Éditeur(s) : IDHM : Institut des Droits de l'Homme de la Martinique IDHM : Institut des Droits de l'Homme de la Martinique
Extrait de : "L'entreprise et le développement durable en Martinique" : Conférence - débat, le 6 mars 2015. Université des Antilles et de la Guyane
Description : Dans un premier temps l'intérêt se portera sur le développement durable dans un contexte historique en rappelant sa définition, puis en l'appliquant à l'entreprise avec des exemples à l'international. Dans un second temps, il sera question de comprendre comment le développement durable est vécu par les entreprises en Martinique ? Comment est-il déployé ? Dans quel domaine ?
Siècle(s) traité(s) : 21
Droits : CC-BY-NC-ND - Attribution - Pas d'utilisation commerciale - Pas de modification
Permalien : http://www.manioc.org/fichiers/V15127
V15127
V15127

Éditeur(s) : HAL CCSD American Geophysical Union (AGU)
Résumé : International audience
[1] Zircons and monazites from 6 samples of the North Ayilari dextral shear zone (NAsz), part of the Karakorum fault zone (KFZ), have been dated with the U-Th-Pb method, using both ID-TIMS and SIMS techniques. The ages reveal (1) inheritance from several events spanning a long period between the late Archean and the Jurassic; (2) an Eocene-Oligocene magmatic event (similar to 35-32 Ma); (3) an Oligo-Miocene magmatic event (similar to 25-22 Ma), at least partly synkinematic to the right-lateral deformation; and (4) a period of metamorphism metasomatism (similar to 22-14 Ma) interpreted as thermal and fluid advection in the shear zone. The Labhar Kangri granite located similar to 375 km farther Southeast along the KFZ is dated at 21.1 +/- 0.3 Ma. Such occurrence of several Oligo-Miocene granites along the KFZ, some of which show evidence for synkinematic emplacement, suggests that the fault zone played an important role in the genesis and /or collection of crustal melts. We discuss several scenarios for the onset and propagation of the KFZ, and offset estimates based on the main sutures zones. Our preferred scenario is an Oligo-Miocene initiation of the fault close to the NA range, and propagation along most of its length prior to similar to 19 Ma. In its southern half, the averaged long-term fault-rate of the KFZ is greater than 8 to 10 mm/a, in good agreement with some shorter-term estimates based on the Indus river course, or Quaternary moraines and geodesy. Our results show the KFZ cannot be considered as a small transient fault but played a major role in the collision history.
ISSN: 0278-7407

hal-00412570
https://hal.archives-ouvertes.fr/hal-00412570
DOI : 10.1029/2007TC002184

Éditeur(s) : HAL CCSD Dunod
Résumé : Ce manuel est un grand classique. Il offre un panorama complet des Sciences de la Terre et de l'Univers, du Big Bang à l'origine de l'Homme en passant par toutes les disciplines des Sciences de la Terre (tectonique des plaques, géologie structurale, géophysique, minéralogie, pétrographie, géochimie, géomorphologie, sédimentologie,...).. L'ouvrage a été complétement refondu et actualisé pour une présentation de l'ensemble des Sciences de la Terre en 40 cours. Un site compagnon, www.elements-geologie.net, accompagne cette 14e édition.
https://hal.archives-ouvertes.fr/hal-00674887

hal-00674887
https://hal.archives-ouvertes.fr/hal-00674887

Éditeur(s) : HAL CCSD American Geophysical Union (AGU)
Résumé : The role of the Karakorum fault zone (KFZ) is debated. South of 33°N, ongoing dextral-oblique slip along the SW edge of the Gar basin exhumes metamorphic and magmatic rocks of the Ayilari range. Minerals have recorded a continuum of deformation from temperatures >600–400°C down to <250_C. The 40Ar/39Ar ages, the oldest being 21.2 ± 1.0 Ma, yield minimum estimates for the initiation of the KFZ. These are in agreement with the U-Th/Pb ages constraining the onset of deformation at ca 25–22 Ma. Thermochronologic results show slow cooling for the period ca 21– 14 Ma, followed by rapid cooling between 14 and 4 Ma. These data demonstrate that right-lateral motion was in progress in the early Miocene and that shear continued at least until 4 Ma, pointing to >20 Ma of deformation along the fault. Greenschist facies deformation superimposed upon the medium- to high-grade deformation marks a kinematic change from pure dextral to dextral-normal motion associated with the onset of rapid cooling. At the regional scale, the coexistence of transtension in the Gar basin with transpression documented along the Pangong range farther north suggests another example of the ‘‘zipper tectonics'' model developed along the Red River fault. The kinematic shift induced the rise of the Ayilari range starting at 16–12 Ma and the incision of major river courses. The Indus River might have become captive of the relief at this time. The river's 120 km of apparent offset implies dextral motion at a long-term rate of ca 8.5 ± 1.5 mm/yr.
ISSN: 0278-7407

hal-00197561
https://hal.archives-ouvertes.fr/hal-00197561
https://hal.archives-ouvertes.fr/hal-00197561/document
https://hal.archives-ouvertes.fr/hal-00197561/file/Valli_Karakorum_thermochron_Tectonics_07_pre_print.pdf
DOI : 10.1029/2005TC001913

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
A dense, local network of 30 geodetic markers covering a 50 × 60 km2 area in the southwestern European Alps (Briançon region) has been temporarily surveyed in 1996, 2006 and 2011 by GPS. The aim is to measure the current deformation in this seismically active area. The study zone is characterized by a majority of extensional and dextral focal mechanisms, along north–south to N160 oriented faults. The combined analysis of the three measurement campaigns over 15 years and up to 16 years of permanent GPS data from the French RENAG network now enables to assess horizontal velocities below 1 mm/year within the local network. The long observation interval and the redundancy of the dense campaign network measurement help to constrain a significant local deformation pattern in the Briançon region, yielding an average E–W extension of 16 ± 11 nanostrain/year. We compare the geodetic deformation field to the seismic deformation rate cumulated over 37 years, and obtain good coherencies both in amplitude and direction. Moreover, the horizontal deformation localized in the Briançon region represents a major part of the Adriatic-European relative plate motion. However, the average uplift of the network in an extensional setting needs the presence of buoyancy forces in addition to plate tectonics.
ISSN: 0264-3707

hal-01119724
https://hal.archives-ouvertes.fr/hal-01119724
DOI : 10.1016/j.jog.2015.02.001

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
In places where sedimentation and erosion compete at fast rates, part of the record of past earthquakes on faults may be buried, hence hidden, in the first few metres below the surface. We developed a novel form of palaeoseismology, of geophysical type, based on the use of a dense pseudo-3-D Ground Penetrating Radar (GPR) survey to investigate such possible buried earthquake traces, on a long, fast-slipping strike-slip fault (Hope fault, New Zealand), at a site (Terako) where marked alluvial conditions prevail. We first used LiDAR data to analyse the ground surface morphology of the 2 km2 site at the greatest resolution. Nineteen morphological markers were observed, mainly alluvial terrace risers and small stream channels that are all dextrally offset by the fault by amounts ranging between 3 and 200 m. The measurements document about 10 past earthquake slip events with a mean coseismic slip of 3.3 +/- 1 m, with the most recent earthquake event having a slip of 3 +/- 0.5 m. We then investigated a detailed area of the site (400 x 600 m2) with pseudo-3-D GPR. We measured 56, similar to 400 m long, 510 m spaced GPR profiles (250 MHz), parallel to the fault and evenly distributed on either side. The analysis revealed the existence of a palaeosurface buried at about 3 m depth, corresponding to the top of alluvial terraces of different ages. That buried surface is incised by a dense network of stream channels that are all dextrally offset by the fault. We measured 48 lateral offsets in the buried channel network, more than twice than at the surface. These offsets range between 6 and 108 m, as observed at the surface, yet provide a more continuous record of the fault slip. The similarity of the successive slip increments suggests a slip per event averaging 4.4 +/- 1 m, fairly similar to that estimated from surface data. From the total surface and buried 67 offset collection, we infer that a minimum of 30 large earthquakes have broken the Hope fault at the Terako site in the last about 67 kyr, with an average coseismic slip of 3.2 +/- 1 m, a minimum average recurrence time of about 200 yr, and a magnitude of at least Mw 7.07.4. Our study therefore confirms that part of the record of past earthquakes may indeed reside in the first few metres below the surface, where it may be explored with geophysical, GPR-based palaeoseismology. Developing such a new palaeoseismological tool should provide rich information that may complement surface observations and help to document the past earthquakes on faults.
ISSN: 0956-540X

hal-00704560
https://hal.archives-ouvertes.fr/hal-00704560
DOI : 10.1111/j.1365-246X.2012.05366.x

Éditeur(s) : HAL CCSD
International Conference on Mechanisms of Mesozoic Continental Extension in Eastern Eurasia
Orléans, France

insu-00610112
https://hal-insu.archives-ouvertes.fr/insu-00610112

Éditeur(s) : HAL CCSD Météo et Climat
Résumé : International audience
D'initiative française, le projet international HyMeX a pour objectif d'améliorer la compréhension du cycle de l'eau en Méditerranée, de sa variabilité, de l'échelle de l'événement météorologique aux échelles saisonnières et interannuelles, et de ses caractéristiques sur une décennie, dans un contexte de changement global. Le projet est motivé par le rôle déterminant des processus de mésoéchelle, couplés entre l'atmosphère, la mer et la terre, sur la variabilité du système climatique et sur le déclenchement d'événements hydrométéorologiques extrêmes (précipitations et inondations, vents forts et convection océanique, canicules et sécheresses). Le projet vise enfin à évaluer les conséquences de ces événements extrêmes sur la vulnérabilité sociale et économique de cette région et sa capacité d'adaptation.
ISSN: 0026-1181

hal-00828758
https://hal.archives-ouvertes.fr/hal-00828758
https://hal.archives-ouvertes.fr/hal-00828758/document
https://hal.archives-ouvertes.fr/hal-00828758/file/meteo_2013_80_23%20%281%29.pdf
DOI : 10.4267/2042/48792

Éditeur(s) : HAL CCSD Météo et Climat
Résumé : International audience
Le premier volet du projet Cyprim vise à mieux identifier les précurseurs des cyclogenèses et des précipitations intenses en région méditerranéenne. Cet article en présente les principaux résultats. Il est question des ingrédients météorologiques à l'origine de ces systèmes, de la grande à la mésoéchelle, des causes des fortes intensités, localisations et parfois stationnarité des récipitations associées. Le coeur de l'article présente des méthodes d'identification des anomalies de tourbillon potentiel liées à l'occurrence d'événements précipitants intenses et dresse une climatologie de ces anomalies. Les perspectives d'exploitation de cette information pour améliorer la qualité des prévisions sont évoquées. ENGLISH VERSION: The first part of the CYPRIM project (Cyclogenesis and intense precipitations in the Mediterranean region) aims at a better identification of the precursor structures of cyclogenesis and heavy precipitation in the Mediterranean region. This article presents the main results. It mentions the meteorological ingredients from which these systems originate from the large to themesoscale, the reasons for large intensities, the localization and sometimes stationarity of the associated precipitations. The heart of the article shows methods for identifiying potential vorticity anomalies involved in the occurrence of heavy precipitation events and sets up a climatology of these anomalies.The perspectives of the usefulness of this information for improving forecast quality are discussed.
ISSN: 0026-1181

insu-00448250
https://hal-insu.archives-ouvertes.fr/insu-00448250
DOI : 10.4267/2042/28828

Éditeur(s) : HAL CCSD Météo et Climat
Résumé : International audience
Les risques hydrométéorologiques sont au coeur du programme de recherche HyMeX sur le cycle de l'eau en Méditerranée. HyMeX a pour ambition d'améliorer leur prévision, de mieux connaître leur variabilité à l'échelle pluriannuelle et de renseigner sur leur évolution, dans le contexte du changement climatique. À cette fin, deux campagnes de mesures dédiées à ces événements extrêmes (SOP1 : pluies intenses et crues rapides ; SOP2 : vents forts et formation d'eaux denses) sont organisées en Méditerranée nord-occidentale, entre septembre 2012 et mars 2013.
ISSN: 0026-1181

hal-00829760
https://hal.archives-ouvertes.fr/hal-00829760
DOI : 10.4267/2042/48793

Éditeur(s) : HAL CCSD Landes Bioscience
Résumé : International audience
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.
Autophagy

hal-00735751
https://hal.archives-ouvertes.fr/hal-00735751
PUBMED : 22966490

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
A network of 26 GPS sites was implemented in Iran and Northern Oman to measure displacements in this part of the Arabia–Eurasia collision zone. We present the GPS velocity field obtained from three surveys performed in 1999 September, 2001 October and 2005 September and the deduced strain tensor. This study refines previous studies inferred from only the two first surveys. Improvements are significant in NE Iran. The present-day shortening rate across the mountain belts of NE Iran is estimated to 5 ± 1 mm yr−1 at about N11°, 2 ± 1 mm yr−1 of NS shortening across the eastern Kopet Dag and 3 ± 1 mm yr−1 of NS shortening across Binalud and Kuh-e-Sorkh. Our GPS measurements emphasize the varying character of the Kopet Dag deformation between its southeastern part with prevailing thrusting at low rates and its northwestern part with dominant strike-slip activity at increasing rates. The principal axes of the horizontal strain tensor appears very homogeneous from the Zagros to the Alborz and the Kopet-Dag (N20°) and in eastern Iran (Makran and Lut block: N30°). Only NW Iran suffers a variable strain pattern which seems to wrap the Caspian basin. The strain tensor map underlines the existence of large homogeneous tectonic provinces in terms of style and amplitude of the deformation.
ISSN: 0956-540X

insu-00346744
https://hal-insu.archives-ouvertes.fr/insu-00346744
DOI : 10.1111/j.1365-246X.2007.03477.x

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The aim of this study is to assess the availability and quality of data from the International GNSS Service (IGS) Global Positioning System (GPS) network in Africa, especially for retrieving zenith tropospheric delay (ZTD), from which precipitable water vapour (PWV) can be derived, in view of application to the African Monsoon Multidisciplinary Analysis (AMMA) project. Three major error sources for the GPS data analysis evaluating PWV in Africa are the accuracy of the satellite orbits, the correction for the radio delay induced by the ionosphere and the vertical site displacements due to ocean loading. The first part of this study examines these error sources and the validity of GPS data for meteorological applications in Africa in dedicated analyses spanning the year 2001. These analyses were performed using the IGS precise orbits. Weak degradation of baseline precision with increasing baseline lengths suggests that the average orbital error is not limiting the GPS analysis in Africa. The impact of the ionosphere has been evaluated during a maximum of solar activity in 2001. The loss of L2 data has actually been observed. It amounts to 2% on average for 2001, with maxima of 8% during magnetic storm events. A slight decrease in formal accuracy of ZTD seems to be related to the loss of L2 data at the end of the day. This indicates that scintillation effects are present in the GPS observations but however are not a major limitation. The impact of ocean loading is found to be significant on ZTD estimates (up to ±2 mm in equivalent PWV). The use of a proper ocean loading model eliminates this effect. The second aspect of this study concerns the IGS analysis quality for the African stations. The accuracy has been assessed through position dispersion between individual solutions and the most recent version of the IGS combined solution IGb00, and residuals from the transformation of the IGS combined solution into the International Terrestrial Reference Frame 2005. The positioning performance of the IGS analysis is consistent with an accuracy in ZTD of ±6 mm (±1 mm in PWV), as requested for meteorological applications such as planned in AMMA.
ISSN: 1364-6826

insu-00347961
https://hal-insu.archives-ouvertes.fr/insu-00347961
DOI : 10.1016/j.jastp.2007.04.008

Éditeur(s) : HAL CCSD American Medical Association (AMA)
Résumé : International audience
IMPORTANCE Although frequently used in treating intensive care unit (ICU) patients with sepsis, empirical antifungal therapy, initiated for suspected fungal infection, has not been shown to improve outcome. OBJECTIVE To determine whether empirical micafungin reduces invasive fungal infection (IFI)-free survival at day 28. DESIGN, SETTING, AND PARTICIPANTS Multicenter double-blind placebo-controlled study of 260 nonneutropenic, nontransplanted, critically ill patients with ICU-acquired sepsis, multiple Candida colonization, multiple organ failure, exposed to broad-spectrum antibacterial agents, and enrolled between July 2012 and February 2015 in 19 French ICUs. INTERVENTIONS Empirical treatment with micafungin (100mg, once daily, for 14 days) (n = 131) vs placebo (n = 129). MAIN OUTCOMES AND MEASURES The primary end pointwas survival without proven IFI 28 days after randomization. Key secondary end points included new proven fungal infections, survival at day 28 and day 90, organ failure, serum (1-3)-beta-D-glucan level evolution, and incidence of ventilator-associated bacterial pneumonia. RESULTS Among 260 patients (mean age 63 years; 91 [35%] women), 251 (128, micafungin group; 123, placebo group) were included in the modified intent-to-treat analysis. Median values were 8 for Sequential Organ Failure Assessment (SOFA) score, 3 for number of Candida-colonized sites, and 99 pg/mL for level of (1-3)-beta-D-glucan. On day 28, there were 82 (68%) patients in the micafungin group vs 79 (60.2%) in the placebo group who were alive and IFI free (hazard ratio [HR], 1.35 [95% CI, 0.87-2.08]). Results were similar among patients with a (1-3)-beta-D-glucan level of greater than 80 pg/mL (n = 175; HR, 1.41 [95% CI, 0.85-2.33]). Day-28 IFI-free survival in patients with a high SOFA score (> 8) was not significantly different when compared between the micafungin vs placebo groups (HR, 1.69 [95% CI, 0.96-2.94]). Use of empirical micafungin decreased the rate of new invasive fungal infection in 4 of 128 patients (3%) in the micafungin group vs placebo (15/123 patients [12%]) (P =.008). CONCLUSIONS AND RELEVANCE Among nonneutropenic critically ill patients with ICU-acquired sepsis, Candida species colonization at multiple sites, and multiple organ failure, empirical treatment with micafungin, compared with placebo, did not increase fungal infection-free survival at day 28.
ISSN: 0098-7484

hal-01405822
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01405822
DOI : 10.1001/jama.2016.14655
PUBMED : 27706483

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
In this paper we investigate finite-frequency effects in crustal tomography. We developed an inversion procedure based on an exact numerical computation of the sensitivity kernels. In this approach we compute the 3D travel-time sensitivity kernels by using (1) graph theory and an additional bending to estimate accurately both rays and travel-times between source/receiver and diffraction points and (2) paraxial ray theory to estimate the amplitude along theses rays. We invert both the velocity and the hypocentre parameters, using these so-called banana-doughnut kernels and the LSQR iterative solver. We compare the ray-theoretical and the finite-frequency tomography to image the intermediate structures beneath the Gulf of Corinth (Greece), which has long been recognized as the most active continental rifting zone in the Mediterranean region. Our dataset consists of 451 local events with 9233 P- firstarrival times recorded in the western part of the Gulf (Aigion area) in the framework of the 3F-Corinth European project. Previous tomographic images showed a complex velocity crustal model and a low-dip surface that may accommodate the deformation. Accurate velocity models will help to better constrain the rifting process, which is still a subject of debate. The main results of this study show that finite-frequency tomography improves crustal tomographic images by providing better resolved images of the 3D complicated velocity structure. Because the kernels spread the information over a volume, finite-frequency tomography results in a sharpening of layer boundaries as we observed for the shallower part of the crust (down to 5 km depth) beneath the Gulf of Corinth.
ISSN: 0016-8025

insu-00354702
https://hal-insu.archives-ouvertes.fr/insu-00354702
DOI : 10.1111/j.1365-2478.2007.00683.x

Éditeur(s) : HAL CCSD BMJ Publishing Group
Résumé : International audience
BACKGROUND: Mutations in the leucine-rich-repeat kinase 2 (LRRK2) gene have been identified in families with autosomal dominant Parkinson's disease (ADPD), the most common of which is the p.G2019S substitution that has been found at varying frequencies worldwide. Because of the size of the LRRK2 gene, few studies have analysed the entire gene in large series of ADPD families. METHODS: We performed extensive mutation analyses of all 51 coding exons of the LRRK2 gene in index cases from 226 Parkinson's disease families compatible with autosomal dominant inheritance, mostly from France (n = 182) and North Africa (n = 14). RESULTS: We found 79 sequence variants, 29 of which were novel. Eight potentially or proven pathogenic mutations were found in 22 probands (9.7%). There were four novel amino acid substitutions that are potentially pathogenic (p.S52F, p.N363S, p.I810V, p.R1325Q) and two novel variants, p.H1216R and p.T1410M, that are probably not causative. The common p.G2019S mutation was identified in 13 probands (5.8%) including six from North Africa (43%). The known heterozygous p.R1441H and p.I1371V mutations were found in two probands each, and the p.E334K variant was identified in one single patient. Most potentially or proven pathogenic mutations were located in the functional domains of the Lrrk2 protein. CONCLUSION: This study leads us to conclude that LRRK2 mutations are a common cause of autosomal dominant Parkinson's disease in Europe and North Africa.
ISSN: 0022-2593

inserm-00529272
http://www.hal.inserm.fr/inserm-00529272
DOI : 10.1136/jmg.2008.062612
PUBMED : 19357115

Éditeur(s) : HAL CCSD
Résumé : International audience
Up-to-date estimates of the health outcomes of preterm children are needed for assessing perinatal care, informing parents, making decisions about care, and providing evidence for clinical guidelines. To determine survival and neonatal morbidity of infants born from 22 through 34 completed weeks' gestation in France in 2011 and compare these outcomes with a comparable cohort in 1997. The EPIPAGE-2 study is a national, prospective, population-based cohort study conducted in all maternity and neonatal units in France in 2011. A total of 2205 births (stillbirths and live births) and terminations of pregnancy at 22 through 26 weeks' gestation, 3257 at 27 through 31 weeks, and 1234 at 32 through 34 weeks were studied. Cohort data were collected from January 1 through December 31, 1997, and from March 28 through December 31, 2011. Analyses for 1997 were run for the entire year and then separately for April to December; the rates for survival and morbidities did not differ. Data are therefore presented for the whole year in 1997 and the 8-month and 6-month periods in 2011. Survival to discharge and survival without any of the following adverse outcomes: grade III or IV intraventricular hemorrhage, cystic periventricular leukomalacia, severe bronchopulmonary dysplasia, retinopathy of prematurity (stage 3 or higher), or necrotizing enterocolitis (stages 2-3). A total of 0.7% of infants born before 24 weeks' gestation survived to discharge: 31.2% of those born at 24 weeks, 59.1% at 25 weeks, and 75.3% at 26 weeks. Survival rates were 93.6% at 27 through 31 weeks and 98.9% at 32 through 34 weeks. Infants discharged home without severe neonatal morbidity represented 0% at 23 weeks, 11.6% at 24 weeks, 30.0% at 25 weeks, 47.5% at 26 weeks, 81.3% at 27 through 31 weeks, and 96.8% at 32 through 34 weeks. Compared with 1997, the proportion of infants surviving without severe morbidity in 2011 increased by 14.4% (P < .001) at 25 through 29 weeks and 6% (P < .001) at 30 through 31 weeks but did not change appreciably for those born at less than 25 weeks. The rates of antenatal corticosteroid use, induced preterm deliveries, cesarean deliveries, and surfactant use increased significantly in all gestational-age groups, except at 22 through 23 weeks. The substantial improvement in survival in France for newborns born at 25 through 31 weeks' gestation was accompanied by an important reduction in severe morbidity, but survival remained rare before 25 weeks. Although improvement in survival at extremely low gestational age may be possible, its effect on long-term outcomes requires further studies. The long-term results of the EPIPAGE-2 study will be informative in this regard.
ISSN: 2168-6211

hal-01258705
http://hal.univ-brest.fr/hal-01258705
PUBMED : 25621457
DOI : 10.1001/jamapediatrics.2014.3351

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
ISSN: 0305-7453

hal-01470808
https://hal.archives-ouvertes.fr/hal-01470808
DOI : 10.1093/jac/dkw352
PUBMED : 27609051

Éditeur(s) : HAL CCSD springer Link
Résumé : International audience
Experimental Astronomy

hal-01094521
https://hal.archives-ouvertes.fr/hal-01094521
BIBCODE : 2014ExA...tmp...41R
DOI : 10.1007/s10686-014-9383-4
ARXIV : 1310.0696

Éditeur(s) : HAL CCSD
Résumé : International audience
OBJECTIVE: To assess sperm production and aneuploidy in Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) before and after treatments. DESIGN: Multicenter, prospective, longitudinal study of lymphoma patients analyzed before treatment and after 3, 6, 12, and 24 months. SETTING: University hospitals. PATIENT(S): Forty-five HL and 13 NHL patients were investigated before and after treatment. Treatment regimens were classified in two groups: ABVD (doxorubicin, bleomycin, vinblastine, dacarbazine) with or without (+/-) radiotherapy, and CHOP (doxorubicin, cyclophosphamide, vincristine, prednisone)/MOPP-ABV (mechlorethamine, oncovin, procarbazine, prednisone-doxorubicin, bleomycin, vinblastine). A control group of 29 healthy men was also studied. INTERVENTION(S): Semen analyses and aneuploidy study by FISH were performed at each time point. MAIN OUTCOME MEASURE(S): Comparison of mean sperm characteristics and percentage of sperm aneuploidy rates before and after treatment. RESULT(S): Before treatment, HL and NHL men had altered semen characteristics and higher sperm aneuploidy rates (median 0.76 [interquartile range 0.56-0.64]) than the control group (0.54 [0.46-0.74]). After treatment, sperm production was significantly lowered 3 and 6 months after ABVD +/- radiotherapy or CHOP/MOPP-ABV. After ABVD +/- radiotherapy, the aneuploidy rate increased significantly only at 3 months, and values obtained 1 or 2 years later were lower than pretreatment values. In contrast, in the CHOP/MOPP-ABV treatment group, semen characteristics and aneuploidy rate did not return to normal levels until 2 years after treatment. CONCLUSION(S): Lymphoma itself has consequences on sperm aneuploidy frequency before treatment. Moreover, lymphoma treatments have deleterious effects on sperm chromosomes related to treatment type and time since treatment. Patient counseling is essential concerning the transient but significant sperm aneuploidy induced by lymphoma and its treatments.
Fertility and sterility

hal-01477204
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01477204
DOI : 10.1016/j.fertnstert.2016.10.001
PUBMED : 27810161