Éditeur(s) : HAL CCSD BioMed Central
Résumé : International audience
Background: HCV treatment uptake has drastically increased in HIV-HCV coinfected patients in France since direct-acting antiviral (DAA) treatment approval, resulting in HCV cure in 63% of all HIV-HCV patients by the end of 2015. We investigated the impact of scaling-up DAA on HCV prevalence in the whole HIV population and in various risk groups over the next 10 years in France using a transmission dynamic compartmental model.Methods: The model was based on epidemiological data from the French Dat’AIDS cohort. Eight risk groups wereconsidered, including high-risk (HR) and low-risk (LR) men who have sex with men (MSM) and male/female heterosexuals,intra-venous drug users, or patients from other risk groups. The model was calibrated on prevalence and incidence dataobserved in the cohort between 2012 and 2015.Results: On January 1, 2016, 156,811 patients were registered as infected with HIV in France (24,900 undiagnosedpatients) of whom 7938 (5.1%) had detectable HCV-RNA (722 undiagnosed patients). Assuming a treatmentcoverage (TC) rate of 30%/year (i.e., the observed rate in 2015), model projections showed that HCV prevalenceamong HIV patients is expected to drop to 0.81% in 2026. Sub-analyses showed a similar decrease of HIV-HCVprevalence in most risk groups, including LR MSM. Due to higher infection and reinfection rates, predicted prevalencein HR MSM remained stable from 6.96% in 2016 to 6.34% in 2026. Increasing annual TC rate in HR MSM to 50/70%would decrease HCV prevalence in this group to 2.35/1.25% in 2026. With a 30% TC rate, undiagnosed patients wouldaccount for 34% of HCV infections in 2026.Conclusions: Our model suggests that DAA could nearly eliminate coinfection in France within 10 years for most riskgroups, including LR MSM. Elimination in HR MSM will require increased TC.
ISSN: 1741-7015

Droits : info:eu-repo/semantics/OpenAccess
inserm-01685739
http://www.hal.inserm.fr/inserm-01685739
http://www.hal.inserm.fr/inserm-01685739/document
http://www.hal.inserm.fr/inserm-01685739/file/2017%2C%20Virlogeux%20-%20Modeling%20HIV-HCV%20coinfection.pdf
DOI : 10.1186/s12916-017-0979-1

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
New outcrops in the Sinis peninsula (Sardinia, Italy) allow a detailed description of the Messinian erosion surface. The correlation between outcrops, industrial seismic data and data collected offshore Oristano from a recent cruise permits reconstruction of the geometry of this surface from presently emerged interfluves to the deep canyons offshore, with: - onshore: an eroded karstic plateau presently cropping out over a 20 km × 5 km area. Well-preserved karst structures occur locally and can form several metres high reliefs. The southernmost edge of the plateau is limited by a cliff. The karstic plateau and the cliff are sealed by transgressive deposits of Pliocene age; - offshore, an interfluve zone with a mostly flat and low-angle dipping plateau, westward dissected by paleovalleys which were identified down to a depth of 2000 m. In the Oristano Gulf, Messinian paleovalleys were also identified. The Capo San Marco paleocliff was probably located on the edge of a canyon. Onshore, only one major erosion surface was identified, located at the top the Messinian sequence. Offshore, this surface extends down to the abyssal plain. The surface was emplaced above deposits related to the Terminal Carbonate Complex. This indicates that the marginal evaporites are older than the major drawdown of the Mediterranean sea-level. The major drawdown is related to the deposition of the deep evaporites.
ISSN: 0037-0738

hal-00407864
https://hal.archives-ouvertes.fr/hal-00407864
DOI : 10.1016/j.sedgeo.2008.06.005

Éditeur(s) : HAL CCSD Météo et Climat
Résumé : International audience
D'initiative française, le projet international HyMeX a pour objectif d'améliorer la compréhension du cycle de l'eau en Méditerranée, de sa variabilité, de l'échelle de l'événement météorologique aux échelles saisonnières et interannuelles, et de ses caractéristiques sur une décennie, dans un contexte de changement global. Le projet est motivé par le rôle déterminant des processus de mésoéchelle, couplés entre l'atmosphère, la mer et la terre, sur la variabilité du système climatique et sur le déclenchement d'événements hydrométéorologiques extrêmes (précipitations et inondations, vents forts et convection océanique, canicules et sécheresses). Le projet vise enfin à évaluer les conséquences de ces événements extrêmes sur la vulnérabilité sociale et économique de cette région et sa capacité d'adaptation.
ISSN: 0026-1181

hal-00828758
https://hal.archives-ouvertes.fr/hal-00828758
https://hal.archives-ouvertes.fr/hal-00828758/document
https://hal.archives-ouvertes.fr/hal-00828758/file/meteo_2013_80_23%20%281%29.pdf
DOI : 10.4267/2042/48792

Éditeur(s) : HAL CCSD Elsevier Masson
Résumé : International audience
Une surface d'émersion majeure (S1) au sein de l'unité récifale Pliocène supérieur à Pléistocène inférieur des « calcaires supérieurs » de Grande-Terre (avant-arc des Petites Antilles) révèle une baisse du niveau marin relatif d'au moins 60 m et permet de définir un nouveau découpage stratigraphique. S1 est surmontée par un cortège transgressif sablo-calcaire, puis par une formation récifale à Acropora. L'ensemble représente l'enregistrement d'un cycle eustatique complet par cette plateforme carbonatée de marge active. La comparaison avec la plate-forme carbonatée de marge stable du banc des Bahamas permet d'estimer que S1 correspond à l'émersion majeure de 1,66 Ma et qu'elle est d'origine glacio-eustatique.
ISSN: 1631-0713

hal-00180663
https://hal.archives-ouvertes.fr/hal-00180663
DOI : 10.1016/j.crte.2005.01.012

Éditeur(s) : HAL CCSD
Résumé : International audience
Up-to-date estimates of the health outcomes of preterm children are needed for assessing perinatal care, informing parents, making decisions about care, and providing evidence for clinical guidelines. To determine survival and neonatal morbidity of infants born from 22 through 34 completed weeks' gestation in France in 2011 and compare these outcomes with a comparable cohort in 1997. The EPIPAGE-2 study is a national, prospective, population-based cohort study conducted in all maternity and neonatal units in France in 2011. A total of 2205 births (stillbirths and live births) and terminations of pregnancy at 22 through 26 weeks' gestation, 3257 at 27 through 31 weeks, and 1234 at 32 through 34 weeks were studied. Cohort data were collected from January 1 through December 31, 1997, and from March 28 through December 31, 2011. Analyses for 1997 were run for the entire year and then separately for April to December; the rates for survival and morbidities did not differ. Data are therefore presented for the whole year in 1997 and the 8-month and 6-month periods in 2011. Survival to discharge and survival without any of the following adverse outcomes: grade III or IV intraventricular hemorrhage, cystic periventricular leukomalacia, severe bronchopulmonary dysplasia, retinopathy of prematurity (stage 3 or higher), or necrotizing enterocolitis (stages 2-3). A total of 0.7% of infants born before 24 weeks' gestation survived to discharge: 31.2% of those born at 24 weeks, 59.1% at 25 weeks, and 75.3% at 26 weeks. Survival rates were 93.6% at 27 through 31 weeks and 98.9% at 32 through 34 weeks. Infants discharged home without severe neonatal morbidity represented 0% at 23 weeks, 11.6% at 24 weeks, 30.0% at 25 weeks, 47.5% at 26 weeks, 81.3% at 27 through 31 weeks, and 96.8% at 32 through 34 weeks. Compared with 1997, the proportion of infants surviving without severe morbidity in 2011 increased by 14.4% (P < .001) at 25 through 29 weeks and 6% (P < .001) at 30 through 31 weeks but did not change appreciably for those born at less than 25 weeks. The rates of antenatal corticosteroid use, induced preterm deliveries, cesarean deliveries, and surfactant use increased significantly in all gestational-age groups, except at 22 through 23 weeks. The substantial improvement in survival in France for newborns born at 25 through 31 weeks' gestation was accompanied by an important reduction in severe morbidity, but survival remained rare before 25 weeks. Although improvement in survival at extremely low gestational age may be possible, its effect on long-term outcomes requires further studies. The long-term results of the EPIPAGE-2 study will be informative in this regard.
ISSN: 2168-6211

hal-01258705
http://hal.univ-brest.fr/hal-01258705
PUBMED : 25621457
DOI : 10.1001/jamapediatrics.2014.3351

Éditeur(s) : HAL CCSD Blackwell Publishing
Résumé : International audience
The study of eight stratigraphic sections at the margin of the semi-enclosed Zsambek Basin (Hungary) allows the sedimentary anatomy of oolitic-bioclastic systems in the Sarmatian of the Central Paratethys to be reconstructed. The mollusc, foraminiferal and ostracod associations indicate that the carbonate systems are Latest Badenian to Late Sarmatian in age. The Lower-Upper Sarmatian deposits are organized in superimposed subaqueous dunes prograding towards the basin on a low-angle ramp. During the Late Sarmatian, the ramp underwent subaerial erosion linked to a moderate relative fall in sea-level. Lagoonal deposits were later formed and microbial-nubeculariid-bryozoan-serpulid buildups were emplaced. The 'abnormal' marine conditions of the Sarmatian, conducive to the development of a poorly diversified flora and fauna and dominant non-skeletal grains, are linked to fluctuating salinities, mesotrophic to eutrophic conditions and perhaps high alkalinity.
ISSN: 1469-3496

hal-00429337
https://hal.archives-ouvertes.fr/hal-00429337
DOI : 10.1111/j.1365-3091.2009.01055.x

Éditeur(s) : HAL CCSD Human Kinetics
Résumé : International audience
The purpose of the present experiment was to examine whether the use of self-handicapping strategies influences participants' anxiety levels before athletic performance. Seventy-one competitive basketball players participated in the study. A repeated measures design was used, such that state cognitive and somatic anxiety intensity and direction were measured before and after participants were given the opportunity to self-handicap. Overall, participants reported their cognitive anxiety to be more facilitating after they had the opportunity to self-handicap. Thus, participants who were given the opportunity to self-handicap (i.e., use claimed and behavioral self-handicaps), reported greater increases in perceptions of cog-nitive anxiety as facilitating their performance. This study shows the importance of looking at anxiety direction, and not just anxiety intensity, when examining self-handicapping's effects on anxiety. Implications for sport psychologists are proposed.
ISSN: 1543-2793

Droits : info:eu-repo/semantics/OpenAccess
hal-01343255
https://hal.univ-antilles.fr/hal-01343255
https://hal.univ-antilles.fr/hal-01343255/document
https://hal.univ-antilles.fr/hal-01343255/file/TSP%2007-54.%20Final%20Manuscript.Self-handicapping%20and%20Anxiety%20in%20Sport%20HAL.pdf
DOI : 10.1123/tsp.22.3.304

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
BACKGROUND:Sickle cell anaemia (SCA) is a severe hereditary haemoglobinopathy characterised by haemorheological abnormalities, which play a role in the occurrence of several acute and chronic clinical complications. While βS -haplotypes and alpha-thalassaemia modulate SCA clinical severity, their effects on blood rheology have been incompletely described. The aim of this study was to test the effects of these genetic modifiers on the haemorheological properties and clinical complication of children with SCA.PROCEDURE:Steady-state haemorheological profile, biological parameters, βS -haplotypes, alpha-globin status, vaso-occlusive crisis (VOC) and acute chest syndrome frequencies were analysed in 128 children (aged 5 to 18 years) with SCA.RESULTS:Patients with alpha-thalassaemia showed increased red blood cell (RBC) deformability and aggregation compared to those without. Median VOC rate was higher in patients with homozygous alpha-thalassaemia compared to those with a normal alpha genotype. Conversely, the haemorheological profile and clinical complications were not influenced by the βS -haplotypes in our study.CONCLUSION:Our results demonstrate that alpha-thalassaemia is associated with higher risk for VOC events in children with SCA, which may be due in part to its effects on RBC deformability and aggregation.
ISSN: 1545-5009

hal-01668317
https://hal.univ-antilles.fr/hal-01668317
DOI : 10.1002/pbc.26455
PUBMED : 28097791