Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
Sponges are a rich source for investigation of bioactive small molecules. They have been mostly investigated for the search of new pharmacological models or therapeutic agents for the treatment of human diseases. Micro-organisms can also represent a virulent pathogen for marine invertebrates such as sponges, which need to protect themselves against these microbes. Sponges' self defence mechanisms involving dialogue molecules thus represent a pertinent research track for potent anti-infective and anti-biofilm activities such as quorum sensing inhibitors (QSIs). The investigation of the QSI crude extract of Leucetta chagosensis Dendy, 1863 led to the isolation of three new alkaloids, isonaamine D, di-isonaamidine A and leucettamine D, along with the known isonaamine A and isonaamidine A. Isonaamidine A and isonaamine D were identified as inhibitors of the three quorum sensing pathways of Vibrio harveyi (CAI-1, AI-2 and harveyi auto inducer), but isonaamidine A displayed the strongest activity on AI-2 biosensor. Both compounds are new examples of natural QSIs of V. harveyi. These results outline the importance of these secondary metabolites for their producing organisms themselves in their natural environment, as well as the potential of the marine resource for aquaculture needs.
ISSN: 0266-8254

hal-01684926
https://hal.archives-ouvertes.fr/hal-01684926
DOI : 10.1111/lam.12461
PUBMED : 26138555

Éditeur(s) : HAL CCSD
Résumé : Given a set of strings, the Common Subsequence Automaton accepts all common subsequences of these strings. Such an automaton can be deduced from other automata like the Directed Acyclic Subsequence Graph or the Subsequence Automaton. In this paper, we introduce some new issues in text algorithm on the basis of Common Subsequences related problems. Firstly, we make an overview of different existing automata, focusing on their similarities and differences. Secondly, we present a new automaton, the Constrained Subsequence Automaton, which extends the Common Subsequence Automaton, by adding an integer $q$ denoted quorum.
https://hal.inria.fr/inria-00257561

inria-00257561
https://hal.inria.fr/inria-00257561
https://hal.inria.fr/inria-00257561/document
https://hal.inria.fr/inria-00257561/file/CSAq.pdf

Éditeur(s) : Lugdun. Batavorum : apud Franciscum Hackium Amsterdam : Elzevier
Résumé : "Titre gravé sur cuivre (f. *1) suivi du faux-titre imprimé (f. *2) : "Guilielmi Pisonis, M. D. Lugduno-Batavi, de medicina Brasiliensi libri quatuor: I. De aëre, aquis, & locis. II. De morbis endemiis. III. De venenatis & antidotis. IV. De facultatibus simplicium. Et Georgii Marcgravii de Liebstad, misnici germani, historiæ rerum naturalium Brasiliæ, libri octo: quorum tres priores agunt de plantis. Quartus de piscibus. Quintus de avibus. Sextus de quadrupedibus & serpentibus. Septimus de insectis. Octavus de ipsa regione, & illius incolis. Cum appendice de Tapuyis, et Chilensibus. Joannes de Laet, Antwerpianus, in ordinem digessit & annotationes addidit, & varia ab auctore omissa supplevit & illustravit". - La 2e partie est précédée du faux-titre : "Georgii Marcgravii de Liebstad, misnici germani, historiæ rerum naturalium Brasiliæ, libri octo: quorum tres priores agunt de plantis. Quartus de piscibus. Quintus de avibus. Sextus de quadrupedibus, et serpentibus. Septimus de insectis. Octavus de ipsa regione, & illius incolis. Cum appendice de Tapuyis, et Chilensibus. Joannes de Laet, Antwerpianus, in ordinem digessit & annotationes addidit multas, & varia ab auctore omissa supplevit & illustravit". - Épître dédicatoire au comte Maurice de Nassau Edition originale. - Frontispice gravé sur cuivre par Theodor Matham. - 436 bois dans le texte, d'après Georg Marcgrave et Albert Eckhout Imprimé à Leyde par Bonaventure et Abraham Elzevier, d'après Rahir. Sig. *6, A-P4, Q2 ; -4, A-Oo4, Pp2. - Demi reliure basane, 19e siècle. - Cachet de l'Académie royale de Bordeaux. - Cachet de la bibliothèque de la Ville de Bordeaux Borba de Moraes II, 675-6. - Garrison-Morton 5303. - Nissen BBI 1553. - Nissen IVB 589. - Rahir 1077. - Sabin 63028. - Willems 1068"
Siècle(s) traité(s) : 17
Droits : Domaine public
Provenance : Ville de Bordeaux. Bibliothèque municipale
Permalien : http://www.manioc.org/patrimon/BBX17010
BBX17010