Éditeur(s) : CRILLASH : Centre de Recherches Interdisciplinaires en Lettres, Langues, Arts et Sciences Humaines CRILLASH : Centre de Recherches Interdisciplinaires en Lettres, Langues, Arts et Sciences Humaines CRILLASH : Centre de Recherches Interdisciplinaires en Lettres, Langues, Arts et Sciences Humaines
Extrait de : Journée des Canaries, le 25 septembre 2014. Université des Antilles et de la Guyane
Description : Allocutions d'ouverture, présentation de la conférence et des différents intervenants.
Siècle(s) traité(s) : 21
Droits : CC-BY-NC-ND - Attribution - Pas d'utilisation commerciale - Pas de modification
Permalien : http://www.manioc.org/fichiers/V15010
V15010
V15010
V15010

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
OBJECTIVES: To compare virological effectiveness in patients who continued on a virologically successful first-line boosted protease inhibitor (PI)-containing combination antiretroviral therapy (cART) regimen or who switched to a PI-free cART including efavirenz, nevirapine or abacavir. METHODS: From the French Hospital Database on HIV, we selected 439 patients with undetectable viral load (VL) on a first-line boosted PI-containing cART regimen who switched to a PI-free combination including efavirenz, nevirapine or abacavir. Each of these patients was matched with three patients who continued to take their first-line cART regimen, on the basis of gender, age, CD4 cell count, VL, date of cART initiation and the duration of VL undetectability. Time to virological failure (VF) was analysed with Kaplan-Meier curves and Cox models. RESULTS: The 12 month probabilities of VF were 3.7% and 5.7% in non-switch and switch patients, respectively, and 3.9%, 7.2% and 9.0% in patients switching to efavirenz-, nevirapine- and abacavir-containing cART, respectively. After adjustment, only patients switching to abacavir-containing cART had a higher risk of VF than non-switch patients (adjusted hazard ratio, 1.99; 95% confidence interval, 1.05-3.79). CONCLUSIONS: Switching from a virologically successful first-line boosted PI-containing cART regimen to a non-nucleoside reverse transcriptase inhibitor-containing cART regimen containing either efavirenz or nevirapine is virologically safe, while switching to abacavir-containing cART should be avoided.
ISSN: 0305-7453

hal-00875284
https://hal.archives-ouvertes.fr/hal-00875284
DOI : 10.1093/jac/dkr208
PUBMED : 21636583

Éditeur(s) : HAL CCSD American Academy of Neurology
Résumé : International audience
OBJECTIVE: We examined if the CNS Penetration-Effectiveness (CPE) score of antiretroviral drugs was associated with survival after a diagnosis of HIV-related encephalopathy, progressive multifocal leukoencephalopathy (PML), cerebral toxoplasmosis, or cryptococcal meningitis. METHODS: Using data from the FHDH-ANRS CO4, we compared the survival of 9,932 HIV-infected patients diagnosed with a first neurologic AIDS-defining event in the pre-combination antiretroviral therapy (cART) (1992-1995), early cART (1996-1998), or late cART (1999-2004) periods. Follow-up was subdivided (CPE < 1.5 and CPE ≥ 1.5), and relative rates (RR) of death were estimated using multivariable Poisson regression models. RESULTS: In the pre-cART and early cART periods, regimens with CPE ≥ 1.5 were associated with lower mortality after HIV-related encephalopathy (RR 0.64; 95% confidence interval [CI] 0.47-0.86 and RR 0.45; 95% CI 0.35-0.58) and after PML (RR 0.79; 95% CI 0.55-1.12 and RR 0.45; 95% CI 0.31-0.65), compared to regimens with CPE < 1.5, while in the late cART period there was no association between the CPE score and the mortality. A higher CPE score was also associated with a lower mortality in all periods after cerebral toxoplasmosis (RR 0.68, 95% CI 0.56-0.84) or cryptococcal meningitis (RR 0.50, 95% CI 0.34-0.74). Whatever the neurologic event, these associations were not maintained after adjustment on updated plasma HIV-RNA (missing, <500, ≥500 copies/mL) with RR ranging from 0.82 (95% CI 0.36-1.91) to 1.02 (0.69-1.52). CONCLUSION: At the beginning of the cART era, the CPE score was of importance for survival after severe neurologic event, while in the late cART period, the additional effect of CPE score vanished with more powerful antiretroviral regimens associated with plasma viral load control.
ISSN: 0028-3878

hal-00875434
https://hal.archives-ouvertes.fr/hal-00875434
DOI : 10.1212/WNL.0b013e31820c3089
PUBMED : 21248274

Éditeur(s) : HAL CCSD
Résumé : International audience
Un certain nombre de travaux montrent que la manière dont les élèves perçoivent et traitent les erreurs en mathématiques est influencée par leurs croyances épistémologiques, conceptions de l’apprentissage et la perception de leurs compétences. Tout en reconnaissant l’importance de ces facteurs d’ordre motivationnel, certains chercheurs insistent sur le rôle que joue l’environnement de la classe sur les perceptions des élèves des erreurs. Pour avancer dans ce sens Van Dyck et al. (2005) proposent le concept de « climat de l’erreur » (ensemble de savoirs et pratiques pédagogiques véhiculés en classe) et suggèrent d’étudier ses effets. La présente recherche s’inscrit dans cette perspective et poursuit les objectifs suivants :1)Identifier les savoirs et les pratiques que les enseignants mobilisent en classe pour traiter différents types d’erreurs. 2)Déterminer la manière dont les élèves perçoivent et interprètent les savoirs et les pratiques des enseignants. Nous avons réalisé une étude par questionnaire (300 élèves de lycée et leurs enseignants) et une observation au sein de deux classes. Les résultats révèlent une discordance enseignants – élèves au niveau du traitement des erreurs, provenant d’une interprétation variée ou en décalage. Cela nous permettra d’aborder la problématique du traitement des erreurs des élèves en difficultés
CRIFPE 4° ColloqueInternationnal en Education
Montréal, Canada

hal-01618422
https://hal.univ-antilles.fr/hal-01618422

Éditeur(s) : HAL CCSD INRP/ENS éditions
Résumé : International audience
La présente recherche, subventionnée par le Fonds national suisse, a pour objectif de décrire les liens entre, d’une part, les croyances des enseignants à l’égard du redoublement et, d’autre part, leurs croyances et conceptions psychopédagogiques dans d’autres domaines : apprentissage, intelligence, évaluation et principes de justice. Il s’agit aussi d’étudier dans quelle mesure la connaissance des recherches sur les effets du redoublement affecte les croyances des enseignants à ce propos. Un questionnaire a été soumis à 125 enseignants du primaire du canton de Genève (Suisse). Les réponses obtenues ont été traitées par des analyses factorielles exploratoires, afin de valider une série d’échelles destinées à les mesurer. Deux croyances relatives au redoublement se dégagent : il offre une seconde chance aux élèves en difficulté et il n’a pas d’effet socio-affectif négatif. Utilisant des méthodes corrélationnelles, y compris la régression linéaire, nous avons examiné les relations entre ces deux croyances et les différentes conceptions psychopédagogiques identifiées ainsi qu’entre ces croyances et la connaissance des recherches et la crédibilité qui leur est accordée, afin de mettre à l’épreuve des faits sept hypothèses formulées en fonction de nos travaux antérieurs. Enfin, distinguant quatre groupes d’enseignants en fonction de leurs croyances relatives aux effets du redoublement, nous avons examiné dans quelle mesure les enseignants qui croient et ceux qui ne croient pas ou plus au redoublement se distinguent par leurs conceptions psychopédagogiques. Deux résultats principaux ressortent de ces analyses. D’une part, il apparaît que la connaissance des recherches portant sur les effets du redoublement influence les croyances des enseignants à propos de cette pratique, les amenant à douter de ses bienfaits ou à en reconnaître les méfaits. D’autre part, contrairement à plusieurs de nos hypothèses, les croyances des enseignants à propos du redoublement ne sont pas (ou relativement peu) affectées par leurs conceptions en matière d’apprentissage et d’intelligence. Ces résultats sont discutés en relation avec les théories classiques postulant que les croyances et représentations sociales sont organisées en systèmes.
ISSN: 0556-7807

hal-01532807
https://hal.univ-antilles.fr/hal-01532807

Éditeur(s) : HAL CCSD
Résumé : International audience
The challenge is to implement research that can estimate the consequences ofclimate changes in terms of impact on terrestrial environments and resources.Emphasis should be placed on regions dependent on natural resources and forwhich demographic pressure is strong. Simulations obtained from climate modelprojections (using different Representative Concentration Pathways (RCPs))predict that the Mediterranean basin and its southern periphery are particularlyvulnerable to water resources and environmental impact (IPCC, AR5, 2013).An annual rainfall decrease by 30% is found for the projection period 2070-2099(IPCC, AR5, 2013) associated with a decrease in water resources by 30 to 50%(Milano, 2012). In addition, several studies using regional atmospheric modelsindicate an increase in the precipitation inter-annual variability with extremeevents and a spatial heterogeneous signature, superimposed on a decrease in thetotal precipitation amount (Giorgi and Lionello, 2008; Raible et al. 2010).Currently, regional climate projections are highly sensitive to the climate modelused. In particular, spatial resolution as well as local climate conditions seemto impact significantly on the simulations (Jacob et al. 2014).The Mediterranean region, at the interface between arid and temperate climateswith several mountainous areas, is a complex climate system affected by theinteractions between mid-latitude and sub-tropical processes. In this context,Morocco, located at the transition between a temperate climate to the North anda tropical climate to the south constitutes a key area for an impact and sensitivitystudy to global climate changes. The climate is influenced by the Atlantic Ocean,the Mediterranean Sea and the Sahara, together with a very steep orography inthe Atlas region. The precipitation distribution is therefore characterised by greatspatial variability, and exhibits a marked seasonality, a strong inter-annualvariability (Ouda et al. 2005) and in general a pronounced gradient from northto south and west to east. At a broader scale, Morocco is located on the subtropicalsubsidence path and between the Acores High and the Saharan Low (Agoussine,2003). Several studies have also identified strong links with inter-annualprecipitation variability and NAO index (Knippertz, 2003) as well as remoteclimate modes (Esper et al. 2007).Continental climate variability at a local/regional scale, if it is to be integratedin climate predictions, needs to be supported by long-term observation.Meteorological stations in Morocco provide climatic data mainly for the last40 years with only a few stations located in the mountainous region (Tramblayet al. 2012; 2013; Driouech et al. 2010). This climate database is also supportedby the IAEA network providing stations for which isotope tracers have beenapplied to daily/monthly rain and water vapour samples over 2 to 3 years between2000 and 2004. Besides the poor coverage of instrumented areas, lacustrinesystems can provide a climatic data set that offers access to short and long-termtime series of climate parameters when knowledge of modern lake water balanceis combined with lacustrine sedimentary-climate records. Lake sediment recordsideally provide high resolution climate/environmental information of the last10,000 years (Magny et al. 2013). This time interval (corresponding to theHolocene) is a key period to investigate short and long-term climate variabilityand to improve prediction in a warming climate.In this study we present an integrated approach focusing on a mountainous lake(Aguelmam Azigza). The modern lake system study is based on site monitoring(2012-2016) and available regional hydro-climatic data. These data show thatlake level changes during the instrumented period were mainly driven byprecipitation following the high inter-annual variability. These data are thencompared with accurately dated short sediment cores retrieved in the same lake.Micro-scale geochemical and sedimentological analyses of these sequencesenable us to identify various sedimentary facies that can be linked with periodsof high (low) lake levels over the past decades.
The Mediterranean Region under Climate ChangeLa méditerranée face au changement climatique

insu-01394690
https://hal-insu.archives-ouvertes.fr/insu-01394690
https://hal-insu.archives-ouvertes.fr/insu-01394690/document
https://hal-insu.archives-ouvertes.fr/insu-01394690/file/Vidaletal.2016-COP22-Chap1.pdf

Éditeur(s) : HAL CCSD
Résumé : International audience
This research aim focused onthe interpretation of the action of pupils for two school professors in mathematics and in physical education. The research is in the field of work concerned with the process of didactic contextalisation (Delcroix, Forissier, Anciaux, 2012). It also mobilizes process of the comparative approach (Mercier, Schubauer-Leoni et Sensevy, 2002). Data processed within the limits of this communication were collected by interview of self-confrontation. The results are used to model the interpretive filters according to three axes: the practical epistemology of the professor through the categories of Shulman (1987), forms of inference employed and his organization. Our study allows us to confront, in this model, the specifics or generics, fruits of disciplinary didactics to the effects of the didactic contextualization. We note that the use of contextualization seems to act as a filter (regardless of the teacher or the discipline concerned) constitutive of a profile kind (in the sense of Clot). Finally, at the end of this research, we discuss the contribution of this type of study for the training of teachers by querying the aspect built of these filters in action-context interaction and by validating the legitimacy of this question: "What is happening in the minds of the students"?Clot, Y. et Faïta, D. (2001). Genre et style en analyse du travail. Concepts et méthodes, Travailler, 6, 7-42Delcroix, A., Forissier, T., & Anciaux, F. (2012). Vers un cadre d’analyse opérationnel des phénomènes de contextualisation didactique. Dans F. Anciaux, T. Forissier et LF. Prudent, Contextualisations didactiques (pp. 141-188). Paris : L’harmattan.Mercier, A., Schubauer-Leoni, ML. & Sensevy, G. (2002). Vers une didactique comparée. Revue française de pédagogie, 141, 5-16.Shulman, L. (1987). « Knowledge and teaching : foundations of the new reform ». Harvard Educational Review, vol. 57, n° 1, p. 1-22.
The Caribbean Academy of Sciences 20th GENERAL MEETING AND BIENNIAL CONFERENCE
Deshaies, Guadeloupe

hal-01618424
https://hal.univ-antilles.fr/hal-01618424

Éditeur(s) : HAL CCSD
Résumé : International audience
Analyses didactiques des pratiques d’enseignement et de formation : quelles perspectives ? Colloque internationnal ARCD
Toulouse, France

hal-01618427
https://hal.univ-antilles.fr/hal-01618427

Éditeur(s) : HAL CCSD The University of Alabama Press
Résumé : International audience
Protecting Heritage in the Caribbean

ISBN : 0817356673
hal-01083227
https://hal.archives-ouvertes.fr/hal-01083227

Éditeur(s) : HAL CCSD Public Library of Science
Résumé : International audience
Chaperone synthesis in response to proteotoxic stress is dependent on a family of transcription factors named heat shock factors (HSFs). The two main factors in this family, HSF1 and HSF2, are co-expressed in numerous tissues where they can interact and form heterotrimers in response to proteasome inhibition. HSF1 and HSF2 exhibit two alternative splicing isoforms, called α and β, which contribute to additional complexity in HSF transcriptional regulation, but remain poorly examined in the literature. In this work, we studied the transcriptional activity of HSF1 and HSF2 splicing isoforms transfected into immortalized Mouse Embryonic Fibroblasts (iMEFs) deleted for both Hsf1 and Hsf2, under normal conditions and after proteasome inhibition. We found that HSF1α is significantly more active than the β isoform after exposure to the proteasome inhibitor MG132. Furthermore, we clearly established that, while HSF2 had no transcriptional activity by itself, short β isoform of HSF2 exerts a negative role on HSF1β-dependent transactivation. To further assess the impact of HSF2β inhibition on HSF1 activity, we developed a mathematical modelling approach which revealed that the balance between each HSF isoform in the cell regulated the strength of the transcriptional response. Moreover, we found that cellular stress such as proteasome inhibition could regulate the splicing of Hsf2 mRNA. All together, our results suggest that relative amounts of each HSF1 and HSF2 isoforms quantitatively determine the cellular level of the proteotoxic stress response.
ISSN: 1932-6203

inserm-00814784
http://www.hal.inserm.fr/inserm-00814784
http://www.hal.inserm.fr/inserm-00814784/document
http://www.hal.inserm.fr/inserm-00814784/file/journal.pone.0056085.pdf
DOI : 10.1371/journal.pone.0056085