Éditeur(s) : Université des Antilles Études caribéennes
Résumé : El presente artículo tiene como objetivo, valorar la conducta ética del profesional en turismo como elemento incidente en el servicio innovador y sostenible de la actividad turística. Es un análisis crítico ya que en él se da una relación constructiva de la teoría y la práctica, de lo que es y el deber ser de las ejecuciones de los profesionales del turismo. Para su abordaje se procedió a un estudio documental, basado en la revisión bibliográfica de material actualizado sobre el tema en cuestión, llegando a la conclusión de que toda innovación turística, desde la identificación y conversión de recurso turístico hasta su puesta en valor como producto turístico, requiere de un sistema de información turística, de una tecnología. Además el turismo sostenible es una estrategia que promueve el desarrollo de comunidades con riquezas paisajísticas, culturales, ambientales, etc. La práctica ética del profesional en turismo es determinante en la calidad del servicio hotelero innovador y en esa medida se contribuye a que éste sea sostenible en el tiempo.
This article aims, assess the ethical conduct of professional tourism as an element incident innovative and sustainable tourism service. It is a critical analysis since it constructive relationship of theory and practice, of what is and what ought to be the executions of tourism professionals is given. For your approach proceeded to a desk study, based on a literature review of current on the subject matter material concluding that all tourism innovation, from identification and conversion of resource to its value as a tourism product requires a tourist information system, a technology. Furthermore sustainable tourism is a strategy that promotes the development of communities Scenic, cultural, environmental wealth, etc. The practice of professional ethics in tourism is crucial to the quality of service and innovative Hotelier this measure helps to make it sustainable over time.

Droits : info:eu-repo/semantics/openAccess
urn:doi:10.4000/etudescaribeennes.9452
http://journals.openedition.org/etudescaribeennes/9452

Éditeur(s) : Littoral 2004, Aberdeen, Scotland, UK, September 2004
Résumé : NAMIBIE (a french acronym for Integrated Multimedia Navigator Within Coastal Environment Data Bases) is a specific tool which first concept has been established by Ifremer and has been developped by an association between research in the field of coastal environment, innovation in the field of new information and communication technologies and services in the field of coastal integrated management and impact studies. The objectives of this tool are to facilitate research, direct access and display of relevant multimedia coastal integrated data and information according to an interactive, widely opened and playfull interface. The principles are based upon the fact that sustainable decision making needs an optimized unterstanding of coastal processes and better consultation between actors. In this purpose the development of the tool has considered that the end-user should and could be free to look after the data and the information he needs for a particular site or environment of interest and for a specific ICZM question according to easy navigation interfaces. That is why NAMIBIE concept is based upon : - a coherent 3D representation of the coasts (i.e. from catchement areas to continental shelf and deep sea), which considers a coherent DEM from land to sea and textural representation of the environment using satellite imagery textural displays, - a 3D navigator which allows the user to fly or dive over and within the coastal environment of interest, - a multimedia database (text, graphs, image, maps, geographic objects, modelling results...) specific to the territory of interest, - an interactive interface which helps in finding relevant information associated to specific questions. The technologies used include VRML data format, integration of standard GIS format (shp, grid, img) within the navigator, integration and display of modelling data. The production chain is realized in C++ and Java scripts allow dialogue between web pages and 3D windows. Applications are presented on the coasts of Languedoc Roussillon region (French Mediterranean border) in the framework of ICZM problematics

Droits : info:eu-repo/semantics/openAccess
http://archimer.ifremer.fr/doc/00089/20055/17696.pdf
http://archimer.ifremer.fr/doc/00089/20055/

Éditeur(s) : HAL CCSD
Résumé : The modernization of agriculture is under scrutiny. It is currently debated within the growing concept and practice of agroecology that applies ecological fundaments to the design and the management of sustainable agroecosystems. In matter of ecologization of agriculture, agroecological transition may be considered as a privileged pathway. It relies on two main forms: the weak (that intends to reduce the use of chemicals by alternative practices such as their substitution by biological inputs) versus strong modernization of agriculture (based on the valorization of biodiversity providing ecosystemic services). In this article, through an analysis of the technological innovations used for the enhancement of mycorrhiza (symbiotic interactions between plants and soil microorganisms) as an illustration of the implementation of the agroecological transition in France, we wonder in what extent a strong modernization of agriculture is likely to occur.This paper shows how the conceptual framework of socio-technical regime is useful to analyze the dynamics of the agroecological transition. Our demonstration relies on an empirical material (survey of the main actors of the mycorrhiza supply chain) that permits to understand how is structured the dominant system and how it impedes the development of the alternative niche. We then give some prerequisites in terms of public action to define in what extent the niche can be supported and can compete the current system.
54. ERSA Congress "Regional development & globalization: Best practices"
Saint-Petersburg, Russia

hal-01606449
https://hal.archives-ouvertes.fr/hal-01606449
PRODINRA : 387723

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
The development of inflammatory granulomas around infected Kupffer cells is necessary for hepatic parasite clearance during visceral leishmaniasis. Invariant NKT (iNKT) cells are predominant T cells in the mouse liver and can synthesize large quantities of IL-4 and IFN-γ, two cytokines involved in granuloma formation. This study analyzed the role of iNKT cells in the hepatic immune response during Leishmania donovani infection, using a murine model of wild-type (WT) and iNKT cell-deficient (Jα18⁻/⁻) C57BL/6 mice sacrificed 15, 30 or 60 days post-infection. We recorded hepatic parasite loads, cytokine expression, and analyzed granulomatous response by immunohistochemistry and hepatic immune cell infiltration by flow cytometry. Whereas WT animals rapidly controlled the infection and developed an inflammatory response associated with a massive influx of iNKT cells observed by flow cytometry, Jα18⁻/⁻ mice had significantly higher parasitic loads on all time points. This lack of control of parasite burden was associated with a delay in granuloma maturation (28.1% of large granulomas at day 60 versus 50.7% in WT). Cytokine transcriptome analysis showed that mRNA of 90/101 genes encoding chemokines, cytokines and their receptors, was underexpressed in Jα18⁻/⁻ mice. Detection of IL-4 and TNF-α by ELISA in liver extracts was also significantly lower in Jα18⁻/⁻ mice. Consistent with flow cytometry analysis, cytokinome profile in WT mice showed a bias of expression towards T cell-chemoattractant chemokines on D15, and displayed a switch towards expression of granulocytes and/or monocytes -chemoattractant chemokines on D60. In Jα18⁻/⁻ mice, the significantly lower expression of CXCL5, MIP-2 and CCL2 mRNA was correlated with a defect in myeloperoxidase positive-cell attraction observed by immunohistochemistry and with a lower granulocyte and monocyte infiltration in the liver, as shown by flow cytometry. These data indicate that iNKT cells play a role in early and sustained pro-inflammatory cytokine response warranting efficient organization of hepatic granulomas and parasite clearance.
ISSN: 1932-6203

hal-00696897
https://hal.archives-ouvertes.fr/hal-00696897
https://hal.archives-ouvertes.fr/hal-00696897/document
https://hal.archives-ouvertes.fr/hal-00696897/file/Invariant_NKT_Cells_Drive-accepted.pdf
DOI : 10.1371/journal.pone.0033413

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
In this study, we report the cloning of three transcripts for leptin receptor in the European sea bass, a marine teleost of economic interest. The two shortest variants, generated by different splice sites, encode all functional extracellular and intracellular domains but missed the transmembrane domain. The resulting proteins are therefore potential soluble binding proteins for leptin. The longest transcript (3605 bp), termed sblepr, includes all the essential domains for binding and transduction of the signal. Thus, it is proposed as the ortholog for the human LEPR gene, the main responsible for leptin signalling. Phylogenetic analysis shows the sblepr clustered within the teleost leptin receptor group in 100% of the bootstrap replicates. The neuroanatomical localization of sblepr expressing cells has been assessed by in situ hybridization in brains of sea bass of both sexes during their first sexual maturation. At histological level, the distribution pattern of sblepr expressing cells in the brain shows no clear differences regarding sex or reproductive season. Transcripts of the sblepr have a widespread distribution throughout the forebrain and midbrain until the caudal portion of the hypothalamus. A high hybridization signal is detected in the telencephalon, preoptic area, medial basal and caudal hypothalamus and in the pituitary gland. In a more caudal region, sblepr expressing cells are identified in the longitudinal torus. The expression pattern observed for sblepr suggests that in sea bass, leptin is very likely to be involved in the control of food intake, energy reserves and reproduction
ISSN: 0016-6480

hal-01290500
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01290500
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01290500/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01290500/file/Leptin%20receptor%20gene%20in%20the%20European%20sea%20bass%20postprint.pdf
DOI : 10.1016/j.ygcen.2016.03.017

Éditeur(s) : HAL CCSD Lippincott, Williams & Wilkins
Résumé : International audience
OBJECTIVES: The ANRS-112 INTERPRIM trial assessed whether fixed-cycles of antiretroviral treatment interruption (ART-STI) combined or not with pegylated interferon alpha-2b (peg-IFN) could lower viral load and achieve a healthier immune system in patients diagnosed during primary HIV-1-infection (PHI). DESIGN AND METHODS: Patients were randomized to receive either continuous ART (cART) during 72 weeks, or cART during 36 weeks followed by three ART-STIs, or the same ART-STIs associated with peg-IFN during the first 14 weeks and each interruption (ART-STI-IFN). Treatment was stopped at week 72. Final evaluation was based on plasma HIV-RNA level 6 months after the last treatment interruption. RESULTS: Eighty-seven percent of patients achieved undetectable HIV-RNA at week 32, with no deleterious impact of sequential treatment interruptions (STIs). Viral rebounds during interruptions were lower in the ART-STI-IFN than in the ART-STI group and during the second and third interruptions compared with the first one. However, HIV-RNA levels, CD4 T-cell counts and CD4 T/CD8 T ratios were similar between groups after the 6-month interruption, with a persistent effect on CD4 T cells and total cell-associated HIV-DNA levels. Predictive factors of virological outcome were HIV-RNA and HIV-DNA levels at PHI and HIV-DNA levels at treatment interruption. HIV-specific responses did not differ between strategies and were not associated with outcome. Forty-eight percent of patients experienced treatment resumption during long-term follow-up without difference between groups. CONCLUSION: When initiated during PHI, STIs associated or not with IFN did not result in a different outcome as compared to cART. All regimens showed a high response rate and a sustained immunological benefit after cessation.
ISSN: 0269-9370

hal-00875175
https://hal.archives-ouvertes.fr/hal-00875175
DOI : 10.1097/QAD.0b013e32835844d9
PUBMED : 22842994