Éditeur(s) : HAL CCSD Institute of Electrical and Electronics Engineers (IEEE)
Résumé : International audience
Non-alcoholic fatty liver disease (NAFLD) is defined as an excessive accumulation of fat in the liver in the absence of excessive drinking of alcohol. Initially considered as benign and self-limited, NAFLD may progress to the malignant stage of non-alcoholic steatohepatitis (NASH) characterized by degenerate hepatocellular ballooning and lobular inflammation. NASH can lead to hepatic fibrosis and ultimately to cirrhosis and hepatocellular carcinoma. Unfortunately, the transition from NAFLD to NASH is difficult to detect so far. In this paper, we propose to evaluate the characterization of NASH using mid infrared fiber evanescent wave spectroscopy on blood serum. We used an heuristic variable selection method and a generalized linear model to classify NAFLD and NASH spectra. The obtained results proved that this technique is a promising non-invasive and simple diagnosis tool for NASH.
ISSN: 1557-170X

inserm-01476033
http://www.hal.inserm.fr/inserm-01476033
http://www.hal.inserm.fr/inserm-01476033/document
http://www.hal.inserm.fr/inserm-01476033/file/EMBC_2016_CameraReady.pdf
DOI : 10.1109/EMBC.2016.7591507

Éditeur(s) : HAL CCSD Impact journals
Résumé : International audience
Interleukin (IL)-33 has been recently reported to be strongly pro-fibrogenic in various models of liver disease. Our aim was to study the role of endogenous IL-33 in a diet-induced model of steatohepatitis. IL-33 deficient mice and wild type (WT) littermates received a high-fat diet (HFD), or a standard diet for 12 weeks. The HFD-induced steatohepatitis was associated with an upregulation of IL-33 transcripts and protein. An insulin tolerance test revealed lower systemic insulin sensitivity in IL33-/-HFD mice than in WT-HFD mice. Nevertheless, IL-33 deficiency did not affect the severity of liver inflammation by histological and transcriptomic analyses, nor the quantity of liver fibrosis. Livers from HFD mice had more myeloid populations, markedly fewer NKT cells and higher proportion of ST2+ Treg cells and ST2+ type 2 innate lymphoid cells (ILC2), all unaffected by IL-33 deficiency. In conclusion, deficiency of endogenous IL-33 does not affect the evolution of experimental diet-induced steatohepatitis towards liver fibrosis.
ISSN: 1949-2553

hal-01578584
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01578584
DOI : 10.18632/oncotarget.18335
PUBMED : 28611297

Éditeur(s) : HAL CCSD American Society for Investigative Pathology
Résumé : International audience
Recent studies suggest that psoriasis may be more severe in patients with nonalcoholic fatty liver disease, particularly in those with the inflammatory stage of steatohepatitis [nonalcoholic steatohepatitis (NASH)]. Herein, we investigated the impact of diet-induced steatohepatitis on the severity of imiquimod-induced psoriasiform dermatitis. Mice fed with a high-fat diet developed steatohepatitis reminiscent of human NASH with ballooning hepatocytes and significant liver fibrosis. Mice with steatohepatitis also displayed moderate cutaneous inflammation characterized by erythema, dermalinfiltrates of CD45(+) leukocytes, and a local production of IL-17A. Moreover, steatohepatitis was associated with an epidermal activation of caspase-1 and cutaneous overexpression of IL-1 beta. Imiquimod-induced psoriasiform dermatitis was exacerbated in mice with steatohepatitis as compared to animals fed with a standard diet. Scale formation and acanthosis were aggravated, in correlation with increased IL-17A and IL-22 expression in inflamed skins. Finally, intradermal injection of IL-17A in standard diet-fed mice recapitulated the cutaneous pathology of mice with steatohepatitis. The results show that high-fat diet induced steatohepatitis aggravates the inflammation in psoriasiform dermatitis, via the cutaneous production of IL-17A. In agreement with clinical data, this description of a novel extrahepatic manifestation of NASH should sensitize dermatologists to the screening and the management of fatty liver in psoriatic patients.
ISSN: 0002-9440

hal-01390977
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01390977
DOI : 10.1016/j.ajpath.2016.05.012
PUBMED : 27423696

Éditeur(s) : HAL CCSD EDP Sciences
Résumé : International audience
In the setting of a real Hilbert space H, we investigate the asymptotic behavior, as time t goes to infinity, of trajectories of second-order damped evolution equations, which are governed by the sum of the gradient operator of a convex differentiable potential function , and a maximal monotone operator which is assumed to be cocoercive. Under a sharp condition involving the viscous and the cocoercive parameters, it is proved that each trajectory weakly converges to an equilibrium. Passing from weak to strong convergence is obtained by introducing an asymptotically vanishing Tikhonov-like regularizing term. As special cases, we recover the asymptotic analysis of the heavy ball with friction dynamic attached to a convex potential, the second-order gradient-projection dynamic, and the second-order dynamic governed by the Yosida approximation of a general maximal monotone operator. The breadth and flexibility of the proposed framework is illustrated through applications in the areas of constrained optimization, dynamical approach to Nash equilibria for noncooperative games, and asymptotic stabilization in the case of a continuum of equilibria.
ISSN: 1292-8119

hal-00803774
https://hal.archives-ouvertes.fr/hal-00803774
https://hal.archives-ouvertes.fr/hal-00803774/document
https://hal.archives-ouvertes.fr/hal-00803774/file/ATTOUCH-MAINGE-09-04-2010-COCV.pdf
DOI : 10.1051/cocv/2010024

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
We present generalizations of the KKM Principle and of the Kakutani-Fan-Glicksberg fixed point theorem adapted to the study of Nash equilibria in games without ordered preferences.
Journal of Mathematical Analysis and applications

hal-00699223
https://hal.archives-ouvertes.fr/hal-00699223

Éditeur(s) : HAL CCSD
Résumé : International audience
The author proposes a generalized proximal method for solving an equilibrium problem which consists in finding x 2 K such that F(x, y) 0, for all y 2 K, where K is a nonempty, convex and closed set of a real Hilbert space X, and F:K ×K !Ris a given bifunction with F(x, x) = 0 for all x 2 K. The weak convergence of the sequence generated by the method is proved under the assumptions of monotonicity and convexity, with respect to the second argument y (for every fixed x 2 K), of the bifunction F. Replacing the assumption of monotonicity with the one of strong monotonicity on F, a strong convergence result is obtained. A second strong convergence theorem is proved under the hypotheses of monotonicity and a new assumption of "co-Lipschitz continuity at 0" of the operator F. Applications to convex optimization, to the problem of finding a zero of a maximal monotone operator and to Nash equilibria problems are provided.
Journal of Natural Geometry

hal-00773194
https://hal.univ-antilles.fr/hal-00773194

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The aim of this paper is twofold. First, it is to extend the sensitivity analysis framework, developed recently for variational inequalities, to mixed equilibrium problems. The second is to propose iterative methods for solving this kind of problems. In the process, we establish an equivalence between an extended version of Wiener-Hopf equations and the given problems relying on a generalization of the Yosida approximation notion. Our results generalize results obtained for optimization, variational inequalities, complementarity problems, and problems of Nash equilibria.
ISSN: 0898-1221

hal-00779234
https://hal.univ-antilles.fr/hal-00779234
DOI : 10.1016/S0898-1221(02)00218-3