Éditeur(s) : HAL CCSD
Résumé : National audience
La Guyane française, de par sa situation géographique et climatique équatoriale – entraînant uneimmense biodiversité – et le caractère multiculturel et multiethnique de sa population, est le siège d’unlarge panel de pathologies infectieuses et tropicales, dont certaines sont assez mal connues.La fièvre Q, la toxoplasmose, la cryptococcose ou l’infection à VIH sont communes aux pays tempérés,mais présentent ici de grandes spécificités, entraînant une prise en charge et un raisonnement médicalparfois différents. De nombreuses pathologies tropicales sont par ailleurs présentes sur un mode endémiqueet/ou épidémique : paludisme, leishmaniose, maladie de Chagas, histoplasmose, dengue, chikungunya, etc.Des personnes ayant séjourné en Guyane peuvent présenter des problèmes infectieux spécifiques deretour sur le continent européen, et ces pathologies doivent pouvoir être évoquées par l’infectiologue.
La Lettre de l'Infectiologue

inserm-01407150
http://www.hal.inserm.fr/inserm-01407150
http://www.hal.inserm.fr/inserm-01407150/document
http://www.hal.inserm.fr/inserm-01407150/file/2016%2C%20Epelboin%20-%20L%27infectiologie%20en%20Guyane%20synth%C3%A8se%20med%20trop.pdf

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
At the North-Ecuadorian convergent margin (1°S–1.5°N), the subduction of the rough Nazca oceanic plate leads to tectonic erosion of the upper plate and complex seismogenic behavior of the megathrust. We used three selected pre-stack depth migrated, multi-channel seismic reflection lines collected during the SISTEUR cruise to investigate the margin structure and decipher the impact of the subducted Atacames seamounts on tectonic erosion, interseismic coupling, and seismogenesis in the region of the 1942 Mw7.8 earthquake.This dataset highlights a subducted ∼30×40 km∼30×40 km, double-peak seamount that belongs to the Atacames seamount chain and that is associated with a deep morphologic re-entrant containing mass transport deposits.The seamount subduction uplifted the margin basement by ∼1.6 km and pervasively broke the margin by deep and intense reverse faulting ahead of the seamount, a process that is likely to weaken considerably the margin. In the seamount wake, the basement reverse fault system rotated counter-clockwise. This faulted basement is overlain with slope sediment sliding along listric normal faults that sole out onto the BSR. This superposition of deep tectonic contraction within the basement and shallow gravitational extension deformation within the sediment highlights the key role of gas hydrate on outer slope erosion.In addition to long-term regional basal erosion, the margin basement has thinned locally by an extra 0.8–1 km in response to the subduction of the Atacames seamount chain and hydrofracturing by overpressured fluids at the margin toe. This pervasively and deeply fractured margin segment is associated with a seismically quiet and GPS-modeled low interseismic coupling corridor that terminates downdip near the 1942 epicenter and locked zone. We suggest that the deeply buried double-peak Atacames seamount triggered the 1942 earthquake ahead of its leading flank. This result supports previous studies proposing that subducted seamounts provide unfavorable conditions for locking the updip segment of the plate boundary limiting the updip extent of seismogenic zones, but may favor large subduction earthquakes at greater depths.
ISSN: 0012-821X

hal-01256399
https://hal.archives-ouvertes.fr/hal-01256399
DOI : 10.1016/j.epsl.2015.10.043

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
OBJECTIVES: To compare virological effectiveness in patients who continued on a virologically successful first-line boosted protease inhibitor (PI)-containing combination antiretroviral therapy (cART) regimen or who switched to a PI-free cART including efavirenz, nevirapine or abacavir. METHODS: From the French Hospital Database on HIV, we selected 439 patients with undetectable viral load (VL) on a first-line boosted PI-containing cART regimen who switched to a PI-free combination including efavirenz, nevirapine or abacavir. Each of these patients was matched with three patients who continued to take their first-line cART regimen, on the basis of gender, age, CD4 cell count, VL, date of cART initiation and the duration of VL undetectability. Time to virological failure (VF) was analysed with Kaplan-Meier curves and Cox models. RESULTS: The 12 month probabilities of VF were 3.7% and 5.7% in non-switch and switch patients, respectively, and 3.9%, 7.2% and 9.0% in patients switching to efavirenz-, nevirapine- and abacavir-containing cART, respectively. After adjustment, only patients switching to abacavir-containing cART had a higher risk of VF than non-switch patients (adjusted hazard ratio, 1.99; 95% confidence interval, 1.05-3.79). CONCLUSIONS: Switching from a virologically successful first-line boosted PI-containing cART regimen to a non-nucleoside reverse transcriptase inhibitor-containing cART regimen containing either efavirenz or nevirapine is virologically safe, while switching to abacavir-containing cART should be avoided.
ISSN: 0305-7453

hal-00875284
https://hal.archives-ouvertes.fr/hal-00875284
DOI : 10.1093/jac/dkr208
PUBMED : 21636583

Éditeur(s) : HAL CCSD
Résumé : Annual report
We present here the results of CRS reprocessing of a 3D real dataset acquired in 2001 on the Tournemire site in France, which is an experimental site for the Institut de Radioprotection et de Sûreté Nucléaire (IRSN) to test geophysical imaging process in the context of geological nuclear waste storage. The main objective was to evaluate the ability of the methodology to recognize, in the carbonate cover of the experimental site clay layer, the prolongation of weak vertical-displacement faults seen in a tunnel within that clay layer. Previous seismic processing using the conventional common midpoint (CMP) approach did not provide satisfactory results in this cover, although the fault has beenrecognized in the carbonates underlying the clay layer. An original strategy was elaborated to define the best-possible parameters of the 3D Common-Reflection-Surface (CRS) stack. The procedure in- cluded refining the velocity search along a velocity guide, using a first CRS stack as the base of a subsequent curvature-parameter search, or a parameter smoothing before stacking. An optimal ap- proach was elaborated on a subset of the data, and furthermore applied to the whole dataset. The resulting image shows improved event continuity in the carbonate cover, which allowed for horizon picking after depth migration, as well as the estimation of post-stack geometrical attributes, such as coherency. The processing indicates a zone of degraded quality of reflection events lying in the N-S direction, above the known fault zone within the underlying formations. Such feature corresponds to an alteration zone at the earth surface. Further investigation at a higher resolution scale is planned to confirm whether this zone could be a spot of possible leakage
https://hal.archives-ouvertes.fr/hal-00857376

hal-00857376
https://hal.archives-ouvertes.fr/hal-00857376