Éditeur(s) : HAL CCSD
Résumé : International audience
Nouv Presse Med

hal-00717095
https://hal.univ-antilles.fr/hal-00717095
PUBMED : 7015275

Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : International audience
Adult lymphatic filariae (Wuchereria bancrofti, Brugia malayi) can cause blocking of lymphatics producing obliterating endolymphitis lesions. The subsequent extravasation of lymph (or chyle when the obstruction is canal) is at the origin of the formation of lymphedema or elephantiasis, in which the main histological finding is great hypertrophy of collagen elements. This theory involving filaria only is not the full picture, and bacterial infection, mainly by streptococci, is an important factor. The association of filaria with microbes is particularly dangerous because the presence of the latter, or its toxins, causes death of local microfilariae and even adult worms, which are known to be more harmful dead than alive. The progression of the disease, especially in cases with lymphedema, which mainly affects the limbs and the genital organs, depends on three factors: the species of filaria, the degree of transmission, and the receptivity of the patient to the parasite. Large differences are found according to the region involved, and in the same endemic zone, according to the individuals affected. However, they almost always occur progressively in areas where there have been recurrent attacks of acute lymphangitis.
ISSN: 0398-0499

hal-00715440
https://hal.univ-antilles.fr/hal-00715440
PUBMED : 7007545

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
The activity of diethylcarbamazine (DEC) and suramin (S) on Litomosoides carinii filariasis was assessed by the study of microfilaraemia in 30 cotton-rats (Sigmodon hispidus). DEC (per os) and S (injected subcutaneously) were administered alone or in combination, at doses of 50 mg/kg/day for five consecutive days. 15 rats were treated at day 91 after infection and 15 others at day 184. The immediate but temporary efficacy observed with DEC was in contrast to the delayed and long-lasting effect of S. With combined therapy there was neither antagonism nor synergism. The demonstration of an apparently smaller reduction of parasitaemia in the rats treated with DEC before the plateau phase of the microfilaraemia was consistent with the lack of action of this drug on microfilariae outside the blood system.
ISSN: 0035-9203

hal-00717073
https://hal.univ-antilles.fr/hal-00717073
PUBMED : 7034313

Éditeur(s) : HAL CCSD
Résumé : International audience
Nouv Presse Med

hal-00715425
https://hal.univ-antilles.fr/hal-00715425
PUBMED : 745979

Éditeur(s) : HAL CCSD
Résumé : International audience
Nouv Presse Med

hal-00717093
https://hal.univ-antilles.fr/hal-00717093
PUBMED : 7015272

Éditeur(s) : HAL CCSD
Résumé : International audience
Realized in French Polynesia among 274 patients with elephantiasis, this survey studied the microfilaremia, the eosinophily, the immunoglobulin titers and the antifilarian antibodies (done by passive hemagglutination) for Wuchereria bancrofti var. pacifica. Patients with elephantiasis seldom have circulating microfilariae in their blood. Hypereosinophily is frequent but rarely high. It is similar to the one patients with microfilaremia. There is a trend towards neutropenia during lymphangitic crisis that occur on an elephantiasis limb. The IgE titer is clearly increased, the IgG one is lesser elevated. The mean values are identical to those encoutered among microfilariae asymptomatic cariers. On the other hand the serodiagnosis is more frequently positive among elephantiasic patients.
Bull Soc Pathol Exot Filiales

hal-00715424
https://hal.univ-antilles.fr/hal-00715424
PUBMED : 385164

Éditeur(s) : HAL CCSD
Résumé : International audience
Ann Soc Belg Med Trop

hal-00717072
https://hal.univ-antilles.fr/hal-00717072
PUBMED : 7018422

Éditeur(s) : HAL CCSD
Résumé : International audience
Ann Soc Belg Med Trop

hal-00717070
https://hal.univ-antilles.fr/hal-00717070
PUBMED : 7008717

Éditeur(s) : HAL CCSD
Résumé : International audience
Ann Soc Belg Med Trop

hal-00717098
https://hal.univ-antilles.fr/hal-00717098
PUBMED : 6456703

Éditeur(s) : HAL CCSD American Society of Tropical Medicine and Hygiene
Résumé : International audience
ISSN: 0002-9637

hal-00717068
https://hal.univ-antilles.fr/hal-00717068
PUBMED : 6154427

Éditeur(s) : HAL CCSD
Résumé : International audience
Lewis blood group specificities are detected in the liver Fluke: Fasciola hepatica. Such specificities had never been reported in nature, other than in the human body. The investigation of this phenomenon might contribute to a better understanding of the mechanisms involved in parasite-host relationship.
C R Seances Acad Sci D

hal-00715437
https://hal.univ-antilles.fr/hal-00715437
PUBMED : 120793

Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : International audience
Four lyophilizated liver flüke antigens and one of hydatid fluid were examined for the presence of blood group like antigens P1, A, B, M and N by an hemagglutination inhibition test with hyperimmune and natural hemagglutinating sera. P1 or P1-like substance was found in the extracts of "Fasciola hepatica" and "F. gigantica" in a lower concentration than in echinoccocal fluid. This presence may explain the occurrence of anti-P1 antibodies in patients infected with liver flüke and belonging to the P2 blood group. However biochemical studies will be necessary to determine if the P1 activity is due to the blood group P1 substance of the red cell itself or due to a P1 like substance.
ISSN: 0369-8114

hal-00715431
https://hal.univ-antilles.fr/hal-00715431
PUBMED : 392420

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
ISSN: 0035-9203

hal-00715418
https://hal.univ-antilles.fr/hal-00715418
PUBMED : 153022

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
An automated assay of anti-P1 allohemagglutinins has been carried out on 133 P2 subjects: 13 with acute hepatic distomiasis (Fascioliasis), 20 with hydatidosis and 100 healthy blood donors. Anti-P1 were detected in 100% of the distomatid sera, in 50% of the hydatid and in 29% of the healthy individuals. When compared to a reference serum test (anti-P1 standard), their concentration was found to be weak in healthy subjects, moderate in hydatidosis and exceptionally increased in acute distomiasis (up to 5-6 times the standard anti-P1 level). The 2-mercaptoethanol treatment showed that even the increased distomatid anti-P1 sera were of an IgM nature. The respective origin, synthesis and strength of these allohemagglutinins are discussed and the advantages of using distomatid IgM anti-P1 as human sera test are emphasized.
ISSN: 0042-9007

hal-00715441
https://hal.univ-antilles.fr/hal-00715441
PUBMED : 7385756

Éditeur(s) : HAL CCSD
Résumé : International audience
Nouv Presse Med

hal-00715420
https://hal.univ-antilles.fr/hal-00715420
PUBMED : 27758

Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : International audience
This observation perfectly illustrates the main epidemiological, clinical and biological peculiarities of this parasitic disease. Particularly, as it concerns a tourist who travelled across Africa for a short period of time it is possible to assess the time of exposure to infecting mosquito bites, the maturation period of time as well as the time of clinical incubation. On the other hand the value of the immunological techniques to make the diagnosis of loaiasis as well as the difficulties to treat this affection are stressed upon.
ISSN: 0181-5512

hal-00715439
https://hal.univ-antilles.fr/hal-00715439
PUBMED : 6939746