Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The brain of the adult teleost fish exhibits intense neurogenic activity and an outstanding capability for brain repair. Remarkably, the brain estrogen-synthesizing enzyme, aromatase B, is strongly expressed, particularly in adult fishes, in radial glial cells, which act as progenitors. Using zebrafish, we tested the hypothesis that estrogens affect adult neurogenesis and brain regeneration by modulating the neurogenic activity of radial glial cells. To investigate this, the estrogenic environment was modified through inhibition of aromatase activity, blockade of nuclear estrogen receptors, or estrogenic treatments. Estrogens significantly decreased cell proliferation and migration at the olfactory bulbs/telencephalon junction and in the mediobasal hypothalamus. It also appears that cell survival is reduced at the olfactory bulbs/telencephalon junction. We also developed a model of telencephalic lesion to assess the role of aromatase and estrogens in brain repair. Proliferation increased rapidly immediately after the lesion in the parenchyma of the injured telencephalon, while proliferation at the ventricular surface appeared after 48 h and peaked at 7 days. At this time, most proliferative cells express Sox2, however, none of these Sox2 positive cells correspond to aromatase B-positive radial glial cells. Interestingly, aromatase B expression was significantly reduced 48 h and 7 days after the injury, but surprisingly, at 72 h after lesion, aromatase B expression appeared de novo expressed in parenchyma cells, suggesting a role for this ectopic expression of aromatase in brain repair mechanisms. Altogether these data suggest that estrogens modulate adult, but not reparative neurogenesis, in zebrafish.
ISSN: 0018-506X

inserm-00831715
http://www.hal.inserm.fr/inserm-00831715
DOI : 10.1016/j.yhbeh.2012.04.003
PUBMED : 22521210

Éditeur(s) : John Libbey Eurotext ltd
Résumé : How may fish domestication participate in sustainable development of aquaculture? The development of fish farming currently compensates for the stagnation of fishery catches while the market demand continues to increase. The development of fish farming relies on an active diversification of farmed fish species. A diversification based on the farming of native species could reduce the environmental impact of fish culture and could better fit to needs of local markets. Such development could also favour a more integrated local economy. In this context, the building of a generic approach for multi-species domestication is required to optimise the use of the technical and financial means available for fish culture diversification.
Cahiers Agricultures (1166-7699) (John Libbey Eurotext ltd), 2009-04 , Vol. 18 , N. 2 , P. 119-124

Droits : 2009 John Libbey Eurotext ltd
http://archimer.ifremer.fr/doc/2009/publication-6557.pdf
DOI:10.1684/agr.2009.0293
http://archimer.ifremer.fr/doc/00000/6557/