-exposure profiles was then assessed through multiple logistic regression. RESULTS: Men and women differed in terms of predominant job category over the lifecourse (68,2% of blue-collar-workers among men, 57,3% of employees among women, p extless 0.0001). Professional trajectories were grouped in four classes as "stable qualified, employee" (21,3%), "stable manual, independent blue-collar-worker" (24,4%), "stable tiring, no gain in qualification" (30,5%), and "very unstable, precarious" (23,8%). Among men, the last two categories were associated with exposure to at least five different occupational carcinogens (ORstable_tiring/stable_qualified=2,0 [1,3;3,1], ORvery_unstable/stable_qualified=2,6 [1,6;4,2]). No such association was found among women. CONCLUSIONS: The association found between the type of professional trajectory and multiple occupational exposures among men should be replicated among people not suffering cancer. Forthcoming analysis will investigate the gendered differences observed.
ISSN: 1351-0711

hal-01063899
https://hal.archives-ouvertes.fr/hal-01063899
DOI : 10.1136/oemed-2014-102362.266

Éditeur(s) : HAL CCSD BioMed Central
Résumé : International audience
BACKGROUND: The aim of this study was to evaluate the role of family history of cancer and personal history of other medical conditions in the aetiology of the oral cavity cancer in France. METHODS: We used data from 689 cases of oral cavity squamous cell carcinoma and 3481 controls included in a population-based case--control study, the ICARE study. Odds-ratios (ORs) associated with family history of cancer and personal medical conditions and their 95% confidence intervals (95% CI) were estimated by unconditional logistic regression and were adjusted for age, gender, area of residence, education, body mass index, tobacco smoking and alcohol drinking. RESULTS: Personal history of oral candidiasis was related to a significantly increased risk of oral cavity cancer (OR 5.0, 95% CI 2.1-12.1). History of head and neck cancers among the first-degree relatives was associated with an OR of 1.9 (95% CI 1.2-2.8). The risk increased with the number of first-degree relatives with head and neck cancer. CONCLUSION: A family history of head and neck cancer is a marker of an increased risk of oral cavity cancer and should be taken into account to target prevention efforts and screening. Further studies are needed to clarify the association between oral cavity cancer and personal history of candidiasis.
ISSN: 1471-2407

inserm-00913514
http://www.hal.inserm.fr/inserm-00913514
http://www.hal.inserm.fr/inserm-00913514/document
http://www.hal.inserm.fr/inserm-00913514/file/1471-2407-13-560.pdf
DOI : 10.1186/1471-2407-13-560

Éditeur(s) : HAL CCSD
https://hal.archives-ouvertes.fr/hal-01664591

Droits : http://creativecommons.org/licenses/by/
hal-01664591
https://hal.archives-ouvertes.fr/hal-01664591
https://hal.archives-ouvertes.fr/hal-01664591/document
https://hal.archives-ouvertes.fr/hal-01664591/file/ID-HAL%2001664591_De%20la%20performance%20%C3%A0%20la%20reperformance_%C3%A9chos%20de%20corps%20en%20action_F.%20LEFRANCOIS.pdf

Éditeur(s) : HAL CCSD Centre National de la Recherche Scientifique
Résumé : International audience
In the fragmented colonial society of the West Indies during the slavery period, building up a stable family required to get over many obstacles. The status differences, the lack of fluidity in the marriage market and the deep redefinition of the gender relations are interrelated phenomenon which question both the marriage as being the unique pattern of family organization and the structuration of family ties. If the official conjugal model remains the norm for white Creole women, it is not true neither for their husband nor for free coloured people and slaves. Therefore, the expansion of adultery and people living as husband and wife, which were denounced particularly by the religious authorities, lead to a high rate and continuous growth of illegitimate births. As a consequence, family ties gradually develop with no institutional control, hence no traces of them in the different sources but it also gives them an obvious flexibility, especially for the slaves.
Dans les sociétés coloniales fragmentées des Antilles de la période esclavagiste, les obstacles à la constitution de familles stables sont nombreux. Les différences de statut, le manque de fluidité du marché matrimonial, et la redéfinition profonde des rapports de genre sont autant de phénomènes articulés qui remettent en cause le mariage comme élément unique d'organisation de la famille et de structuration des relations de parenté. Si le modèle conjugal reconnu par les autorités reste la norme obligée pour les femmes blanches créoles, il n'en est pas de même pour leurs maris et pour les populations de couleur libre ou esclave. Aussi, l'essor du concubinage et des relations adultérines, dénoncé en particulier par les autorités religieuses, se concrétise par une illégitimité des naissances élevée et en croissance continue. Les liens familiaux se construisent ainsi en partie en dehors du contrôle institutionnel, ce qui leur confère une invisibilité dans les sources, mais aussi une souplesse certaine, particulièrement chez les esclaves.
Annales de Demographie Historique

hal-00753581
https://hal-unilim.archives-ouvertes.fr/hal-00753581

Éditeur(s) : HAL CCSD
Résumé : Cet article étudie la distribution des moyennes générales annuelles et des moyennes annuelles en EPS, mathématiques, français, histoire-géographie et philosophie selon le sexe et l'orientation de genre de 499 lycéens et lycéennes. Ces derniers fréquentent un établissement obtenant de forts taux de réussite au baccalauréat général et se caractérisant par une population composée d'élèves provenant plutôt des classes favorisées que des milieux populaires. Nos résultats montrent que les élèves qui possèdent les traits "masculins", qu'ils soient garçons ou filles, réussissent globalement mieux que leurs camarades. Ainsi, les traits "masculins" seraient scolairement plus rentables dans cet établissement.
https://hal.archives-ouvertes.fr/hal-01446074

hal-01446074
https://hal.archives-ouvertes.fr/hal-01446074
https://hal.archives-ouvertes.fr/hal-01446074/document
https://hal.archives-ouvertes.fr/hal-01446074/file/Genre_discpilines_Moniotte_Poggi.pdf

Éditeur(s) : HAL CCSD
Résumé : Journée d'études du 27/04/17 « Révolution, dictature, résistance dans le monde américano-caraïbe »
Située au nord de Trinidad et Tobago, l'île de la Grenade fait partie de ces nations caribéennesaujourd'hui indépendantes dont l'histoire révolutionnaire a été singulièrement marquée par lacolonisation, l'esclavage, et plus récemment, par l'interventionnisme américain, au même titre quel'emblématique Cuba. En fait, les deux révolutions sont idéologiquement et historiquement liées, maisconnaîtront des heurs divers. Certes, il est vrai qu'à l'instar de Cuba, la Grenade – en espagnol, laGranada – possède un passé colonial indélébile, qui a lourdement impacté sur la conscience politique etesthétique de son peuple, mais l'histoire retiendra surtout de la Grenade le souvenir d'une révolutionavortée. A plus d'un titre, l'intériorisation de ce trauma, et la résilience qui en découle, représentent descomposantes essentielles du legs historique participant à la formation de l'identité culturelle caribéenne.De fait, celle-ci s'est exprimée au cours des quatre dernières décennies, sous des modes divers, par lebiais des arts et de la littérature, suivant une logique d'extériorisation et d'esthétisation de la blèsoriginelle. Comment donc passer sous silence – autrement dit, censurer, – la violence, et la gravité del'épisode d'occupation militaire américaine, qui se solda en 1983 par l'assassinat du premier ministregrenadien Maurice Bishop, au profit d'enjeux géopolitiques dits « supérieurs » ? Chassez le refoulé, ilreviendra toujours au galop. Telle est la leçon retenue par les artistes-historiens grenadiens qui se sontpenchés sur la question, et dont nous tâcherons d'élucider la portée du travail, aussi bien sur planplastique, esthétique que politique.
https://hal.archives-ouvertes.fr/hal-01664579

Droits : http://creativecommons.org/licenses/by/
hal-01664579
https://hal.archives-ouvertes.fr/hal-01664579
https://hal.archives-ouvertes.fr/hal-01664579/document
https://hal.archives-ouvertes.fr/hal-01664579/file/D%C3%A9-peindre%20la%20r%C3%A9volution%20grenadienne_traumas%2C%20censures%2C%20lib%C3%A9rations_F.%20LEFRANCOIS.pdf

Éditeur(s) : HAL CCSD
Résumé : International audience
Objective: The objective of this study was to identify the factors associated with presentation for care with CD4 cell count <200/mm3. Design: A Retrospective monocentric cohort study of the Guadeloupe section of French Hospital Database for HIV was conducted. Methods: Group 1 Cohort (CD4 <200/mm3, n=1076), Group 2 (CD4 200-500, n=973) and Group 3 (CD4 >≥ 500/ mm3, n=627) patients were included between 1 January 1988 and 31 December 2009. Factors associated with late presentation (CD4 count <200 cells/μL) were assessed using descriptive statistics and ordered multivariable logistic regression. Results: At the time of diagnosis, 40.21% of patients had than less 200 CD4 lymphocytes/mm3. Age older than 30 years OR: 1.55[1.14-2.10], p=0.005, male gender OR: 1.83[1.58-2.12], p<0.0001, access to care before 1992 OR: 1.56[1.03-2.02], p=0.038 and alcohol use OR: 8.80[2.26-34.36], p=0.002 were independently associated with a low CD4 cell count. Conclusion: The findings of this study (underline the need to expand HIV testing beyond the usual facilities) may be of value in helping to achieve earlier access to treatment in HIV-infected patients in order to minimize the individual risk of morbidity and mortality.
J AIDS Clinic Res

inserm-00915176
http://www.hal.inserm.fr/inserm-00915176
http://www.hal.inserm.fr/inserm-00915176/document
http://www.hal.inserm.fr/inserm-00915176/file/2012_Elenga_-_Risk_Factors_for_Late_Presentation_for_Care_among_HIV-Infected_Patients_in_guadeloupe_1988_2009.pdf
DOI : 10.4172/2155-6113.1000166

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
BACKGROUND: Dengue and malaria are two major public health concerns in tropical settings. Although the pathogeneses of these two arthropod-borne diseases differ, their clinical and biological presentations are unspecific. During dengue epidemics, several hundred patients with fever and diffuse pain are weekly admitted at the emergency room. It is difficult to discriminate them from patients presenting malaria attacks. Furthermore, it may be impossible to provide a parasitological microscopic examination for all patients. This study aimed to establish a diagnostic algorithm for communities where dengue fever and malaria occur at some frequency in adults. METHODOLOGY/PRINCIPAL FINDINGS: A sub-study using the control groups of a case-control study in French Guiana - originally designed to compare dengue and malaria co-infected cases to single infected cases - was performed between 2004 and 2010. In brief, 208 patients with malaria matched to 208 patients with dengue fever were compared in the present study. A predictive score of malaria versus dengue was established using .632 bootstrap procedures. Multivariate analysis showed that male gender, age, tachycardia, anemia, thrombocytopenia, and CRP>5 mg/l were independently associated with malaria. The predictive score using those variables had an AUC of 0.86 (95%CI: 0.82-0.89), and the CRP was the preponderant predictive factor. The sensitivity and specificity of CRP>5 mg/L to discriminate malaria from dengue were of 0.995 (95%CI: 0.991-1) and 0.35 (95%CI 0.32-0.39), respectively. CONCLUSIONS/SIGNIFICANCE: The clinical and biological score performed relatively well for discriminating cases of dengue versus malaria. Moreover, using only the CRP level turned to be a useful biomarker to discriminate feverish patients at low risk of malaria in an area where both infections exist. It would avoid more than 33% of unnecessary parasitological examinations with a very low risk of missing a malaria attack.
ISSN: 1935-2727

inserm-00872353
http://www.hal.inserm.fr/inserm-00872353
http://www.hal.inserm.fr/inserm-00872353/document
http://www.hal.inserm.fr/inserm-00872353/file/journal.pntd.0002420.pdf
DOI : 10.1371/journal.pntd.0002420

Éditeur(s) : HAL CCSD Armand Colin
Résumé : Cette version correspond au texte accepté avant la mise en forme finale (la version éditeur) de l'article publié dans le n°38 de la revue "carrefours de l'éducation".
International audience
Malgré leur meilleure réussite scolaire, les filles réussissent moins bien que les garçons en éducation physique et sportive (EPS). A partir de la sociologie des curricula, nous analysons les curricula réel et caché, ainsi que les représentations des enseignants d’EPS dans un lycée d’enseignement général fréquenté par une population favorisée. Notre étude est centrée sur une analyse thématique des appréciations portées par trois enseignants d’EPS sur les bulletins scolaires. Nos résultats montrent que le curriculum réel est plus proche de la culture des garçons. De plus, les bulletins scolaires véhiculent un curriculum caché affirmant la supériorité des garçons en EPS. Les représentations professorales sont affectées par des biais de perception selon le sexe des élèves. Ces dernières sont transmises au travers du curriculum caché.
ISSN: 1262-3490

Droits : info:eu-repo/semantics/OpenAccess
hal-01425675
https://hal.archives-ouvertes.fr/hal-01425675
https://hal.archives-ouvertes.fr/hal-01425675/document
https://hal.archives-ouvertes.fr/hal-01425675/file/Moniotte_Poggi_Curricula_Carrefours.pdf