Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
OBJECTIVES: To compare virological effectiveness in patients who continued on a virologically successful first-line boosted protease inhibitor (PI)-containing combination antiretroviral therapy (cART) regimen or who switched to a PI-free cART including efavirenz, nevirapine or abacavir. METHODS: From the French Hospital Database on HIV, we selected 439 patients with undetectable viral load (VL) on a first-line boosted PI-containing cART regimen who switched to a PI-free combination including efavirenz, nevirapine or abacavir. Each of these patients was matched with three patients who continued to take their first-line cART regimen, on the basis of gender, age, CD4 cell count, VL, date of cART initiation and the duration of VL undetectability. Time to virological failure (VF) was analysed with Kaplan-Meier curves and Cox models. RESULTS: The 12 month probabilities of VF were 3.7% and 5.7% in non-switch and switch patients, respectively, and 3.9%, 7.2% and 9.0% in patients switching to efavirenz-, nevirapine- and abacavir-containing cART, respectively. After adjustment, only patients switching to abacavir-containing cART had a higher risk of VF than non-switch patients (adjusted hazard ratio, 1.99; 95% confidence interval, 1.05-3.79). CONCLUSIONS: Switching from a virologically successful first-line boosted PI-containing cART regimen to a non-nucleoside reverse transcriptase inhibitor-containing cART regimen containing either efavirenz or nevirapine is virologically safe, while switching to abacavir-containing cART should be avoided.
ISSN: 0305-7453

hal-00875284
https://hal.archives-ouvertes.fr/hal-00875284
DOI : 10.1093/jac/dkr208
PUBMED : 21636583

Résumé : Dans le cas des DOM, singulièrement la Guadeloupe, qui sont à l'aube de l'expérimentation de réformes profondes de politiques économiques, l'élaboration d'un outil de simulation macroéconomique tel qu'un MEGC apparaît naturellement comme une exigence plus que souhaitable. Ce recours à la construction de modèles spécifiques pour les DOM est en parfaite cohérence avec l'une des principales conclusions du rapport d'information diligenté par le Sénat aux lendemains de la crise sociale du début de l'année 2009. Les appels à projet de la Commission europèenne et du Ministère de l'Outre-mer vont justement dans le sens de pallier celte carence puisque la politique économique des RUP de façon générale est conduite à vue sans aucun outil d'investigation ex ante. Nous avons conçu plusieurs modèles. Parmi eux, CloDyn est le premier modèle macroéconomique pour les DOM à vocationopérationnelle. Composée de plus de 2000 équations, ce modèle d'équilibre général calculable tient compte de nombreuses rigidités sur les marchés des biens et services et du travail et se décline sous deux versions: statique et dynamique. Les élasticités ont fait l'objet d'estimations économétriques. Il tient compte de nombreuses spécificités tant au niveau de la fiscalité de ces régions (octroi de mer, taxe sur les carburants, subventions à l'exportation) que du coût des facteurs (exonérations des charges sur les bas salaires, sur rémunératio des fonctionnaires). Il repose sur une formalisation des mécanismes en oeuvre dans ces économies que nous avons appelé le DOM disease pour expliquer les dysfonctionnements persistants sur le plan macroéconomique.
In the case of the French overseas regions, particularly of Guadeloupe, which are just beginning to experiment with economic policies radical reforrns, the development of a macroeconomic simulation tool such as a CGE model appears naturally as a highly desirable requirement. The use of the construction of specifie models for DOM is fully consistent with a major finding of the report commissioned by the Senate in the aftermath of the social crisis of the early 2009. As a malter of facts, the purpose of the calls for project initiated by the European Commission and the Ministry of Overseas is to remedy this deficiency, since the RUP economie policy is generally to conduct no investigation tool ex ante. We designed several models. Among them, CloDyn is the first operational DOM-based macroeconomic rnodel. Composed of more than 2000 equations, this computable general equilibrium model takes into account many rigidities in the markets for goods and services and labor and is available in two versions: static and dynamic. Elasticities have been econometrically estimated. lt rests on many features of both taxation (dock dues, fuel tax, export subsidies) and the cost factors (exemption from charges on low wages, remuneration of civil servants). Il is based on a formalization of the mechanisms at work in these economies we calied the DOM disease to explain the persistent failures in such economies. lt also evaluates the monetary poverty among households with the use of a block of microsimulation model and we allow a profane in GAMS to use this tool and conduct its own analytical work thanks to a user friendly interface.

http://www.theses.fr/2011AGUY0411/document

Éditeur(s) : HAL CCSD IOS Press
Résumé : International audience
Sickle cell anemia (SCA or SS homozygous sickle cell disease) is an inherited blood disorder caused by single 12 nucleotide substitution in the ␤-globin gene that renders their hemoglobin (HbS) much less soluble than normal hemoglobin 13 (HbA) when deoxygenated. The polymerization of HbS upon deoxygenation is the basic pathophysiologic event leading to 14 RBC sickling, hemolysis, vasoocclusion and ultimately to chronic organ damage. The metabolic changes imposed by exercise 15 may initiate sickling and vaso-occlusive episodes. Further, in patients with SCA, exercise limitation may be related to anemia 16 or chronic complications such as pulmonary vascular disease, congestive heart failure and chronic parenchymal lung disease. 17 Few studies have investigated the cardiorespiratory responses of patients with SCA during either symptom-limited maximal 18 exercise test on cyclo-ergometer or during a six minute walk test. Therefore, patients are advised to start exercise slowly and 19 progressively, to maintain adequate hydration during and after exercise, to avoid cold exposure or sudden change in temperature, 20 and to avoid sports associated with mechanical trauma. There are, however, lack of evidence to allow practitioners to prescribe 21 an exercise program for patients with SCA, and individuals are usually encouraged to exercise on a symptom-limited basis. 22 Finally, this review will also highlight the basic principles that are often used for exercise practice and could be used for exercise 23 prescription and rehabilitation in patients with sickle cell anemia.
ISSN: 1386-0291

hal-01163966
https://hal.univ-antilles.fr/hal-01163966
DOI : 10.3233/CH-2011-1465

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
This work deals with the problem of finding for a given industrial target the molecule conformation leading to the most efficient crystal polymorph and/or designing unknown crystal packing of new molecules. The originality of the method relies first on constraining the domain of the most probable crystals, before converging towards the predicted packing by a double genetic-refining optimization algorithm. Validation of this approach is discussed on the case study of 46 energetic crystal compounds, using the semi Ab Initio and Molecular Mechanics code GenMol™. This validation shows that all observed structures are retrieved in any circumstances with a relatively high number of good rankings.
ISSN: 0022-0248

hal-00857875
https://hal.archives-ouvertes.fr/hal-00857875
DOI : 10.1016/j.jcrysgro.2009.04.002

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The timing of E–W extension of the Tibetan plateau provides a test of mechanical models of the geodynamic evolution of the India–Asia convergence zone. In this work we focus on the Kung Co half graben (Southern Tibet, China), bounded by an active N–S normal fault with a minimum vertical offset of 1600 m. To estimate the onset of normal faulting we combined high and medium temperature (U–Pb, Ar/Ar) and low temperature ((U–Th)/He) thermochronometry of the Kung Co pluton, a two-mica granite of the northern Himalayan granitic belt that outcrop in the footwall of the fault. Biotite and muscovite Ar/Ar ages , are close from each other [not, vert, similar 16 Ma ± 0.2 (Ms) and not, vert, similar 15 ± 0.4 Ma (Bt)], which is typical of fast cooling. The zircon and apatite (U–Th)/He ages range from 11.3 to 9.6 Ma and 9.9 to 3.7 Ma respectively. These He ages are indicative of (1) fast initial cooling, from 11.3 to not, vert, similar 9 Ma, gradually decreasing with time and (2) a high geothermal gradient (not, vert, similar 400 °C/km), close to the surface at not, vert, similar 10 Ma. The Kung Co pluton was emplaced at about 22 Ma (U–Pb on zircon) at less than 10 km depth and 520–545 °C. Subsequent to its shallow emplacement, the pluton underwent fast thermal re-equilibration ending around 7.5 Ma, followed by a period of slow cooling caused either by the end of the thermal re-equilibration or by very slow exhumation (0.02–0.03 mm/yr) from not, vert, similar 7.5 Ma to at least 4 Ma. In either case the data suggest that the exhumation rate increased after 4 Ma. We infer this increase to be related to the initiation of the Kung Co normal fault. A critical examination of previously published data show that most not, vert, similar N–S Tibetan normal faults may have formed less than 5 Ma ago rather than in the Miocene as assumed by several authors. Such a young age implies that E–W extension is not related to the Neogene South Tibetan magmatism (25 to 8 Ma). Consequently, models relating E–W extension to magmatism, such as convective removal of the lower lithosphere, may be inappropriate. We rather think that this extension is related with local accommodation of boundary forces and displacements.
ISSN: 0012-821X

hal-00311791
https://hal.archives-ouvertes.fr/hal-00311791
DOI : 10.1016/j.epsl.2007.01.029

Éditeur(s) : HAL CCSD Cold Spring Harbor Laboratory Press
Résumé : International audience
Meiotic recombination is required for the segregation of homologous chromosomes and is essential for fertility. In most mammals, the DNA double-strand breaks (DSBs) that initiate meiotic recombination are directed to a subset of genomic loci (hot spots) by sequence-specific binding of the PRDM9 protein. Rapid evolution of the DNA-binding specificity of PRDM9 and gradual erosion of PRDM9-binding sites by gene conversion will alter the recombination landscape over time. To better understand the evolutionary turnover of recombination hot spots and its consequences, we mapped DSB hot spots in four major subspecies of Mus musculus with different Prdm9 alleles and in their F1 hybrids. We found that hot spot erosion governs the preferential usage of some Prdm9 alleles over others in hybrid mice and increases sequence diversity specifically at hot spots that become active in the hybrids. As crossovers are disfavored at such hot spots, we propose that sequence divergence generated by hot spot turnover may create an impediment for recombination in hybrids, potentially leading to reduced fertility and, eventually, speciation
ISSN: 0890-9369

hal-01281480
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01281480
DOI : 10.1101/gad.270009.115
PUBMED : 26833728

Éditeur(s) : HAL CCSD Geological society of London
Résumé : International audience
We present a synthesis of the tectonic and thermochronological evolution of the Eastern Tibet since the Triassic. The long-term cooling histories obtained on magmatic and metamorphic rocks of the South Songpan-Garze--, Kunlun and Yidun blocks are similar showing a very slow and regular cooling during Late Jurassic and Cretaceous, confirming the suspected lack of major tectonic events between c. 150 and 30 Ma. The exhumation linked to the Tertiary growth of the Tibetan Plateau initiated around 30 Ma and concentrates at the vicinity of the major tectonic structures. Exhumation rates increased again from about 7 Ma in the Longmen Shan. To interpret this very slow cooling rate between Late Jurassic and Early Cenozoic from granites of this area, we use a simple 1D thermal model that takes into account the thermal properties of both sediments and crust. The results suggest that: (1) high temperature (500 8C) can be kept over a long period of time; (2) during Cretaceous, cooling is mostly controlled by the thermal properties of sediments of continental origin; and (3) the initial Late Triassic rapid cooling rate was caused by the large thermal contrast between the granite body and the sedimentary rocks rather than by a high exhumation rate.
Growth and Collapse of the Tibetan Plateau

insu-00610491
https://hal-insu.archives-ouvertes.fr/insu-00610491
DOI : 10.1144/SP353.2

Résumé : Tahiti’s pearl farming industry plays a major socio-economic role in French Polynesia. In an increasingly competitive market where the production of high quality pearls becomes essential, research can help secure and ensure sustainable production. In that context, Ifremer, in close collaboration with the “direction des resources marines” (French Polynesian government agency) has developed research projects on the “sustainable development of pearl farming”. This program is organized along 3 axes: (1) understanding the animal physiology and initiating a genetically selective breeding program of donor oysters; (2) understanding pearl oyster larvae dispersal and recruitment; (3) understanding the molecular mechanisms underlying biomineralization processes during shell and pearl formation. It is in this frame that we have developed a highthroughput Expressed Sequence Tags pyrosequencing program on the calcifying mantle, combined with proteomic analyses of the shell and pearl. We analyzed 276738 EST sequences, leading to the constitution of a P. margaritifera mantle transcripts catalogue of 82 sequences potentially involved in biomineralization. Our results provided direct evidence that our ESTs data set covers a large number of the matrix proteins of P. margaritifera. In addition, our proteomic analysis enabled us to retrieve, in silico, all the sequences from P. margaritifera involved in the biomineralization process already published on databases. Integration of these two methods allowed, for the first time, the global composition of calcifying tissue and calcified structures to be examined in tandem.
Recent Advances in Pearl Research—Proceedings of the International Symposium on Pearl Research 2011.Edited by Shugo Watabe, Kaoru Maeyama and Hiromichi Nagasawa. 2013. ISBN : 978-4-88704-158-5. pp.184-194

Droits : 2013 TERRAPUB. All rights reserved.
http://archimer.ifremer.fr/doc/00167/27840/26049.pdf
http://archimer.ifremer.fr/doc/00167/27840/

Éditeur(s) : HAL CCSD American Chemical Society
Résumé : International audience
The Chromosome-Centric Human Proteome Project (C-HPP) aims at cataloguing the proteins as gene products encoded by the human genome in a chromosome-centric manner. The existence of products of about 82% of the genes has been confirmed at the protein level. However, the number of so-called "missing proteins" remains significant. It was recently suggested that the expression of proteins that have been systematically missed might be restricted to particular organs or cell types, for example, the testis. Testicular function, and spermatogenesis in particular, is conditioned by the successive activation or repression of thousands of genes and proteins including numerous germ cell- and testis-specific products. Both the testis and postmeiotic germ cells are thus promising sites at which to search for missing proteins, and ejaculated spermatozoa are a potential source of proteins whose expression is restricted to the germ cell lineage. A trans-chromosome-based data analysis was performed to catalog missing proteins in total protein extracts from isolated human spermatozoa. We have identified and manually validated peptide matches to 89 missing proteins in human spermatozoa. In addition, we carefully validated three proteins that were scored as uncertain in the latest neXtProt release (09.19.2014). A focus was then given to the 12 missing proteins encoded on chromosomes 2 and 14, some of which may putatively play roles in ciliation and flagellum mechanistics. The expression pattern of C2orf57 and TEX37 was confirmed in the adult testis by immunohistochemistry. On the basis of transcript expression during human spermatogenesis, we further consider the potential for discovering additional missing proteins in the testicular postmeiotic germ cell lineage and in ejaculated spermatozoa. This project was conducted as part of the C-HPP initiatives on chromosomes 14 (France) and 2 (Switzerland). The mass spectrometry proteomics data have been deposited with the ProteomeXchange Consortium under the data set identifier PXD002367
ISSN: 1535-3893

hal-01187320
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01187320
DOI : 10.1021/acs.jproteome.5b00170
PUBMED : 26168773

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
Cytomegalovirus (CMV) infection is common among HIV-infected patients but its repercussion on the course of CD4+ and CD8+ T cells after cART initiation remains elusive. The French Dat'AIDS cohort enrolled 5,688 patients on first-line cART, from which we selected patients who achieved HIV suppression for at least 12 months without modification of cART, and for whom CMV serostatus was available. Five hundred and three patients fulfilled the selection criteria (74% male, median age 43 yrs, 15.5% CDC stage C), of whom 444 (88.3%) were seropositive for CMV (CMV+). Multivariate analyses using mixed-linear models adjusted for the time from HIV suppression, sex, age, transmission risk group, duration of HIV follow-up, the interaction between time from HIV suppression and CMV+ serol-ogy, and the nadir CD4 count revealed a negative correlation between CMV+ and CD4: CD8 ratio (coeff. =-0.16; p = 0.001). This correlation was also observed among patients displaying optimal CD4 recovery (!500 cells/mm3 at M12; coeff. =-0.24; p = 0.002). Hence, CMV+ serostatus antagonizes normalization of the CD4:CD8 ratio, although further analyses of the impact of co-morbidities that associate with CMV serostatus, like HCV infection, are needed to elucidate this antagonism formally. However, this might reflect a premature T cell senescence, thus advocating for a close monitoring of T cells in CMV co-infected patients. In addition, our results raise the question of the benefit of treatment for asymptomatic CMV co-infection in HIV-infected patients.
ISSN: 1932-6203

inserm-01418700
http://www.hal.inserm.fr/inserm-01418700
http://www.hal.inserm.fr/inserm-01418700/document
http://www.hal.inserm.fr/inserm-01418700/file/journal.pone.0165774.PDF
DOI : 10.1371/journal.pone.0165774

Éditeur(s) : HAL CCSD Oxford University Press
Résumé : International audience
The epigenetic events imposed during germline reprogramming and affected by harmful exposure can be inherited and transferred to subsequent generations via gametes inheritance. In this study, we examine the transgenerational effects promoted by widely used herbicide atrazine (ATZ). We exposed pregnant outbred CD1 female mice and the male progeny was crossed for three generations with untreated females. We demonstrate here that exposure to ATZ affects meiosis, spermiogenesis and reduces the spermatozoa number in the third generation (F3) male mice. We suggest that changes in testis cell types originate from modified transcriptional network in undifferentiated spermatogonia. Importantly, exposure to ATZ dramatically increases the number of transcripts with novel transcription initiation sites, spliced variants and alternative polyadenylation sites. We found the global decrease in H3K4me3 occupancy in the third generation males. The regions with altered H3K4me3 occupancy in F3 ATZ-derived males correspond to altered H3K4me3 occupancy of F1 generation and 74% of changed peaks in F3 generation are associated with enhancers. The regions with altered H3K4me3 occupancy are enriched in SP family and WT1 transcription factor binding sites. Our data suggest that the embryonic exposure to ATZ affects the development and the changes induced by ATZ are transferred up to three generations.
ISSN: 0305-1048

hal-01477213
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01477213
DOI : 10.1093/nar/gkw840
PUBMED : 27655631

Éditeur(s) : HAL CCSD Wiley
Résumé : [b]Aim[/b][br/] Many tropical tree species have poorly delimited taxonomic boundaries and contain undescribed or cryptic species. We examined the genetic structure of a species complex in the tree genus Carapa in the Neotropics in order to evaluate age, geographic patterns of diversity and evolutionary relationships, and to quantify levels of introgression among currently recognized species.[br/] [br/] [b]Location[/b][br/] Lowland moist forests in the Guiana Shield, the Central and Western Amazon Basin, Chocó and Central America.[br/] [br/] [b]Methods[/b][br/] Genetic structure was analysed using seven nuclear simple sequence repeats (nuSSR), five chloroplast SSRs (cpSSR), and two chloroplast DNA (cpDNA) intergenic sequences (trnH-psbA and trnC-ycf6). Bayesian clustering analysis of the SSR data was used to infer population genetic structure and to assign 324 samples to their most likely genetic cluster. Bayesian coalescence analyses were performed on the two cpDNA markers to estimate evolutionary relationships and divergence times.[br/] [br/] [b]Results[/b][br/] Two genetic clusters (nu_guianensis and nu_surinamensis) were detected, which correspond to the Neotropical species C. guianensis (sensu latu) and C. surinamensis. Fourteen cpDNA haplotypes clustered into six haplogroups distributed between the two nuclear genetic clusters. Divergence between the haplogroups was initiated in the Miocene, with some haplotype structure evolving as recently as the Pleistocene. The absence of complete lineage sorting between the nuclear and chloroplast genomes and the presence of hybrid individuals suggest that interspecific reproductive barriers are incomplete. NuSSR diversity was highest in C. guianensis and, within C. guianensis, cpDNA diversity was highest in the Central and Western Amazon Basin. Regional genetic differentiation was strong but did not conform to an isolation-by-distance process or exhibit a phylogeographical signal.[br/] [br/] [b]Main conclusions[/b][br/] The biogeographical history of Neotropical Carapa appears to have been influenced by events that took place during the Neogene. Our results point to an Amazonian centre of origin and diversification of Neotropical Carapa, with subsequent migration to the Pacific coast of South America and Central America. Gene flow apparently occurs among species, and introgression events are supported by inconsistencies between chloroplast and nuclear lineage sorting. The absence of phylogeographical structure may be a result of the ineffectiveness of geographical barriers among populations and of reproductive isolation mechanisms among incipient and cryptic species in this species complex.
ISSN: 0305-0270

hal-01032395
https://hal.archives-ouvertes.fr/hal-01032395
DOI : 10.1111/j.1365-2699.2011.02678.x

Éditeur(s) : HAL CCSD Elsevier
Résumé : The Gulf of Aigues-Mortes (NW Mediterranean Sea) is a midshelf zone whose scale is an intermediate between the nearshore scale (0–10 m depth) and the coastal scale (including the whole continental shelf). Its hydrodynamics is investigated for the first time. ADCP, CTD and thermosalinograph data were collected during three short cruises (HYGAM; March 6–7, 20–21, April 5–6, 2005). They were scheduled approximately every 15 days to sample the gulf circulation under different weather conditions. Moreover, the cruise data were used to validate the Symphonie model, a 3D primitive equations circulation model. The circulation features displayed by in situ data were well reproduced by Symphonie. A downscaling modelling approach was implemented, the largest scale being obtained by the replay of the MFSTEP regional model of the North-Western Mediterranean Sea. The analysis, closely coupling in situ measurements and model results, provides information that would not have been obtained using data separately. The great variability of the oceanic circulation at this scale is well evidenced. Winds are the main forces, not only locally but also at a larger scale. North winds generate coherent structures interacting with the general Mediterranean circulation. The explanation of the induced currents is then not straightforward, some of them being, for example, northward. South and southeast winds reinforce the sloping surface, the latter allowing the geostrophic equilibrium with longshore currents. This study, focused on the end of winter 2004–2005, also enhances the heat fluxes from offshore to nearshore, as well as the initiation of shelf dense waters. The knowledge of the midshelf oceanic circulation is then applied to run a numerical experiment which describes both the dispersion of a fictive contaminant from a point S (at the centre of the GAM), and evaluates the risk of contamination of the beaches along the GAM shores.
ISSN: 0278-4343

hal-00196620
https://hal.archives-ouvertes.fr/hal-00196620
DOI : 10.1016/j.csr.2007.06.006

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
We report new structural, microstructural, petrological, and major- and trace-element data on ultramafic rocks from the Kondyor zoned ultramafic complex in Far-East Russia. The ultramafic rocks are subdivided into three subconcentric lithologies, from core to rim: (1) a metasomatic domain where generally phlogopite-rich dykes pervasively intrude dunite; (2) a main dunite core; (3) a pyroxenite rim. The ultramafic rocks have nearly vertical contacts with the surrounding Archaean basement (gneisses, quartzites and marbles) and hornfelsed Riphean sediments. The hornfelsed sediments show a relatively steep ( 60), outward dipping layering, which rapidly flattens to horizontal away from the inner contact. Although the Riphean sediments define a dome-like structure, the inward, shallow dipping foliation of the dunites indicates a synformal structure. Detailed petro-structural investigations indicate that the Kondyor dunites were deformed by solid-state flow under asthenospheric mantle conditions. The outward textural change from coarse- to fine-grained equigranular dunite and the outward-increasing abundance of subgrains and recrystallized olivine grains suggest dynamic recrystallization while fluid circulation was channelized within the core metasomatic zone, with a decreasing melt fraction from core to rim, and also suggest that solid-state deformation induced grain-size reduction towards the cooling border of the Kondyor massif. Based on their geochemistry, the dunites are interpreted as mantle rocks strongly affected by reaction with melts similar to the JurassicCretaceous Aldan Shield lamproites. Rim pyroxenites were formed by a melt-consuming peritectic reaction, implying the existence of at least a small, conductive thermal gradient around the dunite body while the latter was still at near-solidus temperature conditions. This suggests that the zoned structure of Kondyor was initiated at mantle depths, most probably within the subcontinental lithosphere. Upon cooling, the lamproitic melts were progressively focused in the central part of the massif and drained into vein conduits where they reacted with the wall-rock dunite. Two-dimensional numerical modelling based on finite-differences with a marker-in-cell technique incorporates temperature-dependent rheologies for both molten and non-molten host rocks. The modelling consolidates the structural, petrological and geochemical interpretations, which show that the dunites represent the synformal, flat-lying apex of an asthenospheric mantle diapir, triggered by fluid pressure channelized in the core, which nearly reached the Earths surface. We conclude that translithospheric mantle diapirism is an important mode of mass transfer in the Earth.
ISSN: 0022-3530

hal-00424508
https://hal.archives-ouvertes.fr/hal-00424508
DOI : 10.1093/petrology/egn083

Éditeur(s) : HAL CCSD
Résumé : International audience
Le jeu entre opinion et savoir et le moyen d'établir une connaissance objective sont au coeur des débats depuis l'Antiquité, et ont suscité, dans l'histoire des sciences, divers discours de la méthode. Ces thèmes ont également leur résonnance dans l'enseignement des sciences, et sont au coeur des travaux que nous avons menés sur la formation de l'esprit scientifique 1 qui, ne se limitant pas aux sciences, montrent par exemple que de nombreux élèves proposent de s'en remettre aux sondages ou aux opinions de proches sur des problèmes qui pourraient être tranchés par l'expérience, ou encore n'hésitent pas à affirmer leurs certitudes sans pour autant savoir. Selon le philosophe Karl Popper et le neurophysiologiste et prix Nobel John Eccles, la nature appartient au monde 1, les opinions subjectives au monde 2 et la connaissance objective au monde 3. C'est, pour Karl Popper, comme le résume Jacques Monod, une sélection darwinienne qui opère sur la diversité des idées, description évolutionniste de la recherche scientifique que l'enseignant peut adapter en classe, s'il souhaite là aussi emprunter une voie qui conduise du monde 2 au monde 3 : des opinions au savoir. Les travaux effectués avec une équipe d'enseignants de SVT engagent les élèves dans une telle voie, qui fragilise les opinions : le crédit qui est accordé à celles qui toujours surgissent, les siennes comme celles d'autrui, peut alors être interrogé.
ISSN: 2110-6460

Droits : info:eu-repo/semantics/OpenAccess
hal-01535160
https://hal.univ-antilles.fr/hal-01535160
https://hal.univ-antilles.fr/hal-01535160/document
https://hal.univ-antilles.fr/hal-01535160/file/Cariou_RDSTn%C2%B01_2010_Opinions%20vuln%C3%A9rables.pdf
DOI : 10.4000/rdst.163

Résumé : Dans le cadre du plan Etat-Région 1994-1998, un programme de conservatoire de souches a été initié au Laboratoire IFREMER de La Tremblade. Ce conservatoire a pour objectif d'acclimater différentes espèces ou souches d'huîtres creuses (genres Crassostrea et Saccostrea) afin d'acquérir des connaissances sur ces espèces et d'évaluer l'intérêt qu'elles pourraient présenter pour l'ostréiculture locale. L'importation d'espèces étrangères sur les côtes françaises est désormais strictement réglementée: la dissémination d'une nouvelle espèce peut se révéler néfaste d'un point de vue écologique et nuire aux productions existantes. De plus, ces huîtres peuvent être porteuses de pathogènes qui, s'il venaient à se répandre dans le milieu, pourraient toucher les stocks locaux. En conséquence, les huîtres importées sont strictement confinées au laboratoire dans une « salle de quarantaine » dont l'eau est traitée à l'ozone avant rejet afin d'éviter à la fois la dissémination des huîtres et d'éventuels pathogènes...

Droits : 1999 Ifremer
http://archimer.ifremer.fr/doc/00044/15514/12901.pdf
http://archimer.ifremer.fr/doc/00044/15514/

Éditeur(s) : HAL CCSD EDP Sciences
Résumé : International audience
The dynamic model of plant growth GreenLab describes plant architecture and functional growth at the level of individual organs. Structural development is controlled by formal grammars and empirical equations compute the amount of biomass produced by the plant, and its partitioning among the growing organs, such as leaves, stems and fruits. The number of organs initiated at each time step depends on the trophic state of the plant, which is evaluated by the ratio of biomass available in plant to the demand of all the organs. The control of the plant organogenesis by this variable induces oscillations in the simulated plant behaviour. The mathematical framework of the GreenLab model allows to compute the conditions for the generation of oscillations and the value of the period according to the set of parameters. Two case-studies are presented, corresponding to emergence of oscillations associated to fructification and branching. Similar alternating patterns are commonly reported by botanists. In this article, two examples were selected: alternate patterns of fruits in cucumber plants and alternate appearances of branches in Cecropia trees. The model was calibrated from experimental data collected on these plants. It shows that a simple feedback hypothesis of trophic control on plant structure allows the emergence of cyclic patterns corresponding to the observed ones.
ISSN: 0973-5348

hal-00780592
https://hal-ecp.archives-ouvertes.fr/hal-00780592
https://hal-ecp.archives-ouvertes.fr/hal-00780592/document
https://hal-ecp.archives-ouvertes.fr/hal-00780592/file/Mathieu_2012_Published_mmnp201276p47.pdf
DOI : 10.1051/mmnp/20127603

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The investigation of deformation rates on a mountain piedmont can provide key information for improving our understanding of the overall dynamics of a mountain range. Here, we estimate the shortening rate absorbed by a Quaternary emergent detachment fold on the southeastern piedmont of the Tianshan (China). Our work is primarily based on new 10Be cosmogenic exposure dating of deformed alluvial surfaces. The method we have developed combines depth profiling with sampling of surface cobbles, thereby allowing exposure time, erosion rate and inheritance to be simultaneously constrained. The exposure ages of the uppermost uplifted alluvial surfaces are around 140±17 ka140±17 ka, 130±9 ka130±9 ka and 47±9 ka47±9 ka, from west to east. A terrace lying below the 140 ka surface is dated at 65±5 ka65±5 ka. The ages of the uplifted and folded alluvial surfaces were then combined with estimates of shortening obtained using two distinct methods: (1) the excess area method, where sedimentation rates, extracted from magnetostratigraphic studies, are used to determine the amount of sedimentation after the abandonment of the river; and (2) a folding model derived from sandbox experiments. The late Pleistocene shortening rates are shown to be between 0.4±0.1 mm/yr0.4±0.1 mm/yr and 0.8±0.5 mm/yr0.8±0.5 mm/yr on the western part of the fold and 2.1±0.4 mm/yr2.1±0.4 mm/yr along its central part. The central part of the frontal Yakeng anticline therefore accommodates up to 25% of the total shortening currently absorbed across the whole Eastern Tianshan range (8 mm/yr). However, this situation seems to have prevailed for only the last 150 ka, as the shortening rate absorbed by this nascent fold was previously ten times slower. While the initiation of folding of the Yakeng anticline can be traced back to 5.5 Ma ago, the basinward migration of the active deformation front onto the Yakeng fold is a relatively recent phenomenon and appears to be diachronous from west to east, probably in relation to the tectonic activity of the folds in the hinterland.
ISSN: 0012-821X

hal-01306997
https://hal.archives-ouvertes.fr/hal-01306997
DOI : 10.1016/j.epsl.2015.11.041

Éditeur(s) : HAL CCSD American Association for Cancer Research
Résumé : International audience
Homing of CD8+ T lymphocytes to the tumor microenvironment is an important step for mounting a robust antitumor immune response. TGF-β is responsible for CD103 (αEβ7) integrin induction in activated intraepithelial CD8+ T lymphocytes. However, the interplay between TGF-β and CD103 and their contribution to T-cell infiltration and antitumor activity remain unknown. Here, we used viable human lung tumor slices and autologous tumor antigen-specific T-lymphocyte clones to provide evidence that CD103 is directly involved in T-lymphocyte recruitment within epithelial tumor islets and intratumoral early T-cell signaling. Moreover, TGF-β enhanced CD103-dependent T-cell adhesion and signaling, whereas it inhibited leukocyte function-associated antigen (LFA)-1 (αLβ2) integrin expression and LFA-1-mediated T-lymphocyte functions. Mechanistic investigations revealed that TGF-β bound to its receptors (TGFBR), which promoted the recruitment and phosphorylation of integrin-linked kinase (ILK) by TGFBR1. We further show that ILK interacted with the CD103 intracellular domain, resulting in protein kinase B (PKB)/AKT activation thereby initiating integrin inside-out signaling. Collectively, our findings suggest that the abundance of TGF-β in the tumor microenvironment may in fact engage with integrin signaling pathways to promote T-lymphocyte antitumor functions, with potential implications for T-cell-based immunotherapies for cancer
ISSN: 0008-5472

Droits : info:eu-repo/semantics/OpenAccess
hal-01282442
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01282442
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01282442/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01282442/file/TGF%CE%B2%20Signaling%20Intersects%20with%20CD103-boutet2016-final.pdf
DOI : 10.1158/0008-5472.CAN-15-1545

Éditeur(s) : HAL CCSD
Résumé : Correspondance : Dupraz@supagro.inra.fr
En conduite agroforestière, durant leurs premières années de croissance les arbres sont protégés par des abris individuels plastiques ventilés (disponibilité du C02, limitation de l'augmentation de temperature). Les arbres conduits en abri ont une croissance en biomasse totale comparable à celle des arbres sans abris (Dupraz, 1997b), mais présentent une croissance en hauteur plus importante,une croissance en diamètre inferieure (Bergez and Dupraz, 2000) et une biomasse racinaire plus faible de 17% (Dupraz, 1997a). Des études (Bergez and Dupraz, 2000 ; Dupraz and Bergez, 1999) ont conduit à éliminer la responsabilité des facteurs microclimatiques pour expliquer ces diffférences. Il restait un facteur explicatif : I'absence de sollicitation mécanique des arbres dans les abris. En effet, les sollicitations mécaniques telles que le vent induisent des mouvements des axes de plantes. Il a été démontré que les plantes ne perçoivent pas les forces auxquelles elles sont soumises mais leur état de déformation (Coutand and Moulia, 2000). Celle mécano-perception engendre des modifications de la croissance en dimension (Larson, 1954; Coutand et al., 2000) et de l'allocation de la biomasse des vegetaux (Niklas, 1998). Cette expérimentation avait donc pour but de voir si des arbres en abri soumis à des sollicitations mécaniques artificielles retrouvaient une croissance en dimensions et une répartition de la biomasse semblables à celle des arbres de plein vent. L'expérimentation a été conduite sur des merisiers d'un an et comportait 4 traitements : Abri, Abri+flexion artificielles, Sans Abri+vent, Sans abri+tuteurage. Les résultats ne montrent aucune différence de biomasse totale produite entre les 4 traitements. Par contre, les sollicitations mécaniques (naturelles ou artificielles) réduisent la croissance en hauteur (d'environ 60%), stimulent la croissance radiale d'environ 30% et induisent une allocation de la biomasse en faveur des racines. L'absence de sollicitations mécaniques est donc le facteur responsable des différences entre arbres en abri et arbres au vent.Quantitativement, les flexions artificielles n'étaient pas équivalentes à celles induites par le vent et n'ont pas mimé complètement les effets du vent. Reproduire les effets mécaniques du vent dans l'abri nécessite de parvenir à quantifier les variations d'état mécanique induites par le vent sur les axes des arbres. Ceci suppose donc d'abord de comprendre le couplage fluide-structure. Ce type de travail a été initié sur un couvet de luzerne, il explique les couplages vent-mouvements des tiges à la surface du couvert (Py, 2005). Ce type de travail pourrait servir de base à la prolongation de ce travail.
L'arbre isolé
Montpellier, France

hal-01032058
https://hal.archives-ouvertes.fr/hal-01032058