Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
ISSN: 0003-4975

hal-01563338
http://hal.univ-brest.fr/hal-01563338
DOI : 10.1016/j.athoracsur.2016.03.093
PUBMED : 27262916

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Aims: The aims of this study were to compare short-and long-term outcomes for clinical T2N0 oesophageal cancer with analysis of (i) primary surgery (S) versus neoadjuvant therapy plus surgery (NS), (ii) squamous cell carcinoma and adenocarcinoma subsets; and (iii) neoadjuvant chemoradiotherapy versus neoadjuvant chemotherapy.Methods: Data were collected from 30 European centres from 2000 to 2010. Among 2944 included patients, 355 patients (12.1%) had cT2N0 disease; 285 (S) and 70 (NS), were compared in terms of short-and long-term outcomes. Propensity score matching analyses were used to compensate for differences in baseline characteristics.Results: No significant differences between the groups were shown in terms of in hospital morbidity and mortality. Nodal disease was observed in 50% of S-group at the time of surgery, with 20% pN2/N3. Utilisation of neoadjuvant therapy was associated with significant tumour downstaging as reflected by increases in pT0, pN0 and pTNM stage 0 disease, this effect was further enhanced with neoadjuvant chemoradiotherapy. After adjustment on propensity score and confounding factors, for all patients and subset analysis of squamous cell and adenocarcinoma, neoadjuvant therapy had no significant effect upon survival or recurrence (overall, loco-regional, distant or mixed) compared to surgery alone. There were no significant differences between neoadjuvant chemotherapy and chemoradiotherapy in short-or long-term outcomes.Conclusion: The results of this study suggest that a surgery alone treatment approach should be recommended as the primary treatment approach for cT2N0 oesophageal cancer despite 50% of patients having nodal disease at the time of surgery.
ISSN: 0959-8049

hal-01666517
https://hal.univ-lorraine.fr/hal-01666517
DOI : 10.1016/j.ejca.2015.11.024

Éditeur(s) : HAL CCSD
Résumé : International audience
We consider a second-order differential system with Hessian-driven damping . An interesting property of this system is that, after introduction of an auxiliary variable y , it can be equivalently written as a first-order system in time and space. This allows us to extend the analysis to the case of a convex lower semicontinuous potential and so to introduce constraints in the model. When considering the indicator function of a closed convex set, the subdifferential operator takes account of the contact forces. In this setting, by playing with the geometrical damping parameter, we can describe nonelastic shock laws with restitution coefficient. Taking advantage of the infinite dimensional framework, we introduce a nonlinear hyperbolic PDE describing a damped oscillating system with obstacle. The system is dissipative; in the convex case each trajectory weakly converges to a minimizer of the global potential energy function. Exponential stabilization is obtained under strong convexity assumptions.
Differential Equations & Applications

hal-00803214
https://hal.archives-ouvertes.fr/hal-00803214
https://hal.archives-ouvertes.fr/hal-00803214/document
https://hal.archives-ouvertes.fr/hal-00803214/file/Attouch-Mainge-Redont-30August2011.pdf

Éditeur(s) : HAL CCSD American Society for Microbiology
Résumé : International audience
Human leishmaniasis are widely spread diseases with different clinical forms caused by about 20 species within the Leishmania genus. Leishmania species identification is relevant for therapeutic management and prognosis, especially for cutaneous and muco-cutaneous forms. Several methods are available to identify Leishmania species from culture, but they have not been standardized for the majority of the currently described species, with the exception of MultiLocus Enzyme Electrophoresis. Moreover, these techniques are expensive, time-consuming and not available in all laboratories. Within the last decade, mass spectrometry (MS) has been adapted for microorganism identification, including Leishmania However, no commercial reference mass spectral database is available. In this study, a reference mass spectral library (MSL) for Leishmania isolates, accessible through a free web-based application (mass spectral identification, MSI), was constructed and tested. It includes mass spectral data for 33 different Leishmania species, including species that infect humans, animals and phlebotomine vectors. Four laboratories on two continents evaluated MSI performance using 268 samples of which 231 were Leishmania strains. All Leishmania strains, but one, were correctly identified at least at the complex level. A risk of species misidentification within the L. donovani, L. guyanensis and L. braziliensis complexes was observed, as already reported with other techniques. The tested application was reliable, with identification results comparable to those obtained with reference methods, but with a more favorable cost-efficiency ratio. This free online identification system relies on a scalable database and can be implemented directly in the user's computers.
ISSN: 0095-1137

hal-01571305
https://hal.archives-ouvertes.fr/hal-01571305
DOI : 10.1128/JCM.00845-17
PUBMED : 28724559

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
In the Caribbean, Pterocarpus officinalis swamp forest, a coastal freshwater wetland, has been locally transformed by human activities into Colocasia esculenta monoculture (under the swamp forest) or pasture (where deforestation has occurred). The aim of this study was to evaluate the impact of three land uses of this tropical wetland (swamp forest, C. esculenta monoculture and pasture) on soil abiotic and biological features. We hypothesized that increasing the level of ecosystem alteration by agricultural intensification would negatively impact soil chemical characteristics, soil fauna diversity and carbon mineralization. As expected, land use significantly affected soil characteristics and changes followed the increasing intensity of land use. The ‘undisturbed system’, that is swamp forest, was characterized by a large soil organic matter content, a high level of soil moisture, a small phosphorus content and a slightly lower pH. These characteristics were correlated with a small faunal abundance and diversity and slow carbon (C) mineralization. The ‘low disturbance system’, that is C. esculenta monoculture, was the closest to swamp forest characteristics and changes between the both systems principally concerned a very slight decrease in organic matter content and very small increase in C mineralization and Coleoptera diversity. By contrast, all parameters (soil chemical characteristics, C mineralization and faunal abundance and diversity) were impacted in the most intensive land-use, pasture. Our study confirmed that agricultural practices have an influence on soil fauna and C mineralization processes in wetlands. Moreover, our study suggested that a C. esculenta traditional agroecosystem under swamp forest cover could be considered as an ‘eco-friendly’ agricultural practice.
ISSN: 0266-0032

hal-01562423
https://hal.archives-ouvertes.fr/hal-01562423
DOI : 10.1111/sum.12273

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
ISSN: 0309-0167

hal-01118504
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01118504
PUBMED : 20716175
DOI : 10.1111/j.1365-2559.2010.03605.x